专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06716823B1 Noninvasive genetic immunization, expression products therefrom, and uses thereof 有权
公开(公告)号：US06716823B1
公开(公告)日：2004-04-06
申请号：US09533149
申请日：2000-03-23
申请人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
发明人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
IPC分类号： A61K3170
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/08 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55522 , A61K2039/55555 , A61K2039/60 , C12N2710/10043 , C12N2760/16134 , C12N2760/16171
摘要： Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal. The vector can include and express an exogenous nucleic acid molecule encoding an epitope or gene product of interest. The systemic immune response can be to or from the epitope or gene product. The nucleic acid molecule can encode an epitope of interest and/or an antigen of interest and/or a nucleic acid molecule that stimulates and/or modulates an immunological response and/or stimulates and/or modulates expression, e.g., transcription and/or translation, such as transcription and/or translation of an endogenous and/or exogenous nucleic acid molecule; e.g., one or more of influenza hemagglutinin, influenza nuclear protein, influenza M2, tetanus toxin C-fragment, anthrax protective antigen, anthrax lethal factor, rabies glycoprotein, HBV surface antigen, HIV gp 120, HIV gp 160, human carcinoembryonic antigen, malaria CSP, malaria SSP, malaria MSP, malaria pfg, and mycobacterium tuberculosis HSP; and/or a therapeutic, an immunomodulatory gene, such as co-stimulatory gene and/or a cytokine gene. The immune response can be induced by the vector expressing the nucleic acid molecule in the animal's cells. The animal's cells can be epidermal cells. The immune response can be against a pathogen or a neoplasm. A prophylactic vaccine or a therapeutic vaccine or an immunological composition can include the vector. The animal can be a vertebrate, e.g., a mammal, such as human, a cow, a horse, a dog, a cat, a goat, a sheep or a pig; or fowl such as turkey, chicken or duck. The vector can be one or more of a viral vector, including viral coat, e.g., with some or all viral genes deleted therefrom, bacterial, protozoan, transposon, retrotransposon, and DNA vector, e.g., a recombinant vector; for instance, an adenovirus, such as an adenovirus defective in its E1 and/or E3 and/or E4 region(s). The method can encompass applying a delivery device including the vector to the skin of the animal, as well as such a method further including disposing the vector in and/or on the delivery device. The vector can have all viral genes deleted therefrom. The vector can induce a therapeutic and/or an anti-tumor effect in the animal, e.g., by expressing an oncogene, a tumor-suppressor gene, or a tumor-associated gene. Immunological products generated by the expression, e.g., antibodies, cells from the methods, and the expression products, are likewise useful in in vitro and ex vivo applications, and such immunological and expression products and cells and applications are disclosed and claimed. Methods for expressing a gene product in vivo and products therefor and therefrom including mucosal and/or intranasal administration of an adenovirus, advantageously an E1 and/or E3 and/or E4 defective or deleted adenovirus, such as a human adenovirus or canine adenovirus, are also disclosed and claimed.

2. 发明授权

US06348450B1 Noninvasive genetic immunization, expression products therefrom and uses thereof 有权
标题翻译：无创遗传免疫，其表达产物及其用途
公开(公告)号：US06348450B1
公开(公告)日：2002-02-19
申请号：US09563826
申请日：2000-05-03
申请人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi , Kent Rigby van Kampen
发明人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi , Kent Rigby van Kampen
IPC分类号： A61K4800
CPC分类号： A61K39/08 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55555 , A61K2039/60 , C12N2710/10343 , C12N2760/16134
摘要： Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal. The vector can include and express an exogenous nucleic acid molecule encoding an epitope or gene product of interest. The systemic immune response can be to or from the epitope or gene product. The nucleic acid molecule can encode an epitope of interest and/or an antigen of interest and/or a nucleic acid molecule that stimulates and/or modulates an immunological response and/or stimulates and/or modulates expression, e.g., transcription and/or translation, such as transcription and/or translation of an endogenous and/or exogenous nucleic acid molecule; e.g., one or more of influenza hemagglutinin, influenza nuclear protein, tetanus toxin C-fragment, anthrax protective antigen, HIV gp 120, human carcinoembryonic antigen, and/or a therapeutic, an immunomodulatory gene, such as co-stimulatory gene and/or a cytokine gene. The immune response can be induced by the vector expressing the nucleic acid molecule in the animal's cells. The immune response can be against a pathogen or a neoplasm. A prophylactic vaccine or a therapeutic vaccine or an immunological composition can include the vector.
摘要翻译：公开和要求的是在动物中非侵入性遗传免疫的方法和/或在动物中诱导全身性免疫或治疗反应的方法，其产品及其用途。所述方法可以包括使动物的皮肤与有效诱导动物体内免疫或治疗反应的量的载体接触。载体可以包括并表达编码感兴趣的表位或基因产物的外源核酸分子。全身免疫应答可以来自表位或基因产物。核酸分子可以编码感兴趣的表位和/或感兴趣的抗原和/或刺激和/或调节免疫应答和/或刺激和/或调节表达的核酸分子，例如转录和/或翻译，例如内源和/或外源核酸分子的转录和/或翻译; 例如流感血凝素，流感核蛋白，破伤风毒素C片段，炭疽保护性抗原，HIV gp120，人癌胚抗原和/或治疗性免疫调节基因中的一种或多种，例如共刺激基因和/或细胞因子基因。可以通过在动物细胞中表达核酸分子的载体诱导免疫应答。免疫应答可以针对病原体或肿瘤。预防性疫苗或治疗性疫苗或免疫组合物可以包括载体。

3. 发明授权

US06706693B1 Vaccination by topical application of genetic vectors 有权
标题翻译：通过局部应用遗传载体接种疫苗
公开(公告)号：US06706693B1
公开(公告)日：2004-03-16
申请号：US09402527
申请日：2000-01-03
申请人： De-chu Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
发明人： De-chu Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
IPC分类号： A61K4800
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/57 , C12N2799/02 , C12N2799/022
摘要： The present invention provides a method of inducing an immune response in a non-invasive mode, comprising the step of: contacting skin of an individual in need of such treatment topically by applying to said skin an immunologically effective concentration of a genetic vector encoding a gene of interest. Also provided is a method of inducing an anti-tumor immune response in an animal in need of such treatment, comprising the step of: contacting skin of said animal topically by applying to said skin an immunologically effective concentration of a vector encoding a gene which encodes an antigen which induces an anti-tumor effect in said animal following administration. The genetic vector may include adenovirus recombinants, DNA/adenovirus complexes, DNA/liposome complexes, or any other vectors capable of expressing transgenes. Topical application of geneticvectors may preferably include a device as designed therein.
摘要翻译：本发明提供以非侵入性模式诱导免疫应答的方法，其包括以下步骤：通过向所述皮肤施用免疫有效浓度的编码基因的遗传载体，接触需要这种治疗的个体的皮肤，出于兴趣。还提供了在需要这种治疗的动物中诱导抗肿瘤免疫应答的方法，包括以下步骤：通过向所述皮肤施用免疫有效浓度的编码编码的基因的载体来局部接触所述动物的皮肤在给药后在所述动物中诱导抗肿瘤作用的抗原。遗传载体可以包括腺病毒重组体，DNA /腺病毒复合物，DNA /脂质体复合物或能够表达转基因的任何其他载体。遗传医生的局部应用可以优选地包括其中设计的装置。

4. 发明申请

US20110263962A1 BRAIN FUNCTION DECODING PROCESS AND SYSTEM 审中-公开
标题翻译：脑功能解码过程和系统
公开(公告)号：US20110263962A1
公开(公告)日：2011-10-27
申请号：US13083335
申请日：2011-04-08
申请人： Donald H. Marks
发明人： Donald H. Marks
IPC分类号： A61B5/05
CPC分类号： A61B5/16 , A61B5/055
摘要： A method of interpreting cognitive response to a stimulus is disclosed. The method includes collecting baseline neural activity data from a subject absent a stimulus. Neural activity data is collected while the subject is being stimulated through exposure to a stimulus. A unique three-dimensional cognitive engram is then plotted representative of cerebral regions of stimulated neural activity caused by the stimulus. A novel graphical representation is plotted in three dimensions to indicate the brain region response unique to that stimulus.
摘要翻译：公开了一种解释对刺激的认知反应的方法。该方法包括从没有刺激的对象收集基线神经活动数据。当通过暴露于刺激物刺激受试者时收集神经活动数据。然后，将独特的三维认知能谱绘制代表由刺激引起的刺激的神经活动的脑区域。一个新颖的图形表示绘制在三维上，以指示该刺激特有的脑区域反应。

5. 发明授权

US07627370B2 Brain function decoding process and system 有权
标题翻译：脑功能解码过程和系统
公开(公告)号：US07627370B2
公开(公告)日：2009-12-01
申请号：US11180871
申请日：2005-07-13
申请人： Donald H. Marks
发明人： Donald H. Marks
IPC分类号： A61B5/0476 , A61B5/05
CPC分类号： A61B5/16 , A61B5/055
摘要： A method of interpreting cognitive response to a stimulus is disclosed. The method includes collecting baseline neural activity data from a subject absent a stimulus. Neural activity data is collected while the subject is being stimulated through exposure to a stimulus. A unique three-dimensional cognitive engram is then plotted representative of cerebral regions of stimulated neural activity caused by the stimulus. A novel graphical representation is plotted in three dimensions to indicate the brain region response unique to that stimulus.
摘要翻译：公开了一种解释对刺激的认知反应的方法。该方法包括从没有刺激的对象收集基线神经活动数据。当通过暴露于刺激物刺激受试者时收集神经活动数据。然后，将独特的三维认知能谱绘制代表由刺激引起的刺激的神经活动的脑区域。一个新颖的图形表示绘制在三维上，以指示该刺激特有的脑区域反应。

6. 发明申请

US20190159712A1 BRAIN FUNCTION DECODING PROCESS AND SYSTEM 审中-公开
公开(公告)号：US20190159712A1
公开(公告)日：2019-05-30
申请号：US16265045
申请日：2019-02-01
申请人： Donald H. Marks
发明人： Donald H. Marks
IPC分类号： A61B5/16 , A61B5/00 , A61B5/055 , G01R33/48
摘要： A process of correlating cognitive response to a stimulus is provided by collecting biometric data with a camera having a microprocessor for modifying an image by localizing eyes within a face in the image, collecting neural activity data from a subject while exposed to a stimulus and mapping neural activation in response to the stimulus onto neuronal structure of a subject brain. A unique three-dimensional cognitive engram representative of the neural activity caused by the stimulus is then constructed. The cognitive engram is then compiled in a database containing a plurality of engrams, each of which is associated with a different stimulus for interpreting cognitive response. Then, each unique three-dimensional cognitive engram stored in the database is correlated with the biometric data representative of a stimulus.

7. 发明申请

US20100249573A1 BRAIN FUNCTION DECODING PROCESS AND SYSTEM 审中-公开
标题翻译：脑功能解码过程和系统
公开(公告)号：US20100249573A1
公开(公告)日：2010-09-30
申请号：US12731264
申请日：2010-03-25
申请人： Donald H. Marks
发明人： Donald H. Marks
IPC分类号： A61B5/055
CPC分类号： G01R33/4806 , A61B5/055 , A61B5/1176 , G06K9/00
摘要： The present invention provides a process of correlating cognitive response to a stimulus by collecting neural activity data from one or more subjects while the subject is exposed to a stimulus. A unique three-dimensional cognitive engram representative of the neural activity caused by the stimulus is then plotted. A unique three-dimensional cognitive engram with biometric data representative of said stimulus is then correlated.
摘要翻译：本发明提供了一种通过在受试者暴露于刺激中从一个或多个受试者收集神经活动数据来将认知反应与刺激相关联的过程。然后绘制代表由刺激引起的神经活动的独特的三维认知能量图。然后将具有代表所述刺激的生物特征数据的独特的三维认知能量图相关联。

8. 发明申请

US20100069777A1 BRAIN FUNCTION DECODING PROCESS AND SYSTEM 审中-公开
标题翻译：脑功能解码过程和系统
公开(公告)号：US20100069777A1
公开(公告)日：2010-03-18
申请号：US12626208
申请日：2009-11-25
申请人： Donald H. Marks
发明人： Donald H. Marks
IPC分类号： A61B5/0484
CPC分类号： A61B5/16 , A61B5/055
摘要： A method of interpreting cognitive response to a stimulus is disclosed. The method includes collecting baseline neural activity data from a subject absent a stimulus. Neural activity data is collected while the subject is being stimulated through exposure to a stimulus. A unique three-dimensional cognitive engram is then plotted representative of cerebral regions of stimulated neural activity caused by the stimulus. A novel graphical representation is plotted in three dimensions to indicate the brain region response unique to that stimulus.
摘要翻译：公开了一种解释对刺激的认知反应的方法。该方法包括从没有刺激的对象收集基线神经活动数据。当通过暴露于刺激物刺激受试者时收集神经活动数据。然后，将独特的三维认知能谱绘制代表由刺激引起的刺激的神经活动的脑区域。一个新颖的图形表示绘制在三维上，以指示该刺激特有的脑区域反应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式