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1. 发明申请

US20070248975A1 METHODS FOR MONITORING THE EXPRESSION OF ALTERNATIVELY SPLICED GENES 审中-公开
标题翻译：监测异位基因表达的方法
公开(公告)号：US20070248975A1
公开(公告)日：2007-10-25
申请号：US11744763
申请日：2007-05-04
申请人： David Balaban
发明人： David Balaban
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6837 , G16B25/00 , C12Q2565/519 , C12Q2539/105
摘要： Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.
摘要翻译：提供了方法，探针阵列和计算机软件产品来确定序列元素的排列。在一个实施例中，提供了制造和使用外显子芯片的方法。外显子芯片可用于识别和量化剪接变体。

2. 发明申请

US20070212678A1 Method And Apparatus For Predicting Aggregation Kinetics Of A Biologically Active Material 审中-公开
标题翻译：用于预测生物活性材料的聚集动力学的方法和装置
公开(公告)号：US20070212678A1
公开(公告)日：2007-09-13
申请号：US11587168
申请日：2005-04-22
申请人： Richard Remmele Jr , David Balaban , Jian Zhang , Alexander Shoshitaishvili , Mark Durst
发明人： Richard Remmele Jr , David Balaban , Jian Zhang , Alexander Shoshitaishvili , Mark Durst
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G01N33/6803 , G01N33/68 , G16B15/00
摘要： A mechanistic model was developed to extract meaningful thermodynamic and kinetic parameters from an irreversibly denatured process. As a result, methods and computer apparatus have been created that can be used to mathematically determine parameters that are predictive of aggregation kinetics of biologically active materials. Those parameters can then be used to predict stability or aggregation kinetics as a function of time and temperature.
摘要翻译：开发了一种从不可逆变性过程中提取有意义的热力学和动力学参数的机械模型。因此，已经创建了可用于数学确定预测生物活性材料的聚集动力学的参数的方法和计算机装置。这些参数随后可用于预测作为时间和温度的函数的稳定性或聚集动力学。

3. 发明申请

US20060271513A1 Method and apparatus for providing an expression data mining database 审中-公开
标题翻译：提供表达式数据挖掘数据库的方法和装置
公开(公告)号：US20060271513A1
公开(公告)日：2006-11-30
申请号：US11499184
申请日：2006-08-03
申请人： David Balaban , Elina Khurgin
发明人： David Balaban , Elina Khurgin
IPC分类号： G06F17/30
CPC分类号： G06F16/2465 , G06F2216/03 , G16B25/00 , G16B50/00
摘要： According to the invention, a system and method for organizing expression information in a way that facilitates data mining. A database model is provided which may organize information relating to, e.g., sample preparation, expression analysis of experiment results, and intermediate and final results of mining expression and concentration results. The model is readily translatable into database languages such as SQL and the like. The database model scales to permit mining of expression or concentration information collected from large numbers of samples.
摘要翻译：根据本发明，一种用于以促进数据挖掘的方式组织表达信息的系统和方法。提供了一种数据库模型，其可以组织关于例如样品制备，实验结果的表达分析以及挖掘表达和浓度结果的中间和最终结果的信息。该模型很容易翻译成数据库语言，如SQL等。数据库模型可以扩展到允许从大量样本采集的表达或浓度信息的挖掘。

4. 发明授权

US06996475B2 Computer software products for nucleic acid hybridization analysis 有权
公开(公告)号：US06996475B2
公开(公告)日：2006-02-07
申请号：US10315919
申请日：2002-12-09
申请人： David Balaban
发明人： David Balaban
IPC分类号： G06F19/00 , C12Q1/68 , G11C17/00
CPC分类号： G06F19/20
摘要： Methods and computer software products are provided for analyzing gene expression data. In one embodiment, multiple probes are used to detect a single transcript. The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities of the probes. The minimal adjusted hybridization intensity may be used as the measurement of the gene expression.

5. 发明申请

US20060019544A1 Adapter for mogul base open fixture lamps 有权
标题翻译：适用于大理石开放式灯具
公开(公告)号：US20060019544A1
公开(公告)日：2006-01-26
申请号：US11173290
申请日：2005-07-01
申请人： Anthony Tufano , David Balaban
发明人： Anthony Tufano , David Balaban
IPC分类号： H01R25/00
CPC分类号： H01R33/94 , H01R33/22
摘要： A lamp adapter for receiving a lamp having a conductive threaded portion and an extension with a conductive contact electrically insulated from the conductive threaded portion. The lamp adapter has a body with a top portion and a bottom portion. The top portion has a socket with a threaded sleeve adapted to receive the threaded portion of the lamp, a first lead electrically connected to the threaded sleeve, a cavity located with respect to the threaded sleeve so as to receive the extension of the lamp when the lamp is threaded into the threaded sleeve, a metal contact arm located within the cavity so as to make electrical contact with the conductive contact of the lamp when the lamp is threaded into the threaded sleeve, and a second lead electrically connected to the metal contact arm. The bottom portion has a threaded portion suitable for threading into a mating lamp socket, the threaded portion being electrically insulated from the top portion. The lamp adapter includes a recess located within the cavity and a coil spring disposed with a lower portion within the recess and an upper portion above the recess and within the cavity, wherein the metal contact arm is located in cooperation with the coil spring so as to be biased thereon and make contact with the conductive contact of the lamp when the lamp is threaded into the threaded sleeve. The metal contact arm is located with the cavity so as not to make contact with a conductive electrical contact on a lamp not having an extension.
摘要翻译：一种灯适配器，用于接收具有导电螺纹部分的灯和具有与导电螺纹部分电绝缘的导电触头的延伸部。灯适配器具有具有顶部和底部的主体。顶部具有插座，其具有适于容纳灯的螺纹部分的螺纹套筒，电连接到螺纹套筒的第一引线，相对于螺纹套筒定位的腔，以便当接收灯的延伸时灯被拧入螺纹套筒中，金属接触臂位于空腔内，以便当灯被拧入螺纹套筒中时与灯的导电接触件电接触，而第二引线电连接到金属接触臂。底部具有适于穿入配合灯座的螺纹部分，螺纹部分与顶部部分电绝缘。所述灯适配器包括位于所述空腔内的凹部和设置在所述凹部内的下部的螺旋弹簧以及所述凹部内部和所述空腔内的上部，其中所述金属接触臂与所述螺旋弹簧配合，以便被偏置在其上并且当灯被拧入螺纹套筒时与灯的导电接触接触。金属接触臂位于空腔中，以便不与不具有延伸部的灯上的导电电接触接触。

6. 发明申请

US20050214824A1 Methods for monitoring the expression of alternatively spliced genes 审中-公开
标题翻译：监测可变剪接基因表达的方法
公开(公告)号：US20050214824A1
公开(公告)日：2005-09-29
申请号：US11036760
申请日：2005-01-13
申请人： David Balaban
发明人： David Balaban
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G06F19/20 , C12M1/34
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6837 , G16B25/00 , C12Q2565/519 , C12Q2539/105
摘要： Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.
摘要翻译：提供了方法，探针阵列和计算机软件产品来确定序列元素的排列。在一个实施例中，提供了制造和使用外显子芯片的方法。外显子芯片可用于识别和量化剪接变体。

7. 发明申请

US20070067111A1 Computer-aided visualization of expression comparison 审中-公开
标题翻译：计算机辅助可视化的表达比较
公开(公告)号：US20070067111A1
公开(公告)日：2007-03-22
申请号：US11489292
申请日：2006-07-18
申请人： David Mack , Kurt Gish , David Balaban , Elina Khurgin , Josie Dai , Jim Snyder
发明人： David Mack , Kurt Gish , David Balaban , Elina Khurgin , Josie Dai , Jim Snyder
IPC分类号： G06F19/00
CPC分类号： G06T11/206 , C12N15/1089 , C12Q1/68 , G16B25/00 , G16B45/00
摘要： Innovative systems and methods for visualizing information collected from analyzing samples are provided. The samples may include nucleic acids, proteins, or other polymers. Gene expression level as determined from analysis of a nucleic acid sample is one possible analysis result that may be visualized. In one embodiment, a computer system may display the expression levels of multiple genes simultaneously in a way that facilitates user identification of genes whose expression is significant to a characteristic such as disease or resistance to disease. Additionally, the computer system may facilitate display of further information about relevant genes once they are identified.
摘要翻译：提供了从分析样品收集的信息可视化的创新系统和方法。样品可以包括核酸，蛋白质或其它聚合物。从核酸样品的分析确定的基因表达水平是可以被可视化的一个可能的分析结果。在一个实施方案中，计算机系统可以以促进用户识别其表达对特征如疾病或抗性的重要性的基因的方式同时显示多个基因的表达水平。此外，一旦识别出相关基因，计算机系统可以便于显示关于相关基因的进一步信息。

8. 发明申请

US20060142951A1 Computer software products for nucleic acid hybridization analysis 审中-公开
标题翻译：用于核酸杂交分析的计算机软件产品
公开(公告)号：US20060142951A1
公开(公告)日：2006-06-29
申请号：US11348730
申请日：2006-02-06
申请人： David Balaban , Earl Hubbell
发明人： David Balaban , Earl Hubbell
IPC分类号： G06F19/00
CPC分类号： G16B25/00
摘要： Methods and computer software products are provided for analyzing gene expression data In one embodiment, multiple probes are used to detect a single transcript The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities of the probes The minimal adjusted hybridization intensity may be used as the measurement of the gene expression
摘要翻译：提供了用于分析基因表达数据的方法和计算机软件产品。在一个实施方案中，使用多个探针检测单个转录物通过用强度除以探针的亲和力来调节每个探针的杂交强度。最小调整的杂交强度可以是用作基因表达的测量

9. 发明申请

US20050287863A1 Insulation piercing contact alignment system 审中-公开
标题翻译：绝缘穿孔接触对准系统
公开(公告)号：US20050287863A1
公开(公告)日：2005-12-29
申请号：US11145989
申请日：2005-06-07
申请人： Anthony Tufano , David Balaban , Mehmet Tanacan , Denise Chan-Richter
发明人： Anthony Tufano , David Balaban , Mehmet Tanacan , Denise Chan-Richter
IPC分类号： H01R4/24 , H01R13/631 , H01R33/76
CPC分类号： H01R13/631 , H01R4/2404 , H01R33/7664
摘要： A system and method for the alignment of an insulation piercing contact within a two piece switch housing with an insulated electrical wires disposed within the housing. The housing is comprised of two halves whereby when the two halves are brought together during assembly, the insulation piercing contact pierces the insulation of the electrical wires and forms an electrical connection between the contact and the wires. Proper alignment between the insulation piercing contact and the insulated electrical wires is ensured by providing extended prongs on one half of the switch housing. On the other half of the switch housing, channels are provided and arranged to slidably engage and mate with the prongs prior to contact of the electrical wires with the piercing contact. The prongs and channels fix the relative alignment of the contact with the wire before piercing occurs and ensures consistent location of the electrical connection formed during assembly of the switch housing.
摘要翻译：一种用于将绝缘穿刺接触件对准在两件式开关壳体内的绝缘电线的布置在壳体内的系统和方法。壳体由两个半部组成，由此当组装过程中两个半部分组合在一起时，绝缘穿刺接触件刺穿电线的绝缘体，并在接触件和电线之间形成电连接。通过在开关外壳的一半上提供延长的插脚来确保绝缘穿刺触头和绝缘电线之间的正确对准。在开关壳体的另一半上，通道设置并布置成在电线与穿孔触头接触之前可滑动地接合并与插脚配合。在穿刺之前，插脚和通道固定触点与电线的相对对准，并确保在开关壳体组装期间形成的电连接的位置一致。

10. 发明申请

US20070066112A1 Fluorescent lampholder 失效
标题翻译：荧光灯座
公开(公告)号：US20070066112A1
公开(公告)日：2007-03-22
申请号：US11520114
申请日：2006-09-12
申请人： Anthony Tufano , David Balaban
发明人： Anthony Tufano , David Balaban
IPC分类号： H01R33/08
CPC分类号： H01R33/0854 , H01R4/4818 , H01R33/0872
摘要： A fluorescent lampholder with a top portion for supporting a fluorescent lamp and a base portion with a wire opening located on the bottom surface of the base that receives wires without exposing the wires to the exterior surface of a fixture. The lampholder is capable of supporting various types and/or sizes of fluorescent lamps such as “tall”, “medium” and “small” T-8 fluorescent lamps as well as other types and/or sizes of fluorescent lamps.
摘要翻译：具有用于支撑荧光灯的顶部的荧光灯座和具有位于基座的底表面上的线开口的基部，其接收线而不将线暴露于固定装置的外表面。灯座能够支持诸如“高”，“中”和“小”T-8荧光灯以及其他类型和/或尺寸的荧光灯的各种类型和/或尺寸的荧光灯。

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