专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070243254A1 NOVEL DRUG COMPOSITIONS AND DOSAGE FORMS OF TOPIRAMATE 审中-公开
标题翻译：新型药物组合物及其用量
公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
IPC分类号： A61K9/24 , A61P25/06 , A61P25/08
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译：本发明涉及包含所述药物组合物的新型药物组合物和剂型。本发明的药物组合物包含药剂和增溶剂。本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。本发明还涉及制备所述药物组合物和剂型的方法。本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

2. 发明申请

US20070128279A1 Extended Release Dosage Form 有权
标题翻译：延长释放剂型
公开(公告)号：US20070128279A1
公开(公告)日：2007-06-07
申请号：US11673066
申请日：2007-02-09
申请人： David Edgren , Patrick Wong , Gurdish Bhatti , Shu Li , Robert Skluzacek
发明人： David Edgren , Patrick Wong , Gurdish Bhatti , Shu Li , Robert Skluzacek
IPC分类号： A61K31/485 , A61K9/24 , A61K31/16
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
摘要翻译：公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。

3. 发明申请

US20060165798A1 Oral osmotic dosage form having a high flux membrane 审中-公开
标题翻译：具有高通量膜的口服渗透剂型
公开(公告)号：US20060165798A1
公开(公告)日：2006-07-27
申请号：US11341251
申请日：2006-01-27
申请人： David Edgren , Gurdish Bhatti , Shu Li , Robert Skluzacek
发明人： David Edgren , Gurdish Bhatti , Shu Li , Robert Skluzacek
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Disclosed are oral osmotic dosage forms and methods wherein a semi-permeable membrane of the oral osmotic dosage form includes from about 23 wt % to about 50 wt % of a flux enhancer and from about 0.01 wt % to about 5 wt % of antioxidant, based on the total dry weight of the semi-permeable membrane. Such compositions provide high flux membranes with improved mechanical and transport stability during storage on the shelf.
摘要翻译：公开了口服渗透剂型和方法，其中口服渗透剂型的半渗透膜包含约23重量％至约50重量％的助熔剂增强剂和约0.01重量％至约5重量％的抗氧化剂，基于关于半透膜的总干重。这样的组合物在储存在架子上时具有改善的机械和运输稳定性的高通量膜。

4. 发明申请

US20070031496A1 Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties 审中-公开
标题翻译：包含半透膜的渗透剂型与聚合物共混物提供改进的性质
公开(公告)号：US20070031496A1
公开(公告)日：2007-02-08
申请号：US11499008
申请日：2006-08-04
申请人： David Edgren , Shu Li , Gurdish Bhatti , Patrick Wong
发明人： David Edgren , Shu Li , Gurdish Bhatti , Patrick Wong
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Disclosed are osmotic dosage forms including an osmotic core; a semi-permeable membrane that surrounds the osmotic core and comprises a blend of a cellulose acetate polymer and an acrylate copolymer; and an exit formed through the semi-permeable membrane. Also disclosed are methods of making and administering such dosage forms.
摘要翻译：公开了渗透剂型，包括渗透核; 围绕渗透芯并包含醋酸纤维素聚合物和丙烯酸酯共聚物的共混物的半透膜; 以及通过半透膜形成的出口。还公开了制备和施用这种剂型的方法。

5. 发明申请

US20050003006A1 Pharmaceutical coating composition and method of use 失效
标题翻译：药用涂料组合物及其使用方法
公开(公告)号：US20050003006A1
公开(公告)日：2005-01-06
申请号：US10897669
申请日：2004-07-23
申请人： David Edgren , Shu Li , Patrick Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David Edgren , Shu Li , Patrick Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
IPC分类号： A61K9/00 , A61K9/28 , A61K9/36 , A61K9/50 , A61K9/24
CPC分类号： A61K9/2853 , A61K9/0004 , A61K9/282 , A61K9/284 , A61K9/2866
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.
摘要翻译：公开的组合物在溶剂中显示出对聚合物和表面活性剂具有共同的溶解性的聚合物和表面活性剂。该组合物提供了随时间施用药物的剂型。

6. 发明申请

US20070184112A1 Volume Efficient Controlled Release Dosage Form 审中-公开
标题翻译：体积有效的控制释放剂型
公开(公告)号：US20070184112A1
公开(公告)日：2007-08-09
申请号：US11684821
申请日：2007-03-12
申请人： Patrick Wong , Francisco Jao , David Edgren , Robert Skluzacek , Shu Li
发明人： Patrick Wong , Francisco Jao , David Edgren , Robert Skluzacek , Shu Li
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form that facilitates the controlled release of an active agent at a desired release rate or release rate profile includes a bi-layer membrane system and an osmotic core. The bi-layer membrane system includes a semipermeable membrane and an osmosensitive membrane and forms an internal compartment occupied by the osmotic core. The osmotic core includes an active agent composition and a light push layer. A passageway is formed through the bi-layer membrane system and permits expulsion of the active agent composition from the dosage form during operation. The bi-layer membrane system and the osmotic core are formulated and formed to provide controlled release of the active agent included in the active agent composition, while simultaneously facilitating increased loading of active agent within a dosage form of given dimension and increasing the delivery efficiency of such active agent relative to prior osmotic dosage forms including a push layer.
摘要翻译：有利于以期望的释放速率或释放速率曲线控制释放活性剂的剂型包括双层膜系统和渗透核。双层膜系统包括半透膜和渗透膜，并形成由渗透芯占据的内部隔室。渗透芯包括活性剂组合物和轻推层。通过双层膜系统形成通道，并允许活性剂组合物在操作期间从剂型中排出。双层膜系统和渗透芯被配制和形成以提供包含在活性剂组合物中的活性剂的受控释放，同时促进活性剂在给定维度的剂型中的负载增加，并且提高这种活性剂相对于包括推层的先前的渗透剂型。

7. 发明申请

US20050048120A1 Dosage form comprising self-destructive membrane 审中-公开
标题翻译：包含自毁膜的剂型
公开(公告)号：US20050048120A1
公开(公告)日：2005-03-03
申请号：US10957357
申请日：2004-10-01
申请人： David Edgren , Robert Skluzacek , Shu Li , Patrick Wong , Paul Magruder
发明人： David Edgren , Robert Skluzacek , Shu Li , Patrick Wong , Paul Magruder
IPC分类号： A61K9/00 , A61K9/26 , A61K38/01 , A61K9/24 , A61K38/00
CPC分类号： A61K9/0004 , A61K38/01 , A61K2300/00
摘要： A sustained release dosage form is disclosed, which dosage form comprises an interior lipophilic membrane, and an exterior hydrophilic membrane comprising a peptide, that surround a composition comprising a drug. The dosage form at the end of its drug delivery period self-ruptures for enhancing its exit from the environment of use.
摘要翻译：公开了持续释放剂型，其剂型包括内部亲脂性膜，以及包含肽的外部亲水膜，其包围包含药物的组合物。药物输送期结束时的剂型自我破裂，以增强其从使用环境的退出。

8. 发明授权

US07087243B2 Pharmaceutical coating composition and method of use 失效
公开(公告)号：US07087243B2
公开(公告)日：2006-08-08
申请号：US10897669
申请日：2004-07-23
申请人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
IPC分类号： A61K9/20 , A61K9/24 , A61K9/26
CPC分类号： A61K9/2853 , A61K9/0004 , A61K9/282 , A61K9/284 , A61K9/2866
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.

9. 发明授权

US07060734B1 Pharmaceutical coating composition and method of use 失效
标题翻译：药用涂料组合物及其使用方法
公开(公告)号：US07060734B1
公开(公告)日：2006-06-13
申请号：US09721111
申请日：2000-11-22
申请人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
IPC分类号： A01N25/00
CPC分类号： A61K9/0004 , Y10S514/975
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.
摘要翻译：公开的组合物在溶剂中显示出对聚合物和表面活性剂具有共同的溶解性的聚合物和表面活性剂。该组合物提供了随时间施用药物的剂型。

10. 发明申请

US20070207204A1 Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
标题翻译：药物递送时间变化模式的剂型
公开(公告)号：US20070207204A1
公开(公告)日：2007-09-06
申请号：US11744999
申请日：2007-05-07
申请人： David Edgren , Patrick Wong , Shu Li
发明人： David Edgren , Patrick Wong , Shu Li
IPC分类号： A61K9/66
CPC分类号： A61K9/0004 , A61K31/277
摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.
摘要翻译：本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。药物涂层在初始无药物释放间隔后释放。在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式