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1. 发明申请

US20090048502A1 Broadband illuminator for oximetry, hemoglobin, met-hemoglobin, carboxy-hemoglobin, and other blood component monitoring 审中-公开
标题翻译：血氧仪，血红蛋白，血红蛋白，羧基血红蛋白和其他血液成分监测的宽带照明
公开(公告)号：US20090048502A1
公开(公告)日：2009-02-19
申请号：US12113887
申请日：2008-05-01
申请人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0261
摘要： An ischemia detection system in two or more somatic measures, collected simultaneously or near-simultaneously, are provided for direct or computational comparison, in which light from light source A (103A) and source B (103B) is detected by a sensor (155), and a difference-weighted value is determined (167), thereby enhancing the value of the spectroscopic measurements over values taken individually and singly.
摘要翻译：提供用于直接或计算比较的同时或近似同时收集的两个或多个体细胞测量中的缺血检测系统，其中来自光源A（103A）和源B（103B）的光由传感器（155）检测，，并且确定差分加权值（167），从而增强对单独和单独获取的值的光谱测量值。

2. 发明申请

US20100198030A1 Solid-State General Illumination With Broadband White LED And Integrated Heat Sink 审中-公开
标题翻译：宽带白光LED和集成散热器的固态通用照明
公开(公告)号：US20100198030A1
公开(公告)日：2010-08-05
申请号：US12761301
申请日：2010-04-15
申请人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0261
摘要： A solid-state illuminator (103) for improved light delivery efficiency in general illumination in which a solid-state, broadband white LED light source (105) is coupled directly and advantageously to an integrated heat-sink or cooler (347) for thermal management. The integrated heat sink or cooler (347) is in thermal contact with the LED light source wires, bulb or lens, and may be placed prior to the light source end cap. The thermal management advantageously allows for more efficient and lower operating temperature at the LED light source, reducing the amount of power needed to produce a given amount of usable light, allowing delivered light intensity and/or light power density, and further facilitating integration of the illuminator and heat-sink or cooler (347) into a general illumination device or system. Methods of manufacturing are also disclosed.
摘要翻译：一种固态照明器（103），用于改善一般照明中的光传输效率，其中固态宽带白光LED光源（105）直接有利地连接到集成散热器或冷却器（347）上，用于热管理。集成散热器或冷却器（347）与LED光源线，灯泡或透镜热接触，并且可以放置在光源端盖之前。热管理有利地允许在LED光源下更有效和更低的操作温度，减少产生给定量的可用光所需的功率量，允许传递的光强度和/或光功率密度，并进一步促进照明器和散热器或冷却器（347）放入通用照明装置或系统中。还公开了制造方法。

3. 发明申请

US20080287758A1 Illuminator probe with memory device and method 审中-公开
标题翻译：具有记忆装置和方法的照明器探头
公开(公告)号：US20080287758A1
公开(公告)日：2008-11-20
申请号：US12180449
申请日：2008-07-25
申请人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1459 , A61B5/1455 , A61B1/06
CPC分类号： A61B5/412 , A61B1/00165 , A61B5/0075 , A61B5/0084 , A61B5/14558 , A61B5/1459 , A61B5/42 , G01J3/10 , G01N2201/062
摘要： An improved medical illuminator (103) with memory chip (241). The memory element retains information useful in the operation of the illuminator, such as probe identification, probe serial number, use history, calibration details, or other information. Further, the illuminator with information chip can be incorporated into a medical probe or device, such as a pulse oximeter system or probe, as well as to be used in surgical devices or other equipment that require illumination. A method of use is also provided.
摘要翻译：一种具有存储芯片（241）的改进的医疗照明器（103）。存储器元件保留在照明器的操作中有用的信息，例如探针识别，探针序列号，使用历史，校准细节或其他信息。此外，具有信息芯片的照明器可以并入到诸如脉搏血氧计系统或探针的医疗探针或装置中，并且可以用于需要照明的外科装置或其他设备中。还提供了一种使用方法。

4. 发明申请

US20080188727A1 Broadband solid-state spectroscopy illuminator and method 审中-公开
标题翻译：宽带固态光谱仪和方法
公开(公告)号：US20080188727A1
公开(公告)日：2008-08-07
申请号：US12101906
申请日：2008-04-11
申请人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1455 , A61B5/0402
CPC分类号： A61B5/412 , A61B1/00165 , A61B5/0075 , A61B5/0084 , A61B5/14558 , A61B5/1459 , A61B5/42 , G01J3/10 , G01N2201/062
摘要： An improved spectroscopy illuminator (103) for generating broadband light and for delivering the light to a sample with an improved delivery efficiency, for higher optical density and/or reduced thermal transfer uses a solid-state broadband white LED (107) to produce broadband light (114), which is then transmitted to a sample region (125), such as a living tissue or blood in vivo or a biological sample in a spectrophotometer target region. The solid-state source keeps both the illuminator and sample cool during operation, allowing the illuminator to be integrated into the tip of a medical probe, a medical system such as an oximeter, or other monitoring systems or devices making measurements based on light scattering, absorbance, fluorescence, phosphorescence, Raman effects, use of a contrast agent, or other known spectroscopy techniques. Systems incorporating the improved illuminator, and methods of use are also disclosed.
摘要翻译：一种改进的光谱照明器（103），用于产生宽带光并用于将光输送到具有改进的输送效率的样品，用于更高的光密度和/或降低的热转印使用固态宽带白光LED（107）产生宽带光（114），然后将其传播到样品区域（125），例如活体组织或体内血液或分光光度计目标区域中的生物样品。固态源在操作期间保持照明器和样品冷却，允许照明器集成到医疗探针的尖端，诸如血氧计的医疗系统或基于光散射进行测量的其它监测系统或装置，吸光度，荧光，磷光，拉曼效应，造影剂的使用或其他已知的光谱技术。还公开了结合改进的照明器的系统和使用方法。

5. 发明申请

US20090187086A1 Integrated White LED Illuminator and Color Sensor Detector System and Method 审中-公开
标题翻译：集成白色LED照明器和色彩传感器检测器系统和方法
公开(公告)号：US20090187086A1
公开(公告)日：2009-07-23
申请号：US12404006
申请日：2009-03-13
申请人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0261
摘要： An improved illuminator (103) for producing broadband light and delivering said light to a target (125) for measuring the color of the target which incorporates an integrated system comprising a solid-state white LED source (105) to illuminate the target with continuous, broadband illuminating light (114). After interaction with the sample, returning light (107) is either collected by a detector or a light collector such as fiber (141), or processed and analyzed by an analysis system such as color monitor (267), or both, creating a real-time integrated color sensor device or system that enables color detection, monitoring, identification, or analysis. A solid-state illuminator integrated with a color detector advantageously allows for a more compact, reduced heat producing, and more energy efficient manufacturable device, and further facilitates integration of the illuminator and detector into a microchip or lab-on-chip device or system. Methods of use are also disclosed.
摘要翻译：一种改进的照明器（103），用于产生宽带光并将所述光传送到目标（125），用于测量目标的颜色，所述目标的结合包括固态白色LED源（105）的集成系统，以用连续的方式照射目标，宽带照明灯（114）。在与样品相互作用之后，返回光（107）由检测器或诸如光纤（141）的光收集器收集，或者通过分析系统如彩色监视器（267）或两者进行处理和分析，从而产生真实的时间集成的颜色传感器设备或系统，可实现颜色检测，监控，识别或分析。与彩色检测器集成的固态照明器有利地允许更紧凑，更少的发热和更节能的可制造装置，并且进一步便于将照明器和检测器集成到微芯片或片上实验室装置或系统中。还公开了使用方法。

6. 发明申请

US20080226137A1 Metabolism- or Biochemical-Based Anti-Spoofing Biometrics Devices, Systems, and Methods 审中-公开
标题翻译：代谢或生物化学反欺骗生物特征的设备，系统和方法
公开(公告)号：US20080226137A1
公开(公告)日：2008-09-18
申请号：US12049122
申请日：2008-03-14
申请人： David A. Benaron , Illian H. Parachikov , Michael Fierro
发明人： David A. Benaron , Illian H. Parachikov , Michael Fierro
IPC分类号： G06K9/00
CPC分类号： G06K9/0012 , A61B5/0059 , A61B5/117 , A61B5/417 , G01R33/465
摘要： A biometric device for detecting biological tissue based upon ratiometric measurements of metabolic and/or biochemical intermediates is provided in which a radiation source (103) is electromagnetically coupled to a target region (125). A radiation sensor (155) receives emission signals (128) from the target region as a result of emitted radiation (121) interacting with the target region. A CPU (167) receives a signal from the sensor, and provides a biometric output signal based upon the presence of live, healthy tissue versus sham or dead tissue. Optionally, a conventional, non-metabolism, non-biochemical-based biometric sensor can be incorporated into the present invention, and the biometric output signal is then a result of both the metabolism- and/or biochemical based and non-metabolism non-biochemical-based biometric determinations. A method of performing this biometric analysis is also described.
摘要翻译：提供了一种用于基于代谢和/或生物化学中间体的比例测量来检测生物组织的生物测定装置，其中辐射源（103）电磁耦合到目标区域（125）。由于与目标区域相互作用的发射辐射（121）的结果，辐射传感器（155）从目标区域接收发射信号（128）。 CPU（167）从传感器接收信号，并且基于存在的健康组织与假手术或死组织的存在来提供生物测定输出信号。任选地，可以将常规的非代谢非生物化学生物测定传感器并入本发明，然后生物测定输出信号是代谢和/或生物化学和非代谢非生物化学的结果的生物测定。还描述了执行该生物特征分析的方法。

7. 发明申请

US20080241065A1 Systems and methods for the detection and analysis of in vivo circulating cells, entities, and nanobots 审中-公开
标题翻译：用于检测和分析体内循环细胞，实体和纳米机器的系统和方法
公开(公告)号：US20080241065A1
公开(公告)日：2008-10-02
申请号：US11729395
申请日：2007-03-27
申请人： David A. Benaron , Illian H. Parachikov
发明人： David A. Benaron , Illian H. Parachikov
IPC分类号： A61B5/145
CPC分类号： A61K49/0032 , A61B5/0059 , A61B5/412 , A61K47/6901 , A61K49/0052 , A61K49/0058 , A61K49/0093
摘要： An improved circulating cell counter for generating light, and for delivering this light to a site in vivo for determining the presence, absence, concentration or count of a target cell, in which a light source such as a laser diode (121) and integrated optics (153) produce a beam transmitted to an in vivo target region (165), such as a capillary bed with flowing cells in a living tissue. Based upon the movement of cells in and out of this region, a circulating cell count (192) is generated, allowing determination of the presence, absence, concentration or count of the target cell. Use with optical, magnetic, or nanobot contrast agents, and methods of use are also described.
摘要翻译：一种用于产生光的改进的循环细胞计数器，并用于将该光传递到体内部位以确定目标细胞的存在，不存在，浓度或计数，其中诸如激光二极管（121）的光源和集成光学器件（153）产生传播到活体组织中具有流动细胞的毛细管床的体内靶区（165）的束。基于细胞进出该区域的移动，产生循环细胞计数（192），从而确定靶细胞的存在，不存在，浓度或计数。还描述了与光学，磁性或纳米体造影剂的使用，以及使用方法。

8. 发明申请

US20110240885A1 Broadband Solid-State Illuminator for Fluorimetry Device and System 审中-公开
标题翻译：用于荧光测量装置和系统的宽带固态照明器
公开(公告)号：US20110240885A1
公开(公告)日：2011-10-06
申请号：US13016911
申请日：2011-01-28
申请人： David A. Benaron , IIlian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , IIlian H. Parachikov , Michael R. Fierro
IPC分类号： G01N21/64 , G01J3/10 , H01L33/02
CPC分类号： A61B5/14551 , A61B5/0261
摘要： An improved solid-state light source (103) for producing illuminating light (114) generated by interaction of light from an LED source (105) with a quantum dot, in one embodiment located in a well (117). A solid-state illuminator with integrated quantum dots advantageously allows for an efficient broadband or narrow band LED to be produced in a variety of specified colors and color temperatures, and allows for a more compact, less heat producing, and more energy efficient manufacturable illumination device, and further facilitates integration of the illuminator and detector into medical, industrial, and laboratory illuminators, microchips, or lab-on-chip devices or systems. Methods of use are also disclosed.
摘要翻译：一种改进的固态光源（103），用于产生通过来自LED源（105）的光与量子点的相互作用产生的照明光（114），在一个实施例中位于井（117）中。具有集成量子点的固态照明器有利地允许以各种指定的颜色和色温产生有效的宽带或窄带LED，并且允许更紧凑，更少的发热和更节能的制造照明装置并且进一步便于将照明器和检测器集成到医疗，工业和实验室照明器，微芯片或片上实验室装置或系统中。还公开了使用方法。

9. 发明申请

US20100312081A1 Implantable Tissue Ischemia Sensor 审中-公开
标题翻译：植入式组织缺血传感器
公开(公告)号：US20100312081A1
公开(公告)日：2010-12-09
申请号：US12858396
申请日：2010-08-17
申请人： David A. Benaron , Ilian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Ilian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/1455
CPC分类号： A61B5/0031 , A61B5/0261 , A61B5/14542 , A61B5/1459 , A61B5/412
摘要： An implantable ischemia detection system in which a white LED (105) produces a continuous, visible, broadband light illuminating a target site (125). Light backscattered by the target is collected by a sensor (155), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (167). Power is provided by an internal power source (179). The entire implantable device is encapsulated by a biocompatible shell (102) to add long-term safety with regard to implantation.
摘要翻译：一种植入式缺血检测系统，其中白色LED（105）产生照射目标部位（125）的连续的，可见的宽带光。由目标物反向散射的光由传感器（155）收集，允许确定缺血指数，并随后由发送单元（167）发送。电源由内部电源（179）提供。整个可植入装置被生物相容的外壳（102）封装，以增加关于植入的长期安全性。

10. 发明授权

US07813778B2 Implantable tissue ischemia sensor 有权
标题翻译：植入式组织缺血传感器
公开(公告)号：US07813778B2
公开(公告)日：2010-10-12
申请号：US11193071
申请日：2005-07-29
申请人： David A. Benaron , Ilian H. Parachikov , Michael R. Fierro
发明人： David A. Benaron , Ilian H. Parachikov , Michael R. Fierro
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , A61B5/0261 , A61B5/14542 , A61B5/1459 , A61B5/412
摘要： An implantable ischemia detection system in which a white LED (105) produces a continuous, visible, broadband light illuminating a target site (125). Light backscattered by the target is collected by a sensor (155), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (167). Power is provided by an internal power source (179). The entire implantable device is encapsulated by a biocompatible shell (102) to add long-term safety with regard to implantation.
摘要翻译：一种植入式缺血检测系统，其中白色LED（105）产生照射目标部位（125）的连续的，可见的宽带光。由目标物反向散射的光由传感器（155）收集，允许确定缺血指数，并随后由发送单元（167）发送。电源由内部电源（179）提供。整个可植入装置被生物相容的外壳（102）封装，以增加关于植入的长期安全性。

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