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1. 发明申请

US20120239126A1 Visual Prosthesis Including a Flexible Circuit Electrode Array 有权
标题翻译：包括柔性电路电极阵列的视觉假体
公开(公告)号：US20120239126A1
公开(公告)日：2012-09-20
申请号：US13460495
申请日：2012-04-30
申请人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Nevsmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada
发明人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Nevsmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada
IPC分类号： A61F9/08 , B32B37/02 , A61N1/04
CPC分类号： A61N1/0543 , A61N1/0541 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/28 , H05K2201/0133 , H05K2201/0195 , Y10T156/1002
摘要： A visual prosthesis which includes a hermetic package and flexible circuit electrode array is disclosed. The hermetic package includes electrode drivers and contacts. The flexible circuit electrode array includes a polymer base layer, metal traces, including electrodes suitable to stimulate visual neural tissue and bond pads bonded to contacts on the hermetic package, all deposited on the polymer base layer, a polymer top layer deposited on the polymer base layer and deposited on the metal traces, a partial or an entire coating of the polymer base layer and of the polymer top layer by a soft polymer that is softer than the polymer base layer; and the polymer base layer and the polymer top layer contain a plurality of aligned holes to facilitate bonding of the soft polymer.
摘要翻译：公开了一种包括气密封装和柔性电路电极阵列的视觉假体。密封包装包括电极驱动器和触点。柔性电路电极阵列包括聚合物基层，金属迹线，包括适于刺激视觉神经组织的电极和粘合到密封封装上的触点的焊盘，全部沉积在聚合物基底层上，聚合物顶层沉积在聚合物基底上并且通过比聚合物基底层更柔软的软质聚合物沉积在金属迹线上，聚合物基层和聚合物顶层的部分或全部涂层; 并且聚合物基层和聚合物顶层包含多个对准的孔以有助于软聚合物的结合。

2. 发明授权

US08209023B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08209023B2
公开(公告)日：2012-06-26
申请号：US12163658
申请日：2008-06-27
申请人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada , Melody Tabada, legal representative
发明人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada
IPC分类号： A61N1/04 , A61N1/00
CPC分类号： A61N1/0543 , A61N1/0541 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/28 , H05K2201/0133 , H05K2201/0195 , Y10T156/1002
摘要： A flexible circuit electrode array and method of fabrication having a polymer base layer; metal traces deposited on the polymer base layer, including electrodes to stimulate tissue; a polymer top layer deposited on the polymer base layer and metal traces; and a coating of the base and top layer by a soft polymer. A method of preparing a flexible circuit electrode array, comprising: providing a first soft polymer layer; depositing a first a base layer on the first soft polymer layer; providing a metal thin film on the base layer; depositing a top polymer layer on the metal thin film; providing holes in the top polymer layer; depositing a second soft polymer layer on the top polymer layer; providing holes in the second soft polymer layer for bond pads and electrodes; and preparing electrodes in the provided holes.
摘要翻译：柔性电路电极阵列和具有聚合物基底层的制造方法; 沉积在聚合物基层上的金属痕迹，包括刺激组织的电极; 沉积在聚合物基底层上的聚合物顶层和金属痕迹; 以及通过软聚合物涂覆基体和顶层。一种制备柔性电路电极阵列的方法，包括：提供第一软聚合物层; 在第一软质聚合物层上沉积第一基底层; 在基层上提供金属薄膜; 在金属薄膜上沉积顶部聚合物层; 在顶部聚合物层中提供孔; 在顶部聚合物层上沉积第二软聚合物层; 在第二软聚合物层中提供用于接合焊盘和电极的孔; 并在所提供的孔中制备电极。

3. 发明授权

US08489193B2 Visual prosthesis including a flexible circuit electrode array 有权
标题翻译：视觉假体包括柔性电路电极阵列
公开(公告)号：US08489193B2
公开(公告)日：2013-07-16
申请号：US13460495
申请日：2012-04-30
申请人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada
发明人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada
IPC分类号： A61N1/04
CPC分类号： A61N1/0543 , A61N1/0541 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/28 , H05K2201/0133 , H05K2201/0195 , Y10T156/1002
摘要： A flexible circuit electrode array, which comprises: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a partial or entire coating of the base and top layer by a soft polymer.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及通过软聚合物的基底和顶层的部分或全部涂层。

4. 发明申请

US20090264972A1 Flexible Circuit Electrode Array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US20090264972A1
公开(公告)日：2009-10-22
申请号：US12163658
申请日：2008-06-27
申请人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little
发明人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little
IPC分类号： A61N1/05 , B29C70/88 , B05D5/12
CPC分类号： A61N1/0543 , A61N1/0541 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/28 , H05K2201/0133 , H05K2201/0195 , Y10T156/1002
摘要： A flexible circuit electrode array, which comprises: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a partial or entire coating of the base and top layer by a soft polymer.A method of preparing a flexible circuit electrode array, comprising: (a) providing a first soft polymer layer; (b) depositing a first a base layer on the first soft polymer layer; (c) providing a metal thin film on the base layer; (d) depositing a top polymer layer on the metal thin film; (e) providing holes in the top polymer layer; (f) depositing a second soft polymer layer on the top polymer layer; (g) providing holes in the second soft polymer layer for bond pads and electrodes; and (h) preparing electrodes in the provided holes.A method of preparing a flexible circuit electrode array, comprising: (a) providing a first soft polymer layer; (b) depositing a first a base layer on the first soft polymer layer; (c) providing a metal thin film on the base layer; (d) depositing a top polymer layer on the metal thin film; (e) depositing a second soft polymer layer on the top polymer layer; (f) providing holes in the second soft polymer layer and in the top polymer layer for bond pads and electrodes; and (g) preparing electrodes in the provided holes.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及通过软聚合物的基底和顶层的部分或全部涂层。一种制备柔性电路电极阵列的方法，包括：（a）提供第一软聚合物层; （b）在第一软聚合物层上沉积第一基底层; （c）在基层上提供金属薄膜; （d）在金属薄膜上沉积顶部聚合物层; （e）在顶部聚合物层中提供孔; （f）在顶部聚合物层上沉积第二软聚合物层; （g）在第二软聚合物层中为接合焊盘和电极提供孔; 和（h）在所提供的孔中制备电极。一种制备柔性电路电极阵列的方法，包括：（a）提供第一软聚合物层; （b）在第一软聚合物层上沉积第一基底层; （c）在基层上提供金属薄膜; （d）在金属薄膜上沉积顶部聚合物层; （e）在顶部聚合物层上沉积第二软聚合物层; （f）在第二软聚合物层和顶部聚合物层中提供用于接合焊盘和电极的孔; 和（g）在所提供的孔中制备电极。

5. 发明授权

US08738149B2 Flexible circuit electrode array device and a method for backside processing of a flexible circuit electrode device 有权
标题翻译：柔性电路电极阵列器件及柔性电路电极器件的背面处理方法
公开(公告)号：US08738149B2
公开(公告)日：2014-05-27
申请号：US13397604
申请日：2012-02-15
申请人： Qingfang Yao , Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Qingfang Yao , Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543 , B23K26/361 , B23K26/362
摘要： The invention involves a flexible circuit electrode array device comprising: a polymer layer; wherein the polymer layer includes one or more metal traces, an electrode array; one or more bond pads; and the electrode array is located on the opposite side of the polymer layer.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: applying polymer film on a substrate; processing the front side; releasing the polymer film from substrate; flipping over the polymer film and fixing it onto the substrate; processing the backside; and final releasing of the polymer film from the substrate.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: processing the front side without releasing the polymer; processing the backside by sacrificial substrate method, or by laser drilling method; and releasing the polymer film from the substrate.
摘要翻译：本发明涉及一种柔性电路电极阵列器件，包括：聚合物层; 其中所述聚合物层包括一个或多个金属迹线，电极阵列; 一个或多个接合垫; 并且电极阵列位于聚合物层的相对侧上。本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：在基底上施加聚合物膜; 正面加工; 从基材中释放聚合物膜; 翻转在聚合物膜上并将其固定在基底上; 处理背面; 并从基底中最终释放聚合物膜。本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：处理前侧而不释放聚合物; 通过牺牲基板方法或通过激光钻孔方法处理背面; 并从基板上释放聚合物膜。

6. 发明授权

US08180460B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08180460B2
公开(公告)日：2012-05-15
申请号：US11934627
申请日：2007-11-02
申请人： Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

7. 发明申请

US20120150270A1 Flexible Circuit Electrode Array Device and a Method for Backside Processing of a Flexible Circuit Electrode Device 有权
标题翻译：柔性电路电极阵列器件及柔性电路电极器件背面加工方法
公开(公告)号：US20120150270A1
公开(公告)日：2012-06-14
申请号：US13397604
申请日：2012-02-15
申请人： Qingfang Yao , Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Qingfang Yao , Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543 , B23K26/361 , B23K26/362
摘要： The invention involves a flexible circuit electrode array device comprising: a polymer layer; wherein the polymer layer includes one or more metal traces, an electrode array; one or more bond pads; and the electrode array is located on the opposite side of the polymer layer.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: applying polymer film on a substrate; processing the front side; releasing the polymer film from substrate; flipping over the polymer film and fixing it onto the substrate; processing the backside; and final releasing of the polymer film from the substrate.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: processing the front side without releasing the polymer; processing the backside by sacrificial substrate method, or by laser drilling method; and releasing the polymer film from the substrate.
摘要翻译：本发明涉及一种柔性电路电极阵列器件，包括：聚合物层; 其中所述聚合物层包括一个或多个金属迹线，电极阵列; 一个或多个接合垫; 并且电极阵列位于聚合物层的相对侧上。本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：在基底上施加聚合物膜; 正面加工; 从基材中释放聚合物膜; 翻转在聚合物膜上并将其固定在基底上; 处理背面; 并从基底中最终释放聚合物膜。本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：处理前侧而不释放聚合物; 通过牺牲基板方法或通过激光钻孔方法处理背面; 并从基板上释放聚合物膜。

8. 发明申请

US20090143848A1 Cochlear Stimulation Device 有权
标题翻译：耳蜗刺激装置
公开(公告)号：US20090143848A1
公开(公告)日：2009-06-04
申请号：US12267489
申请日：2008-11-07
申请人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
发明人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61N1/0472
摘要： A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
摘要翻译：耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。该设备旨在通过适当的电极设计实现最佳神经刺激，这是相对于市售的手工设备的显着改进。

9. 发明授权

US08874239B2 Cochlear stimulation device 有权
标题翻译：人工耳蜗刺激装置
公开(公告)号：US08874239B2
公开(公告)日：2014-10-28
申请号：US12267489
申请日：2008-11-07
申请人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
发明人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0541 , A61N1/0472
摘要： A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
摘要翻译：耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。该设备旨在通过适当的电极设计实现最佳神经刺激，这是相对于市售的手工设备的显着改进。

10. 发明申请

US20090118805A1 Return Electrode for a Flexible Circuit Electrode Array 审中-公开
标题翻译：用于柔性电路电极阵列的返回电极
公开(公告)号：US20090118805A1
公开(公告)日：2009-05-07
申请号：US12168740
申请日：2008-07-07
申请人： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
发明人： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
IPC分类号： A61F9/08 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large.The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes.The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.
摘要翻译：在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。为了避免用返回电极刺激组织，如果电极很大，则是有利的。本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极从所述刺激电极。柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

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