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1. 发明授权

US08629122B2 Nucleus pulposus filler 有权
标题翻译：髓核填充物
公开(公告)号：US08629122B2
公开(公告)日：2014-01-14
申请号：US13092716
申请日：2011-04-22
申请人： Katsuya Takahashi , Tomoya Sato , Yukihiro Matsuyama
发明人： Katsuya Takahashi , Tomoya Sato , Yukihiro Matsuyama
IPC分类号： A01N43/04
CPC分类号： A61L27/20 , A61L2430/38 , C08L5/08
摘要： The present invention provides a nucleus pulposus filler or the like which is to be packed into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stabley maintained for a long time More preferably, the present invention provides a nucleus pulposus filler comprising a crosslinked chondroitin sulfate as an active ingredient. The photocrosslinked chondroitin sulfate is preferably the following one: a photocrosslinked chondroitin sulfate obtainable by freezing a photoreactive chondroitin sulfate-containing solution comprising: a photoreactive chondroitin sulfate to which a photoreactive group is bound; an aqueous solvent capable of dissolving the photoreactive chondroitin sulfate; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a cheleting agent; irradiating the resulting frozen product with light; and then melting the frozen product. The filler can be provided as a kit by packing it into a container from which the filler can be pushed out.
摘要翻译：本发明提供一种髓核填充物等，其将被包装在变形的椎间盘的区域中，其中应当定位正常的核并且可以长期稳定地保持更好。更优选地，本发明提供了一种髓核填充物，其包含交联的硫酸软骨素作为活性成分。光交联的硫酸软骨素优选如下：通过冷冻含有光反应性硫酸软骨素溶液的光交联的软骨素硫酸盐，其包含：光反应性硫酸软骨素结合的光反应性硫酸软骨素; 能够溶解光反应性硫酸软骨素的水性溶剂; 和选自具有水溶剂混溶性的醇，表面活性剂和螯合剂的任何一种物质; 用光照射所得冷冻产品; 然后熔化冷冻产品。填料可以通过将其包装到容器中作为试剂盒提供，填料可从该容器中推出。

2. 发明申请

US20080249062A1 Nucleus Pulposus Filler 审中-公开
标题翻译：核筋膜填料
公开(公告)号：US20080249062A1
公开(公告)日：2008-10-09
申请号：US11579673
申请日：2005-04-28
申请人： Katsuya Takahashi , Tomoya Sato , Yukihiro Matsuyama
发明人： Katsuya Takahashi , Tomoya Sato , Yukihiro Matsuyama
IPC分类号： A61K31/737
CPC分类号： A61L27/20 , A61L2430/38 , C08L5/08
摘要： The present invention provides a nucleus pulposus filler or the like which is to be packed into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stabley maintained for a long time. More preferably, the present invention provides a nucleus pulposus filler comprising a crosslinked chondroitin sulfate as an active ingredient. The photocrosslinked chondroitin sulfate is preferably the following one: a photocrosslinked chondroitin sulfate obtainable by freezing a photoreactive chondroitin sulfate-containing solution comprising: a photoreactive chondroitin sulfate to which a photoreactive group is bound; an aqueous solvent capable of dissolving the photoreactive chondroitin sulfate; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a cheleting agent; irradiating the resulting frozen product with light; and then melting the frozen product. The filler can be provided as a kit by packing it into a container from which the filler can be pushed out.
摘要翻译：本发明提供一种髓核填充物等，其将被包装在变形椎间盘的区域中，其中应当定位正常的核并且可以长期稳定地保持。更优选地，本发明提供了包含交联的硫酸软骨素作为活性成分的髓核填充物。光交联的硫酸软骨素优选如下：通过冷冻含有光反应性硫酸软骨素溶液的光交联的软骨素硫酸盐，其包含：光反应性硫酸软骨素结合的光反应性硫酸软骨素; 能够溶解光反应性硫酸软骨素的水性溶剂; 和选自具有水溶剂混溶性的醇，表面活性剂和螯合剂的任何一种物质; 用光照射所得冷冻产品; 然后熔化冷冻产品。填料可以通过将其包装到容器中作为试剂盒提供，填料可从该容器中推出。

3. 发明申请

US20110201570A1 NUCLEUS PULPOSUS FILLER 有权
公开(公告)号：US20110201570A1
公开(公告)日：2011-08-18
申请号：US13092716
申请日：2011-04-22
申请人： Katsuya TAKAHASHI , Tomoya Sato , Yukihiro Matsuyama
发明人： Katsuya TAKAHASHI , Tomoya Sato , Yukihiro Matsuyama
IPC分类号： A61K31/738 , A61P29/00
CPC分类号： A61L27/20 , A61L2430/38 , C08L5/08
摘要： The present invention provides a nucleus pulposus filler or the like which is to be packed into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stabley maintained for a long time More preferably, the present invention provides a nucleus pulposus filler comprising a crosslinked chondroitin sulfate as an active ingredient. The photocrosslinked chondroitin sulfate is preferably the following one: a photocrosslinked chondroitin sulfate obtainable by freezing a photoreactive chondroitin sulfate-containing solution comprising: a photoreactive chondroitin sulfate to which a photoreactive group is bound; an aqueous solvent capable of dissolving the photoreactive chondroitin sulfate; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a cheleting agent; irradiating the resulting frozen product with light; and then melting the frozen product. The filler can be provided as a kit by packing it into a container from which the filler can be pushed out.
摘要翻译：本发明提供一种髓核填充物等，其将被包装在变形的椎间盘的区域中，其中应当定位正常的核并且可以长期稳定地保持更好。更优选地，本发明提供了一种髓核填充物，其包含交联的硫酸软骨素作为活性成分。光交联的硫酸软骨素优选如下：通过冷冻含有光反应性硫酸软骨素溶液的光交联的软骨素硫酸盐，其包含：光反应性硫酸软骨素结合的光反应性硫酸软骨素; 能够溶解光反应性硫酸软骨素的水性溶剂; 和选自具有水溶剂混溶性的醇，表面活性剂和螯合剂的任何一种物质; 用光照射所得冷冻产品; 然后熔化冷冻产品。填料可以通过将其包装到容器中作为试剂盒提供，填料可从该容器中推出。

4. 发明申请

US20110059508A1 IMPROVING AGENT FOR DYSFUNCTION DUE TO NEUROPATHY AND RHO KINASE ACTIVATION INHIBITOR 审中-公开
标题翻译：改善神经病和RHO激酶抑制剂的功能障碍
公开(公告)号：US20110059508A1
公开(公告)日：2011-03-10
申请号：US12667178
申请日：2008-06-30
申请人： Kenji Kadomatsu , Yukihiro Matsuyama , Akiomi Tanaka , Sawako Takeshita
发明人： Kenji Kadomatsu , Yukihiro Matsuyama , Akiomi Tanaka , Sawako Takeshita
IPC分类号： C12N9/14
CPC分类号： A61K38/47 , C12N9/2402 , C12Y302/01096
摘要： An object of the present invention is to provide a substance which is able to be an active ingredient for the improvement of dysfunction caused by nerve damage. An improving agent for dysfunction due to nerve damage of the present invention as a means for resolution thereof is characterized in that it comprises an endo-β-N-acetylglucosaminidase type enzyme which hydrolyzes an N-acetylglucosamide bond in a keratan sulfate backbone as an active ingredient. When the improving agent of the present invention is administered, clinical improvement is achieved in motor neuron dysfunction and sensory neuron dysfunction such as neuropathic pain represented by a pain caused by allodynia and hyperalgesic reaction of the object to be treated.
摘要翻译：本发明的目的是提供能够成为用于改善由神经损伤引起的功能障碍的活性成分的物质。由于本发明的神经损伤引起的功能障碍的改善剂作为其解决手段，其特征在于其包含内切β-半乳糖苷酶型酶，其将硫酸角质素骨架中的N-乙酰葡糖酰胺键水解为有效成分。当施用本发明的改善剂时，在运动神经元功能障碍和感觉神经元功能障碍（例如神经性疼痛）中实现临床改善，所述神经性疼痛是由待治疗对象的异常性疼痛和痛觉过敏引起的疼痛所代表的。

5. 发明授权

US06582434B2 Vertebral connecting rod and spinal osteosynthesis device using the same 有权
公开(公告)号：US06582434B2
公开(公告)日：2003-06-24
申请号：US09880072
申请日：2001-06-14
申请人： Noriaki Kawakami , Koji Sato , Yukihiro Matsuyama , Kazuya Oribe , Hiroshi Takamido
发明人： Noriaki Kawakami , Koji Sato , Yukihiro Matsuyama , Kazuya Oribe , Hiroshi Takamido
IPC分类号： A61B1756
CPC分类号： A61B17/7022 , A61B17/70 , A61B17/7002
摘要： A vertebral connecting rod and a spinal osteosynthesis device are disclosed. The vertebral connecting rod 1, which is adapted to be rigidly supported with a pair of spinal implants 5, 5 anchored to vertebral bodies 3, 3 such as thoracic vertebrae or lumbar vertebrae etc., has a pin-shaped section 7 of which one distal end formed with a hook segment 11 for hanging an interconnecting member 9. A slip-out protective member 19 is engageable with the hook segment 11. In a preferred embodiment, the pin-shaped section has at its arbitrary position formed with an engagement convex segment 27 adapted to engage with a corresponding engagement concave recess formed in the spinal implant 5.

6. 发明申请

US20110275137A1 IMPROVING AGENT FOR NEUROPATHIC PAIN 审中-公开
标题翻译：改善神经痛疼痛剂
公开(公告)号：US20110275137A1
公开(公告)日：2011-11-10
申请号：US12937456
申请日：2009-04-14
申请人： Yukihiro Matsuyama , Kenji Kadomatsu , Shiro Imagama , Akiomi Tanaka
发明人： Yukihiro Matsuyama , Kenji Kadomatsu , Shiro Imagama , Akiomi Tanaka
IPC分类号： C12N9/88
CPC分类号： A61K38/51 , C07D471/10 , C12N9/2402 , C12Y302/01096
摘要： An object of the present invention is to provide a substance which can be used as an active ingredient for improving neuropathic pain having a novel mechanism of action different from those of currently available agents and, therefore, provide an improving agent for neuropathic pain which rarely interacts with currently available agents and also does not have adverse reactions similar to those of currently available agents. An improving agent for neuropathic pain due to a hyperalgesic response of the present invention as a means for resolution is characterized by comprising, as an active ingredient, a lyase (an elimination enzyme) which has an activity of degrading a chondroitin sulfate chain of a chondroitin sulfate proteoglycan, and is typified by chondroitinase ABC which selectively removes chondroitin sulfate and dermatan sulfate of a proteoglycan.
摘要翻译：本发明的目的是提供一种物质，其可用作改善神经性疼痛的活性成分，其具有与目前可获得的药剂不同的新作用机制，因此提供了很少相互作用的神经性疼痛的改善剂使用目前可获得的药剂，也没有类似于当前可用药剂的不良反应。作为解决手段的由于本发明的镇痛反应引起的神经性疼痛的改善剂的特征在于，作为活性成分，含有降解软骨素硫酸软骨素链的活性的裂解酶（消除酶）硫酸蛋白聚糖，并且以软骨素酶ABC为代表，其选择性地去除蛋白多糖的硫酸软骨素和硫酸皮肤素。

7. 发明授权

US4888514A Driving apparatus for ultrasonic motor 失效
标题翻译：超声波电机驱动装置
公开(公告)号：US4888514A
公开(公告)日：1989-12-19
申请号：US260505
申请日：1988-10-13
申请人： Ken-ichiroh Takahashi , Ritsuo Inaba , Nobukazu Sugano , Horiyuki Harao , Yukihiro Matsuyama , Hiromi Tanoue , Toru Kishi
发明人： Ken-ichiroh Takahashi , Ritsuo Inaba , Nobukazu Sugano , Horiyuki Harao , Yukihiro Matsuyama , Hiromi Tanoue , Toru Kishi
IPC分类号： H01L41/04 , H02N2/14
CPC分类号： H02N2/14 , H02N2/142 , H02N2/166
摘要： In a driving apparatus for ultrasonic motor, a variable oscillator (44) varies oscillating frequency responding to current level of detected current which flows to a piezoelectric member (1, 2) and is in proportion to mechanical vibration of the piezoelectric member (1, 2) when mechanical resonance frequency varies by change of environmental condition.
摘要翻译：在超声波电动机的驱动装置中，可变振荡器（44）根据流过压电元件（1,2）的检测电流的电流水平而变化振荡频率，并与压电元件（1,2）的机械振动成比例）当机械共振频率随着环境条件的变化而变化时。

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