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1. 发明申请

WO1992004373A1 PEPTIDE HAVING ANTIALLERGIC ACTIVITY 审中-公开
标题翻译：具有抗真菌活性的肽
公开(公告)号：WO1992004373A1
公开(公告)日：1992-03-19
申请号：PCT/JP1991001146
申请日：1991-08-29
申请人： DAINIPPON PHARMACEUTICAL CO., LTD. , AJINOMOTO CO., INC. , NAKAMURA, Hideo , NAKANISHI, Kiyomi , YAKUO, Ikuhisa , ARIYOSHI, Yasuo , NIO, Noriki
发明人： DAINIPPON PHARMACEUTICAL CO., LTD. , AJINOMOTO CO., INC.
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00
摘要： A peptide having an amino acid sequence useful as the preventive and remedy for allergic diseases, represented by the following general formula (I), and salt thereof: A-B-Asp-C-D-Ile-E-F-G, wherein A represents Ala or Pro, B represents Phe or Cha, C represents Ile, Leu, tert-Leu or Val, D represents Phe, Tyr or Cha, E represents Gly, Lys or Arg, F represents Lys, Arg or Orn, and G represents OH, NH2, NHEt, Lys, Ser, Thr, OMe, ( alpha ) or ( beta ), and wherein each amino acid residue may be any of the D, L and racemic forms, provided that at least one among all the amino acid residues must be the D form(s) when A, B, C, D, E, F and G represent Pro, Phe, Leu, Phe, Arg, Lys and OH, respectively.
摘要翻译：由以下通式（I）表示的具有用作过敏性疾病的预防和治疗的氨基酸序列的肽及其盐：AB-Asp-CD-Ile-EFG，其中A表示Ala或Pro，B表示 Phe或Cha，C表示Ile，Leu，叔-Leu或Val，D表示Phe，Tyr或Cha，E表示Gly，Lys或Arg，F表示Lys，Arg或Orn，G表示OH，NH2，NHEt，Lys ，Ser，Thr，OMe，（α）或（β），并且其中每个氨基酸残基可以是D，L和外消旋体中的任何一种，条件是所有氨基酸残基中的至少一个必须是D形式当A，B，C，D，E，F和G分别表示Pro，Phe，Leu，Phe，Arg，Lys和OH时。

2. 发明申请

WO1998013381A1 MODIFIED PHYSIOLOGICALLY ACTIVE PROTEINS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：改良的生理活性蛋白质和含有其的药物组合物
公开(公告)号：WO1998013381A1
公开(公告)日：1998-04-02
申请号：PCT/JP1997003435
申请日：1997-09-26
申请人： AJINOMOTO CO., INC. , TAKAHARA, Yoshiyuki , SATO, Haruya , HAYASHI, Eiko , YATAGAI, Masanobu , SUZUKI, Manabu , TABATA, Tomoyuki , EJIMA, Chieko
发明人： AJINOMOTO CO., INC.
IPC分类号： C07K14/52
CPC分类号： C07H15/08 , A61K38/00 , C07H15/04 , C07K14/00 , C07K14/52 , C07K14/55 , C07K14/56
摘要： Modified physiologically active protein which can be produced by reacting a physiologically active protein having a molecular weight falling within the range of from 1 x 10 to 2 x 10 and carrying at least one Gln residue serving as the substitute of transglutaminase with a branched ligand consisting of an amino acid derivative having a lower binding affinity to the asialoglycoprotein receptor located on hepatic parenchymal cells than that to asialoorsomucoid and carrying an amino group and a galactose (Gal) or N-acetylgalactosamine (GalNAc) group serving as the substrate of transglutaminase in the presence of a transglutaminase originating in a microorganism to thereby form an amide bond between the gamma -carboxyamide group of the glutamate residue in the physiologically active protein and the terminal amino group in the branched ligand; and a process for producing the same.
摘要翻译：可以通过使分子量在1×10 3至2×10 5范围内的生理活性蛋白质和携带至少一个Gln残基作为转谷氨酰胺酶的替代物来生产的改良的生理活性蛋白质具有由与位于肝实质细胞上的脱唾液酸糖蛋白受体的结合亲和力低的氨基酸衍生物的支链配体与携带氨基和携带氨基的半胱氨酸（Gal）或N-乙酰半乳糖胺（GalNAc）在转谷氨酰胺酶存在下，在生物活性蛋白质中的γ-羧基酰胺基团与支链配体中的末端氨基之间形成酰胺键，形成转谷氨酰胺酶底物; 及其制造方法。

3. 发明申请

WO1997008294A1 PROCESS FOR PRODUCING L-GLUTAMIC ACID BY FERMENTATION METHOD 审中-公开
标题翻译：通过发酵方法生产L-谷氨酸的方法
公开(公告)号：WO1997008294A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996001944
申请日：1996-07-12
申请人： AJINOMOTO CO., INC. , MATSUI, Kazuhiko , HUKASE, Kumiko , TSUJIMOTO, Nobuharu
发明人： AJINOMOTO CO., INC.
IPC分类号： C12N01/21
CPC分类号： C12P13/14
摘要： A process for economically and efficiently producing L-glutamic acid by enhancing the L-glutamic acid productivity of a valine-tolerant wild strain from among microorganisms belonging to the genus Escherichia. A strain belonging to the genus Escherichia to which a sensitivity to valine has been imparted and the phosphoenolpyruvate carboxylase activity and the citrate synthase activity of which have been amplified is incubated in a liquid medium and the L-glutamic acid thus accumulated in the culture medium is taken up.
摘要翻译：通过从属于埃希氏杆菌属的微生物中提高缬氨酸耐受性野生株的L-谷氨酸生产力来经济有效地生产L-谷氨酸的方法。将已经赋予缬氨酸敏感性并且已经扩增了磷酸烯醇丙酮酸羧化酶活性和柠檬酸合酶活性已被扩增的属于埃希氏杆菌属的菌株在液体培养基中培养，并且由此积累在培养基中的L-谷氨酸是占用。

4. 发明申请

WO1996037603A1 PROCESS FOR PRODUCING NUCLEOSIDE-5'-PHOSPHATE 审中-公开
标题翻译：生产核苷-5'-磷酸酯的方法
公开(公告)号：WO1996037603A1
公开(公告)日：1996-11-28
申请号：PCT/JP1996001402
申请日：1996-05-24
申请人： AJINOMOTO CO., INC. , MIHARA, Yasuhiro , UTAGAWA, Takashi , YAMADA, Hideaki , ASANO, Yasuhisa
发明人： AJINOMOTO CO., INC.
IPC分类号： C12N09/16
CPC分类号： C12N9/16 , C12P19/32
摘要： A process for efficiently and economically producing a nucleoside-5'-phosphate which comprises treating a nucleoside and a phosphoric acid donor selected from the group consisting of poly-phosphoric acid (salts), phenylphosphoric acid (salts) and carbamylphosphoric acid (salts) with an acid phosphatase, in particular one suffering from a decrease in the nucleotidase activity, at a pH value of 3.0 to 5.5 to thereby form a nucleoside-5'-phosphate and taking up the same.
摘要翻译：一种有效和经济地制备核苷-5'-磷酸的方法，其包括将选自多磷酸（盐），苯基磷酸（盐）和氨基甲酰基磷酸（盐）的核苷和磷酸供体与一种酸性磷酸酶，特别是一种具有降低核苷酸酶活性的酸性磷酸酶，pH值为3.0至5.5，从而形成核苷-5'-磷酸酯并进行摄取。

5. 发明申请

WO1996030501A1 PROCESS FOR PRODUCING NUCLEIC ACIDS 审中-公开
标题翻译：生产核酸的方法
公开(公告)号：WO1996030501A1
公开(公告)日：1996-10-03
申请号：PCT/JP1996000761
申请日：1996-03-22
申请人： AJINOMOTO CO., INC. , USUDA, Yoshihiro , KAWASAKI, Hisashi , SHIMAOKA, Megumi , UTAGAWA, Takashi
发明人： AJINOMOTO CO., INC.
IPC分类号： C12N09/12
CPC分类号： C12N9/12 , C12P19/32
摘要： A process for producing 5'-inosinic acid or 5'-guanylic acid usable in seasonings, etc. from inosine or guanosine or precursors thereof by using a microorganism which carries a DNA encoding a protein having the activity of forming 5'-inosinic acid or 5'-guanylic acid from inosine or guanosine and is capable of reproducing adenosine triphosphate (ATP); a novel protein having an inosine-guanosine kinase activity; a gene encoding this protein; a recombinant DNA containing this gene; and a microorganism transformed thereby.
摘要翻译：通过使用携带编码具有形成5'-肌苷酸的活性的蛋白质的DNA的微生物或其前体，可以从肌苷或鸟苷或其前体产生可用于调味料等的5'-肌苷酸或5'-鸟苷酸的方法，或来自肌苷或鸟苷的5'-鸟苷酸，能够再生三磷酸腺苷（ATP）; 具有肌苷 - 鸟苷激酶活性的新蛋白质; 编码该蛋白的基因; 含有该基因的重组DNA; 和由此转化的微生物。

6. 发明申请

WO1995016042A1 PROCESS FOR PRODUCING L-LYSINE BY FERMENTATION 审中-公开
标题翻译：通过发酵生产L-赖氨酸的方法
公开(公告)号：WO1995016042A1
公开(公告)日：1995-06-15
申请号：PCT/JP1994001994
申请日：1994-11-28
申请人： AJINOMOTO CO., INC. , KOJIMA, Hiroyuki , OGAWA, Yuri , KAWAMURA, Kazue , SANO, Konosuke
发明人： AJINOMOTO CO., INC.
IPC分类号： C12N15/54
CPC分类号： C12Y104/01016 , C12N9/001 , C12N9/0016 , C12N9/1096 , C12N9/12 , C12N9/88 , C12P13/08 , C12Y103/01026
摘要： A process for producing L-Lysine by culturing in a suitable medium an Escherichia bacterium transformed by the introduction into its cells of a DNA coding for an Escherichia-derived dihydrodipicolinate synthase having such a variation as to be released from the feedback inhibition caused by L-lysine and a DNA coding for an Escherichia-derived aspartokinase III having such a variation as to be released from the feedback inhibition caused by L-lysine, preferably the above Escherichia bacterium which further has been enriched with a dihydrodipicolinate reductase gene and a coryneform-derived diaminopimelate dehydrogenase gene (or a succinyldiaminopimelate transaminase gene and a succinyldiaminopimelate deacylase gene), accumulating the produced L-lysine in the medium, and harvesting the accumulated L-lysine from the medium.
摘要翻译：通过在合适的培养基中培养将通过引入到其细胞中的编码由来自大肠杆菌的二氢吡啶二羧酸合成酶的DNA转化的埃希氏菌属细菌，产生L-赖氨酸的方法，其具有这样的变化，以从由L- 赖氨酸和编码大肠杆菌来源的天冬氨酸激酶III的DNA，其具有这样的变化，以便从由L-赖氨酸引起的反馈抑制中释放，优选上述进一步富含二氢吡啶二羧酸还原酶基因和棒状杆菌衍生物二酰基庚二酸脱氢酶基因（或琥珀酰二氨基庚二酸转氨酶基因和琥珀酰二氨基庚二酸酯脱酰酶基因），在培养基中积聚所产生的L-赖氨酸，并从培养基中收集累积的L-赖氨酸。

7. 发明申请

WO1995011985A1 PROCESS FOR PRODUCING SUBSTANCE 审中-公开
标题翻译：生产物质的方法
公开(公告)号：WO1995011985A1
公开(公告)日：1995-05-04
申请号：PCT/JP1994001791
申请日：1994-10-26
申请人： AJINOMOTO CO., INC. , KOJIMA, Hiroyuki , TOTSUKA, Kazuhiko
发明人： AJINOMOTO CO., INC.
IPC分类号： C12P13/04
CPC分类号： C12N15/11 , C12P1/00 , C12P13/04 , Y10S435/849
摘要： The productivity of such substances as L-amino acids, antibiotics, vitamins, growth factors and physiologically active substances in the fermentation using a microorganism is improved by improving the productivity of reduced nicotinamide adenine dinucleotide phosphate in the cells of the microorganisms.
摘要翻译：通过提高微生物细胞中还原型烟酰胺腺嘌呤二核苷酸磷酸酯的生产率，提高了使用微生物的发酵中的L-氨基酸，抗生素，维生素，生长因子和生理活性物质等物质的生产率。

8. 发明申请

WO1995009183A1 PEPTIDE AND ANTITHROMBOTIC AGENT 审中-公开
标题翻译：肽和抗生素代谢
公开(公告)号：WO1995009183A1
公开(公告)日：1995-04-06
申请号：PCT/JP1994001583
申请日：1994-09-27
申请人： AJINOMOTO CO., INC. , FUKUCHI, Naoyuki , ISHII, Koichi , KAIDA, Kenichi , KOBAYASHI, Tsuyoshi
发明人： AJINOMOTO CO., INC.
IPC分类号： C07K14/46
CPC分类号： C07K14/46 , A61K38/00
摘要： A peptide is obtained from a venom derived from Vipera palestina by screening various venoms for peptides that inhibit the binding of Von Willebrand factors with platelets even in a low concentration thereof and do not cause platelet aggregation. The obtained peptide has two differrent peptide chains and its molecular weight as determined by SDS polyacrylamide gel electrophoresis is about 25 kD and about 15 kD, respectively, under nonreducing and reducing conditions.
摘要翻译：通过对各种毒液筛选各种毒液来获得肽，所述多种毒液即使在低浓度下也能抑制血管性血友病因子与血小板的结合，并且不引起血小板聚集。所获得的肽具有两个不同的肽链，并且通过SDS聚丙烯酰胺凝胶电泳测定的分子量分别在非还原和还原条件下分别为约25kD和约15kD。

9. 发明申请

WO1995008334A1 ANTIMALARIAL 审中-公开
标题翻译：抗疟
公开(公告)号：WO1995008334A1
公开(公告)日：1995-03-30
申请号：PCT/JP1994001544
申请日：1994-09-20
申请人： AJINOMOTO CO., INC. , HAVLIK, Ivan , KANEKO, Yutaro , MIMURA, Tohru , CHIHARA, Goro
发明人： AJINOMOTO CO., INC.
IPC分类号： A61K31/725
CPC分类号： A61K31/715 , A61K31/49 , A61K31/727 , A61K31/737 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： A novel antimalarial containing a sulfated polysaccharide or a pharmaceutically acceptable salt thereof alone or together with quinine as the active ingredient and having a high therapeutic effect.
摘要翻译：一种含有硫酸化多糖或其药学上可接受的盐单独或与奎宁一起作为活性成分并具有高治疗效果的新型抗疟药。

10. 发明申请

WO1994028892A1 INHIBITOR FOR REJECTION ACCOMPANYING ORGAN TRANSPLANTATION 审中-公开
标题翻译：用于拒绝接管机构移送的抑制剂
公开(公告)号：WO1994028892A1
公开(公告)日：1994-12-22
申请号：PCT/JP1994000925
申请日：1994-06-08
申请人： AJINOMOTO CO., INC. , KANEKO, Yutaro , OKUMURA, Ko , MIMURA, Tohru , TANAKA, Koichi
发明人： AJINOMOTO CO., INC.
IPC分类号： A61K31/34
CPC分类号： A61K31/365
摘要： An inhibitor for rejection accompanying organ transplantation, containing a mycophenolic acid derivative represented by formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient and having an excellent effect of inhibiting the rejection.
摘要翻译：一种伴随器官移植排斥反应的抑制剂，其含有由式（I）表示的霉酚酸衍生物或其药学上可接受的盐作为活性成分，具有极好的抑制排斥作用。

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