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1. 发明授权

US06420108B2 Computer-aided display for comparative gene expression 失效
标题翻译：用于比较基因表达的计算机辅助显示
公开(公告)号：US06420108B2
公开(公告)日：2002-07-16
申请号：US09020743
申请日：1998-02-09
申请人： David H. Mack , Elina Khurgin , Josie Dai , Kurt Gish , Jim Snyder , David Balaban
发明人： David H. Mack , Elina Khurgin , Josie Dai , Kurt Gish , Jim Snyder , David Balaban
IPC分类号： C12Q168
CPC分类号： G06T11/206 , C12N15/1089 , C12Q1/68 , G06F19/20 , G06F19/26
摘要： Innovative systems and methods for visualizing information collected from analyzing samples are provided. The samples may include nucleic acids, proteins, or other polymers. Gene expression level as determined from analysis of a nucleic acid sample is one possible analysis result that may be visualized. In one embodiment, a computer system may display the expression levels of multiple genes simultaneously in a way that facilitates user identification of genes whose expression is significant to a characteristic such as disease or resistance to disease. Additionally, the computer system may facilitate display of further information about relevant genes once they are identified.
摘要翻译：提供了从分析样品收集的信息可视化的创新系统和方法。样品可以包括核酸，蛋白质或其它聚合物。从核酸样品的分析确定的基因表达水平是可以被可视化的一个可能的分析结果。在一个实施方案中，计算机系统可以以促进用户识别其表达对诸如疾病或抗病性的特征是重要的基因的方式同时显示多个基因的表达水平。此外，一旦识别出相关基因，计算机系统可以便于显示关于相关基因的进一步信息。

2. 发明授权

US07736853B2 Methods of diagnosis of androgen-dependent prostate cancer, prostate cancer undergoing androgen withdrawal, and androgen-independent prostate cancer 有权
标题翻译：雄激素依赖性前列腺癌的诊断方法，进行雄激素停药的前列腺癌和雄激素依赖性前列腺癌
公开(公告)号：US07736853B2
公开(公告)日：2010-06-15
申请号：US11565589
申请日：2006-11-30
申请人： Daniel E. H. Afar , David Agus , David H. Mack
发明人： Daniel E. H. Afar , David Agus , David H. Mack
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57449 , G01N2500/04
摘要： Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein are methods that can be used to identify modulators of prostate cancer.
摘要翻译：本文描述的是其表达在前列腺癌中上调或下调的基因。还描述了这样的基因，其表达在耐药前列腺癌细胞中进一步上调或下调。公开了可用于诊断和治疗前列腺癌的相关方法和组合物。本文还描述了可用于鉴定前列腺癌调节剂的方法。

3. 发明授权

US07435589B2 Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer 有权
标题翻译：卵巢癌诊断方法，筛查卵巢癌调节剂的组成和方法
公开(公告)号：US07435589B2
公开(公告)日：2008-10-14
申请号：US11625458
申请日：2007-01-22
申请人： David H. Mack , Kurt C. Gish
发明人： David H. Mack , Kurt C. Gish
IPC分类号： C12N5/00 , C12N1/20 , C12N15/00 , C12N15/12 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57449 , G01N2500/04 , G01N2800/52
摘要： Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators of ovarian cancer.
摘要翻译：这里描述的是其表达在卵巢癌中上调或下调的基因。公开了可用于诊断和治疗卵巢癌的相关方法和组合物。本文还描述了可用于鉴定卵巢癌调节剂的方法。

4. 发明授权

US06762020B1 Methods of diagnosing breast cancer 有权
公开(公告)号：US06762020B1
公开(公告)日：2004-07-13
申请号：US09642034
申请日：2000-08-18
申请人： David H. Mack , Kurt C. Gish
发明人： David H. Mack , Kurt C. Gish
IPC分类号： C12Q168
CPC分类号： G01N33/5011 , A61K39/00 , C07K14/4748 , G01N33/57415
摘要： Described herein are methods that can be used for diagnosis and prognosis of breast cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate breast cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in breast cancer are described.

5. 发明授权

US06171798B2 P53-regulated genes 失效
标题翻译： P53调控基因
公开(公告)号：US06171798B2
公开(公告)日：2001-01-09
申请号：US09442039
申请日：1999-11-17
申请人： Arnold L. Levine , Maureen Elizabeth Murphy , David H. Mack , Kurt Carlyle Gish , Edward Yat Wah Tom
发明人： Arnold L. Levine , Maureen Elizabeth Murphy , David H. Mack , Kurt Carlyle Gish , Edward Yat Wah Tom
IPC分类号： C12Q168
CPC分类号： G01N33/57484 , C12Q1/6809 , C12Q1/6886 , C12Q2600/136
摘要： Many genes are identified as being p53-regulated which were not heretofore known to be p53-regulated. This includes both genes whose expression is induced and genes whose expression is repressed by the expression of wild-type p53. Monitoring expression of these genes is used to provide indications of p53 status in a cell. Such monitoring can also be used to screen for useful anti-cancer therapeutics, as well as for substances which are carcinogenic. Defects in p53 can be bypassed by supplying p53 induced genes to cells. Defects in p53 can also be bypassed by supplying antisense constructs to p53-repressed genes.
摘要翻译：许多基因被鉴定为p53调节的，这些基因迄今尚未被p53调节。这包括其表达被诱导的基因和通过野生型p53的表达抑制其表达的基因。监测这些基因的表达用于提供细胞中p53状态的指示。此类监测也可用于筛选有用的抗癌治疗剂，以及用于致癌物质。可以通过向细胞提供p53诱导的基因来绕过p53中的缺陷。通过向p53抑制的基因提供反义构建体也可以绕过p53中的缺陷。

6. 发明授权

US07189507B2 Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer 有权
标题翻译：卵巢癌诊断方法，筛查卵巢癌调节剂的组成和方法
公开(公告)号：US07189507B2
公开(公告)日：2007-03-13
申请号：US10173999
申请日：2002-06-17
申请人： David H. Mack , Kurt C. Gish
发明人： David H. Mack , Kurt C. Gish
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57449 , G01N2500/04 , G01N2800/52
摘要： Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators of ovarian cancer.
摘要翻译：本文描述的是其表达在卵巢癌中上调或下调的基因。公开了可用于诊断和治疗卵巢癌的相关方法和组合物。本文还描述了可用于鉴定卵巢癌调节剂的方法。

7. 发明授权

US5176995A Detection of viruses by amplification and hybridization 失效
标题翻译：通过扩增和杂交检测病毒
公开(公告)号：US5176995A
公开(公告)日：1993-01-05
申请号：US394145
申请日：1989-08-15
申请人： John J. Sninsky , Shirley Y. Kwok , David H. Mack , Henry A. Ehrlich , Kary B. Mullis
发明人： John J. Sninsky , Shirley Y. Kwok , David H. Mack , Henry A. Ehrlich , Kary B. Mullis
IPC分类号： B01L7/00 , C07K14/805 , C12N15/10 , C12Q1/68 , C12Q1/70 , C40B40/06 , C40B60/14
CPC分类号： B01L7/52 , C07K14/805 , C12N15/10 , C12Q1/6823 , C12Q1/6853 , C12Q1/686 , C12Q1/6865 , C12Q1/6876 , C12Q1/6881 , C12Q1/6883 , C12Q1/70 , C12Q1/703 , C12Q1/706 , B01J2219/00495 , B01J2219/0059 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/81 , Y10S436/811
摘要： The presence or absence of a nucleic acid sequence associated with one or more related viruses in a sample containing one or more nucleic acids and suspected of containing such sequence can be detected by amplifying the sequence using primers to form extension products as templates and detecting the amplified product if it is present. This may be accomplished by adding a labeled hybridization probe to the amplified product either free in solution or after immobilization on a solid support. Preferably the virus constitutes AIDs viruses and hepadnaviruses.
摘要翻译：可以通过使用引物扩增序列来检测含有一种或多种核酸并且怀疑含有该序列的样品中与一种或多种相关病毒相关的核酸序列，以形成扩增产物作为模板并检测扩增的产品如果存在的话。这可以通过将标记的杂交探针加入到在溶液中游离或固定在固体支持物上的扩增产物来实现。优选地，病毒构成AIDs病毒和肝炎病毒。

8. 发明授权

US5008182A Detection of AIDS associated virus by polymerase chain reaction 失效
标题翻译：通过聚合酶链反应检测艾滋病相关病毒
公开(公告)号：US5008182A
公开(公告)日：1991-04-16
申请号：US394276
申请日：1989-08-15
申请人： John J. Sninsky , Shirley Y. Kwok , David H. Mack
发明人： John J. Sninsky , Shirley Y. Kwok , David H. Mack
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/70 , C12Q1/6823 , C12Q1/686 , C12Q1/703 , C12Q1/706 , Y10T436/143333
摘要： The presence or absence of a nucleic acid sequence associated with AIDS in a sample containing one or more nucleic acids and suspected of containing such sequence can be detected by amplifying the sequence using primers to form extension products as templates and detecting the amplified product if it is present. This may be accomplished by adding a labeled hybridization probe to the amplified product either free in solution or after immobilization on a solid support.
摘要翻译：含有一个或多个核酸并且怀疑含有此类序列的样品中与AIDS相关的核酸序列的存在或不存在可以通过使用引物扩增序列来检测以形成扩增产物作为模板并检测扩增产物当下。这可以通过将标记的杂交探针加入到在溶液中游离或固定在固体支持物上的扩增产物来实现。

9. 发明申请

US20080138838A1 DIAGNOSIS OF ZD1839 RESISTANT TUMORS 审中-公开
标题翻译： ZD1839抗性肿瘤诊断
公开(公告)号：US20080138838A1
公开(公告)日：2008-06-12
申请号：US11941443
申请日：2007-11-16
申请人： Daniel Afar , David Agus , David H. Mack
发明人： Daniel Afar , David Agus , David H. Mack
IPC分类号： G01N33/574
CPC分类号： C07K14/47 , C07H21/04 , C12Q1/6837 , C12Q1/6886 , C12Q2600/136
摘要： Described herein are genes whose expression are regulated in specific cancers. Related methods and compositions that can be used for diagnosis of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.
摘要翻译：本文描述的是其表达在特定癌症中调节的基因。公开了可用于诊断这些癌症的相关方法和组合物。本文还描述了可用于鉴定所选癌症的调节剂的方法。

10. 发明授权

US06733969B2 Expression monitoring for gene function identification 有权
标题翻译：基因功能鉴定的表达监测
公开(公告)号：US06733969B2
公开(公告)日：2004-05-11
申请号：US09836278
申请日：2001-04-18
申请人： David H. Mack
发明人： David H. Mack
IPC分类号： C07H2104
CPC分类号： C12Q1/6809 , C12Q1/68 , C12Q1/6827 , C12Q1/6837 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16
摘要： This invention provides methods, compositions and apparatus for mapping the regulatory relationship among genes by massive parallel monitoring gene expression. In some embodiments, mutations in the up-stream regulatory genes are detected by monitoring the change in down-stream gene expression. Similarly, the function of a specific mutation in a up-stream gene is determined by monitoring the down-stream gene expression. In addition, regulatory function of a target gene can be determined by monitoring the expression of a large number of down-stream genes. The invention also provides specific embodiments for detecting p53 functional homozygous and heterozygous mutations and for determining the function of p53 mutations.
摘要翻译：本发明提供了通过大规模平行监测基因表达来绘制基因之间的调节关系的方法，组合物和装置。在一些实施方案中，通过监测下游基因表达的变化来检测上游调节基因中的突变。类似地，通过监测下游基因表达来确定上游基因中特异性突变的功能。此外，靶基因的调节功能可以通过监测大量下游基因的表达来确定。本发明还提供用于检测p53功能纯合突变和杂合突变并确定p53突变的功能的具体实施方案。

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