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1. 发明申请

US20080206131A1 Compositions and Method for Multimodal Imaging 有权
标题翻译：多模式成像的组成和方法
公开(公告)号：US20080206131A1
公开(公告)日：2008-08-28
申请号：US11816054
申请日：2006-02-10
申请人： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
发明人： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
IPC分类号： A61K49/00 , A61K51/00
CPC分类号： A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
摘要： Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
摘要翻译：提供了用于医学成像的信号调节组合物，其包含载体和两种或更多种对两种或多种成像模态特异的信号调节剂。组合物的特征在于相对于信号调节剂的保留效率，其使得能够延长对比度成像，而信号调节剂不会从载体中显着消耗。本发明的载体是基于脂质或基于聚合物的，其物理化学性质可以被修饰以捕获或螯合不同的信号调节剂及其混合物，并靶向哺乳动物内的特定器官或肿瘤或组织。

2. 发明授权

US08703097B2 Compositions and method for multimodal imaging 有权
标题翻译：多模式成像的组成和方法
公开(公告)号：US08703097B2
公开(公告)日：2014-04-22
申请号：US11816054
申请日：2006-02-10
申请人： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
发明人： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
IPC分类号： A61K49/00 , A61K51/00
CPC分类号： A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
摘要： Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
摘要翻译：提供了用于医学成像的信号调节组合物，其包含载体和两种或更多种对两种或多种成像模态特异的信号调节剂。组合物的特征在于相对于信号调节剂的保留效率，其使得能够延长对比度成像，而信号调节剂不会从载体中显着消耗。本发明的载体是基于脂质或基于聚合物的，其物理化学性质可以被修饰以捕获或螯合不同的信号调节剂及其混合物，并靶向哺乳动物内的特定器官或肿瘤或组织。

3. 发明申请

US20130261371A1 IMAGEABLE ACTIVATABLE AGENT FOR RADIATION THERAPY AND METHOD AND SYSTEM FOR RADIATION THERAPY 审中-公开
标题翻译：用于放射治疗的可成像的激活剂和用于放射治疗的方法和系统
公开(公告)号：US20130261371A1
公开(公告)日：2013-10-03
申请号：US13696005
申请日：2011-05-03
申请人： David A. Jaffray , Christine Allen , Devika Chithrani , Jinzi Zheng , Justin Grant
发明人： David A. Jaffray , Christine Allen , Devika Chithrani , Jinzi Zheng , Justin Grant
IPC分类号： A61N5/00
CPC分类号： A61N5/00 , A61K9/0009 , A61K9/127 , A61K41/0028 , A61K41/0038 , A61K49/1812 , A61M31/005 , A61N5/10 , A61N2005/1094 , A61N2005/1098
摘要： Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.
摘要翻译：使用含有敏化剂或保护剂的可成像的可破坏胶囊来增强放射治疗。可以通过非侵入性成像模式对所述胶囊进行成像，从而允许确定干扰胶囊的精确时间并使用外部能量源释放敏化剂或保护剂。敏感剂或保护剂的这种受控和定时的释放通过优化敏化剂或保护剂向目标组织的递送来提供增强的放射治疗。还教导了包括非侵入性成像模式，外部能量源和辐射能源的系统与这些可成像的可破坏胶囊一起使用。

4. 发明申请

US20100203163A1 INJECTABLE POLYMER-LIPID BLEND FOR LOCALIZED DRUG DELIVERY 审中-公开
标题翻译：用于局部药物输送的可注射聚合物 - 脂质混合物
公开(公告)号：US20100203163A1
公开(公告)日：2010-08-12
申请号：US12664330
申请日：2008-06-12
申请人： Christine Allen
发明人： Christine Allen
IPC分类号： A61K33/24 , A61P35/00 , A61K47/36 , A61K31/337 , A61K38/16 , A61K31/7088 , A61K31/661 , A61K31/704
CPC分类号： A61K31/337 , A61K9/0024 , A61K47/08 , A61K47/12 , A61K47/24 , A61K47/36
摘要： An injectable polymer-lipid blend is provided as a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery
摘要翻译：提供可注射的聚合物 - 脂质混合物作为药物活性剂的局部药物递送系统。共混物可以由壳聚糖基材料，脂肪酸和磷脂制备。基于壳聚糖的材料可以是水溶性壳聚糖衍生物。脂肪酸可以是酰基链长度为C8-C16的脂肪酸或脂肪醛，例如月桂醛。共混物的流变特性涉及组分与脂肪酸的酰基链长度的比例。注射系统非常适合药物活性剂在治疗癌症和需要局部药物递送的其它疾病中的延迟释放

5. 发明授权

US06469132B1 Diblock copolymer and use thereof in a micellar drug delivery system 失效
标题翻译：二嵌段共聚物及其在胶束药物递送系统中的用途
公开(公告)号：US06469132B1
公开(公告)日：2002-10-22
申请号：US09563380
申请日：2000-05-03
申请人： Adi Eisenberg , Dusica Maysinger , Christine Allen
发明人： Adi Eisenberg , Dusica Maysinger , Christine Allen
IPC分类号： C08G6308
CPC分类号： C08G63/664
摘要： The present invention relates to diblock copolymers and more particularly to polycaprolactone-b-polyethylene oxide (PCL-b-PEO) diblock copolymers used in micellar systems, for delivering a biologically active agent to a site. There is provided a diblock copolymer compound comprising a hydrophilic block and a hydrophobic block, the hydrophilic block comprising a polyethylene oxide (PEO) polymer, the hydrophobic block comprising a polycaprolactone (PCL) polymer, the PCL polymer comprising a number of caprolactone monomers selected from 5 to 150, the PEO polymer comprising a number of ethylene oxide monomers selected from 30 to 100. The diblock copolymer compound of the present invention may be used to form a micellar delivery system for delivering biologically active agents such as lipophilic drugs to sites such as the central nervous system. The hydrophobic reservoir obtained enables a larger amount of agent to be incorporated therein, with a slower release and without the damaging effects that such high doses would induce with known delivery systems.
摘要翻译：本发明涉及二嵌段共聚物，更具体地涉及用于胶束体系中的聚己内酯-b-聚环氧乙烷（PCL-b-PEO）二嵌段共聚物，用于将生物活性剂递送至位点。提供包含亲水嵌段和疏水嵌段的二嵌段共聚物化合物，所述亲水性嵌段包含聚环氧乙烷（PEO）聚合物，所述疏水嵌段包含聚己酸内酯（PCL）聚合物，所述PCL聚合物包含多个选自以下的己内酯单体 5至150，PEO聚合物包含多个选自30至100的环氧乙烷单体。本发明的二嵌段共聚物化合物可用于形成胶束递送系统，用于将生物活性剂如亲脂性药物递送至诸如中枢神经系统。获得的疏水性储存容器可以加入更多量的药剂，其释放较慢，并且不会产生这种高剂量可以用已知递送系统诱导的破坏作用。

6. 外观设计

USD993634S1 Brush 有权
公开(公告)号：USD993634S1
公开(公告)日：2023-08-01
申请号：US29777077
申请日：2021-04-02
申请人： Christine Allen
设计人： Christine Allen
摘要： FIG. 1 is a front elevation view
FIG. 2 is a rear elevation view
FIG. 3 is a left side elevation view
FIG. 4 is a right side elevation view
FIG. 5 is a top plan view,
FIG. 6 is a bottom plan view; and,
FIG. 7 is an enlarged view of portion “7” shown in FIG. 1.
The broken lines shown in the drawings show portions of the article and form no part of the claimed design. The dot-dash broken lines shown in FIGS. 1 and 7 are enlarged view indicators, and form no part of the claimed design.

7. 发明授权

US07901707B2 Biodegradable biocompatible implant and method of manufacturing same 失效
标题翻译：可生物降解的生物相容性植入物及其制造方法
公开(公告)号：US07901707B2
公开(公告)日：2011-03-08
申请号：US11079116
申请日：2005-03-15
申请人： Christine Allen , Justin Grant , Micheline Piquette-Miller
发明人： Christine Allen , Justin Grant , Micheline Piquette-Miller
IPC分类号： A61F13/00 , A61K31/722
CPC分类号： A61K9/0024 , A61K31/28 , A61K31/337 , A61K47/24 , A61K47/36
摘要： Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel, paste, solution, film, implant or barrier depending on the intended application. The polymer component of the matrix is the naturally occurring biomaterial, chitosan, or a mixture of chitin and chitosan. The lipid component may include phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidyl or a mixture thereof. The delivery system may be used for delivery of hydrophilic agents, hydrophobic agents or combinations thereof. The therapeutically active agents may be formulated within the matrix as free agents or incorporated into particles. In a preferred embodiment the agents are incorporated into polymeric particles that are dispersed throughout the matrix.
摘要翻译：提供制剂或递送系统用于控制释放治疗活性剂。递送系统由聚合物和脂质材料组成，并且可以根据预期应用制备为凝胶，糊剂，溶液，膜，植入物或屏障。基质的聚合物组分是天然存在的生物材料，壳聚糖或甲壳质和壳聚糖的混合物。脂质组分可包括磷脂酰胆碱，磷脂酰丝氨酸，磷脂酰肌醇，磷脂酰或其混合物。递送系统可用于递送亲水剂，疏水剂或其组合。治疗活性剂可以作为游离剂配制在基质内或并入颗粒中。在优选的实施方案中，将试剂掺入分散在整个基质中的聚合物颗粒中。

8. 发明申请

US20060177495A1 Polymer-lipid delivery vehicles 审中-公开
公开(公告)号：US20060177495A1
公开(公告)日：2006-08-10
申请号：US10496259
申请日：2002-12-23
申请人： Christine Allen , Murray Webb , Paul Tardi , Yumin Yuan
发明人： Christine Allen , Murray Webb , Paul Tardi , Yumin Yuan
IPC分类号： A61K9/127
CPC分类号： A61K31/7072 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/5138 , A61K9/5146 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7048 , A61K31/7076 , A61K33/24 , A61K2300/00
摘要： Delivery vehicles comprising nanoparticles which are composed of: (a) a biodegradable hydrophobic polymer forming a core, and; (b) an outer amphiphilic layer surrounding the polymer core containing a stabilizing lipid are suitable for delivering active agents.

9. 发明申请

US20050208122A1 Biodegradable biocompatible implant and method of manufacturing same 失效
标题翻译：可生物降解的生物相容性植入物及其制造方法
公开(公告)号：US20050208122A1
公开(公告)日：2005-09-22
申请号：US11079116
申请日：2005-03-15
申请人： Christine Allen , Justin Grant , Micheline Piquette-Miller
发明人： Christine Allen , Justin Grant , Micheline Piquette-Miller
IPC分类号： A61K9/00 , A61K9/127 , A61K31/28 , A61K31/282 , A61K31/337 , A61K47/24 , A61K47/36 , A61P35/00
CPC分类号： A61K9/0024 , A61K31/28 , A61K31/337 , A61K47/24 , A61K47/36
摘要： Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel, paste, solution, film, implant or barrier depending on the intended application. The polymer component of the matrix is the naturally occurring biomaterial, chitosan, or a mixture of chitin and chitosan. The lipid component may include phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidyl or a mixture thereof. The delivery system may be used for delivery of hydrophilic agents, hydrophobic agents or combinations thereof. The therapeutically active agents may be formulated within the matrix as free agents or incorporated into particles. In a preferred embodiment the agents are incorporated into polymeric particles that are dispersed throughout the matrix.
摘要翻译：提供制剂或递送系统用于控制释放治疗活性剂。递送系统由聚合物和脂质材料组成，并且可以根据预期应用制备为凝胶，糊剂，溶液，膜，植入物或屏障。基质的聚合物组分是天然存在的生物材料，壳聚糖或甲壳质和壳聚糖的混合物。脂质组分可包括磷脂酰胆碱，磷脂酰丝氨酸，磷脂酰肌醇，磷脂酰或其混合物。递送系统可用于递送亲水剂，疏水剂或其组合。治疗活性剂可以作为游离剂配制在基质内或并入颗粒中。在优选的实施方案中，将试剂掺入分散在整个基质中的聚合物颗粒中。

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