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1. 发明申请

US20070243254A1 NOVEL DRUG COMPOSITIONS AND DOSAGE FORMS OF TOPIRAMATE 审中-公开
标题翻译：新型药物组合物及其用量
公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
IPC分类号： A61K9/24 , A61P25/06 , A61P25/08
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译：本发明涉及包含所述药物组合物的新型药物组合物和剂型。本发明的药物组合物包含药剂和增溶剂。本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。本发明还涉及制备所述药物组合物和剂型的方法。本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

2. 发明申请

US20070128279A1 Extended Release Dosage Form 有权
标题翻译：延长释放剂型
公开(公告)号：US20070128279A1
公开(公告)日：2007-06-07
申请号：US11673066
申请日：2007-02-09
申请人： David Edgren , Patrick Wong , Gurdish Bhatti , Shu Li , Robert Skluzacek
发明人： David Edgren , Patrick Wong , Gurdish Bhatti , Shu Li , Robert Skluzacek
IPC分类号： A61K31/485 , A61K9/24 , A61K31/16
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
摘要翻译：公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。

3. 发明申请

US20060165798A1 Oral osmotic dosage form having a high flux membrane 审中-公开
标题翻译：具有高通量膜的口服渗透剂型
公开(公告)号：US20060165798A1
公开(公告)日：2006-07-27
申请号：US11341251
申请日：2006-01-27
申请人： David Edgren , Gurdish Bhatti , Shu Li , Robert Skluzacek
发明人： David Edgren , Gurdish Bhatti , Shu Li , Robert Skluzacek
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Disclosed are oral osmotic dosage forms and methods wherein a semi-permeable membrane of the oral osmotic dosage form includes from about 23 wt % to about 50 wt % of a flux enhancer and from about 0.01 wt % to about 5 wt % of antioxidant, based on the total dry weight of the semi-permeable membrane. Such compositions provide high flux membranes with improved mechanical and transport stability during storage on the shelf.
摘要翻译：公开了口服渗透剂型和方法，其中口服渗透剂型的半渗透膜包含约23重量％至约50重量％的助熔剂增强剂和约0.01重量％至约5重量％的抗氧化剂，基于关于半透膜的总干重。这样的组合物在储存在架子上时具有改善的机械和运输稳定性的高通量膜。

4. 发明申请

US20070184112A1 Volume Efficient Controlled Release Dosage Form 审中-公开
标题翻译：体积有效的控制释放剂型
公开(公告)号：US20070184112A1
公开(公告)日：2007-08-09
申请号：US11684821
申请日：2007-03-12
申请人： Patrick Wong , Francisco Jao , David Edgren , Robert Skluzacek , Shu Li
发明人： Patrick Wong , Francisco Jao , David Edgren , Robert Skluzacek , Shu Li
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form that facilitates the controlled release of an active agent at a desired release rate or release rate profile includes a bi-layer membrane system and an osmotic core. The bi-layer membrane system includes a semipermeable membrane and an osmosensitive membrane and forms an internal compartment occupied by the osmotic core. The osmotic core includes an active agent composition and a light push layer. A passageway is formed through the bi-layer membrane system and permits expulsion of the active agent composition from the dosage form during operation. The bi-layer membrane system and the osmotic core are formulated and formed to provide controlled release of the active agent included in the active agent composition, while simultaneously facilitating increased loading of active agent within a dosage form of given dimension and increasing the delivery efficiency of such active agent relative to prior osmotic dosage forms including a push layer.
摘要翻译：有利于以期望的释放速率或释放速率曲线控制释放活性剂的剂型包括双层膜系统和渗透核。双层膜系统包括半透膜和渗透膜，并形成由渗透芯占据的内部隔室。渗透芯包括活性剂组合物和轻推层。通过双层膜系统形成通道，并允许活性剂组合物在操作期间从剂型中排出。双层膜系统和渗透芯被配制和形成以提供包含在活性剂组合物中的活性剂的受控释放，同时促进活性剂在给定维度的剂型中的负载增加，并且提高这种活性剂相对于包括推层的先前的渗透剂型。

5. 发明申请

US20050048120A1 Dosage form comprising self-destructive membrane 审中-公开
标题翻译：包含自毁膜的剂型
公开(公告)号：US20050048120A1
公开(公告)日：2005-03-03
申请号：US10957357
申请日：2004-10-01
申请人： David Edgren , Robert Skluzacek , Shu Li , Patrick Wong , Paul Magruder
发明人： David Edgren , Robert Skluzacek , Shu Li , Patrick Wong , Paul Magruder
IPC分类号： A61K9/00 , A61K9/26 , A61K38/01 , A61K9/24 , A61K38/00
CPC分类号： A61K9/0004 , A61K38/01 , A61K2300/00
摘要： A sustained release dosage form is disclosed, which dosage form comprises an interior lipophilic membrane, and an exterior hydrophilic membrane comprising a peptide, that surround a composition comprising a drug. The dosage form at the end of its drug delivery period self-ruptures for enhancing its exit from the environment of use.
摘要翻译：公开了持续释放剂型，其剂型包括内部亲脂性膜，以及包含肽的外部亲水膜，其包围包含药物的组合物。药物输送期结束时的剂型自我破裂，以增强其从使用环境的退出。

6. 发明申请

US20050169992A1 Methods and dosage forms for increasing solubility of drug compositions for controlled delivery 审中-公开
标题翻译：用于增加药物组合物用于受控递送的溶解度的方法和剂型
公开(公告)号：US20050169992A1
公开(公告)日：2005-08-04
申请号：US11023257
申请日：2004-12-22
申请人： Frank Jao , David Edgren , Robert Skluzacek , Noymi Yam
发明人： Frank Jao , David Edgren , Robert Skluzacek , Noymi Yam
IPC分类号： A61K9/00 , A61K9/48 , A61K31/18 , A61K31/7004 , A61K9/22 , A61K9/24
CPC分类号： A61K9/0004 , A61K31/7004
摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of poorly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration.
摘要翻译：描述了通过使用提高药剂的溶解度的药物核心组合物增强药剂的受控递送的剂型和装置。本发明提供了一种在口服药物递送系统中递送高剂量的难溶性药物的方法，其便于吞咽，每天一次给药。

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