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1. 发明申请

WO2004056994A2 QUASIRANDOM STRUCTURE AND FUNCTION GUIDED SYNTHESIS METHODS 审中-公开
标题翻译： QUASIRANDOM结构和功能指导合成方法
公开(公告)号：WO2004056994A2
公开(公告)日：2004-07-08
申请号：PCT/DK2003/000921
申请日：2003-12-19
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , HOLTMANN, Anette , PEDERSEN, Henrik , FRANCH, Thomas
发明人： GOULIAEV, Alex, Haahr , HOLTMANN, Anette , PEDERSEN, Henrik , FRANCH, Thomas
IPC分类号： C12N15/10
CPC分类号： C40B30/04 , C12N15/1068 , C40B20/04 , C40B40/06 , C40B50/04 , C40B50/08 , Y10T436/145555
摘要： The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementory connector ploynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result I the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least on “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.
摘要翻译：本发明涉及分子引导的b连接体多核苷酸（能够与包含至少一个包含至少一个反应性基团的至少一个功能实体的互补连接子聚合核苷酸（CCPN）杂交）的CPN的合成，所述至少一种能够与至少两个CPN，每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN，形成包含多个CPN和多个CCPN的超分子杂交复合体后，功能性实体反应性基团的反应导致I 分子的形成包括共价连接的功能实体。分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移到至少在“受体CCPN”之间，转移的功能实体在其之前不相关联转让。

2. 发明申请

WO2003078625A2 AN IMPROVED METHOD FOR SYNTHESISING TEMPLATED MOLECULES 审中-公开
标题翻译：用于合成模板分子的改进方法
公开(公告)号：WO2003078625A2
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000172
申请日：2003-03-14
申请人： NUEVOLUTION A/S , PEDERSEN, Henrik , HOLTMANN, Anette , FRANCH, Thomas , GOULIAEV, Alex, Haahr , FELDING, Jakob
发明人： PEDERSEN, Henrik , HOLTMANN, Anette , FRANCH, Thomas , GOULIAEV, Alex, Haahr , FELDING, Jakob
IPC分类号： C12N15/10
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能性实体均具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体可以接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

3. 发明申请

WO2007062664A3 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES 审中-公开
公开(公告)号：WO2007062664A3
公开(公告)日：2007-06-07
申请号：PCT/DK2006/000685
申请日：2006-12-01
申请人： NUEVOLUTION A/S , FRANCH, Thomas , LUNDORF, Mikkel Dybro , JAKOBSEN, Søren, Nyboe , OLSEN, Eva Kampmann , ANDERSEN, Anne Lee , HOLTMANN, Anette , HANSEN, Anders Holm , SØRENSEN, Anders Malling , GOLDBECH, Anne , DE LEON, Daen , KALDOR, Ditte Kivsmose , SLØK, Frank Abilgaard , HUSEMOEN, Gitte Nystrup , DOLBERG, Johannes , JENSEN, Kim Birkebæk , PETERSEN, Lene , NØRREGAARD-MADSEN, Mads , GODSKESEN, Michael Anders , GLAD, Sanne Schrøder , NEVE, Søren , THISTED, Thomas , KRONBORG, Tine Titilola Akinleminu , SAMS, Christian, , FELDING, Jakob , FRESKGAARD, Per-Ola , GOULIAEV, Alex Haahr , PEDERSEN, Henrik
发明人： FRANCH, Thomas , LUNDORF, Mikkel Dybro , JAKOBSEN, Søren, Nyboe , OLSEN, Eva Kampmann , ANDERSEN, Anne Lee , HOLTMANN, Anette , HANSEN, Anders Holm , SØRENSEN, Anders Malling , GOLDBECH, Anne , DE LEON, Daen , KALDOR, Ditte Kivsmose , SLØK, Frank Abilgaard , HUSEMOEN, Gitte Nystrup , DOLBERG, Johannes , JENSEN, Kim Birkebæk , PETERSEN, Lene , NØRREGAARD-MADSEN, Mads , GODSKESEN, Michael Anders , GLAD, Sanne Schrøder , NEVE, Søren , THISTED, Thomas , KRONBORG, Tine Titilola Akinleminu , SAMS, Christian, , FELDING, Jakob , FRESKGAARD, Per-Ola , GOULIAEV, Alex Haahr , PEDERSEN, Henrik
IPC分类号： C12N15/10 , C12Q1/68 , C40B40/06 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

4. 发明申请

WO2004039825A2 ENZYMATIC ENCODING 审中-公开
标题翻译： ENZYMATIC编码
公开(公告)号：WO2004039825A2
公开(公告)日：2004-05-13
申请号：PCT/DK2003/000739
申请日：2003-10-30
申请人： NUEVOLUTION A/S , FRESKGÅRD, Per-Ola , FRANCH, Thomas , GOULIAEV, Alex, Haahr , LUNDORF, Mikkel, Dybro , FELDING, Jakob , OLSEN, Eva, Kampmann , HOLTMANN, Anette , JAKOBSEN, Søren, Nyboe , SAMS, Christian , GLAD, Sanne, Schrøder , JENSEN, Kim, Birkebæk , PEDERSEN, Henrik
发明人： FRESKGÅRD, Per-Ola , FRANCH, Thomas , GOULIAEV, Alex, Haahr , LUNDORF, Mikkel, Dybro , FELDING, Jakob , OLSEN, Eva, Kampmann , HOLTMANN, Anette , JAKOBSEN, Søren, Nyboe , SAMS, Christian , GLAD, Sanne, Schrøder , JENSEN, Kim, Birkebæk , PEDERSEN, Henrik
IPC分类号： C07H21/00
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译：公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。

5. 发明申请

WO2003078625A3 AN IMPROVED METHOD FOR SYNTHESISING TEMPLATED MOLECULES 审中-公开
公开(公告)号：WO2003078625A3
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000172
申请日：2003-03-14
申请人： NUEVOLUTION A/S , PEDERSEN, Henrik , HOLTMANN, Anette , FRANCH, Thomas , GOULIAEV, Alex, Haahr , FELDING, Jakob
发明人： PEDERSEN, Henrik , HOLTMANN, Anette , FRANCH, Thomas , GOULIAEV, Alex, Haahr , FELDING, Jakob
IPC分类号： C12N15/10
摘要： The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.

6. 发明申请

WO2004083427A2 LIGATIONAL ENCODING OF SMALL MOLECULES 审中-公开
标题翻译：小分子的编码
公开(公告)号：WO2004083427A2
公开(公告)日：2004-09-30
申请号：PCT/DK2004/000195
申请日：2004-03-22
申请人： NUEVOLUTION A/S , FRANCH, Thomas , JACOBSEN, Soeren, Nyboe , RASMUSSEN, Torben , NEVE, Soeren , PEDERSEN, Henrik , GOULIAEV, Alex, Haahr
发明人： FRANCH, Thomas , JACOBSEN, Soeren, Nyboe , RASMUSSEN, Torben , NEVE, Soeren , PEDERSEN, Henrik , GOULIAEV, Alex, Haahr
IPC分类号： C12N15/10
CPC分类号： C07H21/04 , C12N15/1068 , C12P21/02 , C40B40/06 , C40B50/04
摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.
摘要翻译：本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关联的抗密码子，和ii）将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

7. 发明申请

WO2003078627A3 A BUILDING BLOCK CAPABLE OF FUNCTIONAL ENTITY TRANSFER TO NUCLEOPHIL 审中-公开
公开(公告)号：WO2003078627A3
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000177
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
发明人： GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
IPC分类号： C07H21/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.

8. 发明申请

WO2003078626A2 A BUILDING BLOCK CAPABLE OF TRANSFERRING A FUNCTIONAL ENTITY 审中-公开
标题翻译：传输功能实体的建筑块
公开(公告)号：WO2003078626A2
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000174
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
发明人： GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
IPC分类号： C12N15/10
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译：具有转移遗传信息的双重功能的构建块，例如，通过识别编码元件并将功能实体传送到接收者反应组。构建块可以设计成具有可调节的可转移性，同时考虑到构件的部件。构建单元可以用于生成单个复合体或不同复合物的文库，其中复合物包含与编码元件连接的编码分子。复合物库可用于寻求药物活性化合物。

9. 发明申请

WO2003078627A2 A BUILDING BLOCK CAPABLE OF FUNCTIONAL ENTITY TRANSFER TO NUCLEOPHIL 审中-公开
标题翻译：能够将功能实体转移至核苷酸的构建区块
公开(公告)号：WO2003078627A2
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000177
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
发明人： GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
IPC分类号： C12N15/10
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译：具有通过识别编码元件并将功能实体转移到受体反应性基团来转移遗传信息的双重能力的结构单元被揭示。考虑到构件的组件，可以将构件设计为具有可调整的可转移性。构建模块可用于产生不同复合物的单个复合物或多个文库，其中复合物包含与编码元件连接的编码分子。复合物库可用于寻找药物活性化合物。

10. 发明申请

WO2003078626A3 A BUILDING BLOCK CAPABLE OF TRANSFERRING A FUNCTIONAL ENTITY 审中-公开
公开(公告)号：WO2003078626A3
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000174
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
发明人： GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
IPC分类号： C07H21/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.

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