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1. 发明授权

US08374313B2 Apparatus and methods for radiation treatment of tissue surfaces 有权
标题翻译：组织表面放射治疗的装置和方法
公开(公告)号：US08374313B2
公开(公告)日：2013-02-12
申请号：US12802744
申请日：2010-06-11
申请人： Randall W. Holt , Steve Axelrod , Robert Burnside , Robert G. Neimeyer , Thomas W. Rusch
发明人： Randall W. Holt , Steve Axelrod , Robert Burnside , Robert G. Neimeyer , Thomas W. Rusch
IPC分类号： A61N5/10 , H05G1/02
CPC分类号： A61N5/103 , A61N5/1043 , A61N2005/1091
摘要： A device, system and method for administering radiation therapy to a tissue surface of a patient utilizes an applicator capable of controlled movement and repositioning over a selected area of tissue, under the control of a computer or controller. A servo-controlled manipulator can effect a raster scan of the desired area, such as an area of the skin, and this can be in any desired pattern such as serpentine, spiral, parallel but unidirectional, or irregular patterns. Preferably a third direction of control is included, i.e. a depth direction, with an appropriate form of depth sensor, a signal from which can be used to adjust the radiation source so that radiation of the tissue surface is consistent over varied contoured.
摘要翻译：用于向患者的组织表面施用放射治疗的装置，系统和方法利用在计算机或控制器的控制下能够受控地移动和重新定位在组织的选定区域上的施加器。伺服控制的机械手可以对期望的区域（例如皮肤区域）进行光栅扫描，并且这可以是任何期望的图案，例如蛇形，螺旋，平行但单向或不规则图案。优选地，包括第三控制方向，即具有适当形式的深度传感器的深度方向，可以使用信号来调整辐射源，使得组织表面的辐射在多种轮廓上是一致的。

2. 发明申请

US20110305316A1 Apparatus and methods for radiation treatment of tissue surfaces 有权
标题翻译：组织表面放射治疗的装置和方法
公开(公告)号：US20110305316A1
公开(公告)日：2011-12-15
申请号：US12802744
申请日：2010-06-11
申请人： Randall W. Holt , Steve Axelrod , Robert Burnside , Robert G. Neimeyer , Thomas W. Rusch
发明人： Randall W. Holt , Steve Axelrod , Robert Burnside , Robert G. Neimeyer , Thomas W. Rusch
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/103 , A61N5/1043 , A61N2005/1091
摘要： A device, system and method for administering radiation therapy to a tissue surface of a patient utilizes an applicator capable of controlled movement and repositioning over a selected area of tissue, under the control of a computer or controller. A servo-controlled manipulator can effect a raster scan of the desired area, such as an area of the skin, and this can be in any desired pattern such as serpentine, spiral, parallel but unidirectional, or irregular patterns. Preferably a third direction of control is included, i.e. a depth direction, with an appropriate form of depth sensor, a signal from which can be used to adjust the radiation source so that radiation of the tissue surface is consistent over varied contoured.
摘要翻译：用于向患者的组织表面施用放射治疗的装置，系统和方法利用在计算机或控制器的控制下能够受控地移动和重新定位在组织的选定区域上的施加器。伺服控制的机械手可以对期望的区域（例如皮肤区域）进行光栅扫描，并且这可以是任何期望的图案，例如蛇形，螺旋，平行但单向或不规则图案。优选地，包括第三控制方向，即具有适当形式的深度传感器的深度方向，可以使用信号来调整辐射源，使得组织表面的辐射在多种轮廓上是一致的。

3. 发明申请

US20100074407A1 Treatment of lesions or imperfections in skin, near-skin or in other anatomic tissues, including under direct visualization 审中-公开
标题翻译：治疗皮肤，近皮肤或其他解剖组织中的损伤或缺陷，包括直接观察
公开(公告)号：US20100074407A1
公开(公告)日：2010-03-25
申请号：US12284289
申请日：2008-09-19
申请人： Steve Axelrod , Thomas W. Rusch , Paul A. Lovoi , Anuradha Walawalkar , Sara Z. Yao
发明人： Steve Axelrod , Thomas W. Rusch , Paul A. Lovoi , Anuradha Walawalkar , Sara Z. Yao
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1001 , A61N2005/1091 , A61N2005/1094 , A61N2005/1095
摘要： An apparatus and method for treatment of lesions or imperfections in or near exposed anatomic surfaces using low-level ionizing radiation includes a substantially transparent applicator to administer radiation from an energy source to a surface area with the lesion. The applicator is positioned over the lesion to be treated, a treatment plan is created to achieve the desired therapeutic effect to the lesion, and execution of the treatment plan is executed by the energy source. Verification of the treatment to plan and safety methods are disclosed.
摘要翻译：用于使用低级电离辐射治疗暴露的解剖表面内或附近的损伤或缺陷的装置和方法包括基本上透明的施用器，以将能量源的辐射施加到具有损伤的表面区域。施用器位于要治疗的病变上，创建治疗计划以实现对病变的期望的治疗效果，并且由能量源执行治疗计划的执行。公开了对计划和安全方法的处理的验证。

4. 发明申请

US20100022818A1 Applicators for brachytherapy treatment 审中-公开
标题翻译：近距离放射治疗的施放者
公开(公告)号：US20100022818A1
公开(公告)日：2010-01-28
申请号：US12220717
申请日：2008-07-25
申请人： Steve Axelrod , Thomas W. Rusch , Linda Kelley , Lucymarie Mantese
发明人： Steve Axelrod , Thomas W. Rusch , Linda Kelley , Lucymarie Mantese
IPC分类号： A61M36/04
CPC分类号： A61N5/1015 , A61M25/10 , A61N2005/1094
摘要： An applicator for brachytherapy radiation avoids over-radiation in the distal axial direction from a source positioned in the applicator, by attenuating distal axial radiation which tends to over-radiate, causing a “hot spot” in tissue in the axial direction, when the radiation travels through air space in the lumen.
摘要翻译：用于近距离放射线辐射的施加器避免了远离轴向方向的过度辐射，该辐射通过减弱趋向于过度辐射的远端轴向辐射，从而使得在轴向方向上的组织中产生“热点” 穿过管腔中的空气空间。

5. 发明授权

US08354658B1 Lightweight radiation absorbing shield 有权
标题翻译：轻量吸收屏蔽
公开(公告)号：US08354658B1
公开(公告)日：2013-01-15
申请号：US12800083
申请日：2010-05-06
申请人： Peter C. Smith , Steve Axelrod , Paul A. Lovoi
发明人： Peter C. Smith , Steve Axelrod , Paul A. Lovoi
IPC分类号： G21F3/02
CPC分类号： G21F1/125 , G21F3/02 , G21Y2002/201 , G21Y2002/501 , G21Y2004/30
摘要： A flexible, lightweight radiation absorbing sheet or shield includes heavy metal particles in one layer and mid-atomic number particles in another layer, the layer that will be adjacent to the patient. The shield is particularly intended for protection of the wearer and others from radiation emanating from a therapeutic source positioned within the patient's body. With the disclosed multi-layer shield construction, backscattered radiation off the heavy metal particle layer, affecting the patient's adjacent tissue, is minimized.
摘要翻译：柔性，轻便的辐射吸收片或屏蔽层包括一层中的重金属颗粒和另一层中的原子序数颗粒，该层将与患者相邻。护罩特别用于保护佩戴者和其他人免受来自位于患者体内的治疗源的辐射。利用所公开的多层屏蔽结构，使重金属颗粒层的背散射辐射，影响患者的相邻组织，被最小化。

6. 发明授权

US07771340B2 Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures 有权
标题翻译：用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置
公开(公告)号：US07771340B2
公开(公告)日：2010-08-10
申请号：US11881835
申请日：2007-07-28
申请人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
发明人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61M25/1011 , A61B2017/22069 , A61M25/1002 , A61M2025/1061 , A61N5/1015
摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue farther away from a radiation source within a source guide inside the balloon. In one case a secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape, and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
摘要翻译：气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。这对于使敏感组织更远离辐射源在气囊内的源引导件内是有用的。在一种情况下，次级隔室形成在主气囊上，并且可分开地充气，以便在需要时允许起泡。在另一种形式中，球囊包括单个腔室，但是具有“窗口”或其中球囊壁具有弹性的区域或者比主气囊壁基本上更有弹性的区域，使得球囊到达某一点的膨胀形成基本上规则的气球形状，并且增加进一步的压力将使弹性区域膨胀，从而在气球的期望取向上增加轴与敏感组织之间的距离。

7. 发明授权

US07088456B2 Thin film thickness measurement using multichannel infrared sensor 有权
标题翻译：使用多通道红外传感器的薄膜厚度测量
公开(公告)号：US07088456B2
公开(公告)日：2006-08-08
申请号：US10831074
申请日：2004-04-24
申请人： Igor N. Germanenko , Steve Axelrod
发明人： Igor N. Germanenko , Steve Axelrod
IPC分类号： G01B11/02
CPC分类号： G01B11/0616
摘要： A system and method for analyzing the characteristics of a thin film is provided. The current invention extends the capability of IR sensors to measure thin films through configuring a plurality of detection channels with appropriately chosen filters. With the multichannel infrared sensor, the characteristic signature of interference fringes can be detected simultaneously with, or instead, of absorption-based measurements.
摘要翻译：提供了用于分析薄膜特性的系统和方法。本发明通过配置具有适当选择的滤波器的多个检测通道来扩展IR传感器测量薄膜的能力。利用多通道红外传感器，可以同时或基于吸收式测量来检测干涉条纹的特征。

8. 发明授权

US06961126B2 Optical wavelength splitter 失效
公开(公告)号：US06961126B2
公开(公告)日：2005-11-01
申请号：US10692325
申请日：2003-10-23
申请人： Edward Belotserkovsky , Steve Axelrod , Igor N. Germanenko , Jenson Luis
发明人： Edward Belotserkovsky , Steve Axelrod , Igor N. Germanenko , Jenson Luis
IPC分类号： G01J3/36 , G01N21/25
CPC分类号： G01J3/36
摘要： Preferential optical splitters are used in a multichannel wavelength measurement device. The optical splitters preferentially provide light at a certain wavelength to a detector. Preferentially providing light to the detectors allows for increased optical efficiencies.

9. 发明申请

US20050073694A1 Means for in-place automated calibration of optically-based thickness sensor 有权
公开(公告)号：US20050073694A1
公开(公告)日：2005-04-07
申请号：US10679198
申请日：2003-10-03
申请人： Harriss King , Wesley French , Steve Axelrod , Scott Wiley
发明人： Harriss King , Wesley French , Steve Axelrod , Scott Wiley
IPC分类号： G01B11/28 , G01B21/08
CPC分类号： G01B21/08
摘要： The calibration of a laser caliber is described. The laser caliber uses first and second sensors to determine the distance to different sides of a sheet. A third sensor is used to determine the distance between the first and second sensors. The calibration of the first, second, and third sensors is done by positioning a test object onto the platform sensed by the third sensor. The platform is moved to multiple positions in order to calibrate the first, second and third sensors. Since the displacement of the platform moves the distance to the target of the first, second and third sensors the same amount, the sensors can be accurately calibrated for a number of different positions of the test object. A very accurate calibrating displacement measuring device such as an LVDT can be used.

10. 发明授权

US5315124A Nuclear gauge 失效
标题翻译：核计
公开(公告)号：US5315124A
公开(公告)日：1994-05-24
申请号：US856382
申请日：1992-03-20
申请人： John D. Goss , Steve Axelrod , Mathew Boissevain , Philip M. Hegland , Scott C. Wiley
发明人： John D. Goss , Steve Axelrod , Mathew Boissevain , Philip M. Hegland , Scott C. Wiley
IPC分类号： G01N23/16 , G01B5/02 , G21F5/015 , G21F5/02
CPC分类号： G21F5/02
摘要： A nuclear gauge for making measurements of traveling webs in continuous sheet-making processes includes an enclosure, an encapsulated nuclear source, and a wheel-like member mounted in the enclosure means for carrying the encapsulated nuclear source between two angularly-displaced positions. The first of the angularly-displaced positions is the position where the encapsulated nuclear source makes measurements of a web that travels past the gauge and the second position is the location where the encapsulated nuclear source faces a sidewall of the enclosure means at a location remote from the first position. The nuclear gauge also has an aperture which is formed through the enclosure for providing a window through which the encapsuled nuclear source, when located in the first position, can emit radiation onto a web that travels past the window.
摘要翻译：用于在连续片材制造方法中测量行进幅材的核计量器包括外壳，封装的核源和安装在外壳装置中的轮状构件，用于在两个角度位移位置之间承载封装的核源。角位移位置中的第一个是封装的核源测量行进通过量规的幅材的位置，而第二位置是封装的核源面向外壳的侧壁的位置，远离第一名。核计量器还具有通过外壳形成的孔，用于提供窗口，当位于第一位置时，封装的核源可以通过该窗口将辐射发射到穿过窗户的网上。

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