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1. 发明授权

US06706693B1 Vaccination by topical application of genetic vectors 有权
标题翻译：通过局部应用遗传载体接种疫苗
公开(公告)号：US06706693B1
公开(公告)日：2004-03-16
申请号：US09402527
申请日：2000-01-03
申请人： De-chu Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
发明人： De-chu Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
IPC分类号： A61K4800
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/57 , C12N2799/02 , C12N2799/022
摘要： The present invention provides a method of inducing an immune response in a non-invasive mode, comprising the step of: contacting skin of an individual in need of such treatment topically by applying to said skin an immunologically effective concentration of a genetic vector encoding a gene of interest. Also provided is a method of inducing an anti-tumor immune response in an animal in need of such treatment, comprising the step of: contacting skin of said animal topically by applying to said skin an immunologically effective concentration of a vector encoding a gene which encodes an antigen which induces an anti-tumor effect in said animal following administration. The genetic vector may include adenovirus recombinants, DNA/adenovirus complexes, DNA/liposome complexes, or any other vectors capable of expressing transgenes. Topical application of geneticvectors may preferably include a device as designed therein.
摘要翻译：本发明提供以非侵入性模式诱导免疫应答的方法，其包括以下步骤：通过向所述皮肤施用免疫有效浓度的编码基因的遗传载体，接触需要这种治疗的个体的皮肤，出于兴趣。还提供了在需要这种治疗的动物中诱导抗肿瘤免疫应答的方法，包括以下步骤：通过向所述皮肤施用免疫有效浓度的编码编码的基因的载体来局部接触所述动物的皮肤在给药后在所述动物中诱导抗肿瘤作用的抗原。遗传载体可以包括腺病毒重组体，DNA /腺病毒复合物，DNA /脂质体复合物或能够表达转基因的任何其他载体。遗传医生的局部应用可以优选地包括其中设计的装置。

2. 发明申请

US20050239701A1 Transient and/or permanent modification of sexual behavior and/or fertility using recombinant chimeric GnRH 审中-公开
标题翻译：使用重组嵌合GnRH来暂时和/或永久地修改性行为和/或生育力
公开(公告)号：US20050239701A1
公开(公告)日：2005-10-27
申请号：US10966842
申请日：2004-10-15
申请人： Henry Baker , De-chu Tang , Kent Van Kampen
发明人： Henry Baker , De-chu Tang , Kent Van Kampen
IPC分类号： A61K38/09 , A61K38/16 , A61K38/24 , A61K39/00 , A61K39/385 , A61K48/00 , C07K7/23 , C12N20060101
CPC分类号： C07K7/23 , A61K38/09 , A61K48/00 , C07K2317/00 , C07K2319/00
摘要： The invention provides an immunogenic composition comprising a GnRH multimer and an antigenic carrier, an immunogenic composition comprising a recombinant vector containing a nucleic acid molecule encoding a GnRH multimer and optionally an antigenic carrier, antibodies elicited by the immunogenic compositions, and methods of using the immunogenic compositions and antibodies for modifying sexual physiology and behavior, improving the organoleptic properties of meat, and treating androgen-dependent prostate tumors and GnRH-sensitive ovarian tumors.
摘要翻译：本发明提供了包含GnRH多聚体和抗原载体的免疫原性组合物，包含含有编码GnRH多聚体和任选的抗原载体的核酸分子的重组载体的免疫原性组合物，由免疫原性组合物引发的抗体，以及使用免疫原性用于改变性生理和行为的组合物和抗体，改善肉的感官特性，以及治疗雄激素依赖性前列腺肿瘤和GnRH敏感性卵巢肿瘤。

3. 发明申请

US20070178115A1 Immunization of avians by administration of non-replicating vectored vaccines 审中-公开
标题翻译：通过施用非复制载体疫苗免疫鸟类
公开(公告)号：US20070178115A1
公开(公告)日：2007-08-02
申请号：US11504152
申请日：2006-08-15
申请人： De-chu Tang , Kent Kampen , Haroldo Toro
发明人： De-chu Tang , Kent Kampen , Haroldo Toro
IPC分类号： A61K39/29 , C12N15/861
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/6075 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2760/16122 , C12N2760/16134 , Y02A50/467
摘要： The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to recombinant human adenovirus vectors for delivery of avian immunogens and antigens, such as avian influenza into avians. The invention also provides methods of introducing and expressing an avian immunogen in avian subjects, including avian embryos, as well as methods of eliciting an immunogenic response in avian subjects to avian immunogens.
摘要翻译：本发明一般涉及免疫学和疫苗技术领域。更具体地，本发明涉及用于将鸟类免疫原和抗原（例如禽流感）递送至鸟类的重组人腺病毒载体。本发明还提供了在禽类受试者（包括禽类胚胎）中引入和表达禽类免疫原的方法，以及在禽类受试者中对禽类免疫原引发免疫原性反应的方法。

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