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1. 发明申请

WO2008067283A3 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2008067283A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085585
申请日：2007-11-27
申请人： DIADEXUS, INC. , PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
发明人： PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
IPC分类号： A61K39/395 , C07K16/46
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

2. 发明申请

WO2007016590A2 OVR232V3 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR232V3抗体组合物及其使用方法
公开(公告)号：WO2007016590A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/029995
申请日：2006-07-31
申请人： DIADEXUS, INC. , LIU, Shu-Hui , PAPKOFF, Jackie
发明人： LIU, Shu-Hui , PAPKOFF, Jackie
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/73 , C07K2317/77 , G01N33/5011 , G01N33/56966 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G01N33/57492
摘要： The invention provides isolated anti-ovarian, colon, prostate, or lung cancer antigen (Ovr232v3) antibodies that bind to Ovr232v3 on a mammalian cell. The invention also encompasses compositions containing an anti-Ovr232v3 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr232v3 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr232v3 antibodies. The invention encompasses a method of producing the anti-Ovr232v3 antibodies. Other aspects of the invention are a method of killing an Ovr232v3-expressing cancer cell via contacting the cancer cell with an anti-Ovr232v3 antibody and a method of alleviating or treating an Ovr232v3 -expressing cancer in a mammal via administering a therapeutically effective amount of the anti-Ovr232v3 antibody to the mammal.
摘要翻译：本发明提供了结合哺乳动物细胞上的Ovr232v3的分离的抗卵巢，结肠，前列腺或肺癌抗原（Ovr232v3）抗体。本发明还包括含有抗Ovr232v3抗体和载体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Ovr232v3抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Ovr232v3抗体的细胞。本发明包括产生抗Ovr232v3抗体的方法。本发明的其它方面是通过使癌细胞与抗Ovr232v3抗体接触来杀死表达Ovr232v3的癌细胞的方法，以及通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr232v3的癌症的方法抗Ovr232v3抗体。

3. 发明申请

WO2004053079A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物，群体变异和方法
公开(公告)号：WO2004053079A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038855
申请日：2003-12-08
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui , CHEN, Huei-Mei
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui , CHEN, Huei-Mei
IPC分类号： C12N
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

4. 发明申请

WO2004074430A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物，群体变异和方法
公开(公告)号：WO2004074430A2
公开(公告)日：2004-09-02
申请号：PCT/US2003/038896
申请日：2003-12-08
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

5. 发明申请

WO2020132190A1 ANTIBODIES SPECIFIC TO MUC18 审中-公开
公开(公告)号：WO2020132190A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/067387
申请日：2019-12-19
申请人： MULTITUDE INC. , LIU, Shu-Hui
发明人： LIU, Shu-Hui , HOU, Bing , CHEN, Peng , LIU, Junli , MENG, Xun
IPC分类号： C07K16/30 , C07K16/28 , C07K16/18
摘要： Antibodies specific to MUC18 ( a.k.a. MCAM or CD146) and uses thereof for therapeutic and diagnostic purposes are provided. Also provided herein are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds MUC18 and immune cells expressing such.

6. 发明申请

WO2012059882A2 ENGINEERED POLYPEPTIDE CONJUGATES AND METHODS FOR MAKING THEREOF USING TRANSGLUTAMINASE 审中-公开
标题翻译：工程聚氨酯共聚物及其制备方法使用转氨酶
公开(公告)号：WO2012059882A2
公开(公告)日：2012-05-10
申请号：PCT/IB2011/054899
申请日：2011-11-03
申请人： RINAT NEUROSCIENCE CORPORATION , PFIZER INC. , STROP, Pavel , DORYWALSKA, Magdalena Grazyna , RAJPAL, Arvind , SHELTON, David , LIU, Shu-Hui , PONS, Jaume , DUSHIN, Russell
发明人： STROP, Pavel , DORYWALSKA, Magdalena Grazyna , RAJPAL, Arvind , SHELTON, David , LIU, Shu-Hui , PONS, Jaume , DUSHIN, Russell
IPC分类号： A61K47/48
CPC分类号： C07K17/02 , A61K47/48369 , A61K47/48384 , A61K47/48569 , A61K47/48715 , A61K47/68 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/31 , C07K2317/73
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody- drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
摘要翻译：本发明提供包含酰基供体谷氨酰胺标签和胺供体试剂的工程改造的多肽缀合物（例如，抗体 - 药物偶联物，毒素 - （生物相容性聚合物）缀合物，抗体 - （生物相容性聚合物）缀合物和双特异性抗体）。一方面，本发明提供了包含式（Fc-含多肽）-TA的工程改造的含Fc多肽缀合物，其中T是在特定位点工程化的含酰基供体谷氨酰胺标签，或包含由 Fc多肽工程，其中A是胺供体试剂，其中胺供体试剂与含酰基供体谷氨酰胺的标签或内源性谷氨酰胺位点特异性结合。本发明还提供了使用转谷氨酰胺酶制备工程化多肽缀合物的方法。

7. 发明申请

WO2020159754A2 ANTIBODIES SPECIFIC TO CD44 审中-公开
公开(公告)号：WO2020159754A2
公开(公告)日：2020-08-06
申请号：PCT/US2020/014425
申请日：2020-01-21
申请人： MULTITUDE INC. , LIU, Shu-Hui
发明人： LIU, Shu-Hui , ZHANG, Shaofei , HOU, Bing , CHENG, Guangcun , MENG, Xun
IPC分类号： A61K47/68
摘要： Antibodies having binding specificity to CD44 v7/8, ( a.k.a. CD44 variant 7/8) and antibody-drug conjugates (ADCs) or chimeric antigen receptors comprising such. Also provided herein are uses the anti-CD44 v7/8 antibodies, the ADCs, or immune cells expressing the chimeric antigen receptors for therapeutic and diagnostic purposes.

8. 发明授权

EP2104513B1 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：EP2104513B1
公开(公告)日：2015-05-20
申请号：EP07868854.6
申请日：2007-11-27
申请人： diaDexus, Inc.
发明人： PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
IPC分类号： A61K39/395 , C07K16/46 , C07K16/28 , A61P35/00
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00

9. 发明公开

EP2104513A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：EP2104513A2
公开(公告)日：2009-09-30
申请号：EP07868854.6
申请日：2007-11-27
申请人： Diadexus, Inc.
发明人： PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

10. 发明公开

EP1581641A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组成，剪接变体和方法中涉及OVARIALSPEZIFISCHEN基因和蛋白
公开(公告)号：EP1581641A2
公开(公告)日：2005-10-05
申请号：EP03809207.8
申请日：2003-12-08
申请人： Diadexus, Inc.
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui , CHEN, Huei-Mei
IPC分类号： C12N15/12 , C12N15/11 , C12N15/00 , C12Q1/68 , C12P21/02 , A61K31/7088 , A61K31/711
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

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