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1. 发明授权

US06594518B1 Device and method for classification of tissue 失效
标题翻译：组织分类的装置和方法
公开(公告)号：US06594518B1
公开(公告)日：2003-07-15
申请号：US09012602
申请日：1998-01-23
申请人： David A. Benaron , Boris Rubinsky
发明人： David A. Benaron , Boris Rubinsky
IPC分类号： A61B500
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/14553 , A61B5/4076 , A61B5/415 , A61B5/418 , A61B5/6848 , A61B5/7264 , A61B6/506 , A61B17/068 , A61B18/00 , A61B18/14 , A61B2017/00022 , A61B2017/00123 , A61B2017/00508 , A61B2017/00557 , A61B2560/0276 , A61B2562/0242 , A61B2562/08 , G01N21/4795
摘要： A diagnostic monitor for classifying biological tissue in which a light emitter (102) is optically coupled to the tissue to be diagnosed (145) and a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue. The tissue classifier (184) receives a signal from the detector and provides an optical classification output signal (195), wherein the tissue is classified by type or state, either for detection, localization, or imaging. A method of classifying tissue is also described.
摘要翻译：用于分类生物组织的诊断监视器，其中光发射器（102）光学耦合到要诊断的组织（145）和光检测器（174），光学耦合到组织以检测通过的一部分光组织。组织分类器（184）从检测器接收信号并提供光学分类输出信号（195），其中根据类型或状态对组织进行分类，用于检测，定位或成像。还描述了分类组织的方法。

2. 发明授权

US5752519A Device and method for detection, localization, and characterization of inhomogeneities in turbid media 失效
标题翻译：用于检测，定位和表征混浊介质中不均匀性的装置和方法
公开(公告)号：US5752519A
公开(公告)日：1998-05-19
申请号：US725239
申请日：1996-10-04
申请人： David A. Benaron , Boris Rubinsky
发明人： David A. Benaron , Boris Rubinsky
IPC分类号： A61B5/00 , A61B17/00 , A61B17/068 , A61B18/00 , A61B18/14 , G01N21/47 , A61B6/00
CPC分类号： A61B5/6848 , A61B18/00 , A61B5/0075 , A61B5/0084 , A61B5/14553 , G01N21/4795 , A61B17/068 , A61B18/14 , A61B2017/00022 , A61B2017/00123 , A61B2017/00508 , A61B2017/00557 , A61B2560/0276 , A61B2562/0242 , A61B2562/08 , A61B5/0073
摘要： The present invention provides a detection or imaging device and method that measures an effect upon the path traveled by a radiative wave through a medium where scattering of the radiative wave is strong, and uses this measured path effect to detect, localize, or characterize inhomogeneities in the medium, as well as of the medium itself, over time or space. In this embodiment, a radiative source (43), temporally modulated or intensity quantitated, is emitted into the medium (47). A detector (48) records radiative effects detected after travel through said medium, and the detected signal is measured for a path effect (45). Based upon one or more of these path effects, such as the distance the latest arriving photons have traveled, a quantifiable parameter of the medium is determined (49). This parameter can be the location, distance, speed, or other characteristic of the medium or inhomogeneity. Measurement over space provides additional information as to spatial distribution; measurement over time provides information as to temporal changes in the medium. The device has application in medical and industrial imaging, detection, and localization of objects and other inhomogeneities, as well as characterization of the medium itself, in media which highly scatters radiative waves emitted into the medium.
摘要翻译：本发明提供了一种检测或成像装置和方法，其测量对辐射波通过辐射波散射强的介质对路径的影响，并使用该测量的路径效应来检测，定位或表征不均匀性媒介以及媒体本身，随着时间或空间。在该实施例中，将经时间调制或强度定量的辐射源（43）发射到介质（47）中。检测器（48）记录在行进通过所述介质之后检测到的辐射效应，并且测量检测到的信号的路径效应（45）。基于这些路径效应中的一个或多个，例如最近到达的光子已经行进的距离，确定介质的可量化参数（49）。该参数可以是介质的位置，距离，速度或其他特性或不均匀性。空间测量提供了关于空间分布的更多信息; 时间的测量提供关于介质中的时间变化的信息。该装置在医疗和工业成像，物体和其他不均匀性的检测和定位以及介质本身的表征中的应用，在高度散射辐射到介质中的辐射波的介质中。

3. 发明授权

US5746210A Device and method for detection, localization, and characterization of inhomogeneities in turbid media 失效
公开(公告)号：US5746210A
公开(公告)日：1998-05-05
申请号：US24278
申请日：1993-02-26
申请人： David A. Benaron , Boris Rubinsky
发明人： David A. Benaron , Boris Rubinsky
IPC分类号： A61B5/00 , A61B17/00 , A61B17/068 , A61B18/00 , A61B18/14 , G01N21/47 , A61B6/00
CPC分类号： A61B5/6848 , A61B18/00 , A61B5/0075 , A61B5/0084 , A61B5/14553 , G01N21/4795 , A61B17/068 , A61B18/14 , A61B2017/00022 , A61B2017/00123 , A61B2017/00508 , A61B2017/00557 , A61B2560/0276 , A61B2562/0242 , A61B2562/08 , A61B5/0073
摘要： The present invention provides a detection or imaging device and method that measures an effect upon the path traveled by a radiative wave through a medium where scattering of the radiative wave is strong, and uses this measured path effect to detect, localize, or characterize inhomogeneities in the medium, as well as of the medium itself, over time or space. In this embodiment, a radiative source (43), temporally modulated or intensity quantitated, is emitted into the medium (47). A detector (48) records radiative effects detected after travel through said medium, and the detected signal is measured for a path effect (45). Based upon one or more of these path effects, such as the distance the latest arriving photons have traveled, a quantifiable parameter of the medium is determined (49). This parameter can be the location, distance, speed, or other characteristic of the medium or inhomogeneity. Measurement over space provides additional information as to spatial distribution; measurement over time provides information as to temporal changes in the medium. The device has application in medical and industrial imaging, detection, and localization of objects and other inhomogeneities, as well as characterization of the medium itself, in media which highly scatters radiative waves emitted into the medium.

4. 发明授权

US5987346A Device and method for classification of tissue 失效
公开(公告)号：US5987346A
公开(公告)日：1999-11-16
申请号：US771952
申请日：1996-12-23
申请人： David A. Benaron , Boris Rubinsky
发明人： David A. Benaron , Boris Rubinsky
IPC分类号： A61B5/00 , A61B17/00 , A61B17/068 , A61B18/00 , A61B18/14 , G01N21/47 , A61B6/00
CPC分类号： A61B5/1459 , A61B18/00 , A61B5/0059 , A61B5/14553 , A61B5/4076 , A61B5/415 , A61B5/418 , A61B5/6848 , A61B5/7264 , G01N21/4795 , A61B17/068 , A61B18/14 , A61B2017/00022 , A61B2017/00123 , A61B2017/00508 , A61B2017/00557 , A61B2560/0276 , A61B2562/0242 , A61B2562/08 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B6/506
摘要： A diagnostic monitor for classifying biological tissue in which a light emitter (102) is optically coupled to the tissue to be diagnosed (145) and a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue. The tissue classifier (184) receives a signal from the detector and provides an optical classification output signal (195), wherein the tissue is classified by type or state, either for detection, localization, or imaging. A method of classifying tissue is also described.

5. 发明授权

US08545814B2 Non-invasive localization of a light-emitting conjugate in a mammal 失效
公开(公告)号：US08545814B2
公开(公告)日：2013-10-01
申请号：US11818208
申请日：2007-06-13
申请人： Pamela R. Contag , Christopher H. Contag , David A. Benaron
发明人： Pamela R. Contag , Christopher H. Contag , David A. Benaron
IPC分类号： A61B5/00
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0393 , A61K49/0045 , A61K49/0097 , C07K14/195 , C12N2830/60 , C12Q1/02 , C12Q1/66 , G01N33/582 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

6. 发明申请

US20120133749A1 Rapid, No-Flow, Whole-Blood, and Volumetric Circulating Cell Counting System and Method 有权
标题翻译：快速，无流量，全血和体积循环细胞计数系统和方法
公开(公告)号：US20120133749A1
公开(公告)日：2012-05-31
申请号：US13290058
申请日：2011-11-05
申请人： David A. Benaron
发明人： David A. Benaron
IPC分类号： H04N7/18 , B82Y15/00
CPC分类号： H04N7/18
摘要： A device (101) for determining the presence, absence, concentration, or count of rare cell or cell-like objects in a turbid fluid consisting of a light source (103) for illuminating a chamber (123) containing a solution including complexes of suspended cells or cell-like moieties (261) and an optically-active agent, and further including an imaging detector (145) and an output (147) for providing a determined or displayed result. Methods of enumeration are also disclosed.
摘要翻译：一种用于确定混浊流体中稀有细胞或细胞样物体的存在，不存在，浓度或计数的装置（101），所述混浊流体由用于照射包含包含悬浮的复合物的溶液的溶液（123）的光源细胞或细胞样部分（261）和光学活性剂，并且还包括用于提供确定或显示的结果的成像检测器（145）和输出（147）。还公开了枚举方法。

7. 发明申请

US20110240885A1 Broadband Solid-State Illuminator for Fluorimetry Device and System 审中-公开
标题翻译：用于荧光测量装置和系统的宽带固态照明器
公开(公告)号：US20110240885A1
公开(公告)日：2011-10-06
申请号：US13016911
申请日：2011-01-28
申请人： David A. Benaron , IIlian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , IIlian H. Parachikov , Michael R. Fierro
IPC分类号： G01N21/64 , G01J3/10 , H01L33/02
CPC分类号： A61B5/14551 , A61B5/0261
摘要： An improved solid-state light source (103) for producing illuminating light (114) generated by interaction of light from an LED source (105) with a quantum dot, in one embodiment located in a well (117). A solid-state illuminator with integrated quantum dots advantageously allows for an efficient broadband or narrow band LED to be produced in a variety of specified colors and color temperatures, and allows for a more compact, less heat producing, and more energy efficient manufacturable illumination device, and further facilitates integration of the illuminator and detector into medical, industrial, and laboratory illuminators, microchips, or lab-on-chip devices or systems. Methods of use are also disclosed.
摘要翻译：一种改进的固态光源（103），用于产生通过来自LED源（105）的光与量子点的相互作用产生的照明光（114），在一个实施例中位于井（117）中。具有集成量子点的固态照明器有利地允许以各种指定的颜色和色温产生有效的宽带或窄带LED，并且允许更紧凑，更少的发热和更节能的制造照明装置并且进一步便于将照明器和检测器集成到医疗，工业和实验室照明器，微芯片或片上实验室装置或系统中。还公开了使用方法。

8. 发明申请

US20090048502A1 Broadband illuminator for oximetry, hemoglobin, met-hemoglobin, carboxy-hemoglobin, and other blood component monitoring 审中-公开
标题翻译：血氧仪，血红蛋白，血红蛋白，羧基血红蛋白和其他血液成分监测的宽带照明
公开(公告)号：US20090048502A1
公开(公告)日：2009-02-19
申请号：US12113887
申请日：2008-05-01
申请人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0261
摘要： An ischemia detection system in two or more somatic measures, collected simultaneously or near-simultaneously, are provided for direct or computational comparison, in which light from light source A (103A) and source B (103B) is detected by a sensor (155), and a difference-weighted value is determined (167), thereby enhancing the value of the spectroscopic measurements over values taken individually and singly.
摘要翻译：提供用于直接或计算比较的同时或近似同时收集的两个或多个体细胞测量中的缺血检测系统，其中来自光源A（103A）和源B（103B）的光由传感器（155）检测，，并且确定差分加权值（167），从而增强对单独和单独获取的值的光谱测量值。

9. 发明授权

US06649143B1 Non-invasive localization of a light-emitting conjugate in a mammal 失效
公开(公告)号：US06649143B1
公开(公告)日：2003-11-18
申请号：US09233698
申请日：1999-01-19
申请人： Pamela R. Contag , Christopher H. Contag , David A. Benaron
发明人： Pamela R. Contag , Christopher H. Contag , David A. Benaron
IPC分类号： A61K4900
CPC分类号： G01N33/582 , C07K14/195 , C12Q1/02 , C12Q1/66 , Y10S435/968 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

10. 发明申请

US20080226137A1 Metabolism- or Biochemical-Based Anti-Spoofing Biometrics Devices, Systems, and Methods 审中-公开
标题翻译：代谢或生物化学反欺骗生物特征的设备，系统和方法
公开(公告)号：US20080226137A1
公开(公告)日：2008-09-18
申请号：US12049122
申请日：2008-03-14
申请人： David A. Benaron , Illian H. Parachikov , Michael Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael Fierro
IPC分类号： G06K9/00
CPC分类号： G06K9/0012 , A61B5/0059 , A61B5/117 , A61B5/417 , G01R33/465
摘要： A biometric device for detecting biological tissue based upon ratiometric measurements of metabolic and/or biochemical intermediates is provided in which a radiation source (103) is electromagnetically coupled to a target region (125). A radiation sensor (155) receives emission signals (128) from the target region as a result of emitted radiation (121) interacting with the target region. A CPU (167) receives a signal from the sensor, and provides a biometric output signal based upon the presence of live, healthy tissue versus sham or dead tissue. Optionally, a conventional, non-metabolism, non-biochemical-based biometric sensor can be incorporated into the present invention, and the biometric output signal is then a result of both the metabolism- and/or biochemical based and non-metabolism non-biochemical-based biometric determinations. A method of performing this biometric analysis is also described.
摘要翻译：提供了一种用于基于代谢和/或生物化学中间体的比例测量来检测生物组织的生物测定装置，其中辐射源（103）电磁耦合到目标区域（125）。由于与目标区域相互作用的发射辐射（121）的结果，辐射传感器（155）从目标区域接收发射信号（128）。 CPU（167）从传感器接收信号，并且基于存在的健康组织与假手术或死组织的存在来提供生物测定输出信号。任选地，可以将常规的非代谢非生物化学生物测定传感器并入本发明，然后生物测定输出信号是代谢和/或生物化学和非代谢非生物化学的结果的生物测定。还描述了执行该生物特征分析的方法。

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