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1. 发明授权

US09932635B2 Method for exosomal biomarker detection by electric field-induced release and measurement 有权
公开(公告)号：US09932635B2
公开(公告)日：2018-04-03
申请号：US14119843
申请日：2012-05-24
申请人： David T. Wong , Fang Wei , Wei Liao
发明人： David T. Wong , Fang Wei , Wei Liao
IPC分类号： C12Q1/68 , C12N15/10 , G01N33/50 , G01N33/543 , G01N33/569 , G01N33/49
CPC分类号： C12Q1/6881 , C12N15/1013 , C12Q1/6806 , G01N33/49 , G01N33/5005 , G01N33/5076 , G01N33/54326 , G01N33/56966 , C12Q2563/131 , C12Q2563/143 , C12Q2563/161
摘要： The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.

2. 发明申请

US20140315195A1 METHOD FOR EXOSOMAL BIOMARKER DETECTION BY ELECTRIC FIELD-INDUCED RELEASE AND MEASUREMENT 有权
标题翻译：通过电场诱导释放和测量检测外部生物标记物的方法
公开(公告)号：US20140315195A1
公开(公告)日：2014-10-23
申请号：US14119843
申请日：2012-05-24
申请人： David T. Wong , Fang Wei , Wei Liao
发明人： David T. Wong , Fang Wei , Wei Liao
IPC分类号： C12Q1/68 , G01N33/569
CPC分类号： C12Q1/6881 , C12N15/1013 , C12Q1/6806 , G01N33/49 , G01N33/5005 , G01N33/5076 , G01N33/54326 , G01N33/56966 , C12Q2563/131 , C12Q2563/143 , C12Q2563/161
摘要： The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.
摘要翻译：存在于外来体中的分子在生物科学中起重要作用。外来体研究的非常理想的目标是快速，简单，同时跟踪和定量外来体包涵体分子。本文公开了用于诱导在外来体中携带的生物分子的释放和测量的方法和装置。所公开的电场诱导释放和测量（EFIRM）技术的方法使用电场来同时破坏外来体释放内容物并测量所携带的外来体RNA /蛋白质。外来体囊泡内容物可在数分钟内释放。这提供了用于检测外来体生物分子的潜在的现场方法。

3. 发明申请

US20100330706A1 PROBE IMMOBILIZATION AND SIGNAL AMPLIFICATION FOR POLYMER-BASED BIOSENSOR 有权
标题翻译：用于基于聚合物的生物传感器的探针固定和信号放大
公开(公告)号：US20100330706A1
公开(公告)日：2010-12-30
申请号：US12823988
申请日：2010-06-25
申请人： Fang Wei , Wei Liao
发明人： Fang Wei , Wei Liao
IPC分类号： G01N33/545 , B05D5/12
CPC分类号： C12Q1/6804 , C12Q1/6825 , C12Q2563/155 , C12Q2525/313
摘要： The present invention provides methods of making polymer-based biosensors and the biosensors made by said methods, wherein the biosensors comprise conducting polymers and negatively charged nanoparticles comprising a capture moiety. The present invention also provides methods of detecting analytes in a solution by contacting the solution with said polymer-based biosensors.
摘要翻译：本发明提供了制备基于聚合物的生物传感器和通过所述方法制备的生物传感器的方法，其中生物传感器包括导电聚合物和包含捕获部分的带负电荷的纳米颗粒。本发明还提供了通过使溶液与所述基于聚合物的生物传感器接触来检测溶液中的分析物的方法。

4. 发明授权

US09127304B2 Probe immobilization and signal amplification for polymer-based biosensor 有权
标题翻译：基于聚合物的生物传感器的探针固定和信号放大
公开(公告)号：US09127304B2
公开(公告)日：2015-09-08
申请号：US12823988
申请日：2010-06-25
申请人： Fang Wei , Wei Liao
发明人： Fang Wei , Wei Liao
IPC分类号： G01N33/545 , C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/6825 , C12Q2563/155 , C12Q2525/313
摘要： The present invention provides methods of making polymer-based biosensors and the biosensors made by said methods, wherein the biosensors comprise conducting polymers and negatively charged nanoparticles comprising a capture moiety. The present invention also provides methods of detecting analytes in a solution by contacting the solution with said polymer-based biosensors.
摘要翻译：本发明提供了制备基于聚合物的生物传感器和通过所述方法制备的生物传感器的方法，其中生物传感器包括导电聚合物和包含捕获部分的带负电荷的纳米颗粒。本发明还提供了通过使溶液与所述基于聚合物的生物传感器接触来检测溶液中的分析物的方法。

5. 外观设计

USD1021564S1 Coaster 有权
公开(公告)号：USD1021564S1
公开(公告)日：2024-04-09
申请号：US29919237
申请日：2023-12-01
申请人： Fang Wei
设计人： Fang Wei
摘要： FIG. 1 is a front, left and bottom perspective view of a coaster, showing my design.
FIG. 2 is a rear, right and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.

6. 发明申请

US20180032648A1 SIMULATION METHOD OF CMP PROCESS 审中-公开
公开(公告)号：US20180032648A1
公开(公告)日：2018-02-01
申请号：US15283286
申请日：2016-09-30
申请人： Yun Cao , Huan Kan , Fang Wei , Jun Zhu , Yukun Lv , Xusheng Zhang
发明人： Yun Cao , Huan Kan , Fang Wei , Jun Zhu , Yukun Lv , Xusheng Zhang
IPC分类号： G06F17/50 , H01L21/768
CPC分类号： G06F17/504 , G06F2217/16 , H01L21/76819
摘要： The invention disclosed a simulation method of CMP process, comprising: firstly, building a CMP model, and forming a matrix table of line width logarithm-density according to the CMP model, and making each intersection of the matrix table correspond to each CMP result under the corresponding line width and density; secondly, dividing a layout into a plurality of grids, and converting the equivalent line width and density of each grid into the coordinate of line width logarithm-density in the matrix table; thirdly, fitting and calculating preliminary CMP simulation results of each grid according to the coordinate of each grid in the matrix table and the CMP simulation results of its adjacent intersections of the matrix table; then, fitting and computing final CMP simulation results of each grid according to a related weighting factor which considers the impact of adjacent grids for the current grid on the layout; finally, outputting the final CMP simulation results of the whole layout.

7. 发明申请

US20130115594A1 HIGH SPECIFICITY AND HIGH SENSITIVITY DETECTION BASED ON STERIC HINDRANCE & ENZYME-RELATED SIGNAL AMPLIFICATION 审中-公开
标题翻译：基于超声和酶相关信号放大的高特异度和高灵敏度检测
公开(公告)号：US20130115594A1
公开(公告)日：2013-05-09
申请号：US13462709
申请日：2012-05-02
申请人： Fang Wei , Bernhard G. Zimmerman , David T. W. Wong
发明人： Fang Wei , Bernhard G. Zimmerman , David T. W. Wong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/682 , C12Q1/6825 , C12Q2565/501 , C12Q2565/107 , C12Q2563/131 , C12Q2525/301 , C12Q2565/1025
摘要： The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of a target nucleic acid in a sample. Also disclosed is a detection method using this probe.
摘要翻译：本发明涉及能够对样品中的靶核酸进行高灵敏度和高特异性检测的分子探针。还公开了使用该探针的检测方法。

8. 发明申请

US20100248231A1 HIGH SPECIFICITY AND HIGH SENSITIVITY DETECTION BASED ON STERIC HINDRANCE & ENZYME-RELATED SIGNAL AMPLIFICATION 审中-公开
标题翻译：基于超声和酶相关信号放大的高特异度和高灵敏度检测
公开(公告)号：US20100248231A1
公开(公告)日：2010-09-30
申请号：US12601774
申请日：2008-05-30
申请人： Fang Wei , Bernhard G. Zimmermann , David T.W. Wong
发明人： Fang Wei , Bernhard G. Zimmermann , David T.W. Wong
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q1/682 , C12Q1/6825 , C12Q2565/501 , C12Q2565/107 , C12Q2563/131 , C12Q2525/301 , C12Q2565/1025
摘要： The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of target nucleic acid in a sample. Also disclosed is a detection method using this probe.
摘要翻译：本发明涉及能够对样品中靶核酸进行高灵敏度和高特异性检测的分子探针。还公开了使用该探针的检测方法。

9. 外观设计

USD1033165S1 Coaster 有权
公开(公告)号：USD1033165S1
公开(公告)日：2024-07-02
申请号：US29896844
申请日：2023-07-07
申请人： Fang Wei
设计人： Fang Wei
摘要： FIG. 1 is a front, right and top perspective view of a coaster, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.

10. 发明申请

US20160291458A1 METHOD INTEGRATING TARGET OPTIMIZATION AND OPTICAL PROXIMITY CORRECTION 审中-公开
标题翻译：方法集成目标优化和光学近似校正
公开(公告)号：US20160291458A1
公开(公告)日：2016-10-06
申请号：US14753192
申请日：2015-06-29
申请人： Daquan He , Fang Wei , Jun Zhu , Yukun Lv , Xusheng Zhang
发明人： Daquan He , Fang Wei , Jun Zhu , Yukun Lv , Xusheng Zhang
IPC分类号： G03F1/36 , G06F17/50
CPC分类号： G03F1/36
摘要： A method integrating target optimization and optical proximity correction including: fragmenting sides of a target pattern in the metal layer to form a plurality of fragments; simulating the target pattern and calculating image log slope of each fragment; calculating a target pattern optimal parameter for each fragment which is a product of three parameters including the image log slope, overlap ratio of the target pattern and a via pattern in a via layer, and critical dimension; optimizing the target pattern based on the target pattern optimal parameter; preforming optical proximity correction to the optimized target pattern; determining whether the corrected target pattern meets requirements; if yes, ending the target optimization and optical proximity correction; otherwise, using the corrected target pattern as a current target pattern and iterate from the step of simulating the target pattern and calculating image log slope of each fragment.
摘要翻译：一种集成目标优化和光学邻近校正的方法，包括：金属层中的目标图案的碎裂边以形成多个碎片; 模拟目标模式并计算每个片段的图像对数斜率; 计算每个片段的目标图案最优参数，该三个参数的乘积包括图像对数斜率，目标图案的重叠率和通孔层中的通孔图案以及临界尺寸; 基于目标模式优化参数优化目标模式; 对优化的目标图案进行光学邻近校正; 确定校正的目标模式是否满足要求; 如果是，结束目标优化和光学邻近校正; 否则，使用校正的目标图案作为当前目标图案，并且从模拟目标图案的步骤并且计算每个片段的图像对数斜率来迭代。

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