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1. 发明申请

US20050026203A1 Method and system for providing a probe array chip design database 有权
标题翻译：提供探针阵列芯片设计数据库的方法和系统
公开(公告)号：US20050026203A1
公开(公告)日：2005-02-03
申请号：US10925393
申请日：2004-08-24
申请人： David Balaban , Earl Hubbell , Michael Mittmann , Gloria Cheung , Josie Dai
发明人： David Balaban , Earl Hubbell , Michael Mittmann , Gloria Cheung , Josie Dai
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G06F19/28 , G06F19/20
摘要： Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.
摘要翻译：用于组织与包括寡核苷酸阵列芯片的聚合物探针阵列芯片的设计有关的信息的系统和方法。提供了一种数据库模型，其组织芯片上的信息相关探针，由芯片研究的基因组项目以及与芯片设计有关的序列信息。该模型很容易翻译成数据库语言，如SQL。数据库模型可以存储关于大量具有复杂设计的芯片的信息。

2. 发明申请

US20070067111A1 Computer-aided visualization of expression comparison 审中-公开
标题翻译：计算机辅助可视化的表达比较
公开(公告)号：US20070067111A1
公开(公告)日：2007-03-22
申请号：US11489292
申请日：2006-07-18
申请人： David Mack , Kurt Gish , David Balaban , Elina Khurgin , Josie Dai , Jim Snyder
发明人： David Mack , Kurt Gish , David Balaban , Elina Khurgin , Josie Dai , Jim Snyder
IPC分类号： G06F19/00
CPC分类号： G06T11/206 , C12N15/1089 , C12Q1/68 , G16B25/00 , G16B45/00
摘要： Innovative systems and methods for visualizing information collected from analyzing samples are provided. The samples may include nucleic acids, proteins, or other polymers. Gene expression level as determined from analysis of a nucleic acid sample is one possible analysis result that may be visualized. In one embodiment, a computer system may display the expression levels of multiple genes simultaneously in a way that facilitates user identification of genes whose expression is significant to a characteristic such as disease or resistance to disease. Additionally, the computer system may facilitate display of further information about relevant genes once they are identified.
摘要翻译：提供了从分析样品收集的信息可视化的创新系统和方法。样品可以包括核酸，蛋白质或其它聚合物。从核酸样品的分析确定的基因表达水平是可以被可视化的一个可能的分析结果。在一个实施方案中，计算机系统可以以促进用户识别其表达对特征如疾病或抗性的重要性的基因的方式同时显示多个基因的表达水平。此外，一旦识别出相关基因，计算机系统可以便于显示关于相关基因的进一步信息。

3. 发明申请

US20060142951A1 Computer software products for nucleic acid hybridization analysis 审中-公开
标题翻译：用于核酸杂交分析的计算机软件产品
公开(公告)号：US20060142951A1
公开(公告)日：2006-06-29
申请号：US11348730
申请日：2006-02-06
申请人： David Balaban , Earl Hubbell
发明人： David Balaban , Earl Hubbell
IPC分类号： G06F19/00
CPC分类号： G16B25/00
摘要： Methods and computer software products are provided for analyzing gene expression data In one embodiment, multiple probes are used to detect a single transcript The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities of the probes The minimal adjusted hybridization intensity may be used as the measurement of the gene expression
摘要翻译：提供了用于分析基因表达数据的方法和计算机软件产品。在一个实施方案中，使用多个探针检测单个转录物通过用强度除以探针的亲和力来调节每个探针的杂交强度。最小调整的杂交强度可以是用作基因表达的测量

4. 发明申请

US20050287863A1 Insulation piercing contact alignment system 审中-公开
标题翻译：绝缘穿孔接触对准系统
公开(公告)号：US20050287863A1
公开(公告)日：2005-12-29
申请号：US11145989
申请日：2005-06-07
申请人： Anthony Tufano , David Balaban , Mehmet Tanacan , Denise Chan-Richter
发明人： Anthony Tufano , David Balaban , Mehmet Tanacan , Denise Chan-Richter
IPC分类号： H01R4/24 , H01R13/631 , H01R33/76
CPC分类号： H01R13/631 , H01R4/2404 , H01R33/7664
摘要： A system and method for the alignment of an insulation piercing contact within a two piece switch housing with an insulated electrical wires disposed within the housing. The housing is comprised of two halves whereby when the two halves are brought together during assembly, the insulation piercing contact pierces the insulation of the electrical wires and forms an electrical connection between the contact and the wires. Proper alignment between the insulation piercing contact and the insulated electrical wires is ensured by providing extended prongs on one half of the switch housing. On the other half of the switch housing, channels are provided and arranged to slidably engage and mate with the prongs prior to contact of the electrical wires with the piercing contact. The prongs and channels fix the relative alignment of the contact with the wire before piercing occurs and ensures consistent location of the electrical connection formed during assembly of the switch housing.
摘要翻译：一种用于将绝缘穿刺接触件对准在两件式开关壳体内的绝缘电线的布置在壳体内的系统和方法。壳体由两个半部组成，由此当组装过程中两个半部分组合在一起时，绝缘穿刺接触件刺穿电线的绝缘体，并在接触件和电线之间形成电连接。通过在开关外壳的一半上提供延长的插脚来确保绝缘穿刺触头和绝缘电线之间的正确对准。在开关壳体的另一半上，通道设置并布置成在电线与穿孔触头接触之前可滑动地接合并与插脚配合。在穿刺之前，插脚和通道固定触点与电线的相对对准，并确保在开关壳体组装期间形成的电连接的位置一致。

5. 发明申请

US20060212229A1 Method and system for providing a probe array chip design database 审中-公开
标题翻译：提供探针阵列芯片设计数据库的方法和系统
公开(公告)号：US20060212229A1
公开(公告)日：2006-09-21
申请号：US11429576
申请日：2006-05-05
申请人： David Balaban , Earl Hubbell , Michael Mittmann , Gloria Cheung , Josie Dai
发明人： David Balaban , Earl Hubbell , Michael Mittmann , Gloria Cheung , Josie Dai
IPC分类号： G06F19/00 , G06F17/50 , G06F9/45
CPC分类号： G16B50/00 , G16B25/00
摘要： Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.
摘要翻译：用于组织与包括寡核苷酸阵列芯片的聚合物探针阵列芯片的设计有关的信息的系统和方法。提供了一种数据库模型，其组织芯片上的信息相关探针，由芯片研究的基因组项目以及与芯片设计有关的序列信息。该模型很容易翻译成数据库语言，如SQL。数据库模型可以存储关于大量具有复杂设计的芯片的信息。

6. 发明申请

US20060141506A1 Methods for monitoring the expression of alternatively spliced genes 审中-公开
公开(公告)号：US20060141506A1
公开(公告)日：2006-06-29
申请号：US11287330
申请日：2005-11-23
申请人： David Balaban
发明人： David Balaban
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6837 , G16B25/00 , C12Q2565/519 , C12Q2539/105
摘要： Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.

7. 发明授权

US07011948B2 Detection of ligand-antiligand complex formation by electromagnetically detectable bulk property measurement 失效
标题翻译：通过电磁可检测的体积特性测量检测配体 - 抗配体复合物形成
公开(公告)号：US07011948B2
公开(公告)日：2006-03-14
申请号：US10198465
申请日：2002-07-17
申请人： Robert G. Chapman , Pejman Ghanouni , Igor Shmulevich , David Balaban , Joseph A. Heanue , Andrew P. May , Nikolai Sharkov
发明人： Robert G. Chapman , Pejman Ghanouni , Igor Shmulevich , David Balaban , Joseph A. Heanue , Andrew P. May , Nikolai Sharkov
IPC分类号： C12Q1/68 , C12P19/34 , G01N15/06 , G01N33/00 , B01L3/00
CPC分类号： G01N33/53 , Y10S977/924
摘要： Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i.e., properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.
摘要翻译：公开了用于分析分子结合事件的方法，其中可以在混合物中直接检测配体/反配体配合物的形成，而不需要通过测量混合物的体积特性（即具有贡献的性质）来将混合物的组分彼此分离来自混合物中存在的几种或全部组分）。使用这些技术，可以筛选文库而不标记靶抗配体或配体。本发明还提供了通过进一步分析相同信号来确定配体/抗配体结合强度的方法。

8. 发明申请

US20050164270A1 Methods and system for providing a polymorphism database 审中-公开
标题翻译：提供多态数据库的方法和系统
公开(公告)号：US20050164270A1
公开(公告)日：2005-07-28
申请号：US11038624
申请日：2005-01-18
申请人： David Balaban , Jyoti Baid , Anthony Berno
发明人： David Balaban , Jyoti Baid , Anthony Berno
IPC分类号： C12M1/00 , C12N15/00 , C12N15/09 , C12Q1/68 , G01N15/00 , G01N31/22 , G01N33/48 , G01N33/50 , G01N33/53 , G01N37/00 , G03F7/20 , G06F7/00 , G06F12/00 , G06F17/30 , G06F19/20 , G06F19/28 , G06K9/00 , H04M1/00 , H04M1/725 , H04M3/54 , H04Q7/38 , G06F19/00
CPC分类号： H04M1/006 , C12Q1/6809 , G16B25/00 , G16B50/00 , H04M1/72519 , H04M3/46 , H04M3/54 , H04M2207/206 , Y10S128/922 , Y10S707/925 , Y10S707/955 , Y10S707/99933 , Y10S707/99934 , Y10S707/99945
摘要： Systems and methods for organizing information relating to study of polymorphisms. A database model is provided which interrelates information about one or more of, e.g, subjects from whom samples are extracted, primers used in extracting the DNA from the subjects, about the samples themselves, about experiments done on samples, about particular oligonucleotide probe arrays used to perform experiments, about analysis procedures performed on the samples, and about analysis results. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of subjects, samples, experiments, chips, etc.
摘要翻译：组织多态性研究相关信息的系统和方法。提供了一种数据库模型，其将关于样本提取的一个或多个，例如从受试者提取DNA的引物，关于样品本身，关于样品上进行的实验，关于使用的特定寡核苷酸探针阵列的信息相互关联进行实验，关于样品执行的分析程序以及分析结果。该模型很容易翻译成数据库语言，如SQL。数据库模型规模可以存储关于大量主题，样本，实验，筹码等的信息。

9. 发明申请

US20070248975A1 METHODS FOR MONITORING THE EXPRESSION OF ALTERNATIVELY SPLICED GENES 审中-公开
标题翻译：监测异位基因表达的方法
公开(公告)号：US20070248975A1
公开(公告)日：2007-10-25
申请号：US11744763
申请日：2007-05-04
申请人： David Balaban
发明人： David Balaban
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6837 , G16B25/00 , C12Q2565/519 , C12Q2539/105
摘要： Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.
摘要翻译：提供了方法，探针阵列和计算机软件产品来确定序列元素的排列。在一个实施例中，提供了制造和使用外显子芯片的方法。外显子芯片可用于识别和量化剪接变体。

10. 发明申请

US20070212678A1 Method And Apparatus For Predicting Aggregation Kinetics Of A Biologically Active Material 审中-公开
标题翻译：用于预测生物活性材料的聚集动力学的方法和装置
公开(公告)号：US20070212678A1
公开(公告)日：2007-09-13
申请号：US11587168
申请日：2005-04-22
申请人： Richard Remmele Jr , David Balaban , Jian Zhang , Alexander Shoshitaishvili , Mark Durst
发明人： Richard Remmele Jr , David Balaban , Jian Zhang , Alexander Shoshitaishvili , Mark Durst
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G01N33/6803 , G01N33/68 , G16B15/00
摘要： A mechanistic model was developed to extract meaningful thermodynamic and kinetic parameters from an irreversibly denatured process. As a result, methods and computer apparatus have been created that can be used to mathematically determine parameters that are predictive of aggregation kinetics of biologically active materials. Those parameters can then be used to predict stability or aggregation kinetics as a function of time and temperature.
摘要翻译：开发了一种从不可逆变性过程中提取有意义的热力学和动力学参数的机械模型。因此，已经创建了可用于数学确定预测生物活性材料的聚集动力学的参数的方法和计算机装置。这些参数随后可用于预测作为时间和温度的函数的稳定性或聚集动力学。

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