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1. 发明授权

US5866650A Composition of cyclic amine-initiated elastomers and amorphous silica and process for the production thereof 失效
标题翻译：环胺引发的弹性体和无定形二氧化硅的组成及其制备方法
公开(公告)号：US5866650A
公开(公告)日：1999-02-02
申请号：US893868
申请日：1997-07-11
申请人： David F. Lawson , Hideo Takeichi , William L. Hergenrother , Thomas J. Lynch , James Oziomek
发明人： David F. Lawson , Hideo Takeichi , William L. Hergenrother , Thomas J. Lynch , James Oziomek
IPC分类号： B60C1/00 , C08C19/44 , C08F4/48 , C08F36/04 , C08K3/36 , C08L21/00 , C08C19/22
CPC分类号： C08F36/04 , C08C19/44 , C08K3/36 , Y10S152/905
摘要： The reduction of hysteresis in a silica-filled, vulcanized elastomeric compound is produced by mixing diene monomer and optionally monovinyl aromatic monomer with a lithium amine initiator and, optionally, a modifier; effecting polymerization conditions; terminating polymerization with an amino group producing terminator to form an amine functionalized diene elastomer; compounding the amine functionalized diene elastomer with an amorphous silica filler and a vulcanization agent; and, effecting vulcanization. A pneumatic tire tread stock incorporating the vulcanized elastomer compound exhibits improved reduced hysteresis, or highly balanced wet traction, rolling resistance, snow/ice traction, and mechanical strength when compounded with silica filler and vulcanized, in the tire.
摘要翻译：通过将二烯单体和任选的单乙烯基芳族单体与锂胺引发剂和任选的改性剂混合来制备二氧化硅填充的硫化弹性体化合物中的滞后的降低; 影响聚合条件; 用氨基产生终止剂终止聚合以形成胺官能化二烯弹性体; 将胺官能化二烯弹性体与无定形二氧化硅填料和硫化剂混合; 并进行硫化。包含硫化弹性体复合材料的充气轮胎胎面料在轮胎中与二氧化硅填料混合时，具有改善的滞后性，或者高度平衡的湿牵引力，滚动阻力，雪/冰牵引力和机械强度。

2. 发明授权

US5916961A Amine-initiated elastomers having hysteresis reducing interaction with silica 失效
标题翻译：具有磁滞减少与二氧化硅相互作用的胺引发的弹性体
公开(公告)号：US5916961A
公开(公告)日：1999-06-29
申请号：US893806
申请日：1997-07-11
申请人： William L. Hergenrother , Thomas J. Lynch
发明人： William L. Hergenrother , Thomas J. Lynch
IPC分类号： C08K3/06 , C08C19/44 , C08F4/08 , C08F4/48 , C08F36/04 , C08K3/36 , C08K5/14 , C08L9/00 , C08C19/22
CPC分类号： C08K3/36 , C08C19/44 , C08F36/04 , Y10S152/905 , Y10T152/10495
摘要： The reduction of hysteresis in a silica-filled, vulcanized elastomeric compound is produced by mixing diene monomer and optionally monovinyl aromatic monomer with a lithium amine initiator and, optionally, a modifier; effecting polymerization conditions; terminating polymerization with an amino group producing terminator to form an amine functionalized diene elastomer; compounding the amine functionalized diene elastomer with an amorphous silica filler and a vulcanization agent; and, effecting vulcanization. A pneumatic tire tread stock incorporating the vulcanized elastomer compound exhibits decreased rolling resistance in the tire.
摘要翻译：通过将二烯单体和任选的单乙烯基芳族单体与锂胺引发剂和任选的改性剂混合来制备二氧化硅填充的硫化弹性体化合物中的滞后的降低; 影响聚合条件; 用氨基产生终止剂终止聚合以形成胺官能化二烯弹性体; 将胺官能化二烯弹性体与无定形二氧化硅填料和硫化剂混合; 并进行硫化。包含硫化弹性体复合材料的充气轮胎胎面涂料在轮胎中表现出降低的滚动阻力。

3. 发明授权

US08465916B2 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments 有权
标题翻译：确定癌症对表皮生长因子受体靶向治疗的反应性的方法
公开(公告)号：US08465916B2
公开(公告)日：2013-06-18
申请号：US11894160
申请日：2007-08-20
申请人： Daphne Winifred Bell , Daniel A. Haber , Pasi Antero Janne , Bruce E. Johnston , Thomas J. Lynch , Matthew Meyerson , Juan Guillermo Paez , William R. Sellers , Jeffrey E. Settleman , Raffaella Sordella
发明人： Daphne Winifred Bell , Daniel A. Haber , Pasi Antero Janne , Bruce E. Johnston , Thomas J. Lynch , Matthew Meyerson , Juan Guillermo Paez , William R. Sellers , Jeffrey E. Settleman , Raffaella Sordella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
摘要翻译：本发明涉及确定癌症对表皮生长因子受体（EGFR）治疗的反应性的方法。在优选的实施方案中，erbB1基因的激酶结构域中存在至少一个方差赋予对酪氨酸激酶抑制剂吉非替尼的敏感性。因此，这些突变的诊断测定将允许对最可能对药物作出反应的那些患者施用吉非替尼，厄洛替尼和其他酪氨酸激酶抑制剂。

4. 发明申请

US20080234264A1 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments 有权
标题翻译：确定癌症对表皮生长因子受体靶向治疗的反应性的方法
公开(公告)号：US20080234264A1
公开(公告)日：2008-09-25
申请号：US11894160
申请日：2007-08-20
申请人： Daphne Winifred Bell , Daniel A. Haber , Pasi Antero Janne , Bruce E. Johnston , Thomas J. Lynch , Matthew Meyerson , Juan Guillermo Paez , William R. Sellers , Jeffrey E. Settleman , Raffaella Sordella
发明人： Daphne Winifred Bell , Daniel A. Haber , Pasi Antero Janne , Bruce E. Johnston , Thomas J. Lynch , Matthew Meyerson , Juan Guillermo Paez , William R. Sellers , Jeffrey E. Settleman , Raffaella Sordella
IPC分类号： A61K31/5377 , C12Q1/68 , A61K31/517 , C12N15/12 , C07K14/47 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
摘要翻译：本发明涉及确定癌症对表皮生长因子受体（EGFR）治疗的反应性的方法。在优选的实施方案中，erbB1基因的激酶结构域中存在至少一个方差赋予对酪氨酸激酶抑制剂吉非替尼的敏感性。因此，这些突变的诊断测定将允许对最可能对药物作出反应的那些患者施用吉非替尼，厄洛替尼和其他酪氨酸激酶抑制剂。

5. 发明申请

US20080207615A1 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments 有权
公开(公告)号：US20080207615A1
公开(公告)日：2008-08-28
申请号：US11894159
申请日：2007-08-20
申请人： Daphne Winifred Bell , Daniel A. Haber , Pasi Antero Janne , Bruce E. Johnston , Thomas J. Lynch , Matthew Meyerson , Juan Guillermo Paez , William R. Sellers , Jeffrey E. Settleman , Raffaella Sordella
发明人： Daphne Winifred Bell , Daniel A. Haber , Pasi Antero Janne , Bruce E. Johnston , Thomas J. Lynch , Matthew Meyerson , Juan Guillermo Paez , William R. Sellers , Jeffrey E. Settleman , Raffaella Sordella
IPC分类号： A61K31/5377 , C12Q1/68 , A61K31/517 , C12N15/12 , C07K14/47 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

6. 发明授权

US06177603B1 Organo zinc and rare earth catalyst system in the polymerization of conjugated dienes 失效
标题翻译：有机锌和稀土催化剂体系在共轭二烯聚合中的应用
公开(公告)号：US06177603B1
公开(公告)日：2001-01-23
申请号：US09096905
申请日：1998-06-12
申请人： Thomas J. Lynch
发明人： Thomas J. Lynch
IPC分类号： C07C202
CPC分类号： C08F36/04 , C08F4/545
摘要： The instant invention provides a process for substantially reducing the polymer cement viscosity or reducing the molecular weight distribution of the a conjugated diene polymer synthesized by using a charge of catalytically effective amounts of a rare earth catalyst and an organo magnesium component by adding an organo zinc component to the charge in an amount and under conditions sufficient to reduce the polymer cement viscosity. The invention also contemplates a catalyst compostion for substantially reducing the polymer cement viscosity of a polymer product as well the resultant polymer product.
摘要翻译：本发明提供一种用于通过使用催化有效量的稀土催化剂和有机镁组分的电荷合成的共轭二烯聚合物基本上降低聚合物水泥粘度或降低分子量分布的方法，通过加入有机锌组分在足以降低聚合物粘合剂粘度的条件下进行充电。本发明还考虑了用于大大降低聚合物产物以及所得聚合物产物的聚合物粘合剂粘度的催化剂组合物。

7. 发明授权

US5580265A Sealant compositions and sealed electrical connectors 失效
标题翻译：密封剂组合物和密封电连接器
公开(公告)号：US5580265A
公开(公告)日：1996-12-03
申请号：US297574
申请日：1994-08-29
申请人： Francis F. Koblitz , Thomas J. Lynch , Ricky C. Mellinger
发明人： Francis F. Koblitz , Thomas J. Lynch , Ricky C. Mellinger
IPC分类号： C08L53/00 , C08L53/02 , C09K3/10 , H01B7/282 , H01B7/285 , H01B7/29 , H01R4/24 , H01R4/70 , H01R13/52 , H01B3/44
CPC分类号： H01R13/5216 , C08L53/00 , C08L53/005 , C08L53/02 , C08L53/025 , C09K3/10 , H01B7/282 , H01B7/285 , H01B7/292 , H01R4/2495 , H01R4/70 , C09K2200/0247 , C09K2200/0405 , C09K2200/06 , C09K2200/0617 , C09K2200/062 , C09K2200/0632 , C09K2200/0642 , Y10S439/936
摘要： Disclosed are sealant compositions having excellent slump and spew resistant, even at relatively high operating temperatures for electrical connectors. The sealants, which are flowable at such elevated temperatures, comprise two essential components: elastomeric thermoplastic polymer, preferably an organic polymer composite comprising diblock and triblock copolymers, and extender for the polymer. The extender may comprise a primary and a secondary extender, such as polybutene oil and mineral oil, respectively.
摘要翻译：公开的是具有优异的坍落度和防溅性的密封剂组合物，即使在相对高的操作温度下用于电连接器。可在这样升高的温度下流动的密封剂包括两个必需组分：弹性体热塑性聚合物，优选包含二嵌段和三嵌段共聚物的有机聚合物复合物，以及聚合物的增量剂。增量剂可分别包含初级和次级增量剂，例如聚丁烯油和矿物油。

8. 发明授权

US5285794A Respiratory gas monitor 失效
标题翻译：呼吸气体监测仪
公开(公告)号：US5285794A
公开(公告)日：1994-02-15
申请号：US990203
申请日：1992-12-14
申请人： Thomas J. Lynch
发明人： Thomas J. Lynch
IPC分类号： A61B5/083
CPC分类号： A61B5/083
摘要： A method and apparatus for monitoring the respiratory gas of a patient includes an adjustable volume gas mixing chamber which allows for the differences in lung capacity of patients from neonate to adult. A constant flow of a therapeutic gas mixture is measured by a flow meter in a supply line leading to a face mask breathing device. The mask is by-pass connected to the supply line such that the patient inspires from and exhales into the flow from the supply line. Both by-pass and expired gas mix and enter the adjustable-volume chamber, which contains an internal fan and sensors for detecting percentage content of oxygen and carbon dioxide. The chamber is adjusted to a volume where the sensor readings become stable rather than pulsatile. The change in percentages of oxygen and carbon dioxide content in the chamber, as compared to the content in the supply gas, is then entirely due to total-body consumption and production. Whole body rates can be determined by multiplying the percentage change by the flow rate in the supply line.
摘要翻译：用于监测患者呼吸气体的方法和装置包括可调体积气体混合室，其允许患者从新生儿到成人的肺容量差异。治疗气体混合物的恒定流量通过通向面罩呼吸装置的供应管线中的流量计来测量。掩模被旁路连接到供应管线，使得患者从供应管线起动和呼出。旁路和过期气体混合并进入可调节容积室，其中包含内部风扇和用于检测氧气和二氧化碳含量百分比的传感器。腔室被调节到传感器读数变得稳定而不是脉动的体积。与供应气体的含量相比，室内的氧气和二氧化碳含量的百分比变化完全是由于全身消耗和生产。可以通过将百分比变化乘以供应线中的流量来确定整体体重。

9. 发明授权

US5206654A Passive aircraft monitoring system 失效
标题翻译：被动飞机监控系统
公开(公告)号：US5206654A
公开(公告)日：1993-04-27
申请号：US886112
申请日：1992-05-19
申请人： Marc Finkelstein , Martin J. Geesaman , Thomas J. Lynch
发明人： Marc Finkelstein , Martin J. Geesaman , Thomas J. Lynch
IPC分类号： G01S1/14 , G01S5/02 , G01S13/91 , G01S19/15
CPC分类号： G01S11/10 , G01S1/14 , G01S13/913 , G01S5/02
摘要： A passive aircraft monitoring system (20) receives signals transmitted by an instrument landing system (14, 16) and reflected from aircraft (18). The Doppler shift in the reflected signals is used to calculate the position or velocity of the aircraft. Using the ILS 90 and 150 Hz signals reflected from the aircraft and comparing their magnitude, the altitude and lateral position of the aircraft can also be determined.

10. 发明授权

US4219444A Ethylene polymerization catalysts 失效
标题翻译：乙烯聚合催化剂
公开(公告)号：US4219444A
公开(公告)日：1980-08-26
申请号：US864296
申请日：1977-12-27
申请人： Robert W. Hill , William L. Kehl , Thomas J. Lynch
发明人： Robert W. Hill , William L. Kehl , Thomas J. Lynch
IPC分类号： B01J23/26 , B01J27/18 , C08F4/24 , C08F110/02 , B01J27/14 , B01J31/12
CPC分类号： B01J27/18 , B01J23/26 , C08F110/02
摘要： Novel catalysts are provided for the polymerization of olefins such as ethylene. The catalysts consist essentially of a chromium compound supported upon an inorganic carrier containing aluminum and phosphorus moieties, at least a portion of the chromium having a valence of less than 6. The inorganic carrier is an amorphous precipitate of aluminum phosphate or an amorphous precipitate containing aluminum and phosphorus moieties in an atomic ratio in the range of about 5:1 to 1:1. The catalysts are particularly useful for polymerizing ethylene in a Particle Form Process in that the catalyst has essentially no polymerization induction period and provides ethylene polymers having a desirably broad molecular weight distribution and a desirably high melt flow shear ratio.
摘要翻译：提供了用于烯烃如乙烯的聚合的新型催化剂。催化剂基本上由负载在含有铝和磷部分的无机载体上的铬化合物组成，至少一部分铬的价数小于6.无机载体是磷酸铝的无定形沉淀物或含有铝的无定形沉淀物和原子比为约5:1至1:1的磷部分。催化剂特别可用于在颗粒形成方法中聚合乙烯，因为催化剂基本上没有聚合诱导期，并且提供具有期望的宽分子量分布和期望的高熔体流动剪切比的乙烯聚合物。

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