专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5889013A Pyrimidine acyclonucleoside derivatives 失效
标题翻译：嘧啶阿昔洛韦衍生物
公开(公告)号：US5889013A
公开(公告)日：1999-03-30
申请号：US545682
申请日：1996-01-04
申请人： Dae-Kee Kim , Jongsik Gam , Ganghyeok Kim , Young-Woo Kim , Namkyu Lee , Jinsoo Lim , Hun-Taek Kim , Key Hyup Kim
发明人： Dae-Kee Kim , Jongsik Gam , Ganghyeok Kim , Young-Woo Kim , Namkyu Lee , Jinsoo Lim , Hun-Taek Kim , Key Hyup Kim
IPC分类号： A61K31/505 , A61P31/12 , C07D239/54 , C07D239/56 , C07D239/02
CPC分类号： C07D239/56 , C07D239/54
摘要： The present invention relates to novel pyrimidine acyclonucleoside derivatives represented by the following general formula (I), antiviral agents containing the derivatives as the active ingredients and processes of preparation thereof. ##STR1## wherein R.sup.1 is ethyl or isopropyl; R.sup.2 is (3,5 dimethylphenyl)selenenyl; R.sup.3 is phenyl or methyl; X is oxygen; and Y is oxygen.
摘要翻译： PCT No.PCT / KR94 / 00102 Sec。 371日期1996年1月4日 102（e）日期1996年1月4日PCT提交1994年7月29日PCT公布。公开号WO95 / 23138 日期：1995年8月31日本发明涉及由以下通式（I）表示的新型嘧啶阿昔洛韦衍生物，含有该衍生物作为活性成分的抗病毒剂及其制备方法。（I）其中R1是乙基或异丙基; R2是（3,5-二甲基苯基）硒基; R3是苯基或甲基; X是氧; Y是氧。

2. 发明授权

US5395947A Platinum(II) complex and processes for preparing the same 失效
标题翻译：铂（II）络合物及其制备方法
公开(公告)号：US5395947A
公开(公告)日：1995-03-07
申请号：US117096
申请日：1993-09-14
申请人： Dae-Kee Kim , Ganghyeok Kim , Jongsik Gam , Yong B. Cho , Hun T. Kim , Joo H. Tai , Key H. Kim
发明人： Dae-Kee Kim , Ganghyeok Kim , Jongsik Gam , Yong B. Cho , Hun T. Kim , Joo H. Tai , Key H. Kim
IPC分类号： C07D317/28 , A61K31/555 , C07D317/32 , C07D317/72 , C07F15/00 , C07D317/00
CPC分类号： C07F15/0093
摘要： Disclosed herein are novel platinum(II) complexes having a potent anti-tumor activity which are represented by the formula (1), ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are a hydrogen atom or a C.sub.1-4 alkyl group, respectively, or jointly form a cycloalkane group together with the carbon atom attached thereto; two Xs jointly form a group represented by formula (a) or (b) wherein, R.sub.3 is a hydrogen atom or a methyl group; R.sub.4 and R.sub.5, which may be the same or different, are a hydrogen atom or a C.sub.1-4 alkyl group, respectively, or jointly form a cyclobutane together with the carbon thereto; and the absolute configurations at the respective chiral centers in the 4,5-bis(aminomethyl)-1,3-dioxolane moiety are (4R,5R) or (4S,5S); processes for the preparing the same; and their use for treating animal or human cancer. Further, disclosed herein are novel intermediates useful for the preparation of the platinum(II) complexes and processes for preparing said intermediates.
摘要翻译：本文公开了具有有效抗肿瘤活性的新颖的铂（II）络合物，其由式（1），（IMA）（1）表示：其中R1和R2，其中R1和R2，可以相同或不同，分别为氢原子或C1-4烷基，或与其连接的碳原子一起共同形成环烷烃基; 两个X共同形成由式（a）或（b）表示的基团，其中R3是氢原子或甲基; R4和R5可以相同或不同，分别为氢原子或C1-4烷基，或与其一起共同形成环丁烷; 并且4,5-双（氨基甲基）-1,3-二氧戊环部分各手性中心的绝对构型为（4R，5R）或（4S，5S）; 制备方法; 及其用于治疗动物或人类癌症的用途。此外，本文公开了可用于制备铂（II）络合物的新中间体和用于制备所述中间体的方法。

3. 发明申请

US20080319022A1 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors 有权
标题翻译： 2-吡啶基取代的咪唑作为ALK5和/或ALK4抑制剂
公开(公告)号：US20080319022A1
公开(公告)日：2008-12-25
申请号：US12155989
申请日：2008-06-12
申请人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
发明人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
IPC分类号： A61K31/4439 , C07D405/14 , A61P25/28 , A61P9/10
CPC分类号： C04B35/632 , C07D401/04 , C07D401/14 , C07D405/14
摘要： 2-pyridyl-substituted imidazoles and their use in inhibiting ALK 5 and/or ALK 4 receptors is disclosed.
摘要翻译：公开了2-吡啶基取代的咪唑及其在抑制ALK 5和/或ALK 4受体中的用途。

4. 发明申请

US20130245066A1 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors 审中-公开
标题翻译： 2-吡啶基取代的咪唑作为ALK5和/或ALK4抑制剂
公开(公告)号：US20130245066A1
公开(公告)日：2013-09-19
申请号：US13067737
申请日：2011-06-22
申请人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , II-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
发明人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , II-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709 , C04B35/632 , C07D401/04 , C07D401/14 , C07D405/14
摘要： 2-pyridyl-substituted imidazoles which are used advantageously in the treatment of diseases mediated by ALK 5 or ALK 4 receptor or both.
摘要翻译： 2-吡啶基取代的咪唑，其有利地用于治疗由ALK 5或ALK 4受体或两者介导的疾病。

5. 发明申请

US20080319012A1 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors 审中-公开
标题翻译： 2-吡啶基取代的咪唑作为ALK5和/或ALK4抑制剂
公开(公告)号：US20080319012A1
公开(公告)日：2008-12-25
申请号：US12155984
申请日：2008-06-12
申请人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
发明人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
IPC分类号： A61K31/4709 , C07D401/14 , A61P35/00 , A61P1/16 , A61P25/28
CPC分类号： A61K31/4709 , C04B35/632 , C07D401/04 , C07D401/14 , C07D405/14
摘要： 2-pyridyl-substituted imidazoles which are used advantageously in the treatment of diseases mediated by ALK 5 or ALK 4 receptor or both.
摘要翻译： 2-吡啶基取代的咪唑，其有利地用于治疗由ALK 5或ALK 4受体或两者介导的疾病。

6. 发明授权

US08420685B2 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors 有权
标题翻译： 2-吡啶基取代的咪唑作为ALK5和/或ALK4抑制剂
公开(公告)号：US08420685B2
公开(公告)日：2013-04-16
申请号：US12155989
申请日：2008-06-12
申请人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
发明人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
IPC分类号： A61K31/415
CPC分类号： C04B35/632 , C07D401/04 , C07D401/14 , C07D405/14
摘要： A compound of the formula: Wherein A1, A2, X, R2 and R3 are as defined herein, or a composition containing the same, which compound is useful in treating renal-, liver- or pulmonary fibrosis.
摘要翻译：下式的化合物：其中A1，A2，X，R2和R3如本文所定义，或含有该化合物的组合物，该化合物可用于治疗肾，肝或肺纤维化。

7. 发明授权

US07407958B2 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors 失效
标题翻译： 2-吡啶基取代的咪唑作为ALK5和/或ALK4抑制剂
公开(公告)号：US07407958B2
公开(公告)日：2008-08-05
申请号：US10983227
申请日：2004-11-08
申请人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
发明人： Dae-Kee Kim , Yung-Jue Bang , Hun-Taek Kim , Il-Sang Cho , Myoung-Soon Park , Young Jae An , Joon Hun Choi
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D241/36
CPC分类号： C04B35/632 , C07D401/04 , C07D401/12 , C07D405/14
摘要： Compounds of the formula: wherein R1, R2, R3, A1 and A2 are as defined herein, which are used advantageously in inhibiting the TGF-β and/or activin signaling pathway in mammals.
摘要翻译：下式的化合物：其中R1，R2，R3，A1和A2如本文所定义，其有利地用于抑制哺乳动物中的TGF-β和/或激活素信号通路。

8. 发明授权

US07041635B2 Factor VIII polypeptide 有权
标题翻译：因子VIII多肽
公开(公告)号：US07041635B2
公开(公告)日：2006-05-09
申请号：US10353753
申请日：2003-01-28
申请人： Hun-Taek Kim , In-Young Song , Jae Won Choi , Jin-Wook Jang , Yong-Kook Kim , Ho Soon Lee , Yung-Jue Bang , Dae-Kee Kim
发明人： Hun-Taek Kim , In-Young Song , Jae Won Choi , Jin-Wook Jang , Yong-Kook Kim , Ho Soon Lee , Yung-Jue Bang , Dae-Kee Kim
IPC分类号： A61K35/14 , A61K35/16 , A61K38/00
CPC分类号： C07K14/755 , A61K48/00 , Y10S514/802 , Y10S514/834 , Y10S930/10
摘要： The application discloses Factor VIII polypeptides comprising internal deletions of amino acids within the area of residues 741 to 1689, wherein the thrombin cleavage sites at about 741 and about 1689 are present, and a site at about 1648 is not present, as compared to human Factor VIII.
摘要翻译：该应用公开了包含在残基741至1689的区域内的氨基酸的内部缺失的因子VIII多肽，其中存在约741和约1689的凝血酶切割位点，并且与人因子相比不存在约1648位点八，

9. 发明授权

US09441030B2 Process for producing and purifying factor VIII and its derivatives 有权
标题翻译：生产和净化因子VIII及其衍生物的方法
公开(公告)号：US09441030B2
公开(公告)日：2016-09-13
申请号：US12528204
申请日：2007-02-23
申请人： In-Young Song , Hun-Taek Kim , Jong-Wan Kim , Yong-Kook Kim , Jong-Il Ryu , Dae-Kee Kim
发明人： In-Young Song , Hun-Taek Kim , Jong-Wan Kim , Yong-Kook Kim , Jong-Il Ryu , Dae-Kee Kim
IPC分类号： C07K14/755
CPC分类号： C07K14/755 , C07K1/22
摘要： Disclosed is a method for producing proteins having factor VIII procoagulant activity in serum-free medium by in vitro culturing of mammalian cells, wherein the serum-free medium contains an inhibitor against the protease released from cultured cells. In accordance with this invention, the inhibitor can protect the cleavage of a target protein during cultivation and increase homogeneity of a target molecule, wherein the inhibitor can be a dextran sulfate. This invention also relates to a method of purifying target molecules from the culture medium containing both a target molecule and selected inhibitors by affinity chromatography.
摘要翻译：公开了一种通过体外培养哺乳动物细胞产生在无血清培养基中具有因子VIII促凝血活性的蛋白质的方法，其中无血清培养基含有针对由培养细胞释放的蛋白酶的抑制剂。根据本发明，抑制剂可以保护培养期间靶蛋白的切割并增加目标分子的均匀性，其中抑制剂可以是硫酸葡聚糖。本发明还涉及通过亲和层析从含有靶分子和选择的抑制剂的培养基中纯化目标分子的方法。

10. 发明申请

US20100112641A1 PROCESS FOR PRODUCING AND PURIFYING FACTOR VIII AND ITS DERIVATIVES 有权
标题翻译：生产和净化因子VIII及其衍生物的方法
公开(公告)号：US20100112641A1
公开(公告)日：2010-05-06
申请号：US12528204
申请日：2007-02-23
申请人： In-Young Song , Hun-Taek Kim , Jong-Wan Kim , Yong-Kook Kim , Jong-II Ryu , Dae-Kee Kim
发明人： In-Young Song , Hun-Taek Kim , Jong-Wan Kim , Yong-Kook Kim , Jong-II Ryu , Dae-Kee Kim
IPC分类号： C12P21/04
CPC分类号： C07K14/755 , C07K1/22
摘要： Disclosed is a method for producing proteins having factor VIII procoagulant activity in serum-free medium by in vitro culturing of mammalian cells, wherein the serum-free medium contains an inhibitor against the protease released from cultured cells. In accordance with this invention, the inhibitor can protect the cleavage of a target protein during cultivation and increase homogeneity of a target molecule, wherein the inhibitor can be a dextran sulfate. This invention also relates to a method of purifying target molecules from the culture medium containing both a target molecule and selected inhibitors by affinity chromatography.
摘要翻译：公开了一种通过体外培养哺乳动物细胞产生在无血清培养基中具有因子VIII促凝血活性的蛋白质的方法，其中无血清培养基含有针对由培养细胞释放的蛋白酶的抑制剂。根据本发明，抑制剂可以保护培养期间靶蛋白的切割并增加目标分子的均匀性，其中抑制剂可以是硫酸葡聚糖。本发明还涉及通过亲和层析从含有靶分子和选择的抑制剂的培养基中纯化目标分子的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式