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    • 1. 发明申请
    • DENTAL COMPOSITION
    • 牙科成分
    • WO2011069642A1
    • 2011-06-16
    • PCT/EP2010/007434
    • 2010-12-07
    • DENTSPLY DETREY GMBHKLEE, Joachim, E.RITTER, HelmutPOHLE, SvenELSNER, Oliver
    • KLEE, Joachim, E.RITTER, HelmutPOHLE, SvenELSNER, Oliver
    • A61K6/083C08F8/14C08F8/32C08F8/34C08F290/12
    • C08F8/32A61K6/0835C08F8/14C08F8/34C08F263/06C08F267/00C08F267/02C08F290/00C08F290/12C08L51/003C08F220/06C08L2666/02C08L33/08
    • Dental cement composition comprising (a) a polymerizable polyacidic polymer having repeating units in the polymer backbone, which are represented by the following formula (I) wherein X represents O, S, or NR', whereby R' represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group, Y is a moiety of the following formula (II) wherein L 2 represents a single bond, a straight or branched C 1 -C 6 alkylene group, or a straight or branched C 1 -C 2O alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms; L 3 represents a straight or branched C 1 -C 3 alkylene group, which may optionally include 1 to 4 atoms selected from oxygen and sulfur atoms; X' represents O, S, or NR", whereby R" represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 - C 8 cycloalkylalkyl group; m represents an integer of from 0 to 6; Z represents H or -COOH; Z' represents H or (CH 2 ) X COOH, wherein x is 0, 1, or 2, L 1 represents a single bond, a straight or branched C 1 -C 6 alkylene group, a straight or branched C 1 -C 6 alkylenylene group, or a straight or branched C 1 -C 2O alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms; and having repeating units in the polymer backbone, which are represented by the following formula (III) wherein L 4 represents a single bond, a straight or branched C 1 -C 6 alkylene group, a straight or branched C 1 -C 6 alkylenylene group, or a straight or branched C 1 -C 2O alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms; and Z" represents H or -COOH; (b) a polymerizable monomer having at least one polymerizable functional group; (c) a radical polymerization initiator.
    • 牙科水泥组合物,其包含(a)在聚合物主链中具有重复单元的可聚合的多元酸聚合物,其由下式(I)表示,其中X表示O,S或NR',其中R'表示氢原子或直链 或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,Y是下式(II)的部分,其中L 2表示单键,直链或支链C 1 -C 6亚烷基,或 包含1至8个选自氧和硫原子的原子的直链或支链C1-C2O亚烷基; L3表示直链或支链C1-C3亚烷基,其可以任选地包括选自氧和硫原子的1至4个原子; X'表示O,S或NR“,其中R”表示氢原子或直链或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基; m表示0〜6的整数, Z表示H或-COOH; Z'表示H或(CH 2)XCOOH,其中x为0,1或2,L 1表示单键,直链或支链C 1 -C 6亚烷基,直链或支链C 1 -C 6亚烷基,或直链或支链C 1 -C 6亚烷基 包含1至8个选自氧和硫原子的原子的支链C1-C2O亚烷基; 并且在聚合物主链中具有由下式(III)表示的重复单元,其中L4表示单键,直链或支链C 1 -C 6亚烷基,直链或支链C 1 -C 6亚烷基,或直链或支链C 1 -C 6亚烷基 包含1至8个选自氧和硫原子的原子的支链C1-C2O亚烷基; Z“表示H或-COOH;(b)具有至少一个可聚合官能团的可聚合单体;(c)自由基聚合引发剂。
    • 5. 发明申请
    • DENTAL COMPOSITION
    • 牙科成分
    • WO2011072812A1
    • 2011-06-23
    • PCT/EP2010/007435
    • 2010-12-07
    • DENTSPLY DE TREY GMBHKLEE, Joachim, E.RITTER, HelmutPOHLE, SvenELSNER, Oliver
    • KLEE, Joachim, E.RITTER, HelmutPOHLE, SvenELSNER, Oliver
    • A61K6/00C08F18/14C08F218/06
    • A61K6/0835A61K6/0038A61K6/083C08F218/06C08F265/02C08F267/04C08L33/00
    • Dental cement composition comprising a polymerizable polyacidic polymer having repeating units in the polymer backbone, which are represented by the following formula (I)1 (II), and/or (III): wherein X represents O, S, or NR', whereby R' represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group, Y a group of the following formula (IV), wherein each of L 1 , L 2 , L 3 and L 4 , which are independent from each other represents a single bond, a straight or branched C 1 -C 6 alkylene group, a straight or branched C 1 -C 6 alkenylene, or a straight or branched C 1 -C 20 alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms, X' represents O, S, or NR", whereby R" represents a hydrogen atom or a straight or branched C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, or C 4 -C 8 cycloalkylalkyl group, m is 0 to 3, and n is 1 to 3.
    • 含有聚合物主链中具有重复单元的聚合性聚酸聚合物的牙科水泥组合物,其由下式(I)1(II)和/或(III)表示:其中X表示O,S或NR',由此 R'表示氢原子或直链或支链C1-C6烷基,C3-C6环烷基或C4-C8环烷基烷基,Y为下式(Ⅳ)的基团,其中L1,L2,L3和 L4彼此独立地表示单键,直链或支链C1-C6亚烷基,直链或支链C1-C6亚烯基或包含1至8个选自以下的1至8个原子的直链或支链C 1 -C 20亚烷基 氧原子和硫原子,X'表示O,S或NR“,其中R”表示氢原子或直链或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,m为0 至3,n为1至3。
    • 8. 发明申请
    • DENTAL COMPOSITION
    • WO2014067666A1
    • 2014-05-08
    • PCT/EP2013/003311
    • 2013-11-04
    • DENTSPLY DETREY GMBH
    • KLEE, JoachimELSNER, OliverFIK, ChristophGANSEL, JuliaLAMPE, UlrichMAIER, MaximilianRITTER, HelmutKAVALLAR, Lisa-Maria
    • A61K6/083C07D307/14
    • C07D307/14A61K6/0038C08L33/10A61K6/0023A61K6/0835
    • A composition comprising a polymerizable compound of the following formula (I) A is a group of the following formula (II) wherein X 1 is CO or CS; X 2 is a single bond, CO, CS, CH 2 , or a group Z[X'Z'] k , wherein X' is an oxygen atom, a sulfur atom or NR, (wherein R is a hydrogen atom, a straight chain or branched C 1-16 alkyl group which may be substituted by a C 3-6 cycloalkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -0-PO 3 M 2 or -SO 3 M, a C 3-6 cycloalkyl group which may be substituted by a C 1-16 alkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -0-PO 3 M 2 or -SO 3 M, a C 6-14 aryl or C 3-14 heteroaryl group which may be substituted by -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M), Z is a straight chain or branched C 1-4 alkylene group, Z' is a bond, a straight chain or branched C 1-4 alkylene group, and k is an integer of from 1 to 50; is a monocylic, bicyclic or tricyclic cycloalkyl group having 3 to 20 carbon atoms or a monocylic, bicyclic or tricyclic heterocycloalkyi group having 2 to 20 carbon atoms and 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen atoms, which groups may be substituted with 1 to 3 groups selected from a C 1-16 alkyl group, - COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M; R 1 is a hydrogen atom, -COOM, a straight chain or branched C 1-16 alkyl group which may be substituted by a C 3-6 cycloalkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, a C 3-6 cycloalkyl group which may be substituted by a C 1-16 alkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, a C 6-14 aryl or C 3-14 heteroaryl group which may be substituted by -COOM, -PO 3 M, - O-PO 3 M 2 or -SO 3 M, R 2 is a hydrogen atom, -COOM, a straight chain or branched C 1-16 alkyl group which may be substituted by a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 and -SO 3 M, a C 3-6 cycloalkyl group which may be substituted by a C 1-16 alkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, or a C 6-14 aryl or C 3-14 heteroaryl group which may be substituted by -COOM, -PO 3 M, - O-PO 3 M 2 and -SO 3 M, L is a single bond or an (n+1 ) -valent linker group; B independently is a group according to the definition of A, a group of the following formula (III) wherein X 1 independently has the same meaning as defined for X 1 in formula (II), CH 2 , or a group [X'Z] k , wherein X' is an oxygen atom, a sulfur atom or NH, Z is a straight chain or branched C 1-4 alkylene group, and k' is an integer of from 1 to 50; R 1 and R 2 are independent from each other and independently have the same meaning as defined for formula (II), a group of the following formula (IV) wherein X 2 independently has the same meaning as defined for X 1 in formula (III) wherein X 1 independently has the same meaning as defined for X 1 in formula (II), CH 2 , or a group [X'Z] k' , wherein X' is an oxygen atom, a sulfur atom or NH, Z is a straight chain or branched C 1-4 alkylene group, and k' is an integer of from 1 to 50; R 1 and R 2 are independent from each other and independently have the same meaning as defined for formula (II), R is a hydrogen atom, a straight chain or branched C 1-16 alkyl group which may be substituted by a C 3-6 cycloalkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, a C 3-6 cycloalkyl group which may be substituted by a C 1-16 alkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O- PO 3 M 2 or -SO 3 M, a C 6-14 aryl or C 3-14 heteroaryl group which may be substituted by - COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, a group of the following formula (V) wherein X 3 is CH 2 , CO, -CH 2 CO-, CS, or -CH 2 CS-, R 1 and R 2 which are independent from each other and independently have the same meaning as defined for formula (II), or a group [ Z'X"] m E, wherein Z' is a straight chain or branched C 1-4 alkylene group, X" is an oxygen atom, a sulfur atom or NR, (wherein R is a hydrogen atom, a straight chain or branched C 1-16 alkyl group which may be substituted by a C 3-6 cycloalkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, a C 3-6 cycloalkyl group which may be substituted by a C 1-16 alkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or-SO 3 M, a C 6-14 aryl or C 3-14 heteroaryl group which may be substituted by -COOM, - PO 3 M, -O-PO 3 M 2 or -SO 3 M), E is a hydrogen atom, PO 3 M 2 , a straight chain or branched C 1-16 alkyl group which may be substituted by a C 3-6 cycloalkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, a C 3-6 cycloalkyl group which may be substituted by a C 1-16 alkyl group, a C 6-14 aryl or C 3-14 heteroaryl group, -COOM, -PO 3 M, -O- PO 3 M 2 or -SO 3 M, a C 6-14 aryl or C 3-14 heteroaryl group which may be substituted by - COOM, -PO 3 M, -O-PO 3 M 2 or -SO 3 M, and m is an integer of from 1 to 10; and n is an integer of from from 1 to 6; wherein M which are independent from each other each represent a hydrogen atom or a metal atom; provided that in case L is a single bond, B cannot be a group according to the definition of A or a group of the formula (III) or (IV).