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1. 发明申请

WO2012049173A1 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2012049173A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/067726
申请日：2011-10-11
申请人： DSM IP ASSETS B.V. , WISSELINK, Hendrik Wouter , MARIS, VAN, Antonius Jeroen Adriaan , PRONK, Jacobus Thomas , KLAASSEN, Paul , JONG, DE, René Marcel
发明人： WISSELINK, Hendrik Wouter , MARIS, VAN, Antonius Jeroen Adriaan , PRONK, Jacobus Thomas , KLAASSEN, Paul , JONG, DE, René Marcel
IPC分类号： C12N9/12 , C12N1/18 , C12P7/08 , C07K14/395
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译：本发明涉及在一个或多个对应于SEQ ID NO：55的T219的位置具有突变的多肽，其中多肽与SEQ ID NO：55具有至少50％的序列同一性，并且其中多肽具有通透酶活性。

2. 发明申请

WO2015107050A1 IMPROVED ENZYME VARIANTS OF LACTASE FROM KLUYVEROMYCES LACTIS 审中-公开
标题翻译：来自KLUYVEROMYCES LACTIS的乳酸酶的改良酶变异
公开(公告)号：WO2015107050A1
公开(公告)日：2015-07-23
申请号：PCT/EP2015/050503
申请日：2015-01-13
申请人： DSM IP ASSETS B.V.
发明人： JONG, DE, René Marcel , MÜLLER, Ulrike Maria , DEKKER, Petrus Jacobus Theodorus
IPC分类号： C12N9/38
CPC分类号： C12N9/2471 , A23C9/1526 , A23L29/06 , A23V2002/00 , C12Y302/01107 , C12Y302/01108
摘要： The invention relates to a variant polypeptide having lactase activity. The invention also relates to a nucleic acid sequence encoding such a variant polypeptide, to a nucleic acid construct comprising said nucleic acid sequence, to a recombinant expression vector comprising said nucleic acid construct and to a recombinant host cell comprising said expression vector. Further, the invention relates to a method for producing a lactase variant via use of such a host cell. Also, the invention relates to a method of producing a lactase polypeptide variant. The invention further relates to a composition comprising a lactase variant, to use of such a lactase variant or to the use of a lactase variant-containing composition in the preparation of a dairy product, to a process for the production of a dairy product and to the resulting dairy product.
摘要翻译：本发明涉及具有乳糖酶活性的变体多肽。本发明还涉及编码这种变体多肽的核酸序列，包含所述核酸序列的核酸构建体，包含所述核酸构建体的重组表达载体和包含所述表达载体的重组宿主细胞。此外，本发明涉及通过使用这种宿主细胞产生乳糖酶变体的方法。此外，本发明涉及产生乳糖酶多肽变体的方法。本发明还涉及包含乳糖酶变体，使用这样的乳糖酶变体或在制备乳制品中使用含有乳糖酶变体的组合物的组合物，用于生产乳制品的方法，以及产生的乳制品。

3. 发明申请

WO2016097270A1 PROCESS FOR BLEACHING A FOOD PRODUCT 审中-公开
标题翻译：漂白食品的方法
公开(公告)号：WO2016097270A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080449
申请日：2015-12-18
申请人： DSM IP ASSETS B.V.
发明人： LANGEVELD, Pieter Cornelis , JONG, DE, René Marcel , BOER, Rémon
IPC分类号： A23L5/40 , C12N9/02
CPC分类号： A23L5/49 , A23C21/02 , C12N9/0061 , C12Y110/03002
摘要： The present invention relates to a process for bleaching a food product, comprising incubating an intermediate form of the food product with a laccase which comprises a conserved prosite pattern according to amino acid sequence W-Y-H-X-H- X(3)-Q-Y-C-D-G-X-R-G, wherein X is an amino acid residue A, R, N, D, C, Q, E, G, H, I, L K, M, F, P, S, T, W, Y, or V, and wherein the intermediate form of the food product comprises a colored substance, and producing the food product, wherein the food product is bleached.
摘要翻译：本发明涉及一种用于漂白食品的方法，包括将中间形式的食品与漆酶一起孵育，所述漆酶包含根据氨基酸序列WYHX-X（3）-QYCDGXRG的保守原始图案，其中X是氨基酸残基A，R，N，D，C，Q，E，G，H，I，LK，M，F，P，S，T，W，Y或V，其中食品的中间形式包括有色物质，并且生产该食品，其中该食品被漂白。

4. 发明申请

WO2014131842A1 ALPHA-AMYLASE VARIANTS 审中-公开
公开(公告)号：WO2014131842A1
公开(公告)日：2014-09-04
申请号：PCT/EP2014/053853
申请日：2014-02-27
申请人： DSM IP ASSETS B.V.
发明人： JONG, DE, René Marcel , ABBAS, Hanna Elisabet , RIJ, VAN, Evert Tjeerd
IPC分类号： C12N9/28 , A21D8/04 , C11D3/386
CPC分类号： A21D8/042 , A21D10/005 , C12N9/2417 , C12Y302/01001
摘要： A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 4, 6, 13, 14, 15, 16, 20, 45, 47, 51, 54, 61, 68, 69, 70, 71, 72, 73, 74, 75, 77, 78, 80, 82, 87, 88, 94, 95, 100, 103, 104, 117, 124, 125, 126, 128, 130, 133, 134, 136, 143, 144, 146, 168, 174, 177, 178, 183, 186, 188, 189, 190, 194, 195, 199, 200, 201, 204, 207, 210, 214, 217, 219, 222, 225, 227, 233, 234, 235, 236, 240, 251, 252, 254, 258, 259, 260, 261, 262, 263, 264, 266, 267, 269, 271, 273, 281, 282, 283, 284, 286, 288, 299, 322, 323, 325, 327, 328, 331, 334, 350, 356, 358, 367, 370, 371, 374, 377, 378, 388, 391, 414, 421, 422, 445, 450, 467, 488, 505, 536, 548, 554, 583, 588, 603, 637, 648, 651, 652, 660, 676, 677, said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having alpha-amylase activity. Such a variant polypeptide may be used in the preparation of a baked product.
摘要翻译：具有α-淀粉酶活性的变体多肽，其中所述变体具有当与包含SEQ ID NO：2所示的序列的α-淀粉酶比对时的氨基酸序列包含至少一个对应于任何氨基酸4,6,13,14,15,16,20,45,47,51,54,61,68,69,70,71,72,73,74,75,77,78,80， 82,87,88,94,95,100,103,104,117,124,125,126,128,130,133,134,136,143,144,146,168,174,177,178,183， 186,188,189,190,194,195,199,200,2201,204,207,210,214,217,219,222,225,227,233,234,235,236,240,251,252,252,218,218,218,218,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,2 254,258,258,260,261,262,263,264,266,262,263,264,266,276,263,264,266,276,263,267,271,273,281,282,283,284,286,288,29,322,236,265,276,262,263,264,266,262,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263 331,334,350,356,358,367,370,371,374,377,378,388,391,414,421,422,445,450,467,468,505,536,548,554,583,537,537,536,535,536,358,367,350,356,358,367,350,356,358,367,370,356,358,367,370,356,358,367,370,356,358,367,370,356,358,367,375,356,358,336,375,356,336 588,603,637,648,651,652,660,676,677，所述位置参照SEQ ID NO：2定义，其中所述变异体与具有α-淀粉酶活性的参考多肽相比，nt具有一个或多个改变的性质。这样的变体多肽可用于制备焙烤产品。

5. 发明申请

WO2015082488A1 ICE STRUCTURING PROTEIN 审中-公开
标题翻译： ICE结构蛋白
公开(公告)号：WO2015082488A1
公开(公告)日：2015-06-11
申请号：PCT/EP2014/076291
申请日：2014-12-02
申请人： DSM IP ASSETS B.V.
发明人： JONG, DE, René Marcel , DEKKER, Petrus Jacobus Theodorus
IPC分类号： C12N15/81 , C07K14/39
CPC分类号： C07K14/39 , A23G9/38 , A23V2002/00 , C12N15/81
摘要： The present invention relates to a nucleic acid construct comprising: a nucleic acid sequence encoding an ice structuring protein (ISP) comprising the sequence set out in SEQ ID NO: 1 or a sequence at least 80% identical thereto or comprising the sequence set out in amino acids 21 to 261 of SEQ ID NO: 1 or a sequence at least 80% identical thereto; and, linked operably thereto, control sequences permitting expression of the nucleic acid sequence in a filamentous fungal host cell. The construct may be used in a method for the production of an ISP, wherein the ISP is expressed in a filamentous fungal host cell.
摘要翻译：本发明涉及一种核酸构建体，其包含：编码包含SEQ ID NO：1所示的序列的冰结构蛋白（ISP）的核酸序列或与SEQ ID NO：1所示的序列至少80％的序列或包含SEQ ID NO： SEQ ID NO：1的氨基酸21至261或与其至少80％同一的序列; 并且与其可操作地连接，允许核酸序列在丝状真菌宿主细胞中表达的控制序列。该构建体可以用于生产ISP的方法，其中ISP在丝状真菌宿主细胞中表达。

6. 发明申请

WO2014202621A1 CARBOHYDRATE DEGRADING POLYPEPTIDE AND USES THEREOF 审中-公开
标题翻译：碳水化合物降解聚糖及其用途
公开(公告)号：WO2014202621A1
公开(公告)日：2014-12-24
申请号：PCT/EP2014/062743
申请日：2014-06-17
申请人： DSM IP ASSETS B.V.
发明人： LOS, Alrik Pieter , JONG, DE, René Marcel , APPELDOORN, Maaike
IPC分类号： C12N9/24 , C12N15/80 , C12P7/10 , D21C5/00
CPC分类号： C12Y302/01139 , C12N9/2402 , C12N9/2437 , C12N9/2477 , C12N15/80 , C12P19/02 , C12P19/14 , D21C5/005 , D21C9/1036 , Y02E50/16
摘要： The invention relates to a polypeptide from Rasamsonia emersonii (Talaromyces emersonii) having hemicellulase or alpha-glucuronidase activity and which comprises the amino acid sequence set out in SEQ ID NO: 2 or 13 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO:1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 70% sequence identity with the sequence set out in SEQ ID NO: 2 or 13 or the variant polynucleotide encodes a polypeptide that has at least 70% sequence identity with the sequence set out in SEQ ID NO: 2 or 13. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
摘要翻译：本发明涉及具有半纤维素酶或α-葡糖醛酸糖苷酶活性的Rasamsonia emersonii（Talaromyces emersonii）的多肽，其包含SEQ ID NO：2或13所示的氨基酸序列或由SEQ ID NO：2所示的核苷酸序列编码的氨基酸序列 NO：1或其变体多肽或其变体多核苷酸，其中所述变体多肽与SEQ ID NO：2或13所示的序列具有至少70％的序列同一性，或所述变体多核苷酸编码具有至少70％序列同一性与SEQ ID NO：2或13所示的序列一致。本发明的特征在于新基因的全长编码序列以及全长功能蛋白的氨基酸序列和基因的功能等同物氨基酸序列。本发明还涉及在工业过程中使用该多肽的方法。本发明还包括用适合于生产这些蛋白质的根据本发明的多核苷酸转化的细胞。

7. 发明申请

WO2014118360A3 CARBOHYDRATE DEGRADING POLYPEPTIDE AND USES THEREOF 审中-公开
公开(公告)号：WO2014118360A3
公开(公告)日：2014-08-07
申请号：PCT/EP2014/051998
申请日：2014-02-03
申请人： DSM IP ASSETS B.V.
发明人： LOS, Alrik Pieter , JONG, DE, René Marcel , APPELDOORN, Maaike
IPC分类号： C12N9/24 , C12R1/645
摘要： The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

8. 发明申请

WO2016030448A1 ALICYCLOBACILLUS POHLIAE ALPHA-AMYLASE VARIANTS 审中-公开
公开(公告)号：WO2016030448A1
公开(公告)日：2016-03-03
申请号：PCT/EP2015/069612
申请日：2015-08-27
申请人： DSM IP ASSETS B.V.
发明人： JONG, DE, René Marcel , ABBAS, Hanna Elisabet , GODEFROOIJ, Jeroen
IPC分类号： A21D8/04 , C12N9/26 , C11D3/386
CPC分类号： C12N9/2417 , A21D8/042
摘要： The present invention describes a variant polypeptide having alpha-amylase activity and wherein the variant has one or more altered properties as compared with a reference polypeptide having alpha-amylase activity. Such a variant polypeptide may be used in the food industry such as for example in the preparation of a baked product.
摘要翻译：本发明描述了具有α-淀粉酶活性的变体多肽，其中与具有α-淀粉酶活性的参考多肽相比，变体具有一个或多个改变的特性。这种变体多肽可用于食品工业，例如在制备焙烤产品中。

9. 发明申请

WO2015086839A1 FUMARATE REDUCTASES 审中-公开
标题翻译：减少脂肪
公开(公告)号：WO2015086839A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/077638
申请日：2014-12-12
申请人： DSM IP ASSETS B.V.
发明人： JONG, DE, René Marcel , ZHAO, Zheng , DULK, DEN, Ben , WINTER, Remko Tsjibbe
IPC分类号： C12N9/02
CPC分类号： C12N9/001 , C12P7/46 , C12Y103/01006
摘要： The present invention relates to a variant polypeptide having fumarate reductase activity, which has modified NADP(H)-dependent and/or NAD(H)-dependent activity as compared with a reference polypeptide having fumarate reductase activity. Such a variant may be overexpressed in a host cell in order to improve production of a dicarboxylic acid.
摘要翻译：本发明涉及具有富马酸酯还原酶活性的变体多肽，其与具有富马酸盐还原酶活性的参照多肽相比具有修饰的NADP（H） - 依赖和/或NAD（H） - 依赖性活性。这种变体可以在宿主细胞中过表达，以改善二羧酸的产生。

10. 发明申请

WO2013164479A2 IMPROVED ENZYME VARIANTS 审中-公开
标题翻译：改进的酶变异
公开(公告)号：WO2013164479A2
公开(公告)日：2013-11-07
申请号：PCT/EP2013/059315
申请日：2013-05-03
申请人： DSM IP ASSETS B.V.
发明人： DEKKER, Petrus Jacobus Theodorus , JONG, DE, René Marcel , MUIJLWIJK, Cornelis Marinus
IPC分类号： C12N9/64 , C12N15/59 , A23C19/04 , C12N1/19
CPC分类号： C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
摘要： A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
摘要翻译：具有凝乳酶活性的变体多肽，其中所述变体具有当与包含SEQ ID NO：2所示的序列的凝乳酶比对时的氨基酸序列包含对应于任何氨基酸的氨基酸残基的至少一个取代 2，22，40，48，50，51，53，61，62，76，88，98，99，109，112，117，125，126，135，144，160，161，163，187， 194,2200,201,202,203,221,223,240,242,244,254,267,271,273,278,280,284,289,292,294或295表示所述位置是参照SEQ ID NO：2，其中与具有凝乳酶活性的参照多肽相比，变体具有一个或多个改变的特性。这种变体多肽可用于制备奶酪。

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