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1. 发明授权

US06537829B1 Up-converting reporters for biological and other assays using laser excitation techniques 失效
公开(公告)号：US06537829B1
公开(公告)日：2003-03-25
申请号：US09451930
申请日：1999-12-01
申请人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： G01N33558
CPC分类号： C12Q1/6816 , B01J2219/00315 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B82Y15/00 , C12Q1/6818 , C40B60/14 , G01N21/6428 , G01N21/6458 , G01N33/533 , G01N33/582 , G01N33/588 , G01N2021/6419 , G01N2021/6421 , Y10S435/97 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/806 , Y10T436/117497 , Y10T436/25375 , C12Q2563/00 , C12Q2563/107 , C12Q2537/143
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

2. 发明授权

US5698397A Up-converting reporters for biological and other assays using laser excitation techniques 失效
公开(公告)号：US5698397A
公开(公告)日：1997-12-16
申请号：US482203
申请日：1995-06-07
申请人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q1/68 , C40B60/14 , G01N21/64 , G01N33/533 , G01N33/542 , G01N33/58 , A61B6/00 , G01N33/53 , H01J29/10
CPC分类号： G01N21/645 , B82Y15/00 , C12Q1/6816 , C12Q1/6818 , G01N21/6428 , G01N21/6454 , G01N33/533 , G01N33/542 , G01N33/582 , B01J2219/00315 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , C40B60/14 , G01N2021/6419
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

3. 发明授权

US6159686A Up-converting reporters for biological and other assays 失效
标题翻译：升级转化记者进行生物和其他测定
公开(公告)号：US6159686A
公开(公告)日：2000-12-12
申请号：US016402
申请日：1998-01-30
申请人： Keith W. Kardos , R. Sam Niedbala , Jarrett Lee Burton , David E. Cooper , David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： Keith W. Kardos , R. Sam Niedbala , Jarrett Lee Burton , David E. Cooper , David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q1/68 , C40B60/14 , G01N15/14 , G01N21/64 , G01N33/533 , G01N33/542 , G01N33/58 , C07H21/02 , C07H21/04 , C07K16/00 , G01N33/53 , H05B33/00
CPC分类号： G01N21/6452 , B01J2219/00315 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B82Y15/00 , C12Q1/6816 , C12Q1/6818 , C40B60/14 , G01N21/6428 , G01N21/645 , G01N21/6454 , G01N33/533 , G01N33/542 , G01N33/582 , G01N33/588 , G01N2015/149 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , C12Q2563/00 , C12Q2563/107 , C12Q2537/143
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
摘要翻译：本发明提供了通过用上转换标记标记探针分子来进行分析物例如生物大分子和其它分析物的敏感检测的方法，组合物和装置。上变换标签吸收来自照明源的辐射并以一个或多个更高频率发射辐射，提供增强的信噪比和基本消除背景样品自发荧光。方法，组合物和装置适用于多种分析物的敏感检测和各种临床和环境取样技术。

4. 发明授权

US06399397B1 Up-converting reporters for biological and other assays using laser excitation techniques 失效
标题翻译：使用激光激发技术进行生物和其他测定的上转换记者
公开(公告)号：US06399397B1
公开(公告)日：2002-06-04
申请号：US09690823
申请日：2000-10-18
申请人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： G01N33553
CPC分类号： B82Y15/00 , B01J2219/00315 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , C12Q1/6816 , C12Q1/6818 , C40B60/14 , G01N21/6428 , G01N21/6458 , G01N33/533 , G01N33/582 , G01N33/588 , G01N2021/6419 , G01N2021/6421 , Y10S435/97 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10T436/25375 , C12Q2563/00 , C12Q2563/107 , C12Q2537/143
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
摘要翻译：本发明提供了通过用上转换标记标记探针分子来进行分析物例如生物大分子和其它分析物的敏感检测的方法，组合物和装置。上变换标签吸收来自照明源的辐射并以一个或多个更高频率发射辐射，提供增强的信噪比和基本消除背景样品自发荧光。方法，组合物和装置适用于多种分析物的敏感检测和各种临床和环境取样技术。

5. 发明授权

US5891656A Up-converting reporters for biological and other assays using laser excitation techniques 失效
公开(公告)号：US5891656A
公开(公告)日：1999-04-06
申请号：US887428
申请日：1997-07-02
申请人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q1/68 , C40B60/14 , G01N21/64 , G01N33/58 , G01N33/53
CPC分类号： G01N21/6458 , B82Y15/00 , C12Q1/6816 , C12Q1/6818 , G01N21/6428 , G01N33/582 , G01N33/588 , B01J2219/00315 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , C40B60/14
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

6. 发明授权

US06312914B1 Up-converting reporters for biological and other assays 有权
标题翻译：升级转化记者进行生物和其他测定
公开(公告)号：US06312914B1
公开(公告)日：2001-11-06
申请号：US09690828
申请日：2000-10-18
申请人： Keith W. Kardos , R. Sam Niedbala , Jarrett Lee Burton , David E. Cooper , David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： Keith W. Kardos , R. Sam Niedbala , Jarrett Lee Burton , David E. Cooper , David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q168
CPC分类号： G01N21/6452 , B01J2219/00315 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B82Y15/00 , C12Q1/6816 , C12Q1/6818 , C40B60/14 , G01N21/6428 , G01N21/645 , G01N21/6454 , G01N33/533 , G01N33/542 , G01N33/582 , G01N33/588 , G01N2015/149 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , C12Q2563/00 , C12Q2563/107 , C12Q2537/143
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
摘要翻译：本发明提供了通过用上转换标记标记探针分子来进行分析物例如生物大分子和其它分析物的敏感检测的方法，组合物和装置。上变换标签吸收来自照明源的辐射并以一个或多个更高频率发射辐射，提供增强的信噪比和基本消除背景样品自发荧光。方法，组合物和装置适用于多种分析物的敏感检测和各种临床和环境取样技术。

7. 发明授权

US5736410A Up-converting reporters for biological and other assays using laser excitation techniques 失效
公开(公告)号：US5736410A
公开(公告)日：1998-04-07
申请号：US486393
申请日：1995-06-07
申请人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q1/68 , C40B60/14 , G01N21/64 , G01N33/533 , G01N33/58 , G01N21/01 , G01N21/62
CPC分类号： C12Q1/6816 , B82Y15/00 , C12Q1/6818 , G01N21/6428 , G01N21/6458 , G01N33/533 , G01N33/582 , G01N33/588 , B01J2219/00315 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , C40B60/14 , G01N2021/6419 , G01N2021/6421 , Y10S435/97 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/806 , Y10T436/117497 , Y10T436/25375
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

8. 发明授权

US5674698A Up-converting reporters for biological and other assays using laser excitation techniques 失效
标题翻译：使用激光激发技术进行生物和其他测定的上转换记者
公开(公告)号：US5674698A
公开(公告)日：1997-10-07
申请号：US416023
申请日：1995-03-30
申请人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q1/68 , C40B60/14 , G01N21/64 , G01N33/58 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N21/6458 , B82Y15/00 , C12Q1/6816 , C12Q1/6818 , G01N21/6428 , G01N33/582 , G01N33/588 , B01J2219/00315 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , C40B60/14
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
摘要翻译：本发明提供了通过用上转换标记标记探针分子来进行分析物例如生物大分子和其它分析物的敏感检测的方法，组合物和装置。上变换标签吸收来自照明源的辐射并以一个或多个更高频率发射辐射，提供增强的信噪比和基本消除背景样品自发荧光。方法，组合物和装置适用于多种分析物的敏感检测和各种临床和环境取样技术。

9. 发明授权

US06524856B1 Use of consensus sequences for targeted homologous gene isolation and recombination in gene families 失效
标题翻译：在基因家族中使用共有序列进行靶向同源基因分离和重组
公开(公告)号：US06524856B1
公开(公告)日：2003-02-25
申请号：US09209676
申请日：1998-12-11
申请人： Sushma Pati , David A. Zarling , Hong Zeng
发明人： Sushma Pati , David A. Zarling , Hong Zeng
IPC分类号： C12N1563
CPC分类号： C12N15/1082 , A01K2217/05 , A61K48/00 , C12N15/1034 , C12N15/902 , C12Q1/6811
摘要： The invention relates to compositions and methods for targeting sequence modifications in one or more genes of a related family of genes using enhanced homologous recombination techniques. These techniques may be used to create animal or plant models of disease as well as to identify new targets for drug or pathogen screening.
摘要翻译：本发明涉及使用增强的同源重组技术靶向相关基因家族的一个或多个基因中的序列修饰的组合物和方法。这些技术可用于创建疾病的动物或植物模型，以及确定用于药物或病原体筛选的新靶标。

10. 发明授权

US5763240A In vivo homologous sequence targeting in eukaryotic cells 失效
标题翻译：在真核细胞中的体内同源序列靶向
公开(公告)号：US5763240A
公开(公告)日：1998-06-09
申请号：US275916
申请日：1994-07-14
申请人： David A. Zarling , Elissa P. Sena
发明人： David A. Zarling , Elissa P. Sena
IPC分类号： C12N15/90 , C12N15/64 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/90
摘要： The invention relates to methods for targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a eukaryotic cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence, typically by targeted homologous recombination. In certain embodiments, the invention relates to methods for targeting an exogenous polynucleotide having a linked chemical substituent to a predetermined endogenous DNA sequence in a metabolically active eukaryotic cell, generating a DNA sequence-specific targeting of one or more chemical substituents in an intact nucleus of a metabolically active eukaryotic cell, generally for purposes of altering a predetermined endogenous DNA sequence in the cell. The invention also relates to compositions that contain exogenous targeting polynucleotides, complementary pairs of exogenous targeting polynucleotides, chemical substituents of such polynucleotides, and recombinase proteins used in the methods of the invention.
摘要翻译：本发明涉及通过同源配对将外源多核苷酸或外源互补多核苷酸对靶向靶向预定内源DNA靶序列的方法，特别是用于通常通过靶向同源重组来改变内源DNA序列，例如染色体DNA序列。在某些实施方案中，本发明涉及将具有连接的化学取代基的外源多核苷酸靶向于代谢活性真核细胞中的预定内源性DNA序列的方法，产生在完整核中的一个或多个化学取代基的DNA序列特异性靶向代谢活性真核细胞，通常用于改变细胞中预定的内源性DNA序列。本发明还涉及含有外源靶向多核苷酸，外源靶向多核苷酸的互补对，这种多核苷酸的化学取代基和本发明方法中使用的重组酶的组合物。

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