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1. 发明授权

US08383059B2 Microfluidic interface for highly parallel addressing of sensing arrays 有权
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：US08383059B2
公开(公告)日：2013-02-26
申请号：US11241060
申请日：2005-09-30
申请人： David A. Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce K. Gale , David Myszka
发明人： David A. Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce K. Gale , David Myszka
IPC分类号： B01L3/00
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。点样器使用井，微流体管道和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。每个孔通过微管连接到两个孔。当检测器接触表面时，在孔和表面之间形成密封。相同或不同的物质可能流过每个孔口。任何数量的孔口都可以并入到一个定点器中。鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

2. 发明申请

US20070231880A1 Microfluidic interface for highly parallel addressing of sensing arrays 有权
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：US20070231880A1
公开(公告)日：2007-10-04
申请号：US11241060
申请日：2005-09-30
申请人： David Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce Gale , David Myszka
发明人： David Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce Gale , David Myszka
IPC分类号： C12M3/00 , G01D15/02
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。点样器使用井，微流体管道和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。每个孔通过微管连接到两个孔。当检测器接触表面时，在孔和表面之间形成密封。相同或不同的物质可能流过每个孔口。任何数量的孔口都可以并入到一个定点器中。鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

3. 发明授权

US09682372B2 Tip overlay for continuous flow spotting apparatus 有权
公开(公告)号：US09682372B2
公开(公告)日：2017-06-20
申请号：US12487962
申请日：2009-06-19
申请人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
发明人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01L2300/0819 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

4. 发明申请

US20140171342A1 METHOD AND DEVICE FOR DEPOSITING A SUBSTANCE ON A SUBMERGED SURFACE 审中-公开
标题翻译：用于沉积在表面上的物质的方法和装置
公开(公告)号：US20140171342A1
公开(公告)日：2014-06-19
申请号：US14026705
申请日：2013-09-13
申请人： Bruce K. Gale , Joshua W. Eckman , Adam Miles , Christopher Morrow , James Smith , Sriram Natarajan , Mark Eddings
发明人： Bruce K. Gale , Joshua W. Eckman , Adam Miles , Christopher Morrow , James Smith , Sriram Natarajan , Mark Eddings
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00385 , B01J2219/00387 , B01J2219/00418 , B01J2219/00527 , B01J2219/00659 , B01J2219/00722 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/0289 , B01L2200/0673 , B01L2300/0829 , B01L2400/022 , B01L2400/0487
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter for depositing a substance on a submerged surface. The spotter comprises an outlet cavity defined at least in part by a spotting orifice, a first opening, and a second opening. The spotter also comprises a first conduit fluidly coupled to the first opening and a second conduit fluidly coupled to the second opening. The spotter is adapted so that fluid flowing through the first conduit and the second conduit is communicated among the first opening, the second opening, and a submerged deposition surface when the sealing orifice is sealed against the submerged deposition surface to form a deposition spot on the submerged deposition surface. The submerged deposition surface is within a liquid such that the liquid covers the deposition spot upon removal of the orifice from the deposition surface.
摘要翻译：本公开提供了涉及用于将物质沉积在浸没表面上的点样器的装置，系统和方法。识别器包括至少部分地由点样孔，第一开口和第二开口限定的出口腔。点样器还包括流体地联接到第一开口的第一导管和流体地联接到第二开口的第二导管。调色剂适于使得当密封孔密封在浸没沉积表面上时，流过第一导管和第二导管的流体在第一开口，第二开口和浸没沉积表面之间连通，以形成沉积点浸没沉积表面。浸没沉积表面在液体内，使得液体在从沉积表面移除孔口时覆盖沉积点。

5. 发明申请

US20100248994A1 Tip overlay for continuous flow spotting apparatus 有权
标题翻译：连续流动点样装置的尖端覆盖
公开(公告)号：US20100248994A1
公开(公告)日：2010-09-30
申请号：US12487962
申请日：2009-06-19
申请人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
发明人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
IPC分类号： C40B50/18 , C40B60/14
CPC分类号： B01L3/0268 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01L2300/0819 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.
摘要翻译：本公开提供了涉及用于将物质从载体流体以有序阵列沉积到沉积表面上的识别装置的装置，系统和方法，所述定位装置包括包括第一井和第二井的装载表面; 以及不同的出口表面，包括第一开口和第二开口，其中第一微管将第一孔与第一开口流体耦合，而第二微管将第二孔与第二开口流体耦合。当覆盖层压靠在沉积表面上时，覆盖层被密封到出口表面并被沉积通道穿透，所述沉积通道被定位成在第一开口，第二开口和沉积表面之间连通载体流体。

6. 发明申请

US20100075860A1 MICROASSAY WITH INTERNAL REFERENCING 有权
标题翻译：微型内镜参考
公开(公告)号：US20100075860A1
公开(公告)日：2010-03-25
申请号：US12564448
申请日：2009-09-22
申请人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
发明人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
IPC分类号： C40B30/00 , C40B50/14 , C40B60/12
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：专用的微流体网络用于将物质沉积在传感器表面上。特别地，基于流动的微流体打印头用作将多个分析物递送到传感器用于同时分析的界面。此外，内部参考被并入传感器区域以提高灵敏度。

7. 发明授权

US08211382B2 Microassay with internal referencing 有权
标题翻译：带有内部参考的Microassay
公开(公告)号：US08211382B2
公开(公告)日：2012-07-03
申请号：US12564448
申请日：2009-09-22
申请人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
发明人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：专用的微流体网络用于将物质沉积在传感器表面上。特别地，基于流动的微流体打印头用作将多个分析物递送到传感器用于同时分析的界面。此外，内部参考被并入传感器区域以提高灵敏度。

8. 发明授权

US10242753B2 Method for measuring strength of associations of multidimensional traits 有权
公开(公告)号：US10242753B2
公开(公告)日：2019-03-26
申请号：US11465729
申请日：2006-08-18
申请人： Anthony G. Greenwald , Sriram Natarajan
发明人： Anthony G. Greenwald , Sriram Natarajan
IPC分类号： G09B7/00 , G16H10/20 , A61B5/16
摘要： A method of measuring a subject's strength of associations of multidimensional traits involving each of a first pair of first and second categories with each of a second pair of third and fourth categories includes selecting a first target concept for the first category and a second target concept for the second category and selecting a first trait for the third category and, for the fourth category, a plurality of alternative traits to provide a basis for contrasting with the first trait. The method further includes having the subject respond to a first set of trials in a first manner when there is presented an exemplar of either the first category or the third category and in a second manner when there is presented an exemplar of either the second category or the fourth category and presenting the subject with a first series of exemplars in the first set of trials, the first series including exemplars in all four categories. The method further includes having the subject respond to a second set of trials in one of the two manners when there is presented the exemplar of either the second category or the third category and in the other of the two manners when there is presented the exemplar of either the first category or the fourth category and presenting the subject with a second series of exemplars in the second set of trials, the second series including exemplars in all four categories. Latency is measured in each trial from time of exemplar presentation to the subject to a response by the subject to produce latency measurements. A measure is calculated of the subject's strength of associations involving each of the first and second categories with each of the third and fourth categories from the latency measurements.

9. 发明授权

US09609015B2 Systems and methods for dynamic cloud-based malware behavior analysis 有权
公开(公告)号：US09609015B2
公开(公告)日：2017-03-28
申请号：US14796422
申请日：2015-07-10
申请人： Sriram Natarajan , Narinder Paul , Julien Sobrier , Karthikeyan Thamilarasu , Balakrishna Bayar , Michael Andrew William Sutton
发明人： Sriram Natarajan , Narinder Paul , Julien Sobrier , Karthikeyan Thamilarasu , Balakrishna Bayar , Michael Andrew William Sutton
IPC分类号： H04L29/06 , G06F21/56 , G06F21/53
CPC分类号： H04L63/145 , G06F21/53 , G06F21/566 , G06F2221/03 , H04L51/12 , H04L63/0218 , H04L63/083 , H04L63/1408 , H04L63/1458
摘要： A cloud-based method, a behavioral analysis system, and a cloud-based security system can include a plurality of nodes communicatively coupled to one or more users, wherein the plurality of nodes each perform inline monitoring for one of the one or more users for security comprising malware detection and preclusion; and a behavioral analysis system communicatively coupled to the plurality of nodes, wherein the behavioral analysis system performs offline analysis for any suspicious content from the one or more users which is flagged by the plurality of nodes; wherein the plurality of nodes each comprise a set of known malware signatures for the inline monitoring that is periodically updated by the behavioral analysis system based on the offline analysis for the suspicious content.

10. 发明授权

US07706294B2 Apparatus and method for enabling intelligent Fibre-Channel connectivity over transport 有权
标题翻译：在传输中实现智能光纤通道连接的装置和方法
公开(公告)号：US07706294B2
公开(公告)日：2010-04-27
申请号：US10403896
申请日：2003-03-31
申请人： Sriram Natarajan , Sharat Prasad , Yu Deng , Yanfeng Wang
发明人： Sriram Natarajan , Sharat Prasad , Yu Deng , Yanfeng Wang
IPC分类号： G01R31/08 , H04L12/28 , H04J3/16 , H04B10/08
CPC分类号： H04L49/357 , H04L12/4633 , H04L43/00 , H04L43/0811
摘要： The link status of a Fibre-Channel link interconnecting two Fibre-Channel ports may be determined by a third entity distinct from the two Fibre-Channel ports. The third entity may be a transport interface used to connect one of the Fibre-Channel ports to a transport network that carries the link. The transport interface may also learn the Fibre-Channel port types of the two ports.
摘要翻译：互连两个光纤通道端口的光纤通道链路的链路状态可以由不同于两个光纤通道端口的第三实体来确定。第三实体可以是用于将光纤通道端口中的一个连接到承载链路的传输网络的传输接口。传输接口还可以了解两个端口的光纤通道端口类型。

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