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1. 发明申请

US20070059748A1 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer 审中-公开
公开(公告)号：US20070059748A1
公开(公告)日：2007-03-15
申请号：US11516476
申请日：2006-09-06
申请人： Daniel Afar , Natasha Aziz , Kurt Gish , Peter Hevezi , David Mack , Keith Wilson , Albert Zlotnik
发明人： Daniel Afar , Natasha Aziz , Kurt Gish , Peter Hevezi , David Mack , Keith Wilson , Albert Zlotnik
IPC分类号： C12Q1/68
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011
摘要： Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.

2. 发明申请

US20070042360A1 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer 审中-公开
标题翻译：诊断癌症的方法，筛选癌症调节剂的组合物和方法
公开(公告)号：US20070042360A1
公开(公告)日：2007-02-22
申请号：US10245882
申请日：2002-09-17
申请人： Daniel Afar , Natasha Aziz , Kurt Gish , Peter Hevezi , David Mack , Keith Wilson , Albert Zlotnik
发明人： Daniel Afar , Natasha Aziz , Kurt Gish , Peter Hevezi , David Mack , Keith Wilson , Albert Zlotnik
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011
摘要： Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.
摘要翻译：本文描述的是其表达在特定癌症中上调或下调的基因。公开了可用于诊断和治疗这些癌症的相关方法和组合物。本文还描述了可用于鉴定所选癌症的调节剂的方法。

3. 发明申请

US20070014801A1 Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer 审中-公开
标题翻译：诊断前列腺癌的方法，筛选前列腺癌调节剂的组合物和方法
公开(公告)号：US20070014801A1
公开(公告)日：2007-01-18
申请号：US09976858
申请日：2001-10-12
申请人： Kurt Gish , David Mack , Keith Wilson , Peter Hevezi
发明人： Kurt Gish , David Mack , Keith Wilson , Peter Hevezi
IPC分类号： C12Q1/68 , A61K39/395
CPC分类号： C12Q1/6886 , C07K16/3069 , C12Q2600/136 , G01N2800/52
摘要： Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein are methods that can be used to identify modulators of prostate cancer.
摘要翻译：本文描述的是其表达在前列腺癌中上调或下调的基因。还描述了这样的基因，其表达在耐药前列腺癌细胞中进一步上调或下调。公开了可用于诊断和治疗前列腺癌的相关方法和组合物。本文还描述了可用于鉴定前列腺癌调节剂的方法。

4. 发明申请

US20070059712A1 Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer 审中-公开
公开(公告)号：US20070059712A1
公开(公告)日：2007-03-15
申请号：US11212799
申请日：2005-08-24
申请人： Kurt Gish , David Mack , Keith Wilson , Peter Hevezi
发明人： Kurt Gish , David Mack , Keith Wilson , Peter Hevezi
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34
CPC分类号： C12Q1/6886 , C07K16/3069 , C12Q2600/136 , G01N2800/52
摘要： Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein are methods that can be used to identify modulators of prostate cancer.

5. 发明申请

US20160177895A1 Intake Manifold 有权
标题翻译：进气歧管
公开(公告)号：US20160177895A1
公开(公告)日：2016-06-23
申请号：US15055773
申请日：2016-02-29
申请人： Keith Wilson
发明人： Keith Wilson
IPC分类号： F02M35/10
CPC分类号： F02M35/10052 , F02M35/10078 , F02M35/10085 , F02M35/10091 , F02M35/10098 , F02M35/104 , F02M35/1045 , F02M35/112 , Y02T10/146
摘要： A bolt-on replacement intake manifold has an asymmetrical plenum with a first end including an inlet, a closed terminal end, a concave top surface and a convex bottom surface; a flange; and a plurality of runners extending from the bottom surface of the plenum and terminating at the flange. The plenum defines an interior space in flow communication with the runners. The bottom surface of the plenum is wider than the top surface. The plenum initially widens from the inlet to the first runner and then begins to narrow from the first runner toward the last runner adjacent to the closed terminal end. The runners are tapered, curved, and vary in length. The intake manifold causes air to exit each of the plurality of runners at substantially the same angle. The manifold balances airflow across each runner and increases swirl inside the cylinders enhancing fuel economy, power output, and torque.
摘要翻译：螺栓式更换进气歧管具有不对称的增压室，其第一端包括入口，封闭的末端，凹顶表面和凸底表面; 法兰以及多个流道，其从所述增压室的底表面延伸并终止于所述凸缘处。气室定义了与跑步者流动连通的内部空间。增压室的底面宽于顶面。增压室从入口开始变宽到第一流道，然后开始从第一流道向邻近闭合末端的最后流道变窄。跑步者是锥形，弯曲，长度不同。进气歧管导致空气以基本上相同的角度离开多个跑道中的每一个。歧管平衡每个流道的气流，并增加气缸内的涡流，提高燃油经济性，动力输出和扭矩。

6. 发明申请

US20160145508A1 HYDROPROCESSING FOR DISTILLATE PRODUCTION 审中-公开
标题翻译：蒸馏生产水合物
公开(公告)号：US20160145508A1
公开(公告)日：2016-05-26
申请号：US14932335
申请日：2015-11-04
申请人： Xiaochun Xu , Adrienne C. Lukaski , Keith Wilson , James John Schorfheide , Jeffrey Lawrence Kaufman
发明人： Xiaochun Xu , Adrienne C. Lukaski , Keith Wilson , James John Schorfheide , Jeffrey Lawrence Kaufman
IPC分类号： C10G65/04 , C10G65/02 , C10G65/08
CPC分类号： C10G45/50 , B01J23/882 , B01J23/883 , B01J23/888 , B01J23/8885 , B01J37/20 , C10G35/06 , C10G45/08 , C10G47/06 , C10G65/02 , C10G65/04 , C10G65/08 , C10G65/12 , C10G67/04 , C10G69/02 , C10G69/08 , C10G2300/1048 , C10G2300/202 , C10G2300/301 , C10G2400/00 , C10M101/02
摘要： Methods are provided for hydrotreating a feed to generate a product with a reduced or minimized aromatics content and/or an increased distillate product yield. A distillate boiling range feed having an elevated content of sulfur and/or nitrogen can be hydrotreated using at least two hydrotreating stages with intermediate separation to produce a hydrotreated distillate boiling range product with a reduced or minimized aromatics content. Additionally or alternately, a mixed metal catalyst formed from a suitable precursor can be used during the hydrotreating. A mixed metal catalyst formed from a suitable precursor can provide an unexpectedly superior activity for aromatic saturation. A still further unexpected benefic can be achieved by combining a multi-stage hydrotreating process with intermediate separation with hydrotreating in the presence of a mixed metal catalyst formed from a suitable precursor.
摘要翻译：提供用于加氢处理进料以产生具有降低的或最小化的芳烃含量和/或增加的馏出物产物产率的产物的方法。具有提高的硫和/或氮含量的馏出物沸程进料可以使用至少两个具有中间分离的加氢处理阶段进行加氢处理，以产生具有降低的或最小化的芳烃含量的加氢处理的馏出物沸点产物。另外或者替代地，在加氢处理期间可以使用由合适的前体形成的混合金属催化剂。由合适的前体形成的混合金属催化剂可以提供出乎意料的优异的芳族饱和活性。通过在由合适的前体形成的混合金属催化剂的存在下将多级加氢处理方法与中间分离与加氢处理组合可以实现另外的意想不到的益处。

7. 发明申请

US20130240811A1 ROPE GRIP APPARATUS 审中-公开
公开(公告)号：US20130240811A1
公开(公告)日：2013-09-19
申请号：US13697447
申请日：2011-05-12
申请人： Keith Wilson
发明人： Keith Wilson
IPC分类号： B66D1/74 , A62B1/08
CPC分类号： B66D1/7415 , A62B1/08 , A62B1/10 , B66D5/16
摘要： Rope grip apparatus for raising or lowering a load has a rope-engaging portion with opposing projections. The opposing projections are arranged to grip a rope by compressing the rope between the projections. In use the rope is fed through the apparatus.
摘要翻译：用于提升或降低负载的绳把装置具有带相对突起的绳索啮合部分。相对的突起被布置成通过在突起之间压缩绳索来抓握绳索。在使用中，绳索通过设备进给。

8. 发明申请

US20060073442A1 Globes having marked zones of geographic interest 失效
标题翻译：具有地理感兴趣区域的地球仪
公开(公告)号：US20060073442A1
公开(公告)日：2006-04-06
申请号：US10985185
申请日：2004-11-09
申请人： Keith Wilson
发明人： Keith Wilson
IPC分类号： G09B27/08
CPC分类号： G09B27/08
摘要： An Earth globe is provided for studying continental position theories. The globe comprises graphical image representations of a plurality of land masses at locations representing the current position of the land masses on Earth. A plurality of at least a portion of great circle indication lines are graphically marked on the globe that generally correspond to linear portions of geographic features on the globe. Globes having at least one graphically marked intersection zone corresponding to an area within about 5° of defined geographic points are also provided. Methods for marking globes are also described.
摘要翻译：地球地球仪用于研究大陆位置理论。地球仪包括多个地块的图形图像表示，表示地球上陆地块的当前位置。多个指示线的至少一部分在地球上以图形标记，其通常对应于地球上的地理特征的线性部分。还提供了具有至少一个图形标记的相交区域的地球仪，其对应于定义的地理点的约5°范围内的区域。还描述了标记球体的方法。

9. 发明申请

US20050009844A1 Inhibitors of p38 有权
标题翻译： p38的抑制剂
公开(公告)号：US20050009844A1
公开(公告)日：2005-01-13
申请号：US10622320
申请日：2003-07-17
申请人： Guy Bemis , Francesco Salituro , John Duffy , John Cochran , Edmund Harrington , Mark Murko , Keith Wilson , Michael Su , Vincent Galullo
发明人： Guy Bemis , Francesco Salituro , John Duffy , John Cochran , Edmund Harrington , Mark Murko , Keith Wilson , Michael Su , Vincent Galullo
IPC分类号： C07D213/56 , C07D213/70 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561 , A61K31/519
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译：本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。本发明还涉及生产这些抑制剂的方法。本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。

10. 外观设计

USD492888S1 Nitrous oxide flow solenoid bracket 失效
标题翻译：一氧化二氮电磁铁支架
公开(公告)号：USD492888S1
公开(公告)日：2004-07-13
申请号：US29167531
申请日：2002-09-17
申请人： Keith Wilson
设计人： Keith Wilson

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