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1. 发明申请

US20060065827A1 Target support and method 失效
标题翻译：目标支持和方法
公开(公告)号：US20060065827A1
公开(公告)日：2006-03-30
申请号：US10949275
申请日：2004-09-24
申请人： Dan-Hui Yang , Jennifer Lu , Ying-Lan Chang , Timothy Joyce
发明人： Dan-Hui Yang , Jennifer Lu , Ying-Lan Chang , Timothy Joyce
IPC分类号： H01J49/16
CPC分类号： B82Y10/00 , H01J49/0418
摘要： The invention provides an apparatus that produces analyte ions for detection by a detector. The apparatus includes a matrix based ion source having a target substrate including a carbon nanotube material for producing analyte ions, an ion transport system adjacent to the matrix based ion source for transporting analyte ions from the matrix based ion source; and an ion detector downstream from the ion transport system for detecting the analyte ions. The invention also provides a method for producing and detecting the analyte ions.
摘要翻译：本发明提供一种生成分析物离子以供检测器检测的装置。该装置包括：基质基离子源，其具有包括用于产生分析物离子的碳纳米管材料的目标基底，与基于基质的离子源相邻的离子传输系统，用于从基于基质的离子源输送分析物离子; 以及离子传感系统下游的用于检测分析物离子的离子检测器。本发明还提供了一种用于产生和检测分析物离子的方法。

2. 发明申请

US20060118712A1 Nanostructure sample supports for mass spectrometry 审中-公开
标题翻译：用于质谱的纳米结构样品载体
公开(公告)号：US20060118712A1
公开(公告)日：2006-06-08
申请号：US11003122
申请日：2004-12-03
申请人： Dan-Hui Yang , Ying-Lan Chang , Timothy Joyce
发明人： Dan-Hui Yang , Ying-Lan Chang , Timothy Joyce
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： B82Y10/00 , B82Y30/00 , H01J49/0418
摘要： A sample support for ionizing a sample is described. The sample support comprises a reflective nanostructure material for reflecting incident light to ionize the sample on the sample support.
摘要翻译：描述了用于电离样品的样品支架。样品载体包括用于反射入射光以将样品电离样品载体的反射纳米结构材料。

3. 发明申请

US20060097150A1 Functionalized target support and method 审中-公开
标题翻译：功能化目标支持和方法
公开(公告)号：US20060097150A1
公开(公告)日：2006-05-11
申请号：US10974316
申请日：2004-10-26
申请人： Timothy Joyce , Dan-Hui Yang
发明人： Timothy Joyce , Dan-Hui Yang
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0418 , B82Y10/00 , B82Y30/00
摘要： The invention provides an apparatus that produces analyte ions for detection by a detector. The apparatus includes a matrix based ion source having a target substrate including an aromatic compound and a carbon nanotube material for producing analyte ions, an ion transport system adjacent to the matrix based ion source for transporting analyte ions from the matrix based ion source; and an ion detector downstream from the ion transport system for detecting the analyte ions. The invention also provides a method for producing and detecting the analyte ions.
摘要翻译：本发明提供一种生成分析物离子以供检测器检测的装置。该装置包括基体基离子源，其具有包括芳族化合物的靶基质和用于产生分析物离子的碳纳米管材料，与基质基离子源相邻的离子迁移系统，用于从基质离子源输送分析物离子; 以及离子传感系统下游的用于检测分析物离子的离子检测器。本发明还提供了一种用于产生和检测分析物离子的方法。

4. 发明申请

US20060097149A1 Nanowire target support and method 失效
标题翻译：纳米线目标支持和方法
公开(公告)号：US20060097149A1
公开(公告)日：2006-05-11
申请号：US10971164
申请日：2004-10-22
申请人： Timothy Joyce
发明人： Timothy Joyce
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0418
摘要： The invention provides an apparatus that produces analyte ions for detection by a detector. The apparatus includes a matrix based ion source having a nanowire target substrate for producing analyte ions, an ion transport system adjacent to the matrix based ion source for transporting analyte ions from the matrix based ion source; and an ion detector downstream from the ion transport system for detecting the analyte ions. The invention also provides a method for producing and detecting the analyte ions.
摘要翻译：本发明提供一种生成分析物离子以供检测器检测的装置。该装置包括具有用于产生分析物离子的纳米线靶基质的基于基质的离子源，与基于基质的离子源相邻的离子传输系统，用于将基于离子源的离子源输送到分析物离子; 以及离子传感系统下游的用于检测分析物离子的离子检测器。本发明还提供了一种用于产生和检测分析物离子的方法。

5. 发明申请

US20060081775A1 Ionization chambers for mass spectrometry 失效
公开(公告)号：US20060081775A1
公开(公告)日：2006-04-20
申请号：US10966191
申请日：2004-10-15
申请人： Timothy Joyce , Jennifer Lu
发明人： Timothy Joyce , Jennifer Lu
IPC分类号： H01J49/10
CPC分类号： H01J49/147 , B82Y10/00
摘要： An ionization chamber for a mass spectrometry system is described. The ionization chamber comprises a housing defining an ionization region, and the housing comprises a carbon nanotube material.

6. 发明申请

US20060019259A1 Characterization of biopolymers by resonance tunneling and fluorescence quenching 审中-公开
标题翻译：通过共振隧道和荧光猝灭表征生物聚合物
公开(公告)号：US20060019259A1
公开(公告)日：2006-01-26
申请号：US10898586
申请日：2004-07-22
申请人： Timothy Joyce
发明人： Timothy Joyce
IPC分类号： C12Q1/68 , C12M3/04
CPC分类号： G01N33/6818 , C12Q1/6869 , G01N33/48721 , C12Q2565/631 , C12Q2565/607
摘要： The present invention provides a method and apparatus for determining the identity of a monomeric residue of a biopolymer. The apparatus comprises a substrate having a nanopore, a potential-producing element for producing a ramped potential across electrodes adjacent to the nanopore, and a quenchable excitable moiety adjacent to the nanopore. As a biopolymer passes through the nanopore, the identity of monomeric residues of a biopolymer may be determined by detecting changes in (a) current across the electrodes and (b) a signal of the quenchable excitable molecule. The subject method and apparatus find use in determining the identity of a plurality of monomeric residues of a biopolymer, and, as such, may be employed in a variety of diagnostic and research applications.
摘要翻译：本发明提供了用于测定生物聚合物的单体残基的身份的方法和装置。该装置包括具有纳米孔的底物，用于在邻近纳米孔的电极之间产生斜坡电位的潜在产生元件和与该纳米孔相邻的可淬火的可兴奋部分。当生物聚合物通过纳米孔时，生物聚合物的单体残基的身份可以通过检测（a）跨越电极的电流的变化和（b）可淬灭的可激发分子的信号来确定。本发明的方法和装置用于确定生物聚合物的多个单体残基的身份，并且因此可用于多种诊断和研究应用。

7. 发明申请

US20060243917A1 Apparatus and method for sensor control and feedback 有权
公开(公告)号：US20060243917A1
公开(公告)日：2006-11-02
申请号：US11471954
申请日：2006-06-21
申请人： Steven Fischer , Darrell Gourley , Glen Ingle , Timothy Joyce
发明人： Steven Fischer , Darrell Gourley , Glen Ingle , Timothy Joyce
IPC分类号： H01J27/24
CPC分类号： H01J49/04 , H01J49/10 , H01J49/107 , H01J49/165
摘要： The present invention relates to an apparatus and method for use with a mass spectrometry system. The invention provides an ion source, infrared emitter and sensor with closed control feedback loop coupled to the infrared emitter. Methods of control and heating using the apparatus of the present invention are also disclosed.

8. 发明申请

US20060062194A1 Integration of remote microcell with CDMA infrastructure 有权
公开(公告)号：US20060062194A1
公开(公告)日：2006-03-23
申请号：US11261251
申请日：2005-10-28
申请人： Brian Fiut , Timothy Joyce
发明人： Brian Fiut , Timothy Joyce
IPC分类号： H04B7/216
CPC分类号： H04B7/2609 , H04B7/2628 , H04B2201/70702 , H04W4/18 , H04W24/00
摘要： A method of interconnecting a CDMA cellsite having signal advancing capabilities with at least one remote microcell without re-synchronization capabilities. The method of the present invention sufficiently advances the signal to compensate for the time delay induced by communication signal travel over a fiber optic connection between a base station cellsite and a remote microcell.

9. 发明申请

US20060014293A1 Lock mass ions for use with derivatized peptides for de novo sequencing using tandem mass spectrometry 审中-公开
标题翻译：使用串联质谱法将质子离子锁定用于衍生肽进行从头测序
公开(公告)号：US20060014293A1
公开(公告)日：2006-01-19
申请号：US10938690
申请日：2004-09-10
申请人： Timothy Joyce , Barry Boyes , Gordon Nicol , Hongbin Liu
发明人： Timothy Joyce , Barry Boyes , Gordon Nicol , Hongbin Liu
IPC分类号： G01N33/00
CPC分类号： G01N33/6851 , G01N33/6842 , G01N33/6848 , H01J49/0031 , Y10T436/24
摘要： Multiple derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis. An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is also provided. Lock mass ions mix with the derivatized polypeptide analyte ions prior to mass analysis.
摘要翻译：公开了通过化学反应进行质谱分析的多重衍生化。衍生化增强了MS技术用于分析蛋白质样品的用途，特别是当通过串联MS / MS测定多肽的序列时。描述了准确的质量分析技术用于测序多肽，以及在蛋白质分析中使用测序数据。还提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。在质量分析之前，将质子离子与衍生的多肽分析物离子混合。

10. 发明申请

US20050151090A1 Apparatus and method for ion production enhancement 有权
标题翻译：用于离子生产增强的装置和方法
公开(公告)号：US20050151090A1
公开(公告)日：2005-07-14
申请号：US11015190
申请日：2004-12-16
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J49/04 , H01J49/16 , H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.
摘要翻译：本发明涉及一种与质谱仪一起使用的装置和方法。本发明的离子增强系统用于将加热气体引导到由基于基质的离子源产生的离子并由检测器检测。离子增强系统介于离子源和检测器之间。接触加热气体的分析物离子增强，并且更多的离子更容易被检测器检测。本发明的方法包括从基于基质的离子源产生分析物离子，用离子增强系统增强分析物离子并用检测器检测增强的分析物离子。

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