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1. 发明授权

US06317625B1 Method and apparatus for increasing the low frequency dynamic range of a system for measuring physiological signals with an implantable medical device 失效
标题翻译：用于通过可植入医疗装置增加用于测量生理信号的系统的低频动态范围的方法和装置
公开(公告)号：US06317625B1
公开(公告)日：2001-11-13
申请号：US09713455
申请日：2000-11-15
申请人： Dana J. Olson , David W. Van Ess , Robert W. Stadler , Steven N. Lu , Jeffrey D. Wilkinson , Tara N. Ptak
发明人： Dana J. Olson , David W. Van Ess , Robert W. Stadler , Steven N. Lu , Jeffrey D. Wilkinson , Tara N. Ptak
IPC分类号： A61B50402
CPC分类号： A61B5/0428 , A61B5/7232 , A61N1/3925 , Y10S128/901 , Y10S128/902
摘要： A signal measuring system for use with an Implantable Medical Device (IMD) is provided for measuring physiologic signals having a relatively large effective dynamic range. In one embodiment, the system includes a High-Pass Filter (HPF), an Analog-to-Digital Converter (ADC), a Decimation Filter (DF), and a Compensation Filter (CF). The HPF receives an input signal that includes both the baseline wander imposed on a physiological signal. According to one aspect of the invention, the HPF attenuates low frequency components of the input signal, including a portion of the frequency band within the desired output signal bandwidth. The ADC then oversamples the output signal of the HPF. The DF receives the output samples from the ADC and generates output samples at rate that is at least twice the maximum frequency of the desired output signal. The CF then amplifies the low frequency end of the DF output samples. The gain and cutoff frequency of the CF are selected to offset the HPF attenuation of those low frequency components of the input signal below the cutoff frequency of the HPF and above the minimum frequency of the desired output signal. In one embodiment, the DF and CF are implemented by a processing circuit executing programmed instructions. The processing circuit may be included within the IMD, or may be partially or fully implemented within a device that is external to the IMD.
摘要翻译：提供了一种用于可植入医疗器械（IMD）的信号测量系统，用于测量具有相对较大有效动态范围的生理信号。在一个实施例中，该系统包括高通滤波器（HPF），模数转换器（ADC），抽取滤波器（DF）和补偿滤波器（CF）。 HPF接收包括施加在生理信号上的基线漂移的输入信号。根据本发明的一个方面，HPF衰减输入信号的低频分量，包括期望输出信号带宽内的一部分频带。 ADC然后对HPF的输出信号进行过采样。 DF从ADC接收输出采样，并以至少是所需输出信号的最大频率的两倍的速率生成输出采样。 CF然后放大DF输出样本的低频端。选择CF的增益和截止频率以将输入信号的那些低频分量的HPF衰减降低到低于HPF的截止频率并且高于所需输出信号的最小频率。在一个实施例中，DF和CF由执行编程指令的处理电路实现。处理电路可以包括在IMD内，或者可以部分地或完全地实现在IMD外部的设备中。

2. 发明授权

US07066891B2 Method and apparatus for gauging severity of myocardial ischemic episodes 失效
标题翻译：测量心肌缺血发作严重程度的方法和装置
公开(公告)号：US07066891B2
公开(公告)日：2006-06-27
申请号：US10325076
申请日：2002-12-20
申请人： Robert W. Stadler , Steven N. Lu , Gary W. King , Thomas R. Moore
发明人： Robert W. Stadler , Steven N. Lu , Gary W. King , Thomas R. Moore
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61N1/362 , G06F19/00
摘要： An implantable medical device (IMD) for gauging the severity of ischemia in a patient's heart includes a data collection module configured to receive data about the patient's heart, a data processing module configured to process the data to identify an episode of ischemia in the patient and to determine if the episode is stable or unstable, and a reporting module configured to provide an alarm to the patient if the episode is unstable. A method executable by an implantable medical device to detect ischemia in a human heart suitably includes the steps of receiving data about the heart at the implantable medical device, processing the data within the implantable medical device to determine the severity of ischemia, and providing a response from the implantable medical device to the patient if ischemia is indicated.
摘要翻译：用于测量患者心脏的严重程度的可植入医疗装置（IMD）包括：数据收集模块，被配置为接收关于患者心脏的数据;数据处理模块，被配置为处理所述数据以识别患者的局部缺血发作;以及以确定剧集是否稳定或不稳定，并且报告模块被配置为如果发作不稳定则向患者提供警报。可植入医疗装置可检测人心脏缺血的方法适当地包括以下步骤：在可植入医疗装置处接收关于心脏的数据，处理可植入医疗装置内的数据以确定局部缺血的严重性，并提供反应从可植入的医疗装置到患者，如果指示缺血。

3. 发明授权

US07120484B2 Methods and apparatus for filtering EGM signals detected by an implantable medical device 有权
公开(公告)号：US07120484B2
公开(公告)日：2006-10-10
申请号：US10045722
申请日：2002-01-14
申请人： Steven N. Lu , Robert W. Stadler
发明人： Steven N. Lu , Robert W. Stadler
IPC分类号： A61B5/04
CPC分类号： A61B5/0008 , A61B5/0428 , A61B5/7232 , A61N1/3704
摘要： An analog physiologic signal, e.g., the cardiac EGM, sensed by an IMD is filtered with a high pass filter (HPF), the cut-off frequency of the HPF being within a predetermined frequency bandwidth, wherein a low-band portion of the predetermined frequency bandwidth is attenuated in the filtered physiologic signal. The filtered physiologic signal is digitized in real time order, and the digital data set is filtered in reverse time order employing a digital IIR filter having characteristics substantially matching the cut-off frequency and filter characteristics of the HPF. When the system is implemented within an IMD, the filtered digital data set is compressed by lossy compression algorithm, and the compressed data set is filtered in reverse time order. In certain embodiments, the filtered digital data set is uplink telemetry transmitted to an external medical device, and the uplink telemetered data set is filtered in reverse time order employing a digital backward IIR filter resident in the external medical device.

4. 发明授权

US09480844B2 Method and apparatus for reducing noise in a medical device 有权
标题翻译：减少医疗装置噪音的方法和装置
公开(公告)号：US09480844B2
公开(公告)日：2016-11-01
申请号：US12915093
申请日：2010-10-29
申请人： Robert W. Stadler , Richard P. M. Houben , Tim Dirk Jan Jongen
发明人： Robert W. Stadler , Richard P. M. Houben , Tim Dirk Jan Jongen
IPC分类号： A61N1/37 , A61N1/36 , A61N1/362
CPC分类号： A61N1/3702 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing a cardiac signal, detecting a cardiac event in response to the sensed signal, determining whether an interval associated with the cardiac signal is less than an interval threshold, determining a noise metric in response to an interval associated with the cardiac signal being less than the interval threshold, determining whether the noise metric is greater than a noise metric threshold, and determining whether to inhibit detecting in response to determining whether an interval associated with the cardiac signal is less than the interval threshold and determining whether the noise metric is greater than the noise metric threshold.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测心脏信号，响应于感测信号检测心脏事件，确定与心脏信号相关联的间隔是否小于间隔阈值，确定噪声响应于与所述心脏信号相关联的间隔小于所述间隔阈值的度量，确定所述噪声度量是否大于噪声度量阈值，以及响应于确定与所述心脏信号相关联的间隔是否是禁止检测小于间隔阈值并确定噪声度量是否大于噪声度量阈值。

5. 发明授权

US09180300B2 Left-ventricular pacing site selection guided by electrogram morphology analysis 有权
标题翻译：通过电描记图形态分析指导左心室起搏部位选择
公开(公告)号：US09180300B2
公开(公告)日：2015-11-10
申请号：US13598784
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/00 , A61N1/362 , A61B5/00 , A61B5/0452 , A61N1/368
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译：医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。建立第一形态学模板并存储在设备的存储器中。处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。处理器将确定的心脏信号形态与第一形态学模板进行比较。响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。

6. 发明授权

US09174062B2 Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权
标题翻译：用于检测皮下医疗装置中的心律失常的方法和装置
公开(公告)号：US09174062B2
公开(公告)日：2015-11-03
申请号：US11687094
申请日：2007-03-16
申请人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
发明人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
IPC分类号： A61B5/00 , A61N1/362 , A61N1/39 , A61B5/0464 , A61B5/0468 , A61B5/046 , A61N1/05
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes, determining a relationship between a plurality of characteristics associated with a morphology of the cardiac signals sensed during a predetermined sensing window, generating a threshold in response to the determined relationship, comparing a first characteristic of the plurality of characteristics with the threshold, and determining whether the sensed cardiac signals are associated with the cardiac event in response to the comparing of the first characteristic.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测来自多个电极的心脏信号，确定与在预定感测窗口期间感测到的心脏信号的形态有关的多个特征之间的关系，产生阈值响应于所确定的关系，将所述多个特征的第一特征与所述阈值进行比较，并且响应于所述第一特征的比较，确定所感测的心脏信号是否与心脏事件相关联。

7. 发明授权

US08983585B2 Method and apparatus for detecting and discriminating tachycardia 有权
标题翻译：用于检测和辨别心动过速的方法和装置
公开(公告)号：US08983585B2
公开(公告)日：2015-03-17
申请号：US12768944
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler
发明人： Xusheng Zhang , Robert W. Stadler
IPC分类号： A61B5/04 , A61N1/362 , A61B5/0464 , A61N1/39 , A61B5/00
CPC分类号： A61N1/3622 , A61B5/0464 , A61B5/686 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for monitoring a patient's heart rhythm sensing a cardiac signal determine whether a cardiac signal is noise corrupted by obtaining cardiac signal pulses and generating a pulse amplitude threshold in response to the plurality of signal pulses. The number of signal sample points exceeding the pulse amplitude threshold in each of the of signal pulses is computed. The cardiac signal is determined to be noise corrupted or non-corrupted in response to the computed number of signal sample points.
摘要翻译：用于监测感测心脏信号的患者心律的医疗装置和相关方法通过获得心脏信号脉冲并响应于多个信号脉冲产生脉冲幅度阈值来确定心脏信号是否被噪声破坏。计算每个信号脉冲中超过脉冲振幅阈值的信号采样点数。响应于所计算的信号采样点数，心脏信号被确定为噪声损坏或未被破坏。

8. 发明授权

US08948869B2 Criteria for optimal electrical resynchronization derived from multipolar leads or multiple electrodes during biventricular pacing 有权
标题翻译：在双心室起搏期间从多极引线或多个电极获得的最佳电再同步的标准
公开(公告)号：US08948869B2
公开(公告)日：2015-02-03
申请号：US13464181
申请日：2012-05-04
申请人： Subham Ghosh , Robert W. Stadler
发明人： Subham Ghosh , Robert W. Stadler
IPC分类号： A61N1/00 , A61N1/368
CPC分类号： A61N1/3686 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/371
摘要： Generally, the disclosure is directed one or more methods or systems of cardiac pacing employing a right ventricular electrode and a plurality of left ventricular electrodes. Pacing using the right ventricular electrode and a first one of the left ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Employing sums of the measured activation times to select one of the left ventricular electrodes for delivery of subsequent pacing pulses.
摘要翻译：通常，本公开涉及使用右心室电极和多个左心室电极的一个或多个心脏起搏方法或系统。使用右心室电极和左心室电极中的第一个进行起搏，并测量其他左心室电极的活化时间。使用右心室电极和第二个心室电极进行起搏，并测量其他左心室电极的活化时间。使用所测量的激活时间的总和来选择一个左心室电极用于递送随后的起搏脉冲。

9. 发明授权

US08862212B2 Aggregating cardiac resynchronization therapy data 有权
标题翻译：聚集心脏再同步治疗数据
公开(公告)号：US08862212B2
公开(公告)日：2014-10-14
申请号：US13316177
申请日：2011-12-09
申请人： Helen W. Otto , Kevin T. Ousdigian , Julian Sanchez , Sean R. Landman , Robert W. Stadler
发明人： Helen W. Otto , Kevin T. Ousdigian , Julian Sanchez , Sean R. Landman , Robert W. Stadler
IPC分类号： A61B5/0402 , G06F19/00
CPC分类号： G06F19/3443 , G06F19/00 , G16H50/70
摘要： Cardiac resynchronization therapy (CRT) performance data for a number of patients in which an implantable medical device (IMD) is implanted is aggregated and reports of the aggregated data are generated, e.g., for review by organizations or individual clinicians treating the patients. In one example, a method includes collecting CRT performance data correlated to cardiac rhythm event data for a first group of patients in which an IMD configured to deliver CRT is implanted, aggregating, with a computing device, the CRT performance data correlated to the cardiac rhythm event data for a second group of patients from among the first group of patients, and generating, with the computing device, a report comprising the aggregation of the CRT performance data correlated to the cardiac rhythm event data for the second group of patients.
摘要翻译：对植入了植入式医疗装置（IMD）的许多患者的心脏再同步治疗（CRT）性能数据进行聚合，并且生成聚合数据的报告，例如用于治疗患者的组织或个体临床医师的审查。在一个示例中，一种方法包括收集与其中植入用于递送CRT的IMD相关的第一组患者的与心律事件数据相关的CRT性能数据，与计算设备聚合与心律相关的CRT性能数据生成来自第一组患者的第二组患者的事件数据，并且与计算设备一起生成包括与第二组患者的心律事件数据相关的CRT性能数据的聚集的报告。

10. 发明授权

US08694099B2 Criteria for optimal electrical resynchronization derived from multipolar leads or multiple electrodes during biventricular pacing 有权
标题翻译：在双心室起搏期间从多极引线或多个电极获得的最佳电再同步的标准
公开(公告)号：US08694099B2
公开(公告)日：2014-04-08
申请号：US13464279
申请日：2012-05-04
申请人： Subham Ghosh , Robert W. Stadler
发明人： Subham Ghosh , Robert W. Stadler
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/371
摘要： Generally, the disclosure is directed one or more methods or systems of cardiac pacing employing a right ventricular electrode and a plurality of left ventricular electrodes. Pacing using the right ventricular electrode and a first one of the left ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Employing sums of the measured activation times to select one of the left ventricular electrodes for delivery of subsequent pacing pulses.
摘要翻译：通常，本公开涉及使用右心室电极和多个左心室电极的一个或多个心脏起搏方法或系统。使用右心室电极和左心室电极中的第一个进行起搏，并测量其他左心室电极的活化时间。使用右心室电极和第二个心室电极进行起搏，并测量其他左心室电极的活化时间。使用所测量的激活时间的总和来选择一个左心室电极用于递送随后的起搏脉冲。

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