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1. 发明授权

US07482362B2 Substituted-4-quinolones 失效
标题翻译：取代的4-喹诺酮
公开(公告)号：US07482362B2
公开(公告)日：2009-01-27
申请号：US10450930
申请日：2001-12-17
申请人： David Idris Pritchard , Barrie Walsham Bycroft , Siri Ram Chhabra , Doreen Hooi
发明人： David Idris Pritchard , Barrie Walsham Bycroft , Siri Ram Chhabra , Doreen Hooi
IPC分类号： A01N43/42 , A61K31/47 , C07D215/00
CPC分类号： A61K31/4709 , A61K31/47 , A61K31/496 , A61K2039/55511 , A61K2039/57
摘要： Substituted-4-quinolones of the formula (I): wherein R1 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing 1 to 18 carbon atoms which may optionally be substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR6R7, wherein each of R6 and R7 is independently selected from H and 1-6C alkyl or R6 and R7 together with the N atom to which they are attached form a saturated heterocyclic group selected from piperidino, piperazino and morpholino; R2 is a group selected from H, —OH, halo, —CHO, —CO2H and CONHR8 wherein R8 is H or a 1-6C alkyl; each of R3, R4 and R5 is independently selected form H, —CH3, —OCH3 and halo; or a non-toxic pharmaceutically-acceptable salt thereof, have use in the manufacture of a medicament for the treatment of a disease of a living animal body, including a human, which disease is responsive to the activity of an immunosuppressant. The preferred compound of the formula 1 is 2-n-heptyl-3-hydroxy-4(1H)-quinolone.
摘要翻译：式（I）的取代的4-喹诺酮：其中R 1是含有1至18个碳原子的直链或支链，饱和或不饱和的脂族烃基，其可任选被一个或多个选自以下的取代基取代：卤素， 1-6C烷氧基，羧基，1-6C烷氧基羰基和NR6R7，其中R6和R7各自独立地选自H和1-6C烷基或R6和R7与它们所连接的N原子一起形成饱和杂环基，来自哌啶子基，哌嗪基和吗啉代; R2是选自H，-OH，卤素，-CHO，-CO 2 H和CONHR 8的基团，其中R 8是H或1-6 C烷基; R 3，R 4和R 5各自独立地选自H，-CH 3，-OCH 3和卤素; 或其无毒的药学上可接受的盐可用于制备用于治疗活动动物体（包括人）的疾病的药物，所述疾病对免疫抑制剂的活性有反应。优选的式1化合物是2-正庚基-3-羟基-4（1H） - 喹诺酮。

2. 发明授权

US06602905B1 N-acyl homoserine lactones for the treatment of cardiac tachyarrhythmias, ischaemic heart disease or congestive heart failure 有权
标题翻译：用于治疗心脏性心律失常，缺血性心脏病或充血性心力衰竭的N-酰基高丝氨酸内酯
公开(公告)号：US06602905B1
公开(公告)日：2003-08-05
申请号：US10110465
申请日：2002-08-21
申请人： Sheila Margaret Gardiner , Terence Bennett , Barrie Walsham Bycroft , David Idris Pritchard , Paul Williams
发明人： Sheila Margaret Gardiner , Terence Bennett , Barrie Walsham Bycroft , David Idris Pritchard , Paul Williams
IPC分类号： A01K3134
CPC分类号： A61K31/365
摘要： Compounds having anti-fibrotic effects are provided. Also provided is a method for treating disorders, diseases or conditions associated with pathological fibrotic states. The compounds useful in the present invention are homocysteine thiolactone and selected derivatives thereof.
摘要翻译：提供具有抗纤维化作用的化合物。还提供了用于治疗与病理性纤维化状态相关的疾病，疾病或病症的方法。可用于本发明的化合物是同型半胱氨酸硫内酯及其选择的衍生物。

3. 发明授权

US08049020B2 Substituted N -acyl homoserine lactones 失效
标题翻译：取代的N-酰基高丝氨酸内酯
公开(公告)号：US08049020B2
公开(公告)日：2011-11-01
申请号：US12302258
申请日：2007-05-22
申请人： David Idris Pritchard , Siri Ram Chhabra
发明人： David Idris Pritchard , Siri Ram Chhabra
IPC分类号： C07D307/00
CPC分类号： C07D307/33
摘要： The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2 is H or a 1-4C alkyl group; R3 is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N-acyl homoserine lactones.
摘要翻译：取代的N-酰基高丝氨酸内酯具有式（I），其中R是含有5至14个碳原子的饱和或不饱和直链或支链脂族烃基; R2是H或1-4C烷基; R3为H或F; 及其任何对映异构体。与已知的N-酰基高丝氨酸内酯相比，这些化合物表现出免疫抑制剂活性，同时显示出降低的生物传感器（自动诱导剂）活性。

4. 发明申请

US20100286261A1 SUBSTITUTED N-ACYL HOMOSERINE LACTONES 失效
标题翻译：取代的N-乙酰胆碱酯酶
公开(公告)号：US20100286261A1
公开(公告)日：2010-11-11
申请号：US12302258
申请日：2007-05-22
申请人： David Idris Pritchard , Siri Ram Chhabra
发明人： David Idris Pritchard , Siri Ram Chhabra
IPC分类号： A61K31/341 , C07D307/33
CPC分类号： C07D307/33
摘要： The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2 is H or a 1-4C alkyl group; R3 is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N-acyl homoserine lactones.
摘要翻译：取代的N-酰基高丝氨酸内酯具有式（I），其中R是含有5至14个碳原子的饱和或不饱和直链或支链脂族烃基; R2是H或1-4C烷基; R3为H或F; 及其任何对映异构体。与已知的N-酰基高丝氨酸内酯相比，这些化合物表现出免疫抑制剂活性，同时显示出降低的生物传感器（自动诱导剂）活性。

5. 发明授权

US07144721B1 Treatment of wounds 失效
标题翻译：丝氨酸丝氨酸蛋白酶
公开(公告)号：US07144721B1
公开(公告)日：2006-12-05
申请号：US10111252
申请日：2000-10-20
申请人： David Idris Pritchard
发明人： David Idris Pritchard
IPC分类号： C12N9/64 , C07K1/00
CPC分类号： A61L15/32 , A61K38/00 , C07K14/43577
摘要： An isolated protein, for use in treatment of wounds, is characterized in that it is secreted by the organism Lucilia sericata and it exhibits proteolytic activity against FITC-casein at a pH of 8.0 to 8.5. The protein exhibits proteolytic activity against Tosyl-Gly-Pro-Arg-AMC but not against Suc-Ala-Ala-Phe-AMC, and its proteolytic activity against FITC-casein and Tosyl-Gly-Pro-Arg-AMC is inhibited by the serine proteinase inhibitors PMSF and AMPSF. The protein is also bound by immobilized aminobenzamidine.
摘要翻译：用于治疗伤口的分离的蛋白质的特征在于其由丝氨酸球菌分泌，并且其在8.0至8.5的pH下显示出针对FITC-酪蛋白的蛋白水解活性。该蛋白质表现出对Tosyl-Gly-Pro-Arg-AMC的蛋白水解活性，但不对Suc-Ala-Ala-Phe-AMC表现出蛋白水解活性，其对FITC-酪蛋白和Tosyl-Gly-Pro-Arg-AMC的蛋白水解活性受到丝氨酸蛋白酶抑制剂PMSF和AMPSF。蛋白质也被固定化的氨基脒结合。

6. 发明授权

US06521263B1 Immunomodulatory factors for immunosuppresant and antiallergic treatment 失效
标题翻译：免疫抑制和抗过敏治疗的免疫调节因子
公开(公告)号：US06521263B1
公开(公告)日：2003-02-18
申请号：US09830738
申请日：2001-06-25
申请人： David Idris Pritchard , Paul Williams
发明人： David Idris Pritchard , Paul Williams
IPC分类号： A61K3556
CPC分类号： A61K35/62
摘要： An immunosuppressive agent, obtainable from the nematode Heligmosomoides polygyrus, characterised in that the agent has a molecular weight of less than 12 kDa, is resistant to proteinase K and is not bound to a polypeptide.
摘要翻译：可从线虫Heligmosomoides polygyrus获得的免疫抑制剂，其特征在于该试剂的分子量小于12kDa，对蛋白酶K具有抗性，并且不与多肽结合。

7. 发明申请

US20100008898A1 CHYMOTRYPSIN FROM LUCILIA SERICATA LARVAE AND ITS USE FOR THE TREATMENT OF WOUNDS 审中-公开
标题翻译：来自LUCILIA SERICATA LARVAE的CHYMOTRYPSIN及其治疗伤口的用途
公开(公告)号：US20100008898A1
公开(公告)日：2010-01-14
申请号：US12303010
申请日：2007-05-31
申请人： David Idris Pritchard , Adele J. Horobin , Alan Brown
发明人： David Idris Pritchard , Adele J. Horobin , Alan Brown
IPC分类号： A61K38/48 , C12N9/76
CPC分类号： A61K38/4826 , A61L15/44 , A61L2300/254 , C12N9/6427
摘要： The use of larval enzymes, particularly a chymotrypsin, is described herein. The enzymes are usable in the treatment of wounds for debridement and for cell regeneration.
摘要翻译：本文描述了使用幼虫酶，特别是糜蛋白酶。这些酶可用于治疗伤口清创和细胞再生。

8. 发明申请

US20090304668A1 LARVAL POLYPEPTIDES HAVING A NUCLEASE ACTIVITY 审中-公开
标题翻译：具有核酸活性的LARVAL POLYPEPTIDES
公开(公告)号：US20090304668A1
公开(公告)日：2009-12-10
申请号：US12297129
申请日：2007-04-13
申请人： David Idris Pritchard , Adele J. Horobin , Alan Brown
发明人： David Idris Pritchard , Adele J. Horobin , Alan Brown
IPC分类号： A61K38/47 , C12N9/14
CPC分类号： C12N9/22 , A61K38/00 , A61L15/38
摘要： This invention relates to a polypeptide obtainable from insect larvae, such as those from Lucilia sericata, and which have activity as a nuclease in that they are able to degrade, denature, digest, cut or cleave nucleic acids such as DNA.
摘要翻译：本发明涉及可从昆虫幼虫获得的多肽，例如来自丝绢霉属的多肽，并且它们具有作为核酸酶的活性，因为它们能够降解，变性，消化，切割或切割核酸如DNA。

9. 发明授权

US07371779B2 Synergistic compositions of N-acylhomoserine lactones and 4-quinolones 失效
公开(公告)号：US07371779B2
公开(公告)日：2008-05-13
申请号：US10481373
申请日：2002-07-03
申请人： David Idris Pritchard
发明人： David Idris Pritchard
IPC分类号： C07D31/341
CPC分类号： A61K31/47 , A61K31/365
摘要： A composition having immunosuppressant activity comprises at least one compound of the formula (I) in which R is an acyl group of the formula (II) wherein one of R1 and R2 is H and the other is selected from OR4, SR4 and NHR4, wherein R4 is H or 1-6C alkyl, or R1 and R2 together with the carbon atom to which they are joined form a keto group, and R3 is a straight or branched chain, saturated or unsaturated aliphatic hydrocarbyl group containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR5R6 wherein each of R5 and R6 is selected from H and 1-6C alkyl or R5 and R6 together with the N atom form a morpholino or piperazino group, or any enantiomer thereof; and at least one compound of the formula (III): wherein R7 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing from 1 to 18 carbon atoms which may optionally be substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR12R13, wherein each of R12 and R13 is independently selected from H and 1-6C alkyl or R12 and R13 together with the N atom to which they are attached form a saturated heterocyclic group selected from piperidino, piperazino and morpholino; R8 is a group selected from H, —OH, halo, —CHO, —CO2H and CONHR14 wherein R14 is H or a 1-6C alkyl; each of R9, R10 and R11 is independently selected from H, —CH3, —OCH3 and halo; or a non-toxic pharmaceutically-acceptable salt thereof. The determined immunosuppressant activity of the composition is greater than the sum of the activities of the individual components of the composition when determined separately

10. 发明授权

US07161059B2 Human hookworm model and method for maintaining human hookworm in a non-human primate 失效
标题翻译：人类钩虫模型和在非人灵长类动物中维持人类钩虫的方法
公开(公告)号：US07161059B2
公开(公告)日：2007-01-09
申请号：US10780809
申请日：2004-02-17
申请人： Alan Brown , Doreen S W Hooi , David Idris Pritchard , Gareth David Griffiths , Peter Colin Pearce , Elizabeth Ann Marie Scott
发明人： Alan Brown , Doreen S W Hooi , David Idris Pritchard , Gareth David Griffiths , Peter Colin Pearce , Elizabeth Ann Marie Scott
IPC分类号： A01K67/00 , A61K49/00
CPC分类号： A61K49/0008 , A01K2267/0337 , G01N33/5088
摘要： A method for maintaining a human hookworm strain is provided by infecting a non-human primate with a non-adapted or non-passaged human hookworm and maintaining the non-human primate. Methods of obtaining human hookworm materials and compositions, such as for use as a vaccine, are also provided, along with a model for maintaining and investigating human hookworm.
摘要翻译：通过用非适应或非传播的人类钩虫感染非人灵长类动物并维持非人灵长类动物来提供维持人类钩虫病毒株的方法。还提供了获得人钩虫材料和组合物的方法，例如用作疫苗，以及用于维持和研究人类钩虫的模型。

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