专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007120129A1 SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS 审中-公开
标题翻译：用于可植入葡萄糖传感器的硅胶基膜
公开(公告)号：WO2007120129A1
公开(公告)日：2007-10-25
申请号：PCT/US2006/014127
申请日：2006-04-14
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica
发明人： BOOCK, Robert , RIXMAN, Monica
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , C12Q1/002 , C12Q1/006
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
摘要翻译：介绍了结合有机硅聚合物的膜系统用于可植入分析物传感器。膜系统的一些层可以包括硅氧烷聚合物与亲水性聚合物，例如三嵌段聚（环氧乙烷） - 聚（环氧丙烷） - 聚（环氧乙烷）聚合物的共混物。这种聚合物共混物提供高氧溶解度和水分析物溶解度。

2. 发明申请

WO2007120381A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007120381A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/003881
申请日：2007-02-14
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica , BRAUKER, James, H. , PETISCE, James, R. , SIMPSON, Peter , BRISTER, Mark , TAPSAK, Mark, A. , CARR-BRENDEL, Victoria
发明人： BOOCK, Robert , RIXMAN, Monica , BRAUKER, James, H. , PETISCE, James, R. , SIMPSON, Peter , BRISTER, Mark , TAPSAK, Mark, A. , CARR-BRENDEL, Victoria
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes, for example, a continuous analyte needle-type sensor (34) including a reference electrode (30) helically wound around the working electrode (38), and covered by a membrane system (32) including a silicone-hydrophilic polymer blend membrane.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新颖的硅氧烷亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置，例如连续的分析物针型传感器（34），其包括在工作中螺旋缠绕的参比电极（30）电极（38），并被包括硅氧烷亲水聚合物共混膜的膜系统（32）覆盖。

3. 发明申请

WO2007136390A1 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007136390A1
公开(公告)日：2007-11-29
申请号：PCT/US2006/031496
申请日：2006-08-10
申请人： DEXCOM, INC. , BRAUKER, James, H. , BOOCK, Robert , RIXMAN, Monica , SIMPSON, Peter, C. , BRISTER, Mark
发明人： BRAUKER, James, H. , BOOCK, Robert , RIXMAN, Monica , SIMPSON, Peter, C. , BRISTER, Mark
IPC分类号： A61B5/00 , A61B5/05 , G01N25/26 , G01N33/50
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： Biointerface membranes are provided which can be utilized with implantable device, such as devices for detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levies in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided. Preferably the device comprises a biointerface membrane (68) as a spacer preventing adipose cell (200) from contact with an inserted transcutaneous sensor (34).
摘要翻译：提供生物界面膜，其可以与可植入装置一起使用，例如用于检测生物样品中分析物浓度的装置。更具体地，提供了使用包含这种膜的可植入分析物检测装置监测生物流体样品中的葡萄糖征的方法。优选地，该装置包括作为间隔物的生物界面膜（68），防止脂肪细胞（200）与插入的经皮传感器（34）接触。

4. 发明申请

WO2009121026A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
标题翻译：用于连续分析仪传感器的聚合物膜
公开(公告)号：WO2009121026A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038678
申请日：2009-03-27
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： G01N27/00 , G01R33/00
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise- causing species. The sensing mechanism can be a sensor 34 that includes a membrane system 32 and two electrodes, i.e., a working electrode 38 and at least one additional electrode 30, which may function as a counter or reference electrode.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施例中，该装置具有感测机构和感测膜，其包括至少一个含表面活性基团的聚合物并且位于感测机构上方。感测膜可以具有构造成基本上阻挡非恒定噪声引起物质的影响和/或影响的生物保护层。感测机构可以是传感器34，其包括膜系统32和两个电极，即工作电极38和至少一个附加电极30，其可以用作反电极或参考电极。

5. 发明申请

WO2006127694A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2006127694A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/019889
申请日：2006-05-23
申请人： DEXCOM, INC. , BRAUKER, James, H. , SIMPSON, Peter , BOOCK, Robert , RIXMAN, Monica
发明人： BRAUKER, James, H. , SIMPSON, Peter , BOOCK, Robert , RIXMAN, Monica
IPC分类号： C12M1/34
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device. The sensor 34 can incorporate a working electrode 38 and at least one additional electrode 30, and can further incorporate a sensing mechanism 36 comprising a small structure as adapted for insertion under the host's skin.
摘要翻译：本发明一般涉及与可植入装置一起使用的生物界面膜，例如用于检测生物样品中分析物浓度的装置。更具体地，本发明涉及新颖的生物接触膜，包括这些膜的装置和可植入装置，在可植入装置上或周围形成生物接触膜的方法，以及使用可植入分析物检测来监测生物流体样品中的葡萄糖水平的方法设备。传感器34可以包括工作电极38和至少一个附加电极30，并且还可以包括感测机构36，感测机构36包括适于插入主机皮肤下方的小结构。

6. 发明申请

WO2011041463A2 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译：经皮分析传感器
公开(公告)号：WO2011041463A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/050788
申请日：2010-09-29
申请人： DEXCOM, INC. , NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
发明人： NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供经配置用于连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括被配置用于插入宿主的皮肤180下方的体内部分160和被配置为在传感器插入到主体的传感器之后保持在宿主的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括被配置用于刺穿主体的皮肤180的组织刺穿元件110和包括材料或支撑构件130的传感器主体120，该传感器主体120提供足够的柱强度以允许传感器主体可以在宿主组织中大量屈曲。离体部分170可以被配置成包括（或可操作地连接到）传感器电子单元并且可以包括安装单元150.这里还描述了传感器主体和组织穿透元件的各种配置，其可以用于保护传感器主体的膜。

7. 发明申请

WO2009120240A1 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2009120240A1
公开(公告)日：2009-10-01
申请号：PCT/US2008/082905
申请日：2008-11-07
申请人： DEXCOM, INC. , KAMATH, Apurv, U. , LEACH, Jacob, S. , ESTES, Michael, J. , SHARIATI, Mohammad, Ali , NEALE, Paul, V. , SIMPSON, Peter, C. , YANG, Richard, C. , BOOCK, Robert , LI, Ying
发明人： KAMATH, Apurv, U. , LEACH, Jacob, S. , ESTES, Michael, J. , SHARIATI, Mohammad, Ali , NEALE, Paul, V. , SIMPSON, Peter, C. , YANG, Richard, C. , BOOCK, Robert , LI, Ying
IPC分类号： A61B5/0245
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/7275 , A61M39/10 , A61M2039/1077 , A61M2205/3303
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system (10) includes a vascular access device (12), a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法。在一些实施例中，连续葡萄糖测量系统（10）包括血管进入装置（12），传感器和传感器电子装置，所述系统被配置为插入与主机的循环系统的通信。

8. 发明申请

WO2011003039A2 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040842
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes 802', 802" formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层810，其将导电层820与细长主体分离;膜层，通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

9. 发明申请

WO2011003035A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2011003035A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040838
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.
摘要翻译：提供了用于连续测量分析物浓度的装置和方法。该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。

10. 发明申请

WO2011003036A2 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
标题翻译：连续分析传感器及其制作方法
公开(公告)号：WO2011003036A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040839
申请日：2010-07-01
申请人： DEXCOM, INC. , BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
发明人： BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
IPC分类号： A61B5/155 , A61B5/145 , A61B5/157
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.
摘要翻译：这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在保持溶液的容器的顶部，并且细长导电体前进通过弯液面。该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。例如，提供的细长导电体510通过预涂处理站520，穿过涂覆站530，通过厚度控制站540，穿过干燥或固化站550，穿过厚度测量站560，并通过后涂层处理站570。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式