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1. 发明授权

US09592396B2 Biocompatible bonding method and electronics package suitable for implantation 有权
标题翻译：生物相容性接合方法和电子封装适合植入
公开(公告)号：US09592396B2
公开(公告)日：2017-03-14
申请号：US13351899
申请日：2012-01-17
申请人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
IPC分类号： H05K3/34 , A61N1/375 , A61N1/05 , H05K3/36 , H05K1/03 , H05K3/32 , H05K3/40 , H05K3/42 , H05K3/46
CPC分类号： A61N1/375 , A61N1/0543 , A61N1/36046 , A61N1/3758 , H05K1/0306 , H05K3/321 , H05K3/328 , H05K3/361 , H05K3/4015 , H05K3/423 , H05K3/4652 , H05K3/4691 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/0733 , H05K2203/1446 , Y10T29/49155
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得到的电子封装，其适于植入生物组织中，用于视网膜或皮质电极阵列，以使视力恢复到某些非 - 有个人密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

2. 发明申请

US20120131794A1 Biocompatible Bonding Method and Electronics Package Suitable for Implantation 有权
标题翻译：生物相容性接合方法和适用于植入的电子封装
公开(公告)号：US20120131794A1
公开(公告)日：2012-05-31
申请号：US13351899
申请日：2012-01-17
申请人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
IPC分类号： H05K3/10
CPC分类号： A61N1/375 , A61N1/0543 , A61N1/36046 , A61N1/3758 , H05K1/0306 , H05K3/321 , H05K3/328 , H05K3/361 , H05K3/4015 , H05K3/423 , H05K3/4652 , H05K3/4691 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/0733 , H05K2203/1446 , Y10T29/49155
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得到的电子封装，其适于植入生物组织中，用于视网膜或皮质电极阵列，以使视力恢复到某些非 - 有个人密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

3. 发明授权

US4195665A Fluid valve 失效
标题翻译：流体阀
公开(公告)号：US4195665A
公开(公告)日：1980-04-01
申请号：US881000
申请日：1978-02-24
申请人： Gaillard R. Nolan , William E. Flynn
发明人： Gaillard R. Nolan , William E. Flynn
IPC分类号： F16K11/02 , G01N1/00
CPC分类号： G01N35/1097 , F16K11/027 , Y10T137/86445 , Y10T137/86501 , Y10T137/86911 , Y10T137/8782
摘要： The fluid valve essentially comprises a support structure designed rotatably to support an inlet within a certain oscillatory ambit and stationarily supporting a plurality of outlets within the oscillatory ambit, and operative means for effecting fluid-tight communication seriatim between the inlet and one of the outlets. The inlet is preferably a blunt needle provided with a side port and each of the outlets comprises an inverted "Y"-shaped member formed of an entrance portion and a pair of leg portions. The needle is designed to be thrust into the entrance portion, so that its side port establishes fluid-tight communication with one of the leg portions. Means are provided, including a pneumatic cylinder, for effecting relative motion between the inlet and the outlets. There is also a means for normally closing off all the entrance portions of the outlets except the selected one, and only during the entry of the blunt needle therein. Such means includes a plurality of pinch rods and a cylindrical cam mounted about the pneumatic cylinder and provided with a channel to cooperate with one end of the pinch rods so as to open the selected outlet when the needle is thrust therein. Means are also provided for selectively indexing the needle within the oscillatory ambit which comprises both electrical and mechanical parts.
摘要翻译：流体阀基本上包括支撑结构，该支撑结构可旋转地设计成支撑一定振荡范围内的入口，并且在振荡范围内固定地支撑多个出口，以及用于在入口和一个出口之间进行流体密封通信的操作装置。入口优选是设置有侧端口的钝针，并且每个出口包括由入口部分和一对腿部部分形成的倒置的“Y”形构件。针被设计成被推入入口部分，使得其侧面与腿部之一建立流体密封连通。提供了包括用于在入口和出口之间进行相对运动的气缸的装置。还有一种用于通常关闭出口除了所选择的出口的所有入口部分，并且仅在钝针入口期间的装置。这种装置包括多个夹紧杆和围绕气缸安装的圆柱形凸轮，并且设置有与夹紧杆的一端配合的通道，以便当针被推入时打开所选择的出口。还提供了用于在包括电气和机械部件的振荡范围内选择性地分度针的装置。

4. 发明授权

US09295581B2 Medical tack with a variable effective length 有权
公开(公告)号：US09295581B2
公开(公告)日：2016-03-29
申请号：US11352168
申请日：2006-02-13
申请人： James S. Little , Gaillard R. Nolan , Neil H. Talbot , Robert J. Greenberg
发明人： James S. Little , Gaillard R. Nolan , Neil H. Talbot , Robert J. Greenberg
IPC分类号： A61F2/16 , A61F9/007 , A61B17/064 , A61B17/068 , A61F11/00 , A61B17/10
CPC分类号： A61F9/00727 , A61B17/064 , A61B17/068 , A61B17/10 , A61B2017/0646 , A61B2017/0647 , A61F9/007 , A61F11/004
摘要： The present invention is an improved medical tack. The tack of the present invention includes attachment points at each end where at least one of the attachment points is moveable, varying the effective length of the tack. Varying the length of the medical tack adapts the tack for use with tissue of different thickness.

5. 发明授权

US08121697B2 Biocompatible bonding method and electronics package suitable for implantation 有权
标题翻译：生物相容性接合方法和电子封装适合植入
公开(公告)号：US08121697B2
公开(公告)日：2012-02-21
申请号：US12861729
申请日：2010-08-23
申请人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/0543 , A61N1/36046 , A61N1/3758 , H05K1/0306 , H05K3/321 , H05K3/328 , H05K3/361 , H05K3/4015 , H05K3/423 , H05K3/4652 , H05K3/4691 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/0733 , H05K2203/1446 , Y10T29/49155
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得到的电子封装，其适于植入生物组织中，用于视网膜或皮质电极阵列，以使视力恢复到某些非 - 有个人密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

6. 发明申请

US20090118805A1 Return Electrode for a Flexible Circuit Electrode Array 审中-公开
标题翻译：用于柔性电路电极阵列的返回电极
公开(公告)号：US20090118805A1
公开(公告)日：2009-05-07
申请号：US12168740
申请日：2008-07-07
申请人： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
发明人： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
IPC分类号： A61F9/08 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large.The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes.The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.
摘要翻译：在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。为了避免用返回电极刺激组织，如果电极很大，则是有利的。本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极从所述刺激电极。柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

7. 发明申请

US20110213443A1 Biocompatible Bonding Method and Electronics Package Suitable for Implantation 有权
标题翻译：生物相容性接合方法和适用于植入的电子封装
公开(公告)号：US20110213443A1
公开(公告)日：2011-09-01
申请号：US12861729
申请日：2010-08-23
申请人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
IPC分类号： A61F9/08
CPC分类号： A61N1/375 , A61N1/0543 , A61N1/36046 , A61N1/3758 , H05K1/0306 , H05K3/321 , H05K3/328 , H05K3/361 , H05K3/4015 , H05K3/423 , H05K3/4652 , H05K3/4691 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/0733 , H05K2203/1446 , Y10T29/49155
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得到的电子封装，其适于植入生物组织中，用于视网膜或皮质电极阵列，以使视力恢复到某些非 - 有个人密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

8. 发明授权

US07813796B2 Biocompatible bonding method and electronics package suitable for implantation 有权
标题翻译：生物相容性接合方法和电子封装适合植入
公开(公告)号：US07813796B2
公开(公告)日：2010-10-12
申请号：US11455028
申请日：2006-07-24
申请人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , Neil Talbot , Jerry Ok , Gaillard R. Nolan , Dau Min Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/3758 , A61N1/0543 , A61N1/36046 , A61N1/375 , H01L21/563 , H01L23/49827 , H01L23/49838 , H01L23/4985 , H01L24/81 , H01L2224/0557 , H01L2224/05571 , H01L2224/05573 , H01L2224/13169 , H01L2224/13178 , H01L2224/16225 , H01L2224/16227 , H01L2224/32225 , H01L2224/73204 , H01L2224/81469 , H01L2224/81478 , H01L2224/81815 , H01L2924/00014 , H01L2924/01019 , H01L2924/01046 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/14 , H01L2924/1461 , H05K1/028 , H05K1/0306 , H05K1/09 , H05K1/111 , H05K1/113 , H05K1/115 , H05K1/189 , H05K3/10 , H05K3/188 , H05K3/305 , H05K3/321 , H05K3/328 , H05K3/3436 , H05K3/361 , H05K3/4015 , H05K3/4038 , H05K3/4084 , H05K3/423 , H05K3/4644 , H05K3/4652 , H05K3/4691 , H05K13/0469 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/05 , H05K2203/06 , H05K2203/0733 , H05K2203/09 , H05K2203/107 , H05K2203/1446 , H01L2924/00 , H01L2224/05599
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法以及所得到的电子封装，其适于植入生物组织，例如用于视网膜或皮质电极阵列，以使视力恢复对某些无意识的个人。密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

9. 发明授权

US4817600A Implantable filter 失效
标题翻译：可植入式过滤器
公开(公告)号：US4817600A
公开(公告)日：1989-04-04
申请号：US53354
申请日：1987-05-22
申请人： James K. Herms , Gaillard R. Nolan , Jonathan McGrath , Mark J Tolkoff
发明人： James K. Herms , Gaillard R. Nolan , Jonathan McGrath , Mark J Tolkoff
IPC分类号： A61M1/36 , A61F2/00 , A61F2/01 , A61B17/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/0067
摘要： A blood clot filtration device, for implantation percutaneously, for preventing movement of blood clots within a blood vessel. The device has a head and a plurality of legs extending therefrom. The legs include a first linear leg portion of predetermined length emanating distally from the head generally parallel to the axis of the device; a second multi-angled leg portion of relatively greater length extending generally outwardly from the distal end of the first linear leg portion at an acute angle to the axis, to form, with other second leg portions, a conical aspect, the second leg portion having a series of discrete linear segments arrayed generally tangent to a cone defined by the second leg portions of the set of legs; and a hook portion at the distal end of each the leg extending outwardly, away from the axis in a manner for engaging the blood vessel to fix the position of the device therewithin. The configuration of the legs, including the first linear portion, and the use of a high strength titanium alloy for the head, formed by fusing, and legs produces a filter which is able to tolerate severe compression for introduction percutaneously through a small sheath without yielding. Preferably a central wire segment is disposed axially, with the first linear leg portions of the filter disposed closely thereabout.

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