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1. 发明授权

US06405091B1 Lead assembly with masked microdisk tip electrode and monolithic controlled release device 失效
标题翻译：导线组件，带有掩模微型电极尖端电极和单片控制释放装置
公开(公告)号：US06405091B1
公开(公告)日：2002-06-11
申请号：US09359327
申请日：1999-07-20
申请人： David J. Vachon , Shahram Moaddeb , Gene A. Bornzin , Kevin L. Morgan
发明人： David J. Vachon , Shahram Moaddeb , Gene A. Bornzin , Kevin L. Morgan
IPC分类号： A61N105
CPC分类号： A61N1/0565 , A61N1/057
摘要： A passive fixation, body implantable lead assembly has a cylindrical tip electrode whose outer side surface is covered with a thin dielectric insulating layer so as to mask an active, disk-shaped electrode surface at the distal extremity of the tip electrode. The active electrode surface preferably has an area less than about 1 mm2. An MCRD, in the form of a collar, may be carried by a proximal portion of the tip electrode. Supplementing a set of main tines projecting from the distal end portion of an insulating sheath housing the lead assembly is a set of nubby auxiliary tines extending from the sheath immediately adjacent the distal extremity thereof.
摘要翻译：被动固定体植入式导线组件具有圆柱形末端电极，其外侧表面被薄的电介质绝缘层覆盖，以便掩盖尖端电极的远端处的活性盘形电极表面。活性电极表面优选具有小于约1mm 2的面积。可以由尖端电极的近端部分承载环形形式的MCRD。补充从套管导线组件的绝缘护套的远端部分突出的一组主尖齿是一组从紧靠其远端的护套延伸的辅助辅助齿。

2. 发明授权

US07313444B2 Self-anchoring coronary sinus lead 有权
标题翻译：自固定冠状动脉窦导联
公开(公告)号：US07313444B2
公开(公告)日：2007-12-25
申请号：US10081457
申请日：2002-02-21
申请人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
发明人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： An implantable cardiac lead system suitable for placement in the coronary sinus region of the heart. The lead system comprises a lead having two or more non-helical bends in its distal portion. The two or more non-helical bends cooperate to prevent the lead from dislodgment or displacement inside the coronary sinus. The lead system may further comprise a stylet suitable for steering the lead into at least one of the coronary sinus vein, great cardiac vein, left marginal vein, left posterior ventricular vein, and small cardiac vein. The stylet is tapered in its distal portion to provide enhanced maneuverability and steerability inside the coronary sinus region. The lead system may also comprise an introducer which aids in introducing the lead into the heart.
摘要翻译：适用于放置在心脏冠状静脉窦区域的可植入心脏引导系统。引导系统包括在其远端部分中具有两个或多个非螺旋形弯曲部的引线。两个或更多个非螺旋形弯曲合作以防止铅在冠状窦内发生移位或移位。引导系统还可以包括适于将引线引导到冠状静脉窦静脉，大心静脉，左边缘静脉，左后脑室静脉和小心静脉中的至少一个的探针。探针在其远端部分逐渐变细，以在冠状窦区域内提供增强的机动性和可操纵性。引导系统还可以包括有助于将引入引入心脏的导引器。

3. 发明授权

US07448999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07448999B1
公开(公告)日：2008-11-11
申请号：US11053468
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/0422 , A61B5/6852 , A61B5/6853 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B5/6859 , A61N1/057 , A61N1/0587
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

4. 发明授权

US5674274A Implantable adjustable single-pass A-V lead for use with an implantable stimulation device 失效
标题翻译：可植入式可调式单程A-V引线，用于植入式刺激装置
公开(公告)号：US5674274A
公开(公告)日：1997-10-07
申请号：US572590
申请日：1995-12-14
申请人： Kevin L. Morgan , Gene A. Bornzin
发明人： Kevin L. Morgan , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An adjustable single-pass A-V lead for cardiac pacing comprises a ventricular lead body with a ventricular electrode at its distal tip, and an atrial sheath slidably mounted over the ventricular lead body. An atrial electrode is located on a portion of the atrial sheath that is adapted to form an outwardly-extending atrial bow. A distal portion of the sheath is configured to resist sliding over the ventricular lead body so that the atrial bow is formed when a tubular, proximal portion of the sheath is advanced distally relative to the ventricular lead body. The longitudinal distance between the atrial and ventricular electrodes can be adjusted during implantation by withdrawing the sheath proximally relative to the ventricular lead body. The radial distance between the atrial electrode and the ventricular lead body can then be adjusted by advancing the proximal end of the sheath distally to form the atrial bow, and by manipulating the proximal end of the sheath to control the outward extension of the atrial bow. In an alternative embodiment, the non-tubular portion of the sheath is preformed in a curved configuration, so that the atrial bow forms automatically when a tensional force is released.
摘要翻译：用于心脏起搏的可调节单程A-V引线包括在其远端处具有心室电极的心室引线体和可滑动地安装在心室引导体上的心房皮。心房电极位于心房鞘的适于形成向外延伸的心房弓的一部分上。护套的远端部分构造成抵抗在心室引导体上的滑动，使得当护套的管状近端部分相对于心室引线体向远侧前进时形成心房弓。心房和心室电极之间的纵向距离可以在植入期间通过相对于心室引线体向近侧退出护套来调节。然后可以通过使护套的近端向远侧前进来形成心房弓，并且通过操纵护套的近端来控制心房弓的向外延伸来调节心房电极和心室引线体之间的径向距离。在替代实施例中，护套的非管状部分以弯曲构造预成型，使得当拉伸力释放时，心房弓自动形成。

5. 发明授权

US07450999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07450999B1
公开(公告)日：2008-11-11
申请号：US11053566
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/378
CPC分类号： A61N1/057 , A61B5/02152 , A61B5/02158 , A61B5/6853 , A61B5/6857 , A61B5/6882
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

6. 发明授权

US07340288B1 Trans-septal intra-cardiac lead system 失效
公开(公告)号：US07340288B1
公开(公告)日：2008-03-04
申请号：US11053493
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61N1/3627 , A61N1/36514 , A61N2001/0585
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

7. 发明授权

US07274965B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07274965B1
公开(公告)日：2007-09-25
申请号：US11053373
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/00
CPC分类号： A61N1/00
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

8. 发明授权

US07881810B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US07881810B1
公开(公告)日：2011-02-01
申请号：US11753484
申请日：2007-05-24
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

9. 发明授权

US07056314B1 Steerable obturator 有权
标题翻译：导向闭孔器
公开(公告)号：US07056314B1
公开(公告)日：2006-06-06
申请号：US10452244
申请日：2003-05-30
申请人： Joseph J. Florio , Gene A. Bornzin , Kevin L. Morgan , Sheldon Williams , Janice Barstad
发明人： Joseph J. Florio , Gene A. Bornzin , Kevin L. Morgan , Sheldon Williams , Janice Barstad
IPC分类号： A61M25/01
CPC分类号： A61M25/0152 , A61B17/3478 , A61B2017/003 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61M2025/015 , A61M2025/0161
摘要： An omnidirectionally steerable obturator facilitates the delivery of the distal tip of an introducer sheath into the coronary sinus of a heart. The steerable obturator comprises an obturator body extending longitudinally along a central axis, the obturator body being configured to be received by the introducer sheath. The obturator body further has a flexible, deflectable distal end section terminating in a rounded distal tip. An actuator, controllable from a proximal end of the obturator body, is operatively associated with the flexible distal end section of the obturator body to cause deflection of the flexible distal end section of the obturator body in at least one selected direction to facilitate passage of the distal end section of the obturator body and the distal tip of the introducer sheath into the coronary sinus of the heart.The obturator body is preferably configured to be received in a close fit within at least the tip of the introducer sheath. More preferably, the distal end of the obturator body has an outer surface and the fit between the outer surface of the obturator and at least the tip of the introducer sheath comprises substantially a line-to-line fit.
摘要翻译：全向可操纵的闭孔器有利于将导引鞘的远侧末端递送到心脏的冠状窦。可操纵的闭孔器包括沿着中心轴线纵向延伸的闭孔器，所述封闭器主体构造成由引导器护套容纳。闭孔体还具有终止于圆形远端尖端的柔性的，可偏转的远端部分。从闭塞体的近端可控制的致动器与闭塞体的柔性远端部分可操作地相关联，以使闭塞体的柔性远端部分沿至少一个选定的方向偏转，以便于通过闭塞体的远端部分和导引鞘的远侧末端插入心脏的冠状窦。闭孔体优选构造成在至少引导器护套的尖端内紧密配合。更优选地，闭孔体的远端具有外表面，并且填塞物的外表面与引导器护套的至少末端之间的配合基本上包括线对齐配合。

10. 发明授权

US06456890B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456890B2
公开(公告)日：2002-09-24
申请号：US09797531
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N100
CPC分类号： A61N1/056
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multi-lumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多腔管沿着导丝线前进，直到达到所需的位置，导线从主体和多管腔管中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

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