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    • 2. 发明授权
    • Active device tracking using light with orbital angular momentum to hyperpolarized MRI
    • 有源器件跟踪使用具有轨道角动量的光与超极化MRI
    • US08611982B2
    • 2013-12-17
    • US13131881
    • 2009-11-05
    • Daniel R. ElgortLucian Remus Albu
    • Daniel R. ElgortLucian Remus Albu
    • G01V3/00
    • A61B34/20A61B5/055A61B5/06A61B2034/2051A61B2090/373A61B2090/374
    • One or more light beam endowed with photonic orbital angular momentum generating devices are mounted at preselected locations on an insertable instrument to hyperpolarize nuclear magnetic dipoles in a region of interest. The hyperpolarized nuclear magnetic dipoles are caused to resonate, generating magnetic resonance signals. A controller controls gradient coils to induce a magnetic field gradient across the region of interest, such that the frequency of the resonance signals is indicative of spatial positions. A frequency-to-position decoder converts the resonance signal frequencies into spatial positions. A video processor combines the spatial positions and a portion of a diagnostic image from a diagnostic image memory into a combined image which depicts the location of the region of interest or a portion of the instrument marked on the diagnostic image and displays the combined image on a monitor.
    • 具有光子轨道角动量产生装置的一个或多个光束被安装在可插入仪器上的预选位置处,以在感兴趣的区域中超极化核磁偶极子。 引起超极化核磁偶极子共振,产生磁共振信号。 控制器控制梯度线圈以在感兴趣区域上引起磁场梯度,使得谐振信号的频率指示空间位置。 频率到位置解码器将谐振信号频率转换成空间位置。 视频处理器将空间位置和来自诊断图像存储器的诊断图像的一部分组合成组合图像,该组合图像描绘了标记在诊断图像上的感兴趣区域或仪器的一部分的位置,并将组合图像显示在 监控。
    • 5. 发明授权
    • Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum
    • 磁共振成像通过光与轨道角动量的液体或固体超极化
    • US08765099B2
    • 2014-07-01
    • US12808385
    • 2008-12-19
    • Daniel R. ElgortLucian Remus Albu
    • Daniel R. ElgortLucian Remus Albu
    • A61B5/055
    • G02B5/32G01N24/08G01R33/282G01R33/285G02B27/0037G02B27/4244G02B27/425G02B27/46
    • In magnetic resonance imaging (MRI), selected magnetic dipoles in a subject are aligned with a main magnetic field for later manipulation, and signals received after such manipulations are used to create image representations of the subject. One drawback is that even powerful magnetic fields can only align a very small percentage of dipoles in the region of the field. Electromagnetic radiation endowed with orbital angular momentum (OAM) aligns dipoles along the direction of travel of the radiation, but at a much higher percentage; as high as 100% of the dipoles in the region can be aligned. Resultantly, resonance signals emanating from the region are several orders of magnitude stronger than signals emanated using traditional MRI techniques. All electromagnetic radiation, including visible light can be endowed with OAM and used to hyperpolarize a region of interest.
    • 在磁共振成像(MRI)中,被检体中选定的磁偶极子与主磁场对准以供后续操作,并且使用这些操作之后接收的信号来产生受试者的图像表示。 一个缺点是,甚至强大的磁场只能在场的区域中排列非常小百分比的偶极子。 具有轨道角动量(OAM)的电磁辐射沿着辐射的行进方向对准偶极子,但是以高得多的百分比; 该区域中高达100%的偶极子可以对齐。 结果,从该地区发出的共振信号比使用传统MRI技术发出的信号强大几个数量级。 包括可见光在内的所有电磁辐射都可以被赋予OAM,并用于超极化感兴趣的区域。
    • 7. 发明申请
    • NUCLEAR MAGNETIC RESONANCE MAGNETOMETER EMPLOYING OPTICALLY INDUCED HYPERPOLARIZATION
    • 使用光学诱导的高次谐波的核磁共振磁光计
    • US20130027034A1
    • 2013-01-31
    • US13640052
    • 2011-03-18
    • Daniel R. ElgortLucian Remus Albu
    • Daniel R. ElgortLucian Remus Albu
    • G01R33/26
    • G01R33/26G01R33/282
    • A magnetometer includes: a sample (10) comprising a selected nuclear species; an optical source (12) configured to hyperpolarize the selected nuclear species of the sample by illuminating the sample with optical radiation (14) having orbital angular momentum; a radio frequency generator (20, 26, 30, 150, 152) configured to input radio frequency energy (32) to the hyperpolarized selected nuclear species of the sample over a probed range of radio frequencies; a detector (20, 26, 40, 150, 154, 164, 166) configured to detect a frequency of nuclear magnetic resonance excited in the hyperpolarized selected nuclear species of the sample by the input radio frequency energy; and a signal output generator (64, 66) configured to output a signal indicative of magnetic field strength based on the detected frequency of nuclear magnetic resonance.
    • 磁力计包括:包含选定的核物种的样品(10) 光源(12),被配置为通过用具有轨道角动量的光辐射(14)照射所述样品来超极化所述选定的所述样品的核物种; 配置成通过无线电频率的探测范围将射频能量(32)输入到所述超极化选择的所述核样品的射频发生器(20,26,30,150,152); 经检测器(20,26,40,150,154,164,166),其被配置为通过所述输入射频能量来检测在所述超极化选定核样品中激发的核磁共振的频率; 以及信号输出发生器(64,66),被配置为基于检测到的核磁共振频率输出表示磁场强度的信号。
    • 8. 发明申请
    • ACTIVE DEVICE TRACKING USING LIGHT WITH ORBITAL ANGULAR MOMENTUM TO INDUCE A HYPERPOLARIZED MRI
    • 使用光的有源器件跟踪使用ORBITAL ANGULAR MOMENTUM来诱导超高效MRI
    • US20110230757A1
    • 2011-09-22
    • US13131881
    • 2009-11-05
    • Daniel R. ElgortLucian Remus Albu
    • Daniel R. ElgortLucian Remus Albu
    • A61B5/055
    • A61B34/20A61B5/055A61B5/06A61B2034/2051A61B2090/373A61B2090/374
    • One or more light beam endowed with photonic orbital angular momentum generating devices (18) are mounted at preselected locations on an insertable instrument (14) to hyperpolarize nuclear magnetic dipoles in a region of interest (80). The hyperpolarized nuclear magnetic dipoles are caused to resonate, generating magnetic resonance signals. A controller (42) controls gradient coils to induce a magnetic field gradient across the region of interest, such that the frequency of the resonance signals is indicative of spatial position. A frequency-to-position decoder (50) converts the resonance signal frequencies into spatial positions. A video processor (52) combines the spatial positions and a portion of a diagnostic image from a diagnostic image memory (56) into a combined display which depicts the location of the region of interest or a portion of the instrument marked on the diagnostic image and displays the combined image on a monitor (54).
    • 具有光子轨道角动量产生装置(18)的一个或多个光束安装在可插入仪器(14)上的预选位置,以使感兴趣区域(80)中的核磁偶极子超极化。 引起超极化核磁偶极子共振,产生磁共振信号。 控制器(42)控制梯度线圈以在感兴趣区域上引起磁场梯度,使得谐振信号的频率指示空间位置。 频率到位置解码器(50)将谐振信号频率转换成空间位置。 视频处理器(52)将来自诊断图像存储器(56)的诊断图像的空间位置和一部分组合到组合显示器中,该组合显示器描绘了感兴趣区域的位置或标记在诊断图像上的仪器的一部分, 在监视器上显示组合的图像(54)。