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1. 发明授权

US06523559B2 Self-regulating microfluidic device and method of using the same 有权
标题翻译：自调节微流体装置及其使用方法
公开(公告)号：US06523559B2
公开(公告)日：2003-02-25
申请号：US09917523
申请日：2001-07-27
申请人： David J. Beebe , Jeffrey S. Moore , Robin Liu , David T. Eddington
发明人： David J. Beebe , Jeffrey S. Moore , Robin Liu , David T. Eddington
IPC分类号： G05D1103
CPC分类号： G05D11/08 , G05D21/00 , Y10T137/0329 , Y10T137/2509
摘要： In accordance with the present invention, a microfluidic device and method of using the same is provided for self-regulating the flow of fluid therethrough. The microfluidic device includes a body defining first and second flow channels. The first flow channel has an input for receiving the fluid and an output. The second flow channel has an input for receiving a compensating fluid to modify the value of the property of the fluid and an output communicating with the first flow channel. A polymeric material is disposed in the first flow channel downstream of the output of the second flow channel. The polymeric material has a volume responsive to the value of the property of the fluid. A valve is disposed in the second flow channel and is movable in response to the volume of the material. The valve is movable between the first open position allowing the compensating fluid to flow past the valve into the first flow channel and a second closed position limiting the flow of compensating fluid therepast.
摘要翻译：根据本发明，提供了一种微流体装置及其使用方法，用于自我调节流体的流动。微流体装置包括限定第一和第二流动通道的主体。第一流道具有用于接收流体和输出的输入。第二流动通道具有用于接收补偿流体以修改流体性质的值的输入和与第一流动通道连通的输出。聚合材料设置在第二流动通道的第二流动通道的输出的下游。聚合物材料具有响应于流体性质的值的体积。阀设置在第二流动通道中并且可以响应于材料的体积而移动。所述阀可在所述第一打开位置和所述第一关闭位置之间移动，所述第一打开位置允许所述补偿流体流过所述阀进入所述第一流动通道，以及限制所述补偿流体的流动的第二关闭

2. 发明申请

US20100262077A1 Micro-Fluidic Device For Drug Delivery 有权
标题翻译：用于药物递送的微流体装置
公开(公告)号：US20100262077A1
公开(公告)日：2010-10-14
申请号：US12821743
申请日：2010-06-23
申请人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
发明人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
IPC分类号： A61M5/14
CPC分类号： A61M5/141 , A61M5/14248 , A61M5/14586 , A61M5/16881 , A61M2005/1726
摘要： A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.
摘要翻译：提供了用于将药物递送给个体的微流体装置。微流体装置包括限定用于在其中接收药物的储存器的主体。阀将储存器互连到可插入个人皮肤的输出针。压力源将药物从储存器推向针。所述阀可在关闭位置之间移动，所述关闭位置防止药物从所述贮存器流到所述输出针，以及打开位置，以允许所述药物从所述储存器流动到所述输出针，以响应于所述生理流体中的预定条件个人

3. 发明授权

US08628517B2 Micro-fluidic device for drug delivery 有权
标题翻译：用于药物输送的微流体装置
公开(公告)号：US08628517B2
公开(公告)日：2014-01-14
申请号：US12821743
申请日：2010-06-23
申请人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
发明人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
IPC分类号： A61K9/22
CPC分类号： A61M5/141 , A61M5/14248 , A61M5/14586 , A61M5/16881 , A61M2005/1726
摘要： A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.
摘要翻译：提供了用于将药物递送给个体的微流体装置。微流体装置包括限定用于在其中接收药物的储存器的主体。阀将储存器互连到可插入个人皮肤的输出针。压力源将药物从储存器推向针。所述阀可在关闭位置之间移动，所述关闭位置防止药物从所述贮存器流到所述输出针，以及打开位置，以允许所述药物从所述储存器流动到所述输出针，以响应于所述生理流体中的预定条件个人

4. 发明授权

US07766902B2 Microfluidic device for drug delivery 有权
标题翻译：用于药物输送的微流体装置
公开(公告)号：US07766902B2
公开(公告)日：2010-08-03
申请号：US10762664
申请日：2004-01-22
申请人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
发明人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M5/141 , A61M5/14248 , A61M5/14586 , A61M5/16881 , A61M2005/1726
摘要： A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.
摘要翻译：提供了用于将药物递送给个体的微流体装置。微流体装置包括限定用于在其中接收药物的储存器的主体。阀将储存器互连到可插入个人皮肤的输出针。压力源将药物从储存器推向针。所述阀可在关闭位置之间移动，所述关闭位置防止药物从所述贮存器流到所述输出针，以及打开位置，以允许所述药物从所述储存器流动到所述输出针，以响应于所述生理流体中的预定条件个人

5. 发明申请

US20080220516A1 Multi-well micropatterning by ablation 审中-公开
标题翻译：消融多孔微图案
公开(公告)号：US20080220516A1
公开(公告)日：2008-09-11
申请号：US11974341
申请日：2007-10-12
申请人： David T. Eddington , Sangeeta N. Bhatia
发明人： David T. Eddington , Sangeeta N. Bhatia
IPC分类号： C12M1/22 , B44C1/22
CPC分类号： G01N33/5067 , B01J19/0046 , B01J2219/00317 , B01J2219/00587 , B01J2219/0898 , B01L3/5025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , C12M23/12 , C12M23/20 , C12M25/04 , C12N5/0671 , C12N2502/14 , C12N2535/10 , G01N33/5008 , G01N33/54353 , G01N33/5436
摘要： The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.
摘要翻译：本发明涉及通过用氧等离子体选择性消融物理吸附的生物分子来生成标准实验室材料上的生物分子和细胞的微图案。在某些实施方案中，氧等离子体能够沿着复杂的非线性路径选择性地吸收生物分子（例如，I型胶原，纤连蛋白，层粘连蛋白和Matrigel）的物理吸附层，这些复杂的非线性路径难以或不可能使用替代方法进行模式化。此外，本发明的某些实施例涉及在曲面，多孔板和平底烧瓶上的多种细胞类型的微图案化。本发明还具有用于本发明方法的试剂盒。

6. 发明申请

US20100170796A1 In Vitro Microfluidic Model of Microcirculatory Diseases, and Methods of Use Thereof 审中-公开
标题翻译：微循环微流体模型及其使用方法
公开(公告)号：US20100170796A1
公开(公告)日：2010-07-08
申请号：US12525752
申请日：2008-02-08
申请人： Sangeeta N. Bhatia , David T. Eddington , John M. Higgins , Lakshminarayanan Mahadevan
发明人： Sangeeta N. Bhatia , David T. Eddington , John M. Higgins , Lakshminarayanan Mahadevan
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： B01L3/5027 , B01L2300/0816 , B01L2300/10 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , G01N2800/224
摘要： One aspect of the invention relates to a microfluidic device which recreates important features of the human microcirculation on a microscope stage. In certain embodiments of the invention, the clinical scenario associated with ‘sickle cell crisis’ whereby blood vessels are occluded in various organs causing pain and tissue damage can be recreated. In certain embodiments, one can use a device of the invention to study the processes that lead to crisis, and screen therapies (such as small molecules) that might be used to prevent crisis. Further, certain embodiments of the invention allow one to study and screen therapies for a range of human blood disorders, such as hereditary spherocytosis, disorders of white blood cells, such as Waldenstrom's macroglobulinemia or leukocytosis, disorders of blood platelets and coagulation, such as hemophilia A and B, activated protein C resistance, and essential thrombocythemia.
摘要翻译：本发明的一个方面涉及在显微镜载物台上再现人类微循环的重要特征的微流体装置。在本发明的某些实施方案中，可以重新产生与“镰状细胞危机”有关的临床情景，其中血管被封闭在各种器官中，导致疼痛和组织损伤。在某些实施方案中，可以使用本发明的装置来研究导致危机的过程，以及可能用于预防危机的屏幕治疗（例如小分子）。此外，本发明的某些实施方案允许研究和筛选针对一系列人类血液病症（例如遗传性球状红细胞增多症），白血病病症如瓦尔登斯特伦的巨球蛋白血症或白细胞增多症，血小板和凝血障碍，如血友病 A和B，活化的蛋白C抗性和原发性血小板增多症。

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