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1. 发明申请

WO2006074418A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：WO2006074418A2
公开(公告)日：2006-07-13
申请号：PCT/US2006/000575
申请日：2006-01-09
申请人： DIADEXUS, INC. , PAPKOFF, Jackie , SHROYER, Kenneth, R.
发明人： PAPKOFF, Jackie , SHROYER, Kenneth, R.
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： G01N33/574 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/30
摘要： The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti- Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti- Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti- Ovr110 antibodies. The invention encompasses a method of producing the anti- Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti- Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti- Ovr110 antibody to the mammal.
摘要翻译：本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗头颈部，卵巢，胰腺，肺，子宫内膜或乳腺癌抗原（Ovr110）抗体。本发明还包括包含抗Ovr110抗体和载体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Ovr110抗体的细胞。本发明包括产生抗Ovr110抗体的方法。本发明的其它方面是通过使癌细胞与抗Ovr110抗体接触来杀死表达Ovr110的癌细胞的方法和通过施用治疗有效量的哺乳动物减轻或治疗表达Ovr110的癌症的方法，抗Ovr110抗体。

2. 发明申请

WO2007016590A2 OVR232V3 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR232V3抗体组合物及其使用方法
公开(公告)号：WO2007016590A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/029995
申请日：2006-07-31
申请人： DIADEXUS, INC. , LIU, Shu-Hui , PAPKOFF, Jackie
发明人： LIU, Shu-Hui , PAPKOFF, Jackie
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/73 , C07K2317/77 , G01N33/5011 , G01N33/56966 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G01N33/57492
摘要： The invention provides isolated anti-ovarian, colon, prostate, or lung cancer antigen (Ovr232v3) antibodies that bind to Ovr232v3 on a mammalian cell. The invention also encompasses compositions containing an anti-Ovr232v3 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr232v3 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr232v3 antibodies. The invention encompasses a method of producing the anti-Ovr232v3 antibodies. Other aspects of the invention are a method of killing an Ovr232v3-expressing cancer cell via contacting the cancer cell with an anti-Ovr232v3 antibody and a method of alleviating or treating an Ovr232v3 -expressing cancer in a mammal via administering a therapeutically effective amount of the anti-Ovr232v3 antibody to the mammal.
摘要翻译：本发明提供了结合哺乳动物细胞上的Ovr232v3的分离的抗卵巢，结肠，前列腺或肺癌抗原（Ovr232v3）抗体。本发明还包括含有抗Ovr232v3抗体和载体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Ovr232v3抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Ovr232v3抗体的细胞。本发明包括产生抗Ovr232v3抗体的方法。本发明的其它方面是通过使癌细胞与抗Ovr232v3抗体接触来杀死表达Ovr232v3的癌细胞的方法，以及通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr232v3的癌症的方法抗Ovr232v3抗体。

3. 发明申请

WO2008067283A3 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2008067283A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085585
申请日：2007-11-27
申请人： DIADEXUS, INC. , PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
发明人： PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
IPC分类号： A61K39/395 , C07K16/46
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

4. 发明申请

WO2008127347A1 PRO115 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： PRO115抗体组合物及其使用方法
公开(公告)号：WO2008127347A1
公开(公告)日：2008-10-23
申请号：PCT/US2007/073948
申请日：2007-07-20
申请人： DIADEXUS, INC. , DIEDRICH, Gundo , MILLER, Paul Levi , PAPKOFF, Jackie , STRELOW, Astrid
发明人： DIEDRICH, Gundo , MILLER, Paul Levi , PAPKOFF, Jackie , STRELOW, Astrid
IPC分类号： C07K16/00 , A61K39/395 , G01N33/53
CPC分类号： C07K16/30 , C07K16/40 , C07K2317/34 , C07K2317/76 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438
摘要： The invention provides isolated anti-Pro115 antibodies that bind to Pro115. The invention also encompasses compositions comprising an anti-Pro115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro115 antibodies. The invention encompasses a method of producing the anti-Pro115 antibodies. Other aspects of the invention are a method of killing an Pro115-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro 115 antibody and a method of alleviating or treating an Pro 115 -expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti- Pro115 antibody to the mammal.
摘要翻译：本发明提供了与Pro115结合的分离的抗Pro115抗体。本发明还包括包含抗Pro115抗体和载体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Pro115抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Pro115抗体的细胞。本发明包括产生抗Pro115抗体的方法。本发明的其它方面是杀死表达Pro115的癌细胞的方法，包括使癌细胞与抗Pro 115抗体接触，以及减轻或治疗哺乳动物中表达Pro 115的癌症的方法，包括给予治疗有效量的抗Pro115抗体。

5. 发明申请

WO2008103701A2 OVR115 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR115抗体组合物和使用方法
公开(公告)号：WO2008103701A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/054370
申请日：2008-02-20
申请人： DIADEXUS, INC. , PAPKOFF, Jackie
发明人： PAPKOFF, Jackie
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/303 , C07K2317/73
摘要： The invention encompasses a method of inhibiting growth of tumor cells in vivo, comprising contacting the cells with an anti-Ovrl 15 antibody, or antigen binding fragment thereof. This invention also encompasses a method of alleviating an Ovrl l5-expressing cancer in a mammal, comprising administering a therapeutically effective amount of an anti-Ovrl 15 antibody, or antigen binding fragment thereof, to the mammal.
摘要翻译：本发明包括抑制肿瘤细胞体内生长的方法，包括使细胞与抗Ovr115抗体或其抗原结合片段接触。本发明还包括减轻哺乳动物中表达Ovr115的癌症的方法，包括给哺乳动物施用治疗有效量的抗Ovr115抗体或其抗原结合片段。

6. 发明申请

WO2006053110A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：WO2006053110A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040707
申请日：2005-11-10
申请人： DIADEXUS, INC. , PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , BURCHAM, Timothy, S. , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
发明人： PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , BURCHAM, Timothy, S. , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
IPC分类号： A61K39/395
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/2827 , C07K16/3015 , C07K2317/34 , C07K2317/732 , C07K2317/77
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译：本发明提供在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。本发明还包括包含抗Ovr110抗体和载体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Ovr110抗体的细胞。本发明包括产生抗Ovr110抗体的方法。本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量的抗Ovr110抗体。

7. 发明申请

WO2005046573A3 PRO104 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2005046573A3
公开(公告)日：2005-05-26
申请号：PCT/US2004/020741
申请日：2004-06-28
申请人： DIADEXUS, INC. , PAPKOFF, Jackie , PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , KMET, Muriel , TANG, Jianwen
发明人： PAPKOFF, Jackie , PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , KMET, Muriel , TANG, Jianwen
IPC分类号： C12N1/20
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to (Pro104) on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-(Pro104) antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-(Pro104) antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-(Pro104) antibodies. The invention encompasses a method of producing the anti-(Pro104) antibodies. Other aspects of the invention are a method of killing a (Pro104)-expressing cancer cell, comprising contacting the cancer cell with an anti-(Pro104) antibody and a method of alleviating or treating a (Pro104)-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-(Pro104) antibody to the mammal.

8. 发明申请

WO2004101756A3 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2004101756A3
公开(公告)日：2004-11-25
申请号：PCT/US2004/014490
申请日：2004-05-10
申请人： DIADEXUS, INC. , PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
发明人： PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
IPC分类号： C07K16/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.

9. 发明授权

EP2104513B1 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：EP2104513B1
公开(公告)日：2015-05-20
申请号：EP07868854.6
申请日：2007-11-27
申请人： diaDexus, Inc.
发明人： PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
IPC分类号： A61K39/395 , C07K16/46 , C07K16/28 , A61P35/00
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00

10. 发明公开

EP1646357A2 PRO104 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： Pro104抗体组合物及使用方法
公开(公告)号：EP1646357A2
公开(公告)日：2006-04-19
申请号：EP04816759.7
申请日：2004-06-28
申请人： Diadexus, Inc.
发明人： PAPKOFF, Jackie , PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , KMET, Muriel , TANG, Jianwen
IPC分类号： A61K6/00
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to (Pro104) on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-(Pro104) antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-(Pro104) antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-(Pro104) antibodies. The invention encompasses a method of producing the anti-(Pro104) antibodies. Other aspects of the invention are a method of killing a (Pro104)-expressing cancer cell, comprising contacting the cancer cell with an anti-(Pro104) antibody and a method of alleviating or treating a (Pro104)-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-(Pro104) antibody to the mammal.

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