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1. 发明申请

US20090324741A1 INJECTABLE POLYMER-LIPID BLEND 审中-公开
标题翻译：可注射的聚合物 - 混合物
公开(公告)号：US20090324741A1
公开(公告)日：2009-12-31
申请号：US12200553
申请日：2008-08-28
申请人： Christine ALLEN , Justin GRANT , Jaepyoung CHO , Patrick LIM SOO , Micheline PIQUETTE-MILLER
发明人： Christine ALLEN , Justin GRANT , Jaepyoung CHO , Patrick LIM SOO , Micheline PIQUETTE-MILLER
IPC分类号： A61K47/36 , A61K33/24 , A61K31/282 , A61K31/505 , A61K31/7072 , A61K31/7068 , A61K31/403 , A61K31/66 , A61K31/4164 , A61K31/337 , A61P35/00 , A61K31/704 , A61K38/02 , A61K31/7088
CPC分类号： A61K31/337 , A61K9/0024 , A61K47/08 , A61K47/12 , A61K47/24 , A61K47/36
摘要： An injectable polymer-lipid blend is provided. The blend may provide a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery.
摘要翻译：提供可注射的聚合物 - 脂质混合物。共混物可以提供用于药物活性剂的局部药物递送系统。共混物可以由壳聚糖基材料，脂肪酸和磷脂制备。基于壳聚糖的材料可以是水溶性壳聚糖衍生物。脂肪酸可以是酰基链长度为C8-C16的脂肪酸或脂肪醛，例如月桂醛。共混物的流变特性涉及组分与脂肪酸的酰基链长度的比例。注射系统非常适合药物活性剂在治疗癌症和需要局部药物递送的其它疾病中的延迟释放。

2. 发明申请

US20080311223A1 INJECTABLE POLYMER-LIPID BLEND FOR LOCALIZED DRUG DELIVERY 审中-公开
标题翻译：用于局部药物输送的可注射聚合物 - 脂质混合物
公开(公告)号：US20080311223A1
公开(公告)日：2008-12-18
申请号：US12138141
申请日：2008-06-12
申请人： Christine ALLEN , Justin Grant , Jaepyoung Cho , Patrick Lim Soo , Micheline Piquette-Miller
发明人： Christine ALLEN , Justin Grant , Jaepyoung Cho , Patrick Lim Soo , Micheline Piquette-Miller
IPC分类号： A61K33/24 , A61K47/36 , A61K31/17 , A61K31/505 , A61K31/66 , A61K31/397 , A61K31/4353 , A61K38/02 , A61K31/7052 , A61P35/00 , A61K38/16 , A61K31/704 , A61K31/403 , A61K31/4164 , A61K38/10 , A61K31/4985 , A61K31/282
CPC分类号： A61K31/337 , A61K9/0024 , A61K47/08 , A61K47/12 , A61K47/24 , A61K47/36
摘要： An injectable polymer-lipid blend is provided as a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery.
摘要翻译：提供可注射的聚合物 - 脂质混合物作为药物活性剂的局部药物递送系统。共混物可以由壳聚糖基材料，脂肪酸和磷脂制备。基于壳聚糖的材料可以是水溶性壳聚糖衍生物。脂肪酸可以是酰基链长度为C8-C16的脂肪酸或脂肪醛，例如月桂醛。共混物的流变特性涉及组分与脂肪酸的酰基链长度的比例。注射系统非常适合药物活性剂在治疗癌症和需要局部药物递送的其它疾病中的延迟释放。

3. 发明授权

US07901707B2 Biodegradable biocompatible implant and method of manufacturing same 失效
标题翻译：可生物降解的生物相容性植入物及其制造方法
公开(公告)号：US07901707B2
公开(公告)日：2011-03-08
申请号：US11079116
申请日：2005-03-15
申请人： Christine Allen , Justin Grant , Micheline Piquette-Miller
发明人： Christine Allen , Justin Grant , Micheline Piquette-Miller
IPC分类号： A61F13/00 , A61K31/722
CPC分类号： A61K9/0024 , A61K31/28 , A61K31/337 , A61K47/24 , A61K47/36
摘要： Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel, paste, solution, film, implant or barrier depending on the intended application. The polymer component of the matrix is the naturally occurring biomaterial, chitosan, or a mixture of chitin and chitosan. The lipid component may include phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidyl or a mixture thereof. The delivery system may be used for delivery of hydrophilic agents, hydrophobic agents or combinations thereof. The therapeutically active agents may be formulated within the matrix as free agents or incorporated into particles. In a preferred embodiment the agents are incorporated into polymeric particles that are dispersed throughout the matrix.
摘要翻译：提供制剂或递送系统用于控制释放治疗活性剂。递送系统由聚合物和脂质材料组成，并且可以根据预期应用制备为凝胶，糊剂，溶液，膜，植入物或屏障。基质的聚合物组分是天然存在的生物材料，壳聚糖或甲壳质和壳聚糖的混合物。脂质组分可包括磷脂酰胆碱，磷脂酰丝氨酸，磷脂酰肌醇，磷脂酰或其混合物。递送系统可用于递送亲水剂，疏水剂或其组合。治疗活性剂可以作为游离剂配制在基质内或并入颗粒中。在优选的实施方案中，将试剂掺入分散在整个基质中的聚合物颗粒中。

4. 发明申请

US20050208122A1 Biodegradable biocompatible implant and method of manufacturing same 失效
标题翻译：可生物降解的生物相容性植入物及其制造方法
公开(公告)号：US20050208122A1
公开(公告)日：2005-09-22
申请号：US11079116
申请日：2005-03-15
申请人： Christine Allen , Justin Grant , Micheline Piquette-Miller
发明人： Christine Allen , Justin Grant , Micheline Piquette-Miller
IPC分类号： A61K9/00 , A61K9/127 , A61K31/28 , A61K31/282 , A61K31/337 , A61K47/24 , A61K47/36 , A61P35/00
CPC分类号： A61K9/0024 , A61K31/28 , A61K31/337 , A61K47/24 , A61K47/36
摘要： Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel, paste, solution, film, implant or barrier depending on the intended application. The polymer component of the matrix is the naturally occurring biomaterial, chitosan, or a mixture of chitin and chitosan. The lipid component may include phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidyl or a mixture thereof. The delivery system may be used for delivery of hydrophilic agents, hydrophobic agents or combinations thereof. The therapeutically active agents may be formulated within the matrix as free agents or incorporated into particles. In a preferred embodiment the agents are incorporated into polymeric particles that are dispersed throughout the matrix.
摘要翻译：提供制剂或递送系统用于控制释放治疗活性剂。递送系统由聚合物和脂质材料组成，并且可以根据预期应用制备为凝胶，糊剂，溶液，膜，植入物或屏障。基质的聚合物组分是天然存在的生物材料，壳聚糖或甲壳质和壳聚糖的混合物。脂质组分可包括磷脂酰胆碱，磷脂酰丝氨酸，磷脂酰肌醇，磷脂酰或其混合物。递送系统可用于递送亲水剂，疏水剂或其组合。治疗活性剂可以作为游离剂配制在基质内或并入颗粒中。在优选的实施方案中，将试剂掺入分散在整个基质中的聚合物颗粒中。

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