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1. 发明授权

US07943587B2 Vaccines and gene therapy compositions and methods of making and using the same 有权
标题翻译：疫苗和基因治疗组合物及其制备和使用方法
公开(公告)号：US07943587B2
公开(公告)日：2011-05-17
申请号：US10139423
申请日：2002-05-06
申请人： David B. Weiner , Jong J. Kim , Michael G. Agadjanyan
发明人： David B. Weiner , Jong J. Kim , Michael G. Agadjanyan
IPC分类号： A61K48/00 , C12N15/63
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , C12N2740/16134
摘要： Methods of inducing an immune response against an immunogen in an individual are disclosed. The methods comprise administering to the individual, one or more nucleic acid molecules that comprise a nucleotide sequence that encodes an immunogen and a nucleotide sequence that encodes an Major Histocompatibility Complex antigen. The nucleotide sequences that encode the immunogen and the Major Histocompatibility Complex antigen are expressed when taken up by cells of the individual and an immune response against the immunogen is induced in the individual. Methods of reducing rejection of unmatched donor cells, tissue or organ in an individual undergoing cell, tissue or organ transplantation are disclosed. The methods comprise administering to the individual, one or more nucleic acid molecules that comprise a nucleotide sequence that encodes a death signal or toxin and a nucleotide sequence that encodes a Major Histocompatibility Complex antigen that is matched to the donor cells, tissue or organ. The nucleotide sequences that encode the Major Histocompatibility Complex antigen and death signal or toxin are expressed when taken up by cells of the individual. T cell death through interaction with the death signal or toxin results in a reduction of rejection of unmatched donor cells, tissue or organ. Methods of reducing a dominant immune response in an individual and methods of expanding a subpopulation of T cells associated with a specific immune response are also described. Plasmids and compositions comprising plasmids useful for practicing the method are described.
摘要翻译：公开了在个体中诱导针对免疫原的免疫应答的方法。所述方法包括向个体施用包含编码免疫原的核苷酸序列的一个或多个核酸分子和编码主要组织相容性复合物抗原的核苷酸序列。编码免疫原和主要组织相容性复合物抗原的核苷酸序列在个体细胞吸收时被表达，并且在个体中诱导针对免疫原的免疫应答。公开了在经历细胞，组织或器官移植的个体中减少不匹配的供体细胞，组织或器官的排斥的方法。所述方法包括向个体施用包含编码死亡信号或毒素的核苷酸序列的一个或多个核酸分子和编码与供体细胞，组织或器官相匹配的主要组织相容性复合物抗原的核苷酸序列。编码主要组织相容性复合物抗原和死亡信号或毒素的核苷酸序列由个体细胞摄取时表达。通过与死亡信号或毒素的相互作用导致的T细胞死亡导致不匹配的供体细胞，组织或器官的排斥减少。还描述了减少个体中显性免疫应答的方法和扩增与特异性免疫应答相关的T细胞亚群的方法。描述了包含用于实施该方法的质粒的质粒和组合物。

2. 发明授权

US08202847B2 Mutant human CD80 and compositions for and methods of making and using the same 有权
标题翻译：突变人CD80及其制备方法及其制备和使用方法
公开(公告)号：US08202847B2
公开(公告)日：2012-06-19
申请号：US12211029
申请日：2008-11-10
申请人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
发明人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
IPC分类号： A61K31/713
CPC分类号： C07K14/70532 , A61K39/00
摘要： Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.
摘要翻译：公开了改进的疫苗和使用该疫苗的方法。公开了用于治疗患有自身免疫性疾病或移植物的个体的免疫抑制组合物及其使用方法。

3. 发明授权

US07446189B1 Nucleic acids encoding mutant human CD80 and compositions comprising the same 有权
标题翻译：编码突变体人CD80的核酸及其组合物
公开(公告)号：US07446189B1
公开(公告)日：2008-11-04
申请号：US09980762
申请日：2000-04-27
申请人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
发明人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
IPC分类号： C07H21/00 , C07H21/04 , A61K31/7105 , A61K31/713 , C12N15/00 , C12N15/11
CPC分类号： C07K14/70532 , A61K39/00
摘要： Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.
摘要翻译：公开了改进的疫苗和使用该疫苗的方法。公开了用于治疗患有自身免疫性疾病或移植物的个体的免疫抑制组合物及其使用方法。

4. 发明申请

US20110002956A1 MUTANT HUMAN CD80 AND COMPOSITIONS FOR AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：突变人CD80及其组合物及其制备和使用方法
公开(公告)号：US20110002956A1
公开(公告)日：2011-01-06
申请号：US12211029
申请日：2008-11-10
申请人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
发明人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
IPC分类号： A61K39/12 , C07H21/04 , A61K38/02 , C07K14/705 , A61P31/12 , A61P37/06
CPC分类号： C07K14/70532 , A61K39/00
摘要： Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.
摘要翻译：公开了改进的疫苗和使用该疫苗的方法。公开了用于治疗患有自身免疫性疾病或移植物的个体的免疫抑制组合物及其使用方法。

5. 发明申请

US20120195852A1 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20120195852A1
公开(公告)日：2012-08-02
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

6. 发明申请

US20130045180A9 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20130045180A9
公开(公告)日：2013-02-21
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和减毒活疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

7. 发明授权

US08119395B1 Vaccines, immunotherapeutics and methods for using the same 有权
标题翻译：疫苗，免疫治疗剂及其使用方法
公开(公告)号：US08119395B1
公开(公告)日：2012-02-21
申请号：US09622452
申请日：1999-02-26
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： C12N15/85 , A61K48/00 , C12N15/33
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

8. 发明授权

US11851477B2 DNA monoclonal antibodies targeting influenza virus 有权
公开(公告)号：US11851477B2
公开(公告)日：2023-12-26
申请号：US16098921
申请日：2017-05-05
申请人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
发明人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
IPC分类号： C07K16/28 , C07K16/10 , A61P31/16 , C12Q1/68 , A61K39/00 , C07K16/24
CPC分类号： C07K16/1018 , A61P31/16 , A61K2039/505 , A61K2039/545 , C07K16/248 , C07K16/2866 , C07K2317/76
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.

9. 发明申请

US20190135899A1 DNA Monoclonal Antibodies Targeting Influenza Virus 审中-公开
公开(公告)号：US20190135899A1
公开(公告)日：2019-05-09
申请号：US16098921
申请日：2017-05-05
申请人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
发明人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
IPC分类号： C07K16/10 , A61P31/16
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.

10. 发明授权

US09669091B2 Vaccines having an antigen and interleukin-23 as an adjuvant 有权
公开(公告)号：US09669091B2
公开(公告)日：2017-06-06
申请号：US14775087
申请日：2014-03-13
申请人： David B. Weiner , Jian Yan , Matthew Morrow , Bernadette Ferraro , David Hokey
发明人： David B. Weiner , Jian Yan , Matthew Morrow , Bernadette Ferraro , David Hokey
IPC分类号： C12P21/02 , C12N15/03 , A61K39/39 , C07K14/54 , A61K9/00 , A61K39/015 , A61K39/12 , C12N7/00 , C12P21/00 , C12N15/09 , C12N15/10 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0009 , A61K39/015 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , C07K14/54 , C12N7/00 , C12N15/03 , C12N2710/20033 , C12N2710/20034 , C12P21/02 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and IL-23. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

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