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1. 发明申请

WO2005044075A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2005044075A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/030719
申请日：2004-09-20
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： A61B
CPC分类号： C07K14/47 , C12Q1/6876
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

2. 发明申请

WO2004092338A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO CANCER SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，SPLICE变量和与癌症特异性基因和蛋白质相关的方法
公开(公告)号：WO2004092338A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011104
申请日：2004-04-12
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , TAM, Albert
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , TAM, Albert
IPC分类号： C12N
CPC分类号： C07K14/82 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, colon, lung, ovarian or prostate, identifying breast, colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered normal or cancerous breast, colon, lung, ovarian or prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺，结肠，肺，卵巢或前列腺中的乳腺癌，结肠癌，肺癌，卵巢癌或前列腺癌和非癌性疾病状态，鉴别乳腺癌，结肠癌，肺癌，卵巢癌或卵巢癌前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的产生，以及生产工程化的正常或癌性乳腺癌，结肠癌，肺癌，卵巢癌或前列腺组织用于治疗和研究。

3. 发明申请

WO2004013311A2 COMPOSITIONS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2004013311A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024669
申请日：2003-08-06
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , SALCEDA, Susana , LIU, Chenghua , SUN, Yongming , TURNER, Leah, R.
发明人： MACINA, Roberto, A. , SALCEDA, Susana , LIU, Chenghua , SUN, Yongming , TURNER, Leah, R.
IPC分类号： C12N
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

4. 发明申请

WO0236616A3 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0236616A3
公开(公告)日：2003-09-12
申请号：PCT/US0147739
申请日：2001-10-30
申请人： DIADEXUS INC , SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA , TURNER LEAH R
发明人： SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA , TURNER LEAH R
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , G01N33/574 , A61K38/17 , C07K16/18 , C12N5/10 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

5. 发明申请

WO02077236A3 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO02077236A3
公开(公告)日：2003-08-21
申请号：PCT/US0150385
申请日：2001-10-26
申请人： DIADEXUS INC , RECIPON HERVE , SUN YONGMING , CHEN SEI-YU , LIU CHENGHUA , TURNER LEAH R
发明人： RECIPON HERVE , SUN YONGMING , CHEN SEI-YU , LIU CHENGHUA , TURNER LEAH R
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P35/04 , C07K14/47 , C12N1/21 , C12N15/12 , A61K31/7088 , A61K31/713 , A61K38/17 , A61K39/395 , C07K16/18 , C12N5/10 , C12N15/63 , C12Q1/68 , G01N33/68
CPC分类号： A61K49/0008 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypetides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和鉴定和/或设计本发明的多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

6. 发明申请

WO0242776A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0242776A3
公开(公告)日：2003-07-03
申请号：PCT/US0145654
申请日：2001-11-01
申请人： DIADEXUS INC , SUN YONGMING , RECIPON HERVE , CHEN SEI-YU , LIU CHENGHUA
发明人： SUN YONGMING , RECIPON HERVE , CHEN SEI-YU , LIU CHENGHUA
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P13/08 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57434 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

7. 发明申请

WO2003020899A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2003020899A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027771
申请日：2002-08-29
申请人： DIADEXUS, INC. , SUN, Yongming , LIU, Chenghua , CHEN, Sei-Yu
发明人： SUN, Yongming , LIU, Chenghua , CHEN, Sei-Yu
IPC分类号： C12N
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention, also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

8. 发明申请

WO2002068633A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2002068633A2
公开(公告)日：2002-09-06
申请号：PCT/US2001/043612
申请日：2001-11-21
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
发明人： MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/09
CPC分类号： C07K14/4748 , A61K48/00 , C12Q1/6886 , C12Q2600/158 , G01N33/57423 , G01N33/6884 , G01N2800/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing and antagonists of polypeptide of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或本发明多肽的设计和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

9. 发明申请

WO2002064788A3 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002064788A3
公开(公告)日：2002-08-22
申请号：PCT/US2001/045080
申请日：2001-11-20
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
发明人： MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.

10. 发明申请

WO2002064788A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2002064788A2
公开(公告)日：2002-08-22
申请号：PCT/US2001/045080
申请日：2001-11-20
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
发明人： MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或设计本发明多肽的激动剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

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