专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08664276B2 Stilbene analogs and methods of treating cancer 有权
标题翻译：二苯乙烯类似物和治疗癌症的方法
公开(公告)号：US08664276B2
公开(公告)日：2014-03-04
申请号：US13360109
申请日：2012-01-27
申请人： David Watt , Chunming Liu , Vitaliy M. Sviripa , Wen Zhang
发明人： David Watt , Chunming Liu , Vitaliy M. Sviripa , Wen Zhang
IPC分类号： A61K31/136 , C07C211/45
CPC分类号： A61K31/03 , A61K31/44 , C07C39/21 , C07C43/23 , C07C211/48 , C07C211/52 , C07C291/04 , C07D233/64 , C07D295/073 , C07D495/04 , C09B23/148 , G01N33/57484 , G01N33/582 , G01N2800/52
摘要： Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. Such stilbene analogs include, for example, compounds of the following formula: wherein Ra, Rb, R4, R6, R7, R9 and R10 are all H; R2 and R3 are independently H, halo, amino, alkylamino, dialkylamino, N-oxides of dialkylamino, arylalkylamino, trialkylammonium, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONR11R12, NR11CO(R13), NR11COO(R13) or NR11CONR12R13; R11, R12 and R13, are independently, H, alkyl, aryl, heteroaryl or a fluorine; R8 is NRCRdZ wherein Rc is H, alkyl, alkoxy, aryl or heteroaryl, Rd is an alkyl group, Z is a an unshared pair of electrons, H, alkyl or oxygen; and R1 and R5 are halogen.
摘要翻译：公开了可用于治疗各种癌症的芪类似物和药物组合物，包括但不限于结肠直肠癌（CRC）和乳腺癌。这样的1,2-二苯乙烯类似物包括例如下式的化合物：其中R a，R b，R 4，R 6，R 7，R 9和R 10均为H; R2和R3独立地是H，卤素，氨基，烷基氨基，二烷基氨基，二烷基氨基，芳基烷基氨基，三烷基铵，巯基，烷硫基，烷酰基，硝基，亚硝酰基，氰基，烷氧基，烯氧基，芳基，杂芳基，磺酰基，磺酰胺，CONR11R12 ，NR 11 CO（R 13），NR 11 COO（R 13）或NR 11 CONR 12 R 13; R 11，R 12和R 13独立地为H，烷基，芳基，杂芳基或氟; R8是NRCRdZ，其中Rc是H，烷基，烷氧基，芳基或杂芳基，Rd是烷基，Z是未共享的电子对，H，烷基或氧; 并且R 1和R 5是卤素。

2. 发明申请

US20120196874A1 STILBENE ANALOGS AND METHODS OF TREATING CANCER 有权
标题翻译： STILBENE模拟和治疗癌症的方法
公开(公告)号：US20120196874A1
公开(公告)日：2012-08-02
申请号：US13360109
申请日：2012-01-27
申请人： David WATT , Chunming Liu , Vitaliy M. Sviripa , Wen Zhang
发明人： David WATT , Chunming Liu , Vitaliy M. Sviripa , Wen Zhang
IPC分类号： A61K31/05 , C07C43/23 , A61K31/09 , C07C291/04 , A61K31/136 , C07C211/52 , C07D495/04 , A61K31/4188 , C07D295/073 , A61K31/495 , C07D233/64 , A61K31/4164 , A61P35/00 , G01N33/53 , G01N33/566 , C12Q1/68 , C07C39/21
CPC分类号： A61K31/03 , A61K31/44 , C07C39/21 , C07C43/23 , C07C211/48 , C07C211/52 , C07C291/04 , C07D233/64 , C07D295/073 , C07D495/04 , C09B23/148 , G01N33/57484 , G01N33/582 , G01N2800/52
摘要： Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.
摘要翻译：公开了可用于治疗各种癌症的芪类似物和药物组合物，包括但不限于结肠直肠癌（CRC）和乳腺癌。卤化1,2-二苯乙烯类似物包括二苯乙烯环上的氮杂芳基和/或氨基。

3. 发明申请

US20200043145A1 EYE TEXTURE INPAINTING 审中-公开
公开(公告)号：US20200043145A1
公开(公告)日：2020-02-06
申请号：US16051083
申请日：2018-07-31
申请人： Chen Cao , Wen Zhang , Menglei Chai , Linjie Luo
发明人： Chen Cao , Wen Zhang , Menglei Chai , Linjie Luo
IPC分类号： G06T5/00 , G06K9/00 , G06T5/50 , G06T7/40
摘要： Systems, devices, media, and methods are presented for generating texture models for objects within a video stream. The systems and methods access a set of images as the set of images are being captured at a computing device. The systems and methods determine, within a portion of the set of images, an area of interest containing an eye and extract an iris area from the area of interest. The systems and methods segment a sclera area within the area of interest and generate a texture for the eye based on the iris area and the sclera area.

4. 发明申请

US20140188417A1 Electrical impedance detecting device of portable electrical impedance imaging system and detecting method thereof 有权
标题翻译：便携式电阻抗成像系统的电阻抗检测装置及其检测方法
公开(公告)号：US20140188417A1
公开(公告)日：2014-07-03
申请号：US13877317
申请日：2011-10-13
申请人： Xiuzhen Dong , Xuyang Huo , Fusheng You , Xuetao Shi , Feng Fu , Ruigang Liu , Zhenyu Ji , Canhua Xu , Bin Yang , Min Yang , Jiaxue Qi , Wen Zhang , Nan Wang
发明人： Xiuzhen Dong , Xuyang Huo , Fusheng You , Xuetao Shi , Feng Fu , Ruigang Liu , Zhenyu Ji , Canhua Xu , Bin Yang , Min Yang , Jiaxue Qi , Wen Zhang , Nan Wang
IPC分类号： G01R27/02
CPC分类号： G01R27/02 , A61B5/053 , A61B5/0536 , A61B5/7225 , G01R27/14
摘要： An electrical impedance detecting device of a portable electrical impedance imaging system by utilizing a theory of sending excitation signal and detecting response signal and a method thereof, wherein the excitation signal is a constant square wave excitation current signal, the response voltage signal on a target is transformed to a square wave signal with appropriate amplitudes by buffering, amplifying, RC filtering and differential amplifying circuits, and then is transformed to a digital signal at a proper time by an analog-to-digital converter. The response voltage signal is sampled once when at high level and once when at low level for every circle of the square wave signal by the ADC, and a sample V1 and a sample V2 are obtained respectively, difference of the sample V1 and the sample V2 is taken as a detecting result for one circle. An average value of the detecting result from a plurality of circles may be taken as a final result. Information of electrical impedance is illustrated by the final result because the excitation current signal is constant.
摘要翻译：一种通过利用发送激励信号和检测响应信号的理论的便携式电阻抗成像系统的电阻抗检测装置及其方法，其中激励信号是恒定方波激励电流信号，目标上的响应电压信号是通过缓冲，放大，RC滤波和差分放大电路转换成具有适当幅度的方波信号，然后通过模拟 - 数字转换器在适当的时间转换为数字信号。响应电压信号在高电平时被采样一次，一旦在ADC的每个圆波信号的低电平处被采样一次，并且分别获得样本V1和样本V2，样本V1和样本V2的差作为一个圆的检测结果。可以将来自多个圆的检测结果的平均值作为最终结果。由于激励电流信号是恒定的，所以最终结果说明了电阻抗的信息。

5. 发明授权

US08260988B2 PS/2 to USB keyboard adaptor supporting N-key rollover 有权
标题翻译： PS / 2支持N键翻转的USB键盘适配器
公开(公告)号：US08260988B2
公开(公告)日：2012-09-04
申请号：US12475088
申请日：2009-05-29
申请人： Dang Sheng Cao , Chang-Ti Sung , Wen Zhang
发明人： Dang Sheng Cao , Chang-Ti Sung , Wen Zhang
IPC分类号： G06F13/12 , G06F3/00
CPC分类号： G06F3/023 , G06F13/387 , G06F2213/0042
摘要： A USB converter circuit for converting electrical signals from a key scan circuit (in PS/2 or other formats) into USB signals for a computer while supporting N-key rollover (NKRO) functions. The converter circuit can be implemented as a stand-alone PS/2 to USB keyboard converter or as an integral component of a USB keyboard or KVM switch. The converter circuit includes a converter module that generates keyboard data packets in the USB format having a 16-byte, 64-byte, etc. format representing key press information for up to 8 modifier keys and 14, 62, etc. non-modifier keys, respectively. The converter circuit also includes a USB device controller module which transmits the 16-byte etc. USB keyboard data as one or multiple USB data packets to the host computer. When multiple USB data packets are needed to transmit each keyboard data packet (depending on the USB speed), they are transmitted in consecutive polling periods.
摘要翻译： USB转换器电路，用于将电子信号从键扫描电路（PS / 2或其他格式）转换为计算机的USB信号，同时支持N键翻转（NKRO）功能。转换器电路可以实现为独立的PS / 2至USB键盘转换器或USB键盘或KVM切换器的组成部分。转换器电路包括转换器模块，其以USB格式生成具有16字节，64字节等格式的键盘数据分组，其表示用于多达8个修改键的键按压信息，以及14,62等非修饰键，分别。转换器电路还包括USB设备控制器模块，其将16字节等USB键盘数据作为一个或多个USB数据分组发送到主计算机。当需要多个USB数据包来传输每个键盘数据包（取决于USB速度）时，它们将以连续的轮询周期传输。

6. 发明申请

US20120077074A1 ACTIVE MATERIAL, METHOD OF PRODUCING THE SAME, NONAQUEOUS ELECTROLYTE BATTERY AND BATTERY PACK 有权
标题翻译：活性材料，其制造方法，非电解电解质电池和电池组
公开(公告)号：US20120077074A1
公开(公告)日：2012-03-29
申请号：US13071046
申请日：2011-03-24
申请人： Keigo Hoshina , Wen Zhang , Yuki Otani , Yasuhiro Harada , Hiroki Inagaki , Norio Takami
发明人： Keigo Hoshina , Wen Zhang , Yuki Otani , Yasuhiro Harada , Hiroki Inagaki , Norio Takami
IPC分类号： H01M4/13 , C01G23/04 , H01M10/02
CPC分类号： C01G23/005 , C01G23/047 , C01P2002/54 , C01P2002/76 , C01P2002/82 , C01P2006/12 , C01P2006/80 , H01M4/131 , H01M4/1391 , H01M4/485 , H01M4/525 , H01M10/0468 , H01M2004/021 , H01M2004/027
摘要： According to one embodiment, there is provided an active material including a titanium oxide compound having a monoclinic titanium dioxide crystal structure and satisfying the equation (I). S1/(S2+S3)≦1.9 (I). In the above equation, S1 is the peak area of a peak existing in a wavelength range from 1430 cm−1 to 1460 cm−1, S2 is the peak area of a peak existing in a wavelength range from 1470 cm−1 to 1500 cm−1, and S3 is the peak area of a peak existing in a wavelength range from 1520 cm−1 to 1560 cm−1, in the infrared diffusion reflective spectrum of the active material after pyridine is absorbed and then released.
摘要翻译：根据一个实施方案，提供了包含具有单斜晶二氧化钛晶体结构并满足式（I）的氧化钛化合物的活性材料。 S1 /（S2 + S3）＆nlE; 1.9（I）。在上式中，S1是存在于1430cm -1至1460cm -1的波长范围内的峰的峰面积，S2是存在于1470cm -1至1500cm波长范围内的峰的峰面积 -1，S3是在吡啶被吸收然后释放后的活性材料的红外扩散反射光谱中存在于1520cm -1至1560cm -1的波长范围内的峰的峰面积。

7. 发明申请

US20120071492A1 Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates 有权
标题翻译：寡聚蛋白酪氨酸激酶抑制剂缀合物
公开(公告)号：US20120071492A1
公开(公告)日：2012-03-22
申请号：US13264584
申请日：2010-04-19
申请人： Jennifer Riggs-Sauthier , Wen Zhang
发明人： Jennifer Riggs-Sauthier , Wen Zhang
IPC分类号： A61K31/506 , A61P35/02 , A61P35/00 , C07D417/14
CPC分类号： A61K47/48215 , A61K31/541 , A61K47/60 , C07D417/14
摘要： The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water soluble, non peptidic oligomer.
摘要翻译：本发明涉及（尤其是）低聚物-PTK抑制剂缀合物和相关化合物。本发明的化合物当通过任何多种施用途径施用时，具有优于缺乏水溶性非肽寡聚物的PTK抑制剂化合物的优点。

8. 发明申请

US20100184989A1 De Novo Synthesis of Conjugates 审中-公开
标题翻译： De Novo共轭体合成
公开(公告)号：US20100184989A1
公开(公告)日：2010-07-22
申请号：US12530438
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
发明人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
IPC分类号： A61K47/48
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08L2203/02
摘要： The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
摘要翻译：本发明提供了通过共价连接由水溶性低聚物组合物获得的水溶性低聚物进行化学修饰的小分子药物的制备方法。通过修饰合成途径产生这样的药物，以将低聚物连接到中间体化合物，然后完成合成路径。

9. 发明申请

US20100010194A1 Method for Preparing a Polymer Conjugate 有权
标题翻译：聚合物共轭物的制备方法
公开(公告)号：US20100010194A1
公开(公告)日：2010-01-14
申请号：US12515736
申请日：2007-11-30
申请人： Wen Zhang
发明人： Wen Zhang
IPC分类号： C07K1/107 , C07C41/01 , C07C217/00 , C07H1/00 , C07C67/00 , C07D305/14 , C07D471/12
CPC分类号： C08G65/33344 , A61K47/60 , C07D491/147
摘要： Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to an active agent.
摘要翻译：本文提供了一种用于将聚乙二醇聚合物共价连接到活性剂的简单有效的方法。

10. 发明申请

US20070152972A1 KVM switch system capable of invoking OSD menu by dedicated key 审中-公开
标题翻译： KVM切换系统能够通过专用键调用OSD菜单
公开(公告)号：US20070152972A1
公开(公告)日：2007-07-05
申请号：US11325905
申请日：2006-01-05
申请人： Wen Zhang
发明人： Wen Zhang
IPC分类号： G06F3/02
CPC分类号： G06F3/0227 , G06F3/023
摘要： A keyboard-video-mouse (KVM) switch system capable of invoking an on-screen display menu or a hotkey menu with one keystroke rather than a sequence of keystrokes. The KVM switch system includes a KVM processor and at least one menu key. The menu key generates at least one trigger signal based on the keystroke and at least one command is issued to the KVM processor. The KVM processor controls an OSD module and an OSD output control circuit according to the received command to invoke the menu. The OSD module generates the video signals constituting the menu (either OSD menu or hotkey menu). The OSD output control circuit enables the video signals of the menu to be displayed on the monitor of the console.
摘要翻译：键盘视频鼠标（KVM）切换系统，能够通过一键击而不是一连串的按键来调用屏幕显示菜单或热键菜单。 KVM切换器系统包括KVM处理器和至少一个菜单键。菜单键基于击键产生至少一个触发信号，并向KVM处理器发出至少一个命令。 KVM处理器根据接收到的命令控制OSD模块和OSD输出控制电路以调用菜单。 OSD模块生成构成菜单的视频信号（OSD菜单或热键菜单）。 OSD输出控制电路使菜单的视频信号显示在控制台的监视器上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式