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1. 发明授权

US5072007A Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivatives 失效
标题翻译：制备聚烷基-2-羟基-7-羟基喹啉衍生物的方法
公开(公告)号：US5072007A
公开(公告)日：1991-12-10
申请号：US547132
申请日：1990-07-03
申请人： Daisuke Fukuoka , Takeshi Ishitoku , Katsuya Takahashi , Takashi Tashiro , Junichi Imuta , Hiroaki Tan , Masaharu Ishiguro , Noriaki Kihara , Teruaki Mukaiyama
发明人： Daisuke Fukuoka , Takeshi Ishitoku , Katsuya Takahashi , Takashi Tashiro , Junichi Imuta , Hiroaki Tan , Masaharu Ishiguro , Noriaki Kihara , Teruaki Mukaiyama
IPC分类号： C07D311/20
CPC分类号： C07D311/20
摘要： Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V): ##STR1## wherein R.sup.1 denotes lower primary alkyl, R.sup.2 denotes hydrogen or lower primary alkyl and R.sup.3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and an alcohol of the formula (II):R.sup.3 OH (II)wherein R.sup.3 is as defined above, in the presence of an acid catalyst, or an aliphatic ketone acetal of the general formula (III): ##STR3## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, in the presence of an acid catalyst.

2. 发明授权

US4814500A Cyanoguanidine derivative and process for preparation thereof 失效
标题翻译：氰基胍衍生物及其制备方法
公开(公告)号：US4814500A
公开(公告)日：1989-03-21
申请号：US91850
申请日：1987-09-01
申请人： Noriaki Kihara , Teruaki Mukaiyama , Takeshi Ishitoku , Katsuya Takahashi
发明人： Noriaki Kihara , Teruaki Mukaiyama , Takeshi Ishitoku , Katsuya Takahashi
IPC分类号： C07C319/18 , C07C319/20 , C07C323/44 , C07C129/08
CPC分类号： C07C323/44
摘要： A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N"-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer.This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.

3. 发明授权

US5837791A Unsaturated copolymer of ethylene and process for preparing the same 失效
标题翻译：乙烯的不饱和共聚物及其制备方法
公开(公告)号：US5837791A
公开(公告)日：1998-11-17
申请号：US915914
申请日：1997-08-21
申请人： Toshihiro Sagane , Masaaki Kawasaki , Hidenari Nakahama , Tatsuyoshi Ishida , Katsuya Takahashi , Toshiyuki Tsutsui , Hitoshi Onishi , Masaaki Yasuda , Noriaki Kihara
发明人： Toshihiro Sagane , Masaaki Kawasaki , Hidenari Nakahama , Tatsuyoshi Ishida , Katsuya Takahashi , Toshiyuki Tsutsui , Hitoshi Onishi , Masaaki Yasuda , Noriaki Kihara
IPC分类号： C07C2/04 , C07C11/21 , C08F4/659 , C08F4/6592 , C08F210/18 , C08F236/20 , C08F255/02
CPC分类号： C08F255/02 , C07C11/21 , C07C2/04 , C08F210/18 , C07C2531/14 , C07C2531/24 , C08F4/65908 , C08F4/6592 , C08F4/65922
摘要： A novel unsaturated copolymer of ethylene comprises a random copolymer of (i) ethylene, (ii) an .alpha.-olefin of 3 to 20 carbon atoms and (iii) at least one straight chain or branched chain nonconjugated triene or tetraene having one vinyl group in the molecule, which contains 30-92% by mol of ethylene units (i), 6-70% by mol of .alpha.-olefin units (ii) and 0.1-30% by mol of triene or tetraene units (iii), and which has a molar ratio of ethylene units (i) to .alpha.-olefin units (ii) of 40/60 to 92/8 (ethylene units (i)/.alpha.-olefin units (ii)) and an intrinsic viscosity (.eta.), measured in Decalin at 135.degree. C., of 0.05 to 10 dl/g. This novel unsaturated copolymer of ethylene is excellent in weathering resistance, heat resistance and ozone resistance and has a high vulcanizing rate.
摘要翻译：一种新型的乙烯不饱和共聚物包括（i）乙烯，（ii）3-20个碳原子的α-烯烃和（iii）至少一个具有一个乙烯基的直链或支链非共轭三烯或四烯的无规共聚物该分子含有30-92摩尔％的乙烯单元（i），6-70摩尔％的α-烯烃单元（ii）和0.1-30摩尔％的三烯或四烯单元（iii），其中具有40/60至92/8（乙烯单元（i）/α-烯烃单元（ii））的乙烯单元（i）与α-烯烃单元（ii）的摩尔比和特性粘度（η），测量在135℃的十氢化萘中为0.05〜10dl / g。该新颖的乙烯不饱和共聚物耐候性，耐热性和耐臭氧性优异，硫化速度高。

4. 发明授权

US4838924A Aromatic urea derivatives and their use as herbicide 失效
标题翻译：芳香族脲衍生物及其作为除草剂的用途
公开(公告)号：US4838924A
公开(公告)日：1989-06-13
申请号：US39457
申请日：1987-04-01
申请人： Tetsuo Takematsu , Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
发明人： Tetsuo Takematsu , Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
IPC分类号： A01N47/30 , A01N47/36 , C07D307/77 , C07D307/79 , C07D307/83 , C07D307/86 , C07D307/91 , C07D307/94 , C07D311/04 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/72 , C07D311/78 , C07D311/94 , C07D317/46 , C07D317/64 , C07D405/12 , C07D493/10
CPC分类号： C07D307/79 , A01N47/30 , A01N47/36 , C07D307/83 , C07D307/86 , C07D307/91 , C07D307/94 , C07D311/04 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/72 , C07D311/78 , C07D311/94 , C07D317/46 , C07D317/64 , C07D405/12 , C07D493/10
摘要： This invention relates to novel compounds of formula [I], a process for their production, and their use as a herbicide. ##STR1## wherein A represents the bond ##STR2## in which X is a hydrogen atom, a chlorine atom, a nitro group or a trifluoromethyl group;B represents a hydrogen atom, a methyl group or a methoxy group; andAr represents one member selected from the group consisting of ##STR3## in which R.sup.1 to R.sup.38, are as defined hereinafter.
摘要翻译： PCT No.PCT / JP86 / 00398 Sec。 371日期1987年4月1日 102（e）日期1987年4月1日PCT提交1986年8月4日PCT公布。第WO87 / 00840号公报日本公开1987年2月12日。本发明涉及式[I]的新化合物，其生产方法及其作为除草剂的用途。其中A表示其中X为氢原子，氯原子，硝基或三氟甲基的键。 B表示氢原子，甲基或甲氧基; 并且Ar表示从下列定义的从 + TR 中选择的一个成员。

5. 发明授权

US5011950A Aromatic amine derivatives 失效
标题翻译：芳香族胺衍生物
公开(公告)号：US5011950A
公开(公告)日：1991-04-30
申请号：US151594
申请日：1988-02-02
申请人： Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
发明人： Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
IPC分类号： C07D213/73 , C07D307/79 , C07D307/80 , C07D307/83 , C07D307/86 , C07D307/91 , C07D311/04 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/78 , C07D311/94 , C07D311/96 , C07D317/46 , C07D317/54 , C07D317/64 , C07D317/72 , C07D405/12 , C07D493/08 , C07D493/10
CPC分类号： C07D307/79 , C07D307/83 , C07D307/86 , C07D307/91 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/78 , C07D311/96 , C07D317/46 , C07D317/64 , C07D317/72 , C07D405/12 , C07D493/10
摘要： Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are as defined herein.

6. 发明授权

US5189183A Aromatic amine derivatives 失效
标题翻译：芳香族胺衍生物
公开(公告)号：US5189183A
公开(公告)日：1993-02-23
申请号：US598061
申请日：1990-10-16
申请人： Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
发明人： Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
IPC分类号： C07D307/79 , C07D307/83 , C07D307/86 , C07D307/91 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/78 , C07D311/96 , C07D317/46 , C07D317/64 , C07D317/72 , C07D405/12 , C07D493/10
CPC分类号： C07D307/79 , C07D307/83 , C07D307/86 , C07D307/91 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/78 , C07D311/96 , C07D317/46 , C07D317/64 , C07D317/72 , C07D405/12 , C07D493/10
摘要： Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are as defined herein.
摘要翻译：具有特殊结构的新型芳香胺衍生物是除草剂的有用中间体。芳族胺化合物具有式[I]所示的结构：其中Ar和A如本文所定义。

7. 发明申请

US20080306022A1 Agent for Applying to Mucosa and Method for the Production Thereof 审中-公开
标题翻译：应用于粘膜的药剂及其生产方法
公开(公告)号：US20080306022A1
公开(公告)日：2008-12-11
申请号：US12083189
申请日：2006-10-12
申请人： Kenji Miyamoto , Katsuya Takahashi , Yuuji Shimojima
发明人： Kenji Miyamoto , Katsuya Takahashi , Yuuji Shimojima
IPC分类号： A61K31/728 , C07H5/06 , A61P27/02
CPC分类号： A61K31/7008 , A61K9/0034 , A61K9/0048 , A61K9/006 , A61K31/726 , A61K31/728 , A61K47/61 , A61K49/0043 , A61K49/0054
摘要： An agent for applying to mucosa capable of persistently exerting a therapeutic effect on disorders such as inflammation and lesions in the mucosa even by a lower frequency of administration because the agent can stay at a diseased site for a long period of time by exhibiting a high staying property in a mucosal epithelial layer is provided, said agent for application to mucosa containing glycosaminoglycan (GAG) into which a hydrophobic group is introduced via a binding chain, as an active ingredient.
摘要翻译：一种适用于粘膜的药剂，即使是较低的给药频率也能够持续地对诸如炎症和粘膜中的病变的疾病施加治疗效果，因为该药剂可以通过显示高停留时间长时间地停留在患病部位提供粘膜上皮层中的特性，所述用于施用于通过结合链引入疏水基团的含有糖胺聚糖（GAG）的粘膜作为活性成分的药剂。

8. 发明授权

US08889652B2 Pharmaceutical agent having long-lasting effect of treating arthritic disorders 有权
标题翻译：具有治疗关节炎疾病长期作用的药剂
公开(公告)号：US08889652B2
公开(公告)日：2014-11-18
申请号：US12448064
申请日：2007-12-06
申请人： Kenji Miyamoto , Keiji Yoshioka , Katsuya Takahashi
发明人： Kenji Miyamoto , Keiji Yoshioka , Katsuya Takahashi
IPC分类号： A61K31/728 , A61K31/738 , A61P19/02
CPC分类号： A61K31/728 , A61K9/0019 , A61K9/06 , A61K31/738 , A61K47/02 , C08B37/0072
摘要： The present invention relates to an injection solution for intra-articular administration for treating arthritic disorders comprising a cross-linked hyaluronic acid derivative wherein part of functional groups of a hyaluronic acid are cross-linked with a cross-linking group to the extent of 0.6 to 15% of cross-linking extent as an active ingredient in an amount having a long-lasting analgesic effect and a pharmaceutically acceptable carrier, and an analgesic composition for suppressing a cartilage degeneration caused by arthritic disorders or a composition for suppressing a cartilage degeneration or an inflammation of synovium caused by arthritic disorders each comprising the cross-linked hyaluronic acid derivative and a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及用于治疗关节炎疾病的关节内给药的注射液，其包含交联的透明质酸衍生物，其中透明质酸的官能团的一部分与交联基团交联至0.6〜具有持久镇痛效果的量的作为活性成分的交联程度的15％和药学上可接受的载体，以及用于抑制由关节炎病症引起的软骨退化的镇痛组合物或用于抑制软骨退化的组合物或由关节炎病症引起的滑膜的炎症各自包含交联的透明质酸衍生物和药学上可接受的载体。

9. 发明申请

US20080249062A1 Nucleus Pulposus Filler 审中-公开
标题翻译：核筋膜填料
公开(公告)号：US20080249062A1
公开(公告)日：2008-10-09
申请号：US11579673
申请日：2005-04-28
申请人： Katsuya Takahashi , Tomoya Sato , Yukihiro Matsuyama
发明人： Katsuya Takahashi , Tomoya Sato , Yukihiro Matsuyama
IPC分类号： A61K31/737
CPC分类号： A61L27/20 , A61L2430/38 , C08L5/08
摘要： The present invention provides a nucleus pulposus filler or the like which is to be packed into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stabley maintained for a long time. More preferably, the present invention provides a nucleus pulposus filler comprising a crosslinked chondroitin sulfate as an active ingredient. The photocrosslinked chondroitin sulfate is preferably the following one: a photocrosslinked chondroitin sulfate obtainable by freezing a photoreactive chondroitin sulfate-containing solution comprising: a photoreactive chondroitin sulfate to which a photoreactive group is bound; an aqueous solvent capable of dissolving the photoreactive chondroitin sulfate; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a cheleting agent; irradiating the resulting frozen product with light; and then melting the frozen product. The filler can be provided as a kit by packing it into a container from which the filler can be pushed out.
摘要翻译：本发明提供一种髓核填充物等，其将被包装在变形椎间盘的区域中，其中应当定位正常的核并且可以长期稳定地保持。更优选地，本发明提供了包含交联的硫酸软骨素作为活性成分的髓核填充物。光交联的硫酸软骨素优选如下：通过冷冻含有光反应性硫酸软骨素溶液的光交联的软骨素硫酸盐，其包含：光反应性硫酸软骨素结合的光反应性硫酸软骨素; 能够溶解光反应性硫酸软骨素的水性溶剂; 和选自具有水溶剂混溶性的醇，表面活性剂和螯合剂的任何一种物质; 用光照射所得冷冻产品; 然后熔化冷冻产品。填料可以通过将其包装到容器中作为试剂盒提供，填料可从该容器中推出。

10. 发明授权

US06232301B1 Remedies for bladder disorders 有权
标题翻译：膀胱功能障碍
公开(公告)号：US06232301B1
公开(公告)日：2001-05-15
申请号：US09142032
申请日：1998-08-27
申请人： Katsuya Takahashi , Satoshi Miyauchi
发明人： Katsuya Takahashi , Satoshi Miyauchi
IPC分类号： A61K3170
CPC分类号： A61K31/715 , A61K9/0034
摘要： In order to provide an agent for treatment of bladder troubles that has vesical mucosa epithelium dilatation promoting action and/or vesical mucosa healing action, and exhibits excellent curative effect for bladder troubles, in particular, non-bacterial intractable bladder troubles, the agent for treatment of bladder troubles is formulated with hyaluronic acid and/or a pharmaceutically acceptable salt thereof, preferably hyaluronic acid and/or a pharmaceutically acceptable salt thereof having the following physicochemical properties: (A) endotoxin content; 0.03 EU (endotoxin unit)/10 mg or less, (B) sulfur content; 0.01% or less as determined by coulometric titration, (C) iron content; 20 ppm or less, (D) protein content; 0.1% or less, and (E) weight average molecular weight; 500,000 or more, in an amount effective for promoting vesical mucosa epithelium dilatation and/or healing vesical mucosa, preferably in an amount of 0.2-0.6% by weight based on total amount of the agent.
摘要翻译：为了提供具有膀胱粘膜上皮扩张促进作用和/或膀胱粘膜愈合作用的膀胱麻烦的治疗剂，对膀胱麻烦，特别是非细菌难治性膀胱麻烦，治疗剂膀胱麻烦的透明质酸和/或其药学上可接受的盐，优选透明质酸和/或其药学上可接受的盐，具有以下物理化学性质：（A）内毒素含量; 0.03欧盟（内毒素单位）/ 10毫克或更少，（B）硫含量; 0.01％以下，通过库仑滴定测定，（C）铁含量; 20ppm以下，（D）蛋白质含量; 0.1％以下，（E）重均分子量; 500,000或更多，其量有效促进膀胱粘膜上皮扩张和/或愈合膀胱粘膜，优选为基于试剂总量的0.2-0.6重量％。

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