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1. 发明申请

WO2005087918A3 FUNGAL LIPOLYTIC ENZYMES 审中-公开
公开(公告)号：WO2005087918A3
公开(公告)日：2005-09-22
申请号：PCT/IB2005/000875
申请日：2005-03-10
申请人： DANISCO A/S , BRUNSTEDT, Janne , MIKKELSEN, Jørn, Dalgaard , PEDERSEN, Henrik , SØE, Jørn, Borch
发明人： BRUNSTEDT, Janne , MIKKELSEN, Jørn, Dalgaard , PEDERSEN, Henrik , SØE, Jørn, Borch
IPC分类号： C12N9/00
摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipidAriglyceride hydrolysing activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolysing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID No. 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.

2. 发明申请

WO2004029084A2 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2004029084A2
公开(公告)日：2004-04-08
申请号：PCT/IB2003/004585
申请日：2003-09-26
申请人： DANISCO A/S , PEDERSEN, Henrik , POULSEN, Charlotte, Horsmans , SØE, Jørn, Borch , ZARGAHI, Masoud, Rajabi
发明人： PEDERSEN, Henrik , POULSEN, Charlotte, Horsmans , SØE, Jørn, Borch , ZARGAHI, Masoud, Rajabi
IPC分类号： C07K14/415
CPC分类号： A21D8/042 , C07K14/415 , C11D3/384 , C11D3/38627 , C12N9/18 , C12N9/20 , C12Q1/44 , G01N2500/04
摘要： The present invention relates to the isolation of and characterization of a novel lipase inhibitor and its effect on different lipases. The present invention also relates to the use of a lipase inhibitor as a screen for lipases. The present invention also relates to the use of the inhibitor and/or lipases identified by a lipase inhibitor in food and/or feed technologies.
摘要翻译：本发明涉及新型脂肪酶抑制剂的分离和表征及其对不同脂肪酶的作用。本发明还涉及脂肪酶抑制剂作为脂肪酶筛选的用途。本发明还涉及在食品和/或饲料技术中由脂肪酶抑制剂鉴定的抑制剂和/或脂肪酶的用途。

3. 发明公开

EP3218427A1 DESIGN OF COMPOSITE MATERIALS WITH DESIRED CHARACTERISTICS 审中-公开
标题翻译：具有所需特性的复合材料设计
公开(公告)号：EP3218427A1
公开(公告)日：2017-09-20
申请号：EP15797248.0
申请日：2015-11-11
申请人： NANOCORE APS , Lundorf, Mikkel Dybro , Pedersen, Henrik
发明人： LUNDORF, Mikkel Dybro , PEDERSEN, Henrik , DEHLI, Tore
IPC分类号： C08J5/00 , B82Y30/00 , B82Y40/00
CPC分类号： C08J5/005 , B82Y30/00 , B82Y40/00 , C01B32/05 , C01B32/152 , C01B32/174 , C01B32/194 , C08K3/041 , C08K3/042 , C08K9/04 , C08K9/08 , C08K2201/001 , C08K2201/011 , C08L23/04
摘要： Composite material, where the matrix material and the additive are held togehter by covalently or non-covalently bound ligands. The linker unit between matrix and additive has the structure Ligandl - LinkerL - Ligand 2, whrein Ligandl and Ligand2 are a bond or a chemical entity that is capable of binding covalently or non-covalently to a structural entity, such as a polymer matrix or the additive (ex. CNT, graphene, carbon nanofiber, etc), and LinkerL is a chemical bond or entity that links Ligandl and Ligand2.
摘要翻译：复合材料，其中基质材料和添加剂通过共价或非共价结合的配体保持形成。基质和添加剂之间的接头单元具有结构配体1 - 接头L - 配体2，其中配体1和配体2是能够共价或非共价结合至结构实体的键或化学实体，例如聚合物基质或添加剂（例如CNT，石墨烯，碳纳米纤维等），并且连接子L是连接配体1和配体2的化学键或实体。

4. 发明公开

EP3218479A1 METHOD FOR IDENTIFICATION OF MOLECULES WITH DESIRED CHARACTERISTICS 审中-公开
标题翻译：鉴定具有所需特性的分子的方法
公开(公告)号：EP3218479A1
公开(公告)日：2017-09-20
申请号：EP15801669.1
申请日：2015-11-11
申请人： Nanocore ApS , Lundorf, Mikkel Dybro , Pedersen, Henrik
发明人： LUNDORF, Mikkel Dybro , PEDERSEN, Henrik , DEHLI, Tore
IPC分类号： C12N15/10
CPC分类号： C12N15/1034 , C12N15/1065 , C12N15/1068
摘要： A method for identifying molecules with desired characteristics such as high affinity for a surface or material is described. A particularly useful method covered by the present invention allows identification of molecules which bind a material with high affinity in the presence of fluid or soluble polymers, such that said molecules can be used to produce a composite in which they efficiently anchor a material in a matrix comprising solid forms of a polymer. Compositions/kits useful for identification of molecules with desired characteristics are also described.
摘要翻译：描述了用于鉴定具有期望特性（例如对表面或材料的高亲和力）的分子的方法。本发明所涵盖的特别有用的方法允许鉴定在流体或可溶性聚合物存在下以高亲和力结合材料的分子，使得所述分子可用于生产复合物，其中它们有效地将材料锚定在基质中包含固体形式的聚合物。还描述了用于鉴定具有期望特性的分子的组合物/试剂盒。

5. 发明申请

WO2020159418A1 A METHOD AND APPARATUS FOR CHEMICAL VAPOUR DEPOSITION 审中-公开
公开(公告)号：WO2020159418A1
公开(公告)日：2020-08-06
申请号：PCT/SE2020/050036
申请日：2020-01-15
申请人： PEDERSEN, Henrik , NADHOM, Hama
发明人： PEDERSEN, Henrik , NADHOM, Hama
IPC分类号： C23C20/02
摘要： The present disclosure relates to a method for chemical vapour deposition on a substrate, the method comprising a precursor step and a reactant step, wherein the precursor step comprises chemisorbing a layer of precursor molecules on the substrate (170), and wherein the reactant step comprises adding to at least part of the substrate (170) surface species able to reduce the precursor molecule, whereby at least a part of the reduced precursor molecule is deposited on the substrate (170) surface, characterized by applying by means of a voltage source (130) a positive bias to at least part of the substrate (170) surface during at least part of the reactant step, wherein the step of adding the reducing species comprises providing by means of an electron source (150) electrons as free particles, whereby during the reactant step a closed electrical circuit is formed as the free electrons are transmitted to the substrate (170) surface.

6. 发明申请

WO2012092930A2 TOILET HINGE ARRANGEMENT 审中-公开
标题翻译：卫生间铰链安排
公开(公告)号：WO2012092930A2
公开(公告)日：2012-07-12
申请号：PCT/DK2011/050519
申请日：2011-12-23
申请人： PRESSALIT A/S , PEDERSEN, Henrik , RATHKE, Morten
发明人： PEDERSEN, Henrik , RATHKE, Morten
IPC分类号： A47K13/12
CPC分类号： A47K13/12
摘要： Toilet hinge arrangement for releasable fastening of a toilet cover assembly, including a toilet seat and/or a toilet cover, to a toilet bowl, so that the toilet cover assembly can pivot about a substantially horizontal rotation axis, where dampening means are acti- vated for dampening the downward movement of said toilet seat and/or cover, said toilet hinge arrangement includes a base member with a lower side adapted to abut the surface of the toilet bowl, where said base member has a shaft member projecting up¬ wards from the base member, said shaft being suitable to releasably engage a hinge part characterised in that the hinge part comprises: - a dampener, said dampener having a first end rotatable relative to the dampener body, where the rotation of the first end is dampened relative to the body - an engagement part where said engagement part has means for engaging a first end of said dampener; a first ring-shaped connection eye of the toilet seat or cover, having an opening such that the ring-shaped connection eye is arranged about the dampener; a second ring-shaped connection eye of the toilet seat or cover, having means for engaging the free end of the dampener body in a non-rotatable manner where said dampener is provided with first fastening means adjacent the free end of the dampener body, where said second ring shaped connection eye is provided with means for accommodating and firmly engaging said dampener' s first fastening means; and where said engagement part is provided with second fastening means which second fastening means will firmly engage the first end of the dampener where both first and second fastening means will maintain the dampener in fixed relationship axially along the rotation axis.
摘要翻译：卫生间铰链装置，用于将马桶盖组件（包括马桶座圈和/或马桶盖）可释放地紧固到马桶上，使得马桶盖组件可围绕基本上水平的旋转轴线枢转，其中阻尼装置被激活为了抑制所述马桶座和/或盖的向下运动，所述马桶铰链装置包括底部构件，其具有适于邻接马桶的表面的下侧，其中所述基座构件具有从所述马桶座和/ 所述轴适于可释放地接合铰链部件，其特征在于，所述铰链部件包括： - 阻尼器，所述阻尼器具有相对于所述阻尼器主体可旋转的第一端，其中所述第一端部的旋转相对于所述第一端部被阻尼主体 - 接合部分，其中所述接合部分具有用于接合所述阻尼器的第一端的装置; 马桶座或盖的第一环形连接眼，具有开口，使得环形连接眼围绕阻尼器布置; 所述马桶座或盖的第二环形连接眼具有用于以不可旋转的方式接合所述阻尼器本体的自由端的装置，其中所述阻尼器设置有邻近所述阻尼器主体的自由端的第一紧固装置，其中所述第二环形连接眼设置有用于容纳并牢固地接合所述阻尼器的第一紧固装置的装置; 并且其中所述接合部分设置有第二紧固装置，第二紧固装置将牢固地接合阻尼器的第一端，其中第一和第二紧固装置将沿着旋转轴线轴向保持阻尼器处于固定关系。

7. 发明申请

WO2010037402A1 MOLECULAR VACCINES FOR INFECTIOUS DISEASE 审中-公开
标题翻译：感染性疾病的分子疫苗
公开(公告)号：WO2010037402A1
公开(公告)日：2010-04-08
申请号：PCT/DK2009/050262
申请日：2009-10-02
申请人： DAKO DENMARK A/S , SCHØLLER, Jørgen , PEDERSEN, Henrik , BRIX, Liselotte
发明人： SCHØLLER, Jørgen , PEDERSEN, Henrik , BRIX, Liselotte
IPC分类号： A61K38/17 , A61K39/00 , A61K47/48 , A61P31/04 , A61P31/18 , C07K14/705
CPC分类号： A61K39/00 , A61K38/00 , A61K39/12 , A61K39/21 , A61K47/61 , A61K47/646 , A61K2039/5154 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55516 , A61K2039/55583 , A61K2039/6087 , A61K2039/625 , C07K14/70539 , C12N2740/16134 , C12N2740/16234 , Y02A50/464 , Y02A50/487 , Y02A50/489 , Y02A50/491
摘要： The present invention relates to methods for construction of pharmamers i.e. vaccine components characterized by their multimerization domain and the attached biologically active molecules, and their use in preparation of vaccines that contains the pharmamers alone or in combination with other molecules. The individual molecules of the construct can be bound to each other or the multimerization domain(s) by covalent or non-covalent bonds, directly or via linkers. The invention further relates to the use of such preparations in vaccine settings aimed to function as preventive/prophylactic or therapeutic vaccines in humans and animals.
摘要翻译：本发明涉及用于构建药剂的方法，即以其多聚化结构域和附着的生物活性分子为特征的疫苗组分及其在制备包含单独或与其它分子组合的药剂的疫苗中的用途。构建体的各个分子可以通过共价或非共价键直接或通过接头彼此结合或多聚化结构域。本发明还涉及在旨在作为人和动物中的预防/预防或治疗性疫苗的疫苗设置中使用这种制剂。

8. 发明申请

WO2010037395A2 MHC MULTIMERS IN CANCER VACCINES AND IMMUNE MONITORING 审中-公开
标题翻译： MHC多抗在癌症疫苗和免疫监测中的应用
公开(公告)号：WO2010037395A2
公开(公告)日：2010-04-08
申请号：PCT/DK2009/050255
申请日：2009-10-01
申请人： DAKO DENMARK A/S , BRIX, Liselotte , SCHØLLER, Jørgen , PEDERSEN, Henrik
发明人： BRIX, Liselotte , SCHØLLER, Jørgen , PEDERSEN, Henrik
IPC分类号： C07K14/705 , A61K39/00 , A61K47/48 , G01N33/50 , A61P35/00
CPC分类号： A61K39/0011 , A61K47/6901 , C07K14/705 , C07K14/70539 , G01N33/56972
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising cancer antigenic peptides and uses there of.
摘要翻译：本发明涉及MHC-肽复合物及其在诊断，治疗或预防个体疾病中的用途。更具体地说，本发明公开了包含癌抗原肽的MHC复合物及其用途。

9. 发明申请

WO2004056994A2 QUASIRANDOM STRUCTURE AND FUNCTION GUIDED SYNTHESIS METHODS 审中-公开
标题翻译： QUASIRANDOM结构和功能指导合成方法
公开(公告)号：WO2004056994A2
公开(公告)日：2004-07-08
申请号：PCT/DK2003/000921
申请日：2003-12-19
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , HOLTMANN, Anette , PEDERSEN, Henrik , FRANCH, Thomas
发明人： GOULIAEV, Alex, Haahr , HOLTMANN, Anette , PEDERSEN, Henrik , FRANCH, Thomas
IPC分类号： C12N15/10
CPC分类号： C40B30/04 , C12N15/1068 , C40B20/04 , C40B40/06 , C40B50/04 , C40B50/08 , Y10T436/145555
摘要： The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementory connector ploynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result I the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least on “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.
摘要翻译：本发明涉及分子引导的b连接体多核苷酸（能够与包含至少一个包含至少一个反应性基团的至少一个功能实体的互补连接子聚合核苷酸（CCPN）杂交）的CPN的合成，所述至少一种能够与至少两个CPN，每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN，形成包含多个CPN和多个CCPN的超分子杂交复合体后，功能性实体反应性基团的反应导致I 分子的形成包括共价连接的功能实体。分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移到至少在“受体CCPN”之间，转移的功能实体在其之前不相关联转让。

10. 发明申请

WO2002102820A1 NUCLEOSIDE DERIVATIVES FOR LIBRARY PREPARATION 审中-公开
标题翻译：用于图书馆准备的核苷酸衍生物
公开(公告)号：WO2002102820A1
公开(公告)日：2002-12-27
申请号：PCT/DK2002/000420
申请日：2002-06-20
申请人： NUEVOLUTION A/S , PEDERSEN, Henrik , ABILGAARD SLØK, Frank , GODSKESEN, Michael, Anders , HYLDTOFT, Lene , KLARNER SAMS, Christian
发明人： PEDERSEN, Henrik , ABILGAARD SLØK, Frank , GODSKESEN, Michael, Anders , HYLDTOFT, Lene , KLARNER SAMS, Christian
IPC分类号： C07H19/06
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： Nucleoside derivatives as building blocks for templated libraries are described.
摘要翻译：描述了核苷衍生物作为模板文库的构建块。

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