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1. 发明申请

US20070060880A1 Adjustable stiffness catheter 有权
标题翻译：可调刚度导管
公开(公告)号：US20070060880A1
公开(公告)日：2007-03-15
申请号：US11218857
申请日：2005-09-02
申请人： Daniel Gregorich , Soo-Young Yoon , Michael Meyer , Liza Davis
发明人： Daniel Gregorich , Soo-Young Yoon , Michael Meyer , Liza Davis
IPC分类号： A61M29/00
CPC分类号： A61M25/0051 , A61B1/00078 , A61M25/0045 , A61M25/0053 , A61M25/0054 , A61M25/0097 , A61M2025/0046 , A61M2025/0058 , A61M2025/0063 , A61M2025/0065
摘要： Medical devices such as catheters can include structure or provision that permit a physician or other health care professional to adjust the stiffness of at least a portion of the medical device. In some instances, the medical device may be adjusted prior to inserting the medical device into a patient. In some cases, the medical device may be adjusted while in use within the patient.
摘要翻译：诸如导管的医疗装置可以包括允许医师或其他保健专业人员调节医疗装置的至少一部分的刚度的结构或规定。在一些情况下，可以在将医疗装置插入病人之前调整医疗装置。在一些情况下，医疗装置可在患者使用期间进行调整。

2. 发明申请

US20070208323A1 IMPROVED MEDICAL DEVICE SHAFT DESIGNS 有权
标题翻译：改进的医疗设备轴设计
公开(公告)号：US20070208323A1
公开(公告)日：2007-09-06
申请号：US11276554
申请日：2006-03-06
申请人： Daniel Gregorich , Soo-Young Yoon , Liza Davis , Tracee Eidenschink
发明人： Daniel Gregorich , Soo-Young Yoon , Liza Davis , Tracee Eidenschink
IPC分类号： A61M25/00
CPC分类号： A61M25/0023 , A61M25/0043 , A61M25/10 , A61M2025/0059
摘要： Devices and methods for transferring forces down a catheter shaft while also maintaining an open fluid pathway are disclosed. In some of the designs, inner and outer members of the catheter interact, allowing improved transfer of forces down the catheter shaft. These designs also allow for maintenance of a fluid pathway along the length of the shaft, including at locations where the inner and outer members are interacting with one another. Structures are disclosed which extend at least a portion of the length of the shaft, allowing improved force transfer and resistance to kinking. Structures are also disclosed which specifically allow for inner and outer members to engage one another at at least one point along the shaft, improving the transfer of forces down the shaft.
摘要翻译：公开了用于在导管轴下方传递力同时保持开放流体路径的装置和方法。在一些设计中，导管的内部和外部构件相互作用，允许改善力沿导管轴的传递。这些设计还允许维持沿着轴的长度的流体路径，包括在内部和外部构件彼此相互作用的位置处。公开了延伸轴的长度的至少一部分的结构，允许改进的力传递和抵抗扭结。还公开了具体允许内部构件和外部构件在沿着轴的至少一个点处彼此接合的结构，从而改善了沿轴的力的传递。

3. 发明申请

US20070233233A1 Tethered expansion columns for controlled stent expansion 审中-公开
标题翻译：用于受控支架扩张的松弛扩张柱
公开(公告)号：US20070233233A1
公开(公告)日：2007-10-04
申请号：US11395743
申请日：2006-03-31
申请人： Jim McGovern , Daniel Gregorich , Liza Davis , Michael Meyer
发明人： Jim McGovern , Daniel Gregorich , Liza Davis , Michael Meyer
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2230/0054 , A61F2250/0067
摘要： A tethered stent made up of interconnected struts which together form expansion columns. At least some of the struts are connected to each other by tethers. When the stent expands, the tethers pull on the interconnected struts and limit how far apart from each other the struts can move when expanding. This limitation allows for greater control over what overall shape the expanded stent will assume and how particular portions of the stent will deploy. The tethers also add density to the stent and increases surface area which leads to better stent scaffolding and greater effectiveness of drug coatings.
摘要翻译：由连接的支柱构成的系绳支架，其一起形成扩张柱。至少一些支柱通过系绳相互连接。当支架膨胀时，系绳拉动互连的支柱，并限制支柱在扩张时可以移动多远。这种限制允许更好地控制扩张的支架的总体形状以及支架的特定部分将如何部署。系链还增加了支架的密度，并增加了表面积，这导致更好的支架支架和药物涂层的更大的有效性。

4. 发明申请

US20110066227A1 Stent with Dynamic Drug Reservoirs 审中-公开
标题翻译：动态药物支架支架
公开(公告)号：US20110066227A1
公开(公告)日：2011-03-17
申请号：US12561781
申请日：2009-09-17
申请人： Michael P. Meyer , Timothy S. Girton , Dennis Boismier , Daniel Gregorich , Kim Robertson , Liza Davis , Cory Hitzman , Samuel Robaina , Doug Thesingh
发明人： Michael P. Meyer , Timothy S. Girton , Dennis Boismier , Daniel Gregorich , Kim Robertson , Liza Davis , Cory Hitzman , Samuel Robaina , Doug Thesingh
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2250/0035 , A61F2250/0068
摘要： A stent having one or more beneficial agents which enhance the healing effect of the stent. The agent is positioned within a reservoir. The reservoir dynamically releases the agent when the stent is expanded. The reservoir makes use of various changes in stent shape during expansion to assure proper release of the agent. Agent release can be modulated at various points along the stent and with various rates of release. The reservoirs can also be cooperatively combined with features that enhance stent flexibility, structural integrity, and which prevent recoil.
摘要翻译：具有增强支架愈合效果的一种或多种有益剂的支架。试剂位于储存器内。当支架扩张时，储层动态释放药剂。储存器在膨胀期间利用支架形状的各种变化，以确保试剂的适当释放。药剂释放可以在支架的各个点处以各种释放速率进行调节。储存器还可以与增强支架柔性，结构完整性以及防止反冲的特征协同结合。

5. 发明申请

US20100269838A1 MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION 有权
标题翻译：用于将治疗药物递送至目标位置的磁性颗粒
公开(公告)号：US20100269838A1
公开(公告)日：2010-10-28
申请号：US12765369
申请日：2010-04-22
申请人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David Sogard , Liza Davis
发明人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David Sogard , Liza Davis
IPC分类号： A61B19/00
CPC分类号： A61K9/0009 , A61K9/1676 , A61K9/501 , A61K9/5094 , A61K9/5115
摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.
摘要翻译：提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

6. 发明申请

US20070269479A1 Medical devices coated with drug carrier macromolecules 有权
标题翻译：用药物载体大分子涂覆的医疗器械
公开(公告)号：US20070269479A1
公开(公告)日：2007-11-22
申请号：US11435690
申请日：2006-05-18
申请人： Liza Davis , Kim Robertson , Richard Tooley
发明人： Liza Davis , Kim Robertson , Richard Tooley
IPC分类号： A61K39/395 , A61F2/02
CPC分类号： A61L31/16 , A61L27/227 , A61L27/34 , A61L27/54 , A61L31/04 , A61L31/10 , A61L2300/602
摘要： A medical device coated with carrier macromolecules, wherein the carrier macromolecules are conjugated with a therapeutic agent. The carrier macromolecules may be antibodies which bind the therapeutic agent at the antigen binding site or by covalent bonding. The carrier macromolecules may be tethered to the surface of or dispersed within a coating on the medical device. The carrier macromolecules may release the therapeutic agent upon exposure to a trigger, which may be exposure to an aqueous environment, or a change in the pH or the ionic strength of the environment. The carrier macromolecules may also be bispecific antibodies directed to both a therapeutic agent and a target antigen. In some cases, binding of the target antigen causes the therapeutic agent to be released from the bispecific antibody. Also provided are methods of controlling the release and targeting of therapeutic agents eluted from a medical device.
摘要翻译：涂覆有载体大分子的医疗装置，其中载体大分子与治疗剂缀合。载体大分子可以是在抗原结合位点或通过共价键结合治疗剂的抗体。载体大分子可以连接到医疗装置上的涂层的表面或分散在其中。载体大分子可能暴露于可能暴露于水性环境的触发剂或pH或环境离子强度的变化下释放治疗剂。载体大分子也可以是针对治疗剂和靶抗原的双特异性抗体。在一些情况下，靶抗原的结合导致治疗剂从双特异性抗体释放。还提供了控制从医疗装置洗脱的治疗剂的释放和靶向的方法。

7. 发明授权

US07951193B2 Drug-eluting stent 失效
标题翻译：药物洗脱支架
公开(公告)号：US07951193B2
公开(公告)日：2011-05-31
申请号：US12178180
申请日：2008-07-23
申请人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
发明人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. At least one strut has at least one first well region and at least one second well region. The at least one first well region has a first thickness, the at least one second well region has a second thickness, the first thickness being greater than the second thickness. Each well region defines a well having a depth. At least some of the wells contain a therapeutic agent.
摘要翻译：用于将治疗剂递送到体腔的支架包括多个周向蛇形带，每个带包括多个支柱。至少一个支柱具有至少一个第一阱区域和至少一个第二阱区域。所述至少一个第一阱区域具有第一厚度，所述至少一个第二阱区域具有第二厚度，所述第一厚度大于所述第二厚度。每个井区域定义具有深度的井。至少一些孔含有治疗剂。

8. 发明申请

US20100292777A1 Stent 审中-公开
标题翻译：支架
公开(公告)号：US20100292777A1
公开(公告)日：2010-11-18
申请号：US12465443
申请日：2009-05-13
申请人： Michael P. Meyer , Samuel Robaina , Dennis Boismier , Jason T. Lenz , Liza Davis , Kim Robertson , Doug Thesingh , Cory Hitzman , Timothy S. Girton
发明人： Michael P. Meyer , Samuel Robaina , Dennis Boismier , Jason T. Lenz , Liza Davis , Kim Robertson , Doug Thesingh , Cory Hitzman , Timothy S. Girton
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/9155 , A61F2002/91566 , A61F2002/91591 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： An expandable stent has a plurality of expandable rings formed of a plurality of struts and at least one first connector interconnecting adjacent expandable rings. The plurality of struts include a first strut and the at least one first connector has a first arm. A first portion of the first arm is engaged to a first portion of the first strut so that the first portion of the first arm and the first portion of the first strut define a through hole.
摘要翻译：可扩张支架具有由多个支柱形成的多个可膨胀环以及互连相邻可膨胀环的至少一个第一连接器。所述多个支柱包括第一支柱，并且所述至少一个第一连接器具有第一臂。第一臂的第一部分接合到第一支柱的第一部分，使得第一臂的第一部分和第一支柱的第一部分限定通孔。

9. 发明申请

US20070250159A1 Medical device having a coating comprising an adhesion promoter 有权
标题翻译：具有包含粘合促进剂的涂层的医疗装置
公开(公告)号：US20070250159A1
公开(公告)日：2007-10-25
申请号：US11409468
申请日：2006-04-20
申请人： Liza Davis
发明人： Liza Davis
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0035 , A61F2250/0067 , A61L31/14 , A61L2300/406 , A61L2300/416 , A61L2300/61
摘要： This invention is directed to a coating for a medical device, such as an intravascular stent, in which the coating, which comprises a first coating region comprising an adhesion promoter and a therapeutic agent. The coating can also include a second coating region which is substantially free of the adhesion promoter or any adhesion promoter. The invention is also directed to a method for manufacturing such a coated medical device.
摘要翻译：本发明涉及用于医疗装置如血管内支架的涂层，其中涂层包括包含粘合促进剂和治疗剂的第一涂层区域。涂层还可以包括基本上不含粘合促进剂或任何粘合促进剂的第二涂层区域。本发明还涉及一种用于制造这种涂覆的医疗装置的方法。

10. 发明申请

US20100023115A1 DRUG-ELUTING STENT 失效
标题翻译：药物治疗
公开(公告)号：US20100023115A1
公开(公告)日：2010-01-28
申请号：US12178180
申请日：2008-07-23
申请人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
发明人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. At least one strut has at least one first well region and at least one second well region. The at least one first well region has a first thickness, the at least one second well region has a second thickness, the first thickness being greater than the second thickness. Each well region defines a well having a depth. At least some of the wells contain a therapeutic agent.
摘要翻译：用于将治疗剂递送到体腔的支架包括多个周向蛇形带，每个带包括多个支柱。至少一个支柱具有至少一个第一阱区域和至少一个第二阱区域。所述至少一个第一阱区域具有第一厚度，所述至少一个第二阱区域具有第二厚度，所述第一厚度大于所述第二厚度。每个井区域定义具有深度的井。至少一些孔含有治疗剂。

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