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    • 2. 发明专利
    • Improvements in Railway and Tramway Rails.
    • GB190428512A
    • 1905-10-19
    • GB190428512D
    • 1904-12-28
    • CUTHBERT DAVID WATT
    • CUTHBERT DAVID WATT
    • 28,512. Cuthbert, D. W. Dec. 28. Rails are constructed with renewable tread portions bolted or secured by studs or otherwise to the web o r head of the main rail. Fig. 1 shows the renewable V-shaped tread portion D secured by studs G to the heavier flange B of the main rail. In a modified form, the tread portion is shortenel on one side and the slightly concave flange C forms the guard-rail for the wheel flanges. Fig. 3 shows an approximately triangularsectioned tread portion D, which is longitudinally reversible, as the flange C forms the guard-lip. For a railway rail of this type, the flange C has the guard portion omitted and is made shorter than the flange B. Fig. 6 shows the application to a main rail constructed in two portions. The tread portion has a depending flange H, and is bolted through the web portions of the main rail. This form of fastening is shown applied to a tread portion of similar form to that shown in Fig. 1. Corrugations may be formed on the underside of the tread portion in each case, fitting into similar corrugations on the main rail.
    • 6. 发明专利
    • Improvements in or connected with Rails for Railways, Tramways, and the like.
    • GB190322503A
    • 1904-08-25
    • GB190322503D
    • 1903-10-19
    • CUTHBERT DAVID WATT
    • CUTHBERT DAVID WATT
    • 22,503. Cuthbert, D. W. Oct. 19. Rails; rail joints.-Relates to rails having a separate head or tread portion, and means for securing the same. The tread portions A, shown in Figs. 1 and 4, fit on the heads of the main rails B, preferably so as to break joint therewith, and may be secured at intervals by bolts, plates, or cottars. In the form shown in Fig. 1, the hooked top end of the bolt E engages with projecting lips D, and the bottom end passes through a hole in a plate F, or through the flange of a flat-bottomed rail. The projecting lips D may be made broad enough to allow the bolts to be passed through them, or the bolts may be formed with projections engaging holes in the sides of the tread portion A. Plates J, shown in Fig. 4, may be formed with projections K entering holes in the sides of the tread portion A, or may engage lips in a similar manner to the bolts E, or may be riveted or fastened to the flanges C. The plates fit, and are bolted to, the web of the main rail B, and when placed at the joints of the main rail may be shaped to fit over the usual fishplates, or may be made in one with them. The lower ends of the plates may be formed with horizontally-projecting lugs secured by bolts to the foot of a flat-bottomed rail or to a separate plate placed underneath the main rail. According to another modification, the tread portion may be secured by cottars passing through the head of the main rail, and through both the depending flanges.
    • 7. 发明申请
    • SYSTEM AND METHOD FOR NAVIGATING THROUGH WEBSITES AND LIKE INFORMATION SOURCES
    • 通过网站导航和类似信息来源的系统和方法
    • WO2004095314A3
    • 2005-04-07
    • PCT/GB2004001749
    • 2004-04-23
    • STEVENSON DAVID WATT
    • STEVENSON DAVID WATT
    • G06F17/30
    • G06F17/30873
    • An interactive/electronic guide (10) for allowing navigation around a group of electronic documents, such as on internet or in an intranet site or such like, the guide being operable automatically to present a plurality of topic identifiers (14) together with an indication (16) of the importance of the topics identified within a site. Each topic (14,16) is user selectable. Selection of a given topic (14,16) provides access to information on that topic. Preferably, the guide (10) also provides information about multiple sites that are potentially related by content as well as an indication of a degree of similarity in content between such multiple sites.
    • 一种互动/电子指南(10),用于允许在诸如因特网或内部网站点等的一组电子文档之间导航,所述指南可自动地操作以将多个主题标识符(14)与指示 (16)在网站内确定的主题的重要性。 每个主题(14,16)是用户可选择的。 选择给定的主题(14,16)提供了有关该主题的信息。 优选地,指南(10)还提供关于可能与内容相关的多个站点的信息以及这些多个站点之间的内容的相似程度的指示。
    • 8. 发明申请
    • NAVIGATING THROUGH WEBSITES AND LIKE INFORMATION SOURCES
    • 通过网站导航和类似的信息来源
    • WO2004095314A2
    • 2004-11-04
    • PCT/GB2004/001749
    • 2004-04-23
    • STEVENSON, David, Watt
    • STEVENSON, David, Watt
    • G06F17/30
    • G06F17/30873
    • An interactive/electronic guide (10) for allowing navigation around a group of electronic documents, such as on internet or in an intranet site or such like, the guide being operable automatically to present a plurality of topic identifiers (14) together with an indication (16) of the importance of the topics identified within a site. Each topic (14,16) is user selectable. Selection of a given topic (14,16) provides access to information on that topic. Preferably, the guide (10) also provides information about multiple sites that are potentially related by content as well as an indication of a degree of similarity in content between such multiple sites.
    • 一种互动/电子指南(10),用于允许在诸如因特网或内部网站点等的一组电子文档之间导航,所述指南可自动地操作以将多个主题标识符(14)与指示 (16)在网站内确定的主题的重要性。 每个主题(14,16)是用户可选择的。 选择给定的主题(14,16)提供了有关该主题的信息。 优选地,指南(10)还提供关于可能与内容相关的多个站点的信息以及这些多个站点之间的内容的相似程度的指示。
    • 10. 发明授权
    • Stilbene analogs and methods of treating cancer
    • 二苯乙烯类似物和治疗癌症的方法
    • US08664276B2
    • 2014-03-04
    • US13360109
    • 2012-01-27
    • David WattChunming LiuVitaliy M. SviripaWen Zhang
    • David WattChunming LiuVitaliy M. SviripaWen Zhang
    • A61K31/136C07C211/45
    • A61K31/03A61K31/44C07C39/21C07C43/23C07C211/48C07C211/52C07C291/04C07D233/64C07D295/073C07D495/04C09B23/148G01N33/57484G01N33/582G01N2800/52
    • Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. Such stilbene analogs include, for example, compounds of the following formula: wherein Ra, Rb, R4, R6, R7, R9 and R10 are all H; R2 and R3 are independently H, halo, amino, alkylamino, dialkylamino, N-oxides of dialkylamino, arylalkylamino, trialkylammonium, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONR11R12, NR11CO(R13), NR11COO(R13) or NR11CONR12R13; R11, R12 and R13, are independently, H, alkyl, aryl, heteroaryl or a fluorine; R8 is NRCRdZ wherein Rc is H, alkyl, alkoxy, aryl or heteroaryl, Rd is an alkyl group, Z is a an unshared pair of electrons, H, alkyl or oxygen; and R1 and R5 are halogen.
    • 公开了可用于治疗各种癌症的芪类似物和药物组合物,包括但不限于结肠直肠癌(CRC)和乳腺癌。 这样的1,2-二苯乙烯类似物包括例如下式的化合物:其中R a,R b,R 4,R 6,R 7,R 9和R 10均为H; R2和R3独立地是H,卤素,氨基,烷基氨基,二烷基氨基,二烷基氨基,芳基烷基氨基,三烷基铵,巯基,烷硫基,烷酰基,硝基,亚硝酰基,氰基,烷氧基,烯氧基,芳基,杂芳基,磺酰基,磺酰胺,CONR11R12 ,NR 11 CO(R 13),NR 11 COO(R 13)或NR 11 CONR 12 R 13; R 11,R 12和R 13独立地为H,烷基,芳基,杂芳基或氟; R8是NRCRdZ,其中Rc是H,烷基,烷氧基,芳基或杂芳基,Rd是烷基,Z是未共享的电子对,H,烷基或氧; 并且R 1和R 5是卤素。