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1. 发明申请

US20070134690A1 Diagnosis of systemic onset juvenile idiopathic arthritis through blood leukocyte microarray analysis 审中-公开
标题翻译：通过血液白细胞微阵列分析诊断全身性发作青少年特发性关节炎
公开(公告)号：US20070134690A1
公开(公告)日：2007-06-14
申请号：US11544377
申请日：2006-10-06
申请人： Maria Pascual , Jacques Banchereau , Damien Chaussabel , Florence Allantaz
发明人： Maria Pascual , Jacques Banchereau , Damien Chaussabel , Florence Allantaz
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) using microarrays.
摘要翻译：本发明包括使用微阵列进行早期检测和一致测定全身性发作幼年特发性关节炎（SoJIA）的组合物，系统和方法。

2. 发明申请

US20070238094A1 Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis 审中-公开
标题翻译：通过血液白细胞微阵列分析诊断，预后和监测系统性红斑狼疮疾病进展
公开(公告)号：US20070238094A1
公开(公告)日：2007-10-11
申请号：US11446825
申请日：2006-06-05
申请人： Damien Chaussabel , Maria Pascual , Jacques Banchereau
发明人： Damien Chaussabel , Maria Pascual , Jacques Banchereau
IPC分类号： C12Q1/70 , C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6883 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B40/00 , Y02A90/24 , Y02A90/26
摘要： The present invention includes compositions, systems, arrays and methods for the early detection and consistent determination of SLE using modular analysis of gene expression data.
摘要翻译：本发明包括使用基因表达数据的模块分析来早期检测和一致确定SLE的组合物，系统，阵列和方法。

3. 发明申请

US20070231816A1 Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles 审中-公开
标题翻译：外周血白细胞转录谱的模块级分析
公开(公告)号：US20070231816A1
公开(公告)日：2007-10-04
申请号：US11608815
申请日：2006-12-09
申请人： Damien Chaussabel , Jacques Banchereau
发明人： Damien Chaussabel , Jacques Banchereau
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G16B40/00 , C12Q1/6883 , G16B25/00 , Y02A90/26
摘要： The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.
摘要翻译：本发明包括通过从获自一种或多种具有疾病或病症的患者获得的细胞获得单个基因表达水平来开发和使用转录模块的装置，系统和方法; 记录表中每个基因的表达值分为簇; 通过以下方式迭代地选择一个或多个转录模块的基因表达值：为模块选择在每种疾病或病症中匹配的每个簇的基因; 从分析中去除所选择的基因; 并重复基因表达价值选择过程，其中所述基因分布在疾病或病症的亚分数中; 并迭代地重复模块的生成。

4. 发明申请

US20140179807A1 MODULE-LEVEL ANALYSIS OF PERIPHERAL BLOOD LEUKOCYTE TRANSCRIPTIONAL PROFILES 审中-公开
标题翻译：外周血淋巴细胞转录物种的模块水平分析
公开(公告)号：US20140179807A1
公开(公告)日：2014-06-26
申请号：US14056776
申请日：2013-10-17
申请人： Damien Chaussabel , Jacques Banchereau
发明人： Damien Chaussabel , Jacques Banchereau
IPC分类号： G06F19/24 , C12Q1/68
CPC分类号： G16B40/00 , C12Q1/6883 , G16B25/00 , Y02A90/26
摘要： The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.
摘要翻译：本发明包括通过从获自一种或多种具有疾病或病症的患者获得的细胞获得单个基因表达水平来开发和使用转录模块的装置，系统和方法; 记录表中每个基因的表达值分为簇; 通过以下方式迭代地选择一个或多个转录模块的基因表达值：为模块选择在每种疾病或病症中匹配的每个簇的基因; 从分析中去除所选择的基因; 并重复基因表达价值选择过程，其中所述基因分布在疾病或病症的亚分数中; 并迭代地重复模块的生成。

5. 发明授权

US08333965B2 Anti-inteferon alpha monoclonal antibodies and methods for use 有权
标题翻译：抗全蛋白α单克隆抗体及其使用方法
公开(公告)号：US08333965B2
公开(公告)日：2012-12-18
申请号：US13252335
申请日：2011-10-04
申请人： Jacques Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
发明人： Jacques Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
IPC分类号： A61K39/395 , A61K38/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFNα”) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和至少两种干扰素α（IFNα）蛋白亚型对于蛋白质亚型A，2，B2，C，F，G，H2，I，J1，K的生物活性的抗体， 4a，4b和WA，但不中和IFNα蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子的活化或抗病毒活性及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和性，本发明的抗体可用于检测样品或组织和/或治疗应用中的IFNα亚型，包括但不限于IFNα相关病症的治疗和/或改善，例如如SLE，狼疮，I型糖尿病，牛皮癣，艾滋病和移植物抗宿主病。

6. 发明申请

US20050266445A1 Purified mammalian CTLA-8 antigens and related reagents 审中-公开
标题翻译：纯化的哺乳动物CTLA-8抗原及相关试剂
公开(公告)号：US20050266445A1
公开(公告)日：2005-12-01
申请号：US11097622
申请日：2005-03-31
申请人： Pierre Golstein , Eric Rouvier , Francois Fossiez , Serge Lebecque , Odile Djossou , Jacques Banchereau
发明人： Pierre Golstein , Eric Rouvier , Francois Fossiez , Serge Lebecque , Odile Djossou , Jacques Banchereau
IPC分类号： A61K38/00 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/24 , C07K16/30 , C12N5/06 , C12N15/09 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/244 , Y10S435/975
摘要： CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的CTLA-8抗原，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述抗原的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

7. 发明授权

US06812004B1 Mammalian dendritic cell chemokine reagents 失效
标题翻译：哺乳动物树突状细胞趋化因子试剂
公开(公告)号：US06812004B1
公开(公告)日：2004-11-02
申请号：US08799028
申请日：1997-02-10
申请人： Christophe Caux , Serge J. E. Lebecque , Jacques Banchereau
发明人： Christophe Caux , Serge J. E. Lebecque , Jacques Banchereau
IPC分类号： C12N1519
CPC分类号： C07K14/523 , C07K2319/00
摘要： A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的新型CC趋化因子，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述趋化因子的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

8. 发明授权

US06274711B1 Purified mammalian CTLA-8 antigens and related reagents 失效
标题翻译：纯化的哺乳动物CTLA-8抗原及相关试剂
公开(公告)号：US06274711B1
公开(公告)日：2001-08-14
申请号：US08432994
申请日：1995-05-02
申请人： Pierre Golstein , Eric Rouvier , Francois Fossiez , Serge J. E. Lebecque , Odile Djossou , Jacques Banchereau
发明人： Pierre Golstein , Eric Rouvier , Francois Fossiez , Serge J. E. Lebecque , Odile Djossou , Jacques Banchereau
IPC分类号： C07K1600
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/244 , Y10S435/975
摘要： CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的CTLA-8抗原，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述抗原的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

9. 发明授权

US6004807A In vitro generation of human dendritic cells 失效
标题翻译：人树突状细胞的体外产生及其用途
公开(公告)号：US6004807A
公开(公告)日：1999-12-21
申请号：US637880
申请日：1996-04-25
申请人： Jacques Banchereau , Christophe Caux
发明人： Jacques Banchereau , Christophe Caux
IPC分类号： A61K39/00 , C12N5/0783 , C12N5/0784 , C12N5/00
CPC分类号： C12N5/0636 , A61K39/0011 , C12N5/0639 , A61K2039/5158 , A61K2039/57 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2502/11
摘要： A method is provided for generating human dendritic cells in vitro by treating CD34.sup.+ cells with tumor necrosis factor-.alpha. and interleukin-3 or with GM-CSF. The invention also includes cellular compositions of dendritic cells produced by this method. Dendritic cells of the invention can be used widely as components in many diagnostic and therapeutic systems, including improved mixed lymphocyte reactions for assaying tissue rejection, adoptive immunotherapy of cancer, adoptive immunotherapy of HIV and other viral infections, and SCID-hu mice for human antibody production.
摘要翻译：提供了通过用肿瘤坏死因子-α和白介素-3或GM-CSF处理CD34 +细胞在体外产生人树突状细胞的方法。本发明还包括通过该方法产生的树突细胞的细胞组合物。本发明的树突状细胞可以广泛地用作许多诊断和治疗系统中的组分，包括用于测定组织排斥反应的改进的混合淋巴细胞反应，癌症的过继性免疫治疗，HIV的过继性免疫治疗和其他病毒感染，以及用于人抗体的SCID-hu小鼠生产。

10. 发明授权

US4948738A Monoclonal antibodies to gamma-interferon, hybridomas producing such antibodies, and kit for using such antibodies 失效
标题翻译：产生这种抗体的γ-干扰素单克隆抗体，使用这种抗体的试剂盒
公开(公告)号：US4948738A
公开(公告)日：1990-08-14
申请号：US380760
申请日：1989-07-14
申请人： Jacques Banchereau , Odile Djossou , John Wijdenes , Helene Cabrillat , Catherine Favre
发明人： Jacques Banchereau , Odile Djossou , John Wijdenes , Helene Cabrillat , Catherine Favre
IPC分类号： G01N33/53 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/57 , C07K16/00 , C07K16/24 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/249 , C07K2317/34 , Y10S435/967 , Y10S436/815
摘要： Monoclonal antibodies to .gamma.-interferon and hybridomas producing such antibodies are disclosed. The antibodies are preferably of the immunoglobulin subclass IgG.sub.1, .kappa., and do not bind to interferon-.alpha..sub.2.
摘要翻译：公开了产生这种抗体的γ-干扰素单克隆抗体和杂交瘤。抗体优选为免疫球蛋白亚类IgG1，κ而不与干扰素-α2结合。

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