专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09061066B2 Immunoadjuvant compounds and uses thereof 有权
标题翻译：免疫佐剂化合物及其用途
公开(公告)号：US09061066B2
公开(公告)日：2015-06-23
申请号：US13701882
申请日：2011-06-06
申请人： Jean-Pierre Gorvel , Jacques Banchereau , Anna Martirosyan , Eynav Klechevsky , Sangkon Oh
发明人： Jean-Pierre Gorvel , Jacques Banchereau , Anna Martirosyan , Eynav Klechevsky , Sangkon Oh
IPC分类号： A61K39/39 , A61K39/00 , A61K47/36
CPC分类号： A61K47/36 , A61K39/39 , A61K2039/55583
摘要： Cyclic beta glucan compounds function as an immunoadjuvant when administered prior to, concommitantly with, or subsequent to the administration of one or more antigens to a subject. These adjuvant compounds may be effectively used as dendritic cell activating molecules.
摘要翻译：当向受试者施用一种或多种抗原之前，同时或之后施用时，β-葡聚糖化合物作为免疫佐剂起作用。这些佐剂化合物可以有效地用作树枝状细胞活化分子。

2. 发明申请

US20140154239A1 Anti-interferon alpha monoclonal antibodies and methods for use 审中-公开
标题翻译：抗干扰素α单克隆抗体及其使用方法
公开(公告)号：US20140154239A1
公开(公告)日：2014-06-05
申请号：US13705289
申请日：2012-12-05
申请人： Jacques Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
发明人： Jacques Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
IPC分类号： C07K16/24
CPC分类号： C07K16/249 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFNα”) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和至少两种干扰素α（“IFNα”）蛋白亚型对于蛋白质亚型A，2，B2，C，F，G，H2，I，J1的生物活性的抗体， K，4a，4b和WA，但不中和IFNα蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子的活化或抗病毒活性及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和性，本发明的抗体可用于检测样品或组织和/或治疗应用中的IFNα亚型，包括但不限于IFNα相关病症的治疗和/或改善，例如如SLE，狼疮，I型糖尿病，牛皮癣，艾滋病和移植物抗宿主病。

3. 发明申请

US20090275735A1 MONOCLONAL ANTIBODIES TO HUMAN CTLA-8 (IL-17A) 失效
标题翻译：人类CTLA-8（IL-17A）单克隆抗体
公开(公告)号：US20090275735A1
公开(公告)日：2009-11-05
申请号：US11930368
申请日：2007-10-31
申请人： Pierre Golstein , Eric Rouvier , Francois Fossiez , Serge J. E. Lebecque , Odile Djossou , Jacques Banchereau
发明人： Pierre Golstein , Eric Rouvier , Francois Fossiez , Serge J. E. Lebecque , Odile Djossou , Jacques Banchereau
IPC分类号： C07K16/00
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/244 , Y10S435/975
摘要： Human CTLA-8 protein, antibodies that specifically bind to human CTLA-8, and nucleic acids encoding human CTLA-8. Methods of using these molecules and diagnostic kits are also provided.
摘要翻译：人CTLA-8蛋白，与人CTLA-8特异性结合的抗体，以及编码人CTLA-8的核酸。还提供了使用这些分子和诊断试剂盒的方法。

4. 发明申请

US20080286314A1 Dendritic cells loaded with heat shocked melanoma cell bodies 审中-公开
标题翻译：树突细胞装载有热激黑素瘤细胞体
公开(公告)号：US20080286314A1
公开(公告)日：2008-11-20
申请号：US11932095
申请日：2007-10-31
申请人： Anna Karolina Palucka , Jacques Banchereau
发明人： Anna Karolina Palucka , Jacques Banchereau
IPC分类号： A61K39/00 , C12N5/02 , A61P35/04
CPC分类号： A61K35/28 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/6043
摘要： The present invention includes compositions and methods for the isolation, purification and preparation of immunogenic antigens for the production of customized cancer vaccines that include dendritic cells that are contacted with an antigen that includes heat-shocked cancer cells.
摘要翻译：本发明包括用于分离，纯化和制备用于生产定制的癌症疫苗的免疫原性抗原的组合物和方法，其包括与包含热休克癌细胞的抗原接触的树突状细胞。

5. 发明申请

US20070238094A1 Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis 审中-公开
标题翻译：通过血液白细胞微阵列分析诊断，预后和监测系统性红斑狼疮疾病进展
公开(公告)号：US20070238094A1
公开(公告)日：2007-10-11
申请号：US11446825
申请日：2006-06-05
申请人： Damien Chaussabel , Maria Pascual , Jacques Banchereau
发明人： Damien Chaussabel , Maria Pascual , Jacques Banchereau
IPC分类号： C12Q1/70 , C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6883 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B40/00 , Y02A90/24 , Y02A90/26
摘要： The present invention includes compositions, systems, arrays and methods for the early detection and consistent determination of SLE using modular analysis of gene expression data.
摘要翻译：本发明包括使用基因表达数据的模块分析来早期检测和一致确定SLE的组合物，系统，阵列和方法。

6. 发明申请

US20070231816A1 Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles 审中-公开
标题翻译：外周血白细胞转录谱的模块级分析
公开(公告)号：US20070231816A1
公开(公告)日：2007-10-04
申请号：US11608815
申请日：2006-12-09
申请人： Damien Chaussabel , Jacques Banchereau
发明人： Damien Chaussabel , Jacques Banchereau
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G16B40/00 , C12Q1/6883 , G16B25/00 , Y02A90/26
摘要： The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.
摘要翻译：本发明包括通过从获自一种或多种具有疾病或病症的患者获得的细胞获得单个基因表达水平来开发和使用转录模块的装置，系统和方法; 记录表中每个基因的表达值分为簇; 通过以下方式迭代地选择一个或多个转录模块的基因表达值：为模块选择在每种疾病或病症中匹配的每个簇的基因; 从分析中去除所选择的基因; 并重复基因表达价值选择过程，其中所述基因分布在疾病或病症的亚分数中; 并迭代地重复模块的生成。

7. 发明申请

US20070118914A1 Oncohumouse 审中-公开
公开(公告)号：US20070118914A1
公开(公告)日：2007-05-24
申请号：US11544230
申请日：2006-10-06
申请人： Jacques Banchereau , Anna Palucka
发明人： Jacques Banchereau , Anna Palucka
IPC分类号： A01K67/027
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A01K2267/0381
摘要： The present invention includes a model system and use of the same for the study, manipulation and focusing of the human immune in a mammal, e.g., a nonhuman mammal that is immune deficient with one or more human hematopoietic progenitor cells and one or more human tumor cell lines.
摘要翻译：本发明包括模型系统及其用于研究，操纵和聚焦哺乳动物（例如，与一种或多种人类造血祖细胞和一种或多种人肿瘤免疫缺陷的非人哺乳动物）的用途细胞系。

8. 发明申请

US20070059717A1 Systemic lupus erythematosus diagnostic assay 失效
标题翻译：系统性红斑狼疮诊断测定
公开(公告)号：US20070059717A1
公开(公告)日：2007-03-15
申请号：US11228586
申请日：2005-09-15
申请人： Marla Pascual , Jacques Banchereau , Lynda Bennett
发明人： Marla Pascual , Jacques Banchereau , Lynda Bennett
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile of a suitable sample by screening for the presence of a differentially expressed SLE-associated gene isolated from a sample containing or suspected of containing a cell that can differentially express an SLE-associated gene.
摘要翻译：本发明提供了用于帮助受试者中SLE的诊断，监测和预后以及用于鉴定治疗和/或改善与SLE相关的症状的潜在治疗剂的组合物和方法。因此，本发明的实施方案涉及通过筛选从含有或怀疑含有可差异表达SLE的细胞的样品分离的差异表达的SLE相关基因的存在来鉴定合适样品的基因表达谱的方法相关基因。

9. 发明申请

US20060239962A1 Rapid one-step generation of antigen loaded dendritic cell vaccine from precursors 审中-公开
标题翻译：从前体快速一步生成抗原负载的树突状细胞疫苗
公开(公告)号：US20060239962A1
公开(公告)日：2006-10-26
申请号：US10537682
申请日：2003-12-04
申请人： Jacques BANCHEREAU
发明人： Jacques BANCHEREAU
IPC分类号： A61K39/00 , A61K9/127 , A61K38/19
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154 , C12N5/0639 , C12N2501/22 , C12N2501/25
摘要： A one-step method for producing antigen loaded antigen-presenting cells from monocytes ex vivo has been found which comprises contacting the monocytes with a composition comprising an activator such as TNF alpha preferably in combination with at least one growth factor such as GM-CSF and at least one soluble or particulate antigen. According to the methods of the present invention, antigen-loaded dendritic cell vaccines can be generated within as little as three (3) days. In another method of the present invention, antigen loaded antigen-presenting cells are produced from monocytes ex vivo by contacting the monocytes with TNF alpha and granulocyte-macrophage colony stimulating factor at one time point to form antigen-presenting cells and then contacting antigen-presenting cells with soluble or particulate antigenic material antigen-presenting cells, wherein the antigen loaded antigen-presenting cells are produced in less than four days. The present invention also includes a vaccine which comprises monocyte-derived antigen loaded antigen-presenting cells, wherein the antigenpresenting cells are composed of two or more subsets selected from the group consisting of Langerhans cells with surface markers (CD 1 a+CD207+); interstitial dendritic cells with surface markers (CD 1a+CD207−); double negative dendritic cells with surface markers 20 (CD 1 a−CD 14−); and dendritic cells with surface markers (CD 14+CD 1 a−CD209+).
摘要翻译：已经发现从体外从单核细胞产生抗原负载抗原呈递细胞的一步法包括使单核细胞与包含活化剂如TNFα的组合物接触，优选与至少一种生长因子如GM-CSF和至少一种可溶或微粒抗原。根据本发明的方法，可以在短短三（3）天内产生抗原负载的树突状细胞疫苗。在本发明的另一种方法中，抗原呈递细胞由单核细胞通过单核细胞与TNFα和粒细胞 - 巨噬细胞集落刺激因子在一个时间点接触形成抗原呈递细胞，然后使抗原呈递细胞接触具有可溶性或微粒抗原性材料抗原呈递细胞的细胞，其中抗原呈递细胞的抗原呈递细胞在不到四天的时间内产生。本发明还包括一种疫苗，其包含单核细胞衍生的抗原负载抗原呈递细胞，其中所述抗原呈递细胞由两个或更多个选自具有表面标记的朗格汉斯细胞（CD1a + CD207 +）的子集组成; 具有表面标志物的间质树突状细胞（CD 1a + CD207-）; 具有表面标记20的双负性树突状细胞（CD 1 a-CD 14-）; 和具有表面标志物（CD14 + CD1a-CD209 +）的树突状细胞。

10. 发明授权

US08333965B2 Anti-inteferon alpha monoclonal antibodies and methods for use 有权
标题翻译：抗全蛋白α单克隆抗体及其使用方法
公开(公告)号：US08333965B2
公开(公告)日：2012-12-18
申请号：US13252335
申请日：2011-10-04
申请人： Jacques Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
发明人： Jacques Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
IPC分类号： A61K39/395 , A61K38/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFNα”) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和至少两种干扰素α（IFNα）蛋白亚型对于蛋白质亚型A，2，B2，C，F，G，H2，I，J1，K的生物活性的抗体， 4a，4b和WA，但不中和IFNα蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子的活化或抗病毒活性及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和性，本发明的抗体可用于检测样品或组织和/或治疗应用中的IFNα亚型，包括但不限于IFNα相关病症的治疗和/或改善，例如如SLE，狼疮，I型糖尿病，牛皮癣，艾滋病和移植物抗宿主病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式