专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140171342A1 METHOD AND DEVICE FOR DEPOSITING A SUBSTANCE ON A SUBMERGED SURFACE 审中-公开
标题翻译：用于沉积在表面上的物质的方法和装置
公开(公告)号：US20140171342A1
公开(公告)日：2014-06-19
申请号：US14026705
申请日：2013-09-13
申请人： Bruce K. Gale , Joshua W. Eckman , Adam Miles , Christopher Morrow , James Smith , Sriram Natarajan , Mark Eddings
发明人： Bruce K. Gale , Joshua W. Eckman , Adam Miles , Christopher Morrow , James Smith , Sriram Natarajan , Mark Eddings
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00385 , B01J2219/00387 , B01J2219/00418 , B01J2219/00527 , B01J2219/00659 , B01J2219/00722 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/0289 , B01L2200/0673 , B01L2300/0829 , B01L2400/022 , B01L2400/0487
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter for depositing a substance on a submerged surface. The spotter comprises an outlet cavity defined at least in part by a spotting orifice, a first opening, and a second opening. The spotter also comprises a first conduit fluidly coupled to the first opening and a second conduit fluidly coupled to the second opening. The spotter is adapted so that fluid flowing through the first conduit and the second conduit is communicated among the first opening, the second opening, and a submerged deposition surface when the sealing orifice is sealed against the submerged deposition surface to form a deposition spot on the submerged deposition surface. The submerged deposition surface is within a liquid such that the liquid covers the deposition spot upon removal of the orifice from the deposition surface.
摘要翻译：本公开提供了涉及用于将物质沉积在浸没表面上的点样器的装置，系统和方法。识别器包括至少部分地由点样孔，第一开口和第二开口限定的出口腔。点样器还包括流体地联接到第一开口的第一导管和流体地联接到第二开口的第二导管。调色剂适于使得当密封孔密封在浸没沉积表面上时，流过第一导管和第二导管的流体在第一开口，第二开口和浸没沉积表面之间连通，以形成沉积点浸没沉积表面。浸没沉积表面在液体内，使得液体在从沉积表面移除孔口时覆盖沉积点。

2. 发明授权

US09682372B2 Tip overlay for continuous flow spotting apparatus 有权
公开(公告)号：US09682372B2
公开(公告)日：2017-06-20
申请号：US12487962
申请日：2009-06-19
申请人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
发明人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01L2300/0819 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

3. 发明申请

US20100248994A1 Tip overlay for continuous flow spotting apparatus 有权
标题翻译：连续流动点样装置的尖端覆盖
公开(公告)号：US20100248994A1
公开(公告)日：2010-09-30
申请号：US12487962
申请日：2009-06-19
申请人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
发明人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
IPC分类号： C40B50/18 , C40B60/14
CPC分类号： B01L3/0268 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01L2300/0819 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.
摘要翻译：本公开提供了涉及用于将物质从载体流体以有序阵列沉积到沉积表面上的识别装置的装置，系统和方法，所述定位装置包括包括第一井和第二井的装载表面; 以及不同的出口表面，包括第一开口和第二开口，其中第一微管将第一孔与第一开口流体耦合，而第二微管将第二孔与第二开口流体耦合。当覆盖层压靠在沉积表面上时，覆盖层被密封到出口表面并被沉积通道穿透，所述沉积通道被定位成在第一开口，第二开口和沉积表面之间连通载体流体。

4. 发明授权

US08383059B2 Microfluidic interface for highly parallel addressing of sensing arrays 有权
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：US08383059B2
公开(公告)日：2013-02-26
申请号：US11241060
申请日：2005-09-30
申请人： David A. Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce K. Gale , David Myszka
发明人： David A. Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce K. Gale , David Myszka
IPC分类号： B01L3/00
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。点样器使用井，微流体管道和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。每个孔通过微管连接到两个孔。当检测器接触表面时，在孔和表面之间形成密封。相同或不同的物质可能流过每个孔口。任何数量的孔口都可以并入到一个定点器中。鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

5. 发明申请

US20130204275A1 METHODS, DEVICES AND APPARATUS FOR PERFORMING A VASCULAR ANASTOMOSIS 审中-公开
标题翻译：用于执行血管分析的方法，装置和装置
公开(公告)号：US20130204275A1
公开(公告)日：2013-08-08
申请号：US13640467
申请日：2011-04-15
申请人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
发明人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/00349 , A61B2017/00477 , A61B2017/00867 , A61B2017/00893 , A61B2017/1103 , A61B2017/1107 , A61B2017/1121 , A61B2017/1125 , A61B2017/1132
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to the second end tissue by mating the coupling device to a mating anastomosis device.
摘要翻译：公开了用于执行血管吻合的方法，装置，装置，组件和试剂盒。用于血管吻合的装置包括可在至少两种构型之间移动的组织接合部分。在一些实施例中，组织接合部分不借助移动部分移动，而在其它实施例中，组织接合部分从一个或多个活动翼部延伸。当处于部署前配置时，组织接合部分可以分开第一距离，并且当处于展开配置时，组织接合部分可以分开第一距离。一种方法包括将耦合装置的多个组织接合构件抵靠第一端组织接合。在选择性地接合组织接合构件和第一端部组织之后，通过至少移动组织接合构件来拉伸第一端部组织。拉伸的第一端组织通过将联接装置配合到配合的吻合装置而联接到第二端组织。

6. 发明申请

US20120089113A1 INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS 有权
标题翻译：内镜药物递送装置及相关方法
公开(公告)号：US20120089113A1
公开(公告)日：2012-04-12
申请号：US13211169
申请日：2011-08-16
申请人： Balamurali K. Ambati , Bruce K. Gale
发明人： Balamurali K. Ambati , Bruce K. Gale
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device (40) having an active agent reservoir (44) disposed in an annular body (42), the annular body (42) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule.
摘要翻译：用于将活性剂递送到受试者眼睛的装置，系统和方法可以包括具有设置在环形体（42）中的活性剂储存器（44）的眼部活性剂递送装置（40），所述环形体 42）被配置为装配在透镜胶囊内部并且至少部分地环绕眼镜片内的眼内透镜的视线。

7. 发明申请

US20110282328A1 Intraocular Drug Delivery Device and Associated Methods 有权
标题翻译：眼内药物输送装置及相关方法
公开(公告)号：US20110282328A1
公开(公告)日：2011-11-17
申请号：US12945428
申请日：2010-11-12
申请人： Balamurali K. Ambati , Bruce K. Gale
发明人： Balamurali K. Ambati , Bruce K. Gale
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部，至少部分地包围晶状体囊内的眼内透镜的视线。装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。

8. 发明授权

US10064819B2 Intraocular drug delivery device and associated methods 有权
公开(公告)号：US10064819B2
公开(公告)日：2018-09-04
申请号：US13543597
申请日：2012-07-06
申请人： Balamurali K. Ambati , Bruce K. Gale , Srinivas Rao Chennamaneni
发明人： Balamurali K. Ambati , Bruce K. Gale , Srinivas Rao Chennamaneni
IPC分类号： A61M31/00 , A61K9/00 , A61K31/573 , A61K9/20
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the delivery device is adapted to fit within a lens capsule or ciliary sulcus of an eye. The delivery device can be inserted into the lens capsule or ciliary sulcus of an eye during cataract surgery or for treatment of uveitis.

9. 发明授权

US09642623B2 Methods, devices and apparatus for performing a vascular anastomosis 有权
公开(公告)号：US09642623B2
公开(公告)日：2017-05-09
申请号：US13640467
申请日：2011-04-15
申请人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
发明人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
IPC分类号： A61B17/11 , A61B17/00
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/00349 , A61B2017/00477 , A61B2017/00867 , A61B2017/00893 , A61B2017/1103 , A61B2017/1107 , A61B2017/1121 , A61B2017/1125 , A61B2017/1132
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to the second end tissue by mating the coupling device to a mating anastomosis device.

10. 发明授权

US08395468B2 High field strength magentic field generation system and associated methods 有权
标题翻译：高场强磁场生成系统及相关方法
公开(公告)号：US08395468B2
公开(公告)日：2013-03-12
申请号：US12159927
申请日：2007-01-04
申请人： James C. Stephenson , Bruce K. Gale , Cynthia Furse
发明人： James C. Stephenson , Bruce K. Gale , Cynthia Furse
IPC分类号： H01F7/02
CPC分类号： H01F7/0284 , G01R33/3806 , G01R33/383
摘要： A magnetic field generation system includes first (28a) and second (28b) magnetic flux concentrators spaced apart to form a sample volume (30). A first set of auxiliary permanent magnets (10a, 10b) can be symmetrically oriented about and in contact with a portion of the first magnetic flux concentrator (28a). Similarly, a second set of auxiliary permanent magnets (10c, 10d) can be symmetrically oriented about and in contact with a portion of the second magnetic flux concentrator (28b). The first(10a, 10b) and second (10c, 10d) sets of auxiliary magnets can be magnetically associated via the first (28a) and second (28b) magnetic flux concentrators. Magnetically soft shunts (38) can be movably oriented to allow variation of the magnetic field strength across the sample volume by disrupting the field flux across the magnetic flux concentrators.
摘要翻译：磁场产生系统包括间隔开以形成样品体积（30）的第一（28a）和第二（28b）磁通集中器。第一组辅助永磁体（10a，10b）可以对称地定向并且与第一磁通集中器（28a）的一部分接触。类似地，第二组辅助永磁体（10c，10d）可以对称地定向并且与第二磁通集中器（28b）的一部分接触。第一（10a，10b）和第二（10c，10d）组辅助磁体可以经由第一（28a）和第二（28b）磁通量集中器磁性地相关联。磁软分流器（38）可以可移动地定向以允许通过扰动磁通量集中器上的磁场通量来改变样品体积上的磁场强度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式