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1. 发明授权

US07270966B2 Human pyrimidine receptor 有权
标题翻译：人嘧啶受体
公开(公告)号：US07270966B2
公开(公告)日：2007-09-18
申请号：US10753695
申请日：2004-01-08
申请人： Didier Communi , Marc Parmentier , Jean-Marie Boeynaems , Sabine Pirotton
发明人： Didier Communi , Marc Parmentier , Jean-Marie Boeynaems , Sabine Pirotton
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide
摘要翻译：本发明提供了对嘌呤核苷酸优先选择嘧啶核苷酸优选尿苷三磷酸的受体。对嘌呤核苷酸优先选择嘧啶核苷酸的受体是指嘧啶核苷酸和嘌呤核苷酸不具有同等活性和等同性的受体。这意味着在这些激动剂存在下，根据本发明的受体具有功能性反应（优选三聚磷酸肌醇（IP3），二酰基甘油（DAG）或钙离子）的积累）以降低嘧啶核苷酸浓度，优选尿苷三磷酸嘌呤核苷酸或与嘌呤核苷酸相似浓度的嘧啶核苷酸的更重要的功能反应

2. 发明申请

US20060078918A1 Natural ligand for orphan G protein coupled receptor GPR86 and methods of use 失效
标题翻译：孤儿G蛋白偶联受体GPR86的天然配体及其使用方法
公开(公告)号：US20060078918A1
公开(公告)日：2006-04-13
申请号：US11216987
申请日：2005-08-31
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a method of detecting the dysregulation of GPR86 activity.
摘要翻译：本发明涉及检测GPR86活性失调的方法。

3. 发明申请

US20050158800A1 G-coupled receptor showing selective affinity for ATP 有权
公开(公告)号：US20050158800A1
公开(公告)日：2005-07-21
申请号：US10976678
申请日：2004-10-29
申请人： Didier Communi , Jean-Marie Boeynaems
发明人： Didier Communi , Jean-Marie Boeynaems
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61P35/00 , A61P37/04 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/705 , C12N2799/021
摘要： The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.

4. 发明授权

US07485703B2 Antibody against G-protein coupled receptor showing selective affinity for ATP and uses therefor 有权
标题翻译：抗G蛋白偶联受体的抗体显示出对ATP的选择性亲和力并用于其
公开(公告)号：US07485703B2
公开(公告)日：2009-02-03
申请号：US11384733
申请日：2006-03-20
申请人： Didier Communi , Jean-Marie Boeynaems
发明人： Didier Communi , Jean-Marie Boeynaems
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to isolated antibodies both polyclonal and monoclonal, that specifically bind to a G-protein coupled receptor showing selective affinity for ATP. The invention further comprises a pharmaceutical composition comprising antibodies that specifically bind to the G-protein coupled receptor showing selective affinity for ATP.
摘要翻译：本发明涉及分离的多克隆和单克隆抗体，其特异性结合显示对ATP的选择性亲和力的G蛋白偶联受体。本发明还包括药物组合物，其包含特异性结合G蛋白偶联受体的抗体，其表现出对ATP的选择性亲合力。

5. 发明授权

US06946244B2 Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13) 有权
标题翻译：识别G蛋白偶联受体GPR86（P2Y13）的配体，激动剂和拮抗剂的方法
公开(公告)号：US06946244B2
公开(公告)日：2005-09-20
申请号：US09924125
申请日：2001-08-07
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillion , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillion , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： A01K67/027 , A61K31/7076 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/00 , A61P19/10 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/06 , A61P37/08 , C07K14/47 , C07K14/705 , C07K16/28 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01N37/00 , C12Q1/00 , G01N35/567
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
摘要翻译：本发明涉及表达编码G蛋白偶联受体的核苷酸序列的重组细胞，其具有与SEQ ID NO.1具有超过70％序列同一性的氨基酸序列，以及使用药物筛选方法和试剂盒，其使用孤儿G蛋白偶联受体GPR86（以下称为ADP（P2Y 13 N）的受体）和同源序列，相应的多核苷酸和所述重组细胞鉴定适用于诊断的激动剂，反向激动剂和拮抗剂化合物，预防和/或治疗各种疾病和障碍。

6. 发明授权

US07422846B2 Natural ligand for orphan G protein coupled receptor GPR86 and methods of use 失效
标题翻译：孤儿G蛋白偶联受体GPR86的天然配体及其使用方法
公开(公告)号：US07422846B2
公开(公告)日：2008-09-09
申请号：US11216987
申请日：2005-08-31
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillian , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillian , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： C12Q1/00 , G01N33/53 , G01N35/567
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a method of detecting the dysregulation of GPR86 activity.
摘要翻译：本发明涉及检测GPR86活性失调的方法。

7. 发明申请

US20070044166A1 P2Y4 Receptor transgenic and knockout non-human mammals 审中-公开
标题翻译： P2Y4受体转基因和敲除非人哺乳动物
公开(公告)号：US20070044166A1
公开(公告)日：2007-02-22
申请号：US11483432
申请日：2006-07-07
申请人： Didier Communi , Sabine Pirotton , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Sabine Pirotton , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： A01K67/027
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide
摘要翻译：本发明提供了对嘌呤核苷酸优先选择嘧啶核苷酸优选尿苷三磷酸的受体。对嘌呤核苷酸优先选择嘧啶核苷酸的受体是指嘧啶核苷酸和嘌呤核苷酸不具有同等活性和等同性的受体。这意味着在这些激动剂存在下，根据本发明的受体具有功能性反应（优选三聚磷酸肌醇（IP3），二酰基甘油（DAG）或钙离子）的积累）以降低嘧啶核苷酸浓度，优选尿苷三磷酸嘌呤核苷酸或与嘌呤核苷酸相似浓度的嘧啶核苷酸的更重要的功能反应

8. 发明申请

US20060160149A1 G-coupled receptor showing selective affinity for ATP 有权
公开(公告)号：US20060160149A1
公开(公告)日：2006-07-20
申请号：US11384733
申请日：2006-03-20
申请人： Didier Communi , Jean-Marie Boeynaems
发明人： Didier Communi , Jean-Marie Boeynaems
IPC分类号： G01N33/567 , C07K16/28
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.

9. 发明申请

US20050203282A1 G-coupled receptor showing selective affinity for ATP 有权
标题翻译： G耦合受体显示出对ATP的选择性亲和力
公开(公告)号：US20050203282A1
公开(公告)日：2005-09-15
申请号：US10977395
申请日：2004-10-29
申请人： Didier Communi , Jean-Marie Boeynaems
发明人： Didier Communi , Jean-Marie Boeynaems
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61P35/00 , A61P37/04 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , C07K16/28
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/705 , C12N2799/021
摘要： The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
摘要翻译：本发明涉及分离的G蛋白偶联受体，编码受体的核酸序列和能够表达受体的宿主细胞。本发明还包括用于检测G蛋白偶联受体的表达的方法，以及用于鉴定受体的激动剂或拮抗剂的方法。本发明还包括制备分离的G蛋白偶联受体的方法。

10. 发明授权

US07312317B2 P2Y4 antibodies 有权
标题翻译： P2Y4抗体
公开(公告)号：US07312317B2
公开(公告)日：2007-12-25
申请号：US10811198
申请日：2004-03-26
申请人： Didier Communi , Jean-Marie Boeynaems , Marc Parmentier , Sabine Pirotton
发明人： Didier Communi , Jean-Marie Boeynaems , Marc Parmentier , Sabine Pirotton
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide.
摘要翻译：本发明提供了对嘌呤核苷酸优先选择嘧啶核苷酸优选尿苷三磷酸的受体。对嘌呤核苷酸优先选择嘧啶核苷酸的受体是指嘧啶核苷酸和嘌呤核苷酸不具有同等活性和等同性的受体。这意味着在这些激动剂存在下，根据本发明的受体具有功能性反应（优选三聚磷酸肌醇（IP3），二酰基甘油（DAG）或钙离子）的积累）以降低嘧啶核苷酸浓度，优选尿苷三磷酸嘌呤核苷酸或与嘌呤核苷酸相似浓度的嘧啶核苷酸的更重要的功能反应。

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