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1. 发明申请

WO2009128661A3 A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF 审中-公开
标题翻译：新型苯并噻唑苯并咪唑衍生物，包含其的药物组合物及其用途
公开(公告)号：WO2009128661A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009001977
申请日：2009-04-16
申请人： DAE WOONG PHARMA , KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK HYUNJIN , PARK EUNKYUNG
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK HYUNJIN , PARK EUNKYUNG
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention relates to a novel benzoxazine benzimidazole derivative, which is a vanilloid receptor-1 antagonist, to a pharmaceutical composition comprising the same, and to a use thereof. The benzoxazine benzimidazole derivative according to the present invention can be beneficially used in the prevention and treatment of medical conditions associated with vanilloid receptor antagonist activity.
摘要翻译：本发明涉及一种新颖的苯并恶嗪苯并咪唑衍生物，其为香草酸受体-1拮抗剂，涉及含有该化合物的药物组合物及其用途。根据本发明的苯并恶嗪苯并咪唑衍生物可有利地用于预防和治疗与香草素受体拮抗剂活性相关的医学病症。

2. 发明公开

EP2054405A4 NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：新BIARYLBENZIMIDAZOLDERIVATE和药物组合物包含此
公开(公告)号：EP2054405A4
公开(公告)日：2011-01-19
申请号：EP07768695
申请日：2007-07-11
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , KIM IN WOO , HYUN HYAE JUNG
IPC分类号： C07D401/14 , A61K31/4439 , A61P29/00 , C07D401/04 , C07D413/14 , C07D471/04
CPC分类号： C07D401/10 , C07D401/04 , C07D401/14 , C07D413/14 , C07D471/04

3. 发明公开

EP2264031A4 A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF 有权
标题翻译：新型苯并恶嗪苯并咪唑衍生物，药物组合物和正确使用THEREOF
公开(公告)号：EP2264031A4
公开(公告)日：2012-06-13
申请号：EP09733372
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG
IPC分类号： C07D413/04 , A61K31/538 , A61P29/00 , C07D413/14
CPC分类号： C07D413/14 , C07D413/04

4. 发明公开

EP1861387A4 NOVEL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：新型苯并咪唑为了衍生物及其药物组合物
公开(公告)号：EP1861387A4
公开(公告)日：2011-04-13
申请号：EP06715777
申请日：2006-01-27
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG CHUL , KIM IN WOO , HYUN HYAE JUNG
IPC分类号： C07D401/04 , A61K31/4164 , A61K31/4184 , A61P17/04 , A61P29/00 , C07D235/04
CPC分类号： C07D401/10 , C07D235/12 , C07D235/14 , C07D401/04 , C07D403/10 , C07D403/14 , C07D471/04

5. 发明专利

PL1861387T3 Pochodne benzoimidazolu i ich kompozycje farmaceutyczne 未知
公开(公告)号：PL1861387T3
公开(公告)日：2014-08-29
申请号：PL06715777
申请日：2006-01-27
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK 401-1701 SEOHONG MAEUL HYOSUNG APT , YOON HONG CHUL , KIM IN WOO , HYUN HYAE JUNG
IPC分类号： C07D401/04 , A61K31/4164 , A61K31/4184 , A61P17/04 , A61P29/00 , C07D235/04

6. 发明专利

ES2468221T3 Derivados de bencimidazol y composiciones farmacéuticas del mismo 未知
公开(公告)号：ES2468221T3
公开(公告)日：2014-06-16
申请号：ES06715777
申请日：2006-01-27
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG CHUL , KIM IN WOO , HYUN HYAE JUNG
IPC分类号： C07D401/04 , A61K31/4164 , A61K31/4184 , A61P17/04 , A61P29/00 , C07D235/04
摘要： Un compuesto, o una sal farmacéuticamente aceptable del mismo, seleccionado de entre el grupo que consiste en 2-[4-(3-cloropiridin-2-il)fenil]-6-trifluorometil-1H-bencimidazol, 6-cloro-2-[4-(3-cloropiridin-2-il)fenil]-1H-bencimidazol, 6-terc-butil-2-[4-(3-cloropiridin-2-il)fenil]-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-6-fluoro-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-6-metoxi-1H-bencimidazol, 4-cloro-2-[4-(3-cloropiridin-2-il)fenil]-6-trifluorometil-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-4,6-bistrifluorometil-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-6-trifluorometil-1H-imidazo[4,5-b] piridina, 2-[4-(3-cloropiridin-2-il)fenil]-3H-imidazo[4,5-b] piridina, 2-[4-(3-cloropiridin-2-il)fenil]-6,7-dimetil-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-5,6-dicloro-1H-bencimidazol, 6-bromo-2-(4-(3-cloropiridin-2-il)fenil)-1H-bencimidazol, 4-bromo-2-(4-(3-cloropiridin-2-il)fenil)-6-(trifluorometil)-1H-bencimidazol, 6-bromo-2-(4-(3-cloropiridin-2-il)fenil-1H-imidazo[4,5-b] piridina, 4,6-dibromo-2-[4-(3-cloropiridin-2-il)fenil]-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-6-morfolin-4-il-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-6-tiomorfolin-4-il-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-4-morfolin-4-il-6-trifluorometil-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-4-tiomorfolin-4-il-6-trifluorometil-1H-bencimidazol, 2-[4-(3-cloropiridin-2-il)fenil]-4-pirrolidin-1-il-6-trifluorometil-1H-bencimidazol, {2-[4-(3-cloropiridin-2-il)fenil]-6-trifluorometil-1H-bencimidazol-4-il} dietilamina, 2-[4-(3-cloropiridin-2-il)fenil]-6-morfolin-4-il-1H-imidazo[4,5-b] piridina, 2-[4-(3-cloropiridin-2-il)fenil]-6-pirrolidin-1-il-1H-imidazo[4,5-b] piridina, 6-terc-butil-2-[4-(3,5-dicloropiridin-2-il)fenil]-1H-bencimidazol, 2-[4-(3,5-dicloropiridin-2-il)fenil]-4,6-bistrifluorometil-1H-bencimidazol, 6-terc-butil-2-[4-(3-cloro-5-trifluorometil-piridin-2-il)fenil]-1H-bencimidazol, 2-[4-(3-cloro-5-trifluorometilpiridin-2-il)fenil]-4,6-bistrifluorometil-1H-bencimidazol, 2-[4-(3-cloro-5-trifluorometilpiridin-2-il)fenil]-5,7-bistrifluorometil-1H-bencimidazol, N-[4'-(4,6-bistrifluorometil-1H-bencimidazol-2-il)-3-fluorobifenil-4-il] metansulfonamida, 6-terc-butil-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 4-cloro-6-trifluorometil-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 6-cloro-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 4,6-bistrifluorometil-2-[4-(3-trifluorometil piridin-2-il)fenil]-1H-bencimidazol, 6-trifluorometil-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-imidazo[4,5-b] piridina, 5,6-dicloro-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 4-bromo-6-(trifluorometil)-2-(4-(3-(trifluoro-metil)piridin-2-il)fenil)-1H-bencimidazol, 6-bromo-2-(4-(3-(trifluorometil)piridin-2-il)fenil)-1H-bencimidazol, 6-fluoro-2-(4-(3-(trifluorometil)piridin-2-il)fenil)-1H-bencimidazol, 6-bromo-2-(4-(3-(trifluorometil)piridin-2-il)fenil-1H-imidazo[4,5-b] piridina, 4,6-dibromo-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 6-morfolin-4-il-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 6-tiomorfolin-4-il-2-[4-(3-trifluorometil-piridin-2-il)fenil]-1H-bencimidazol, dietil-{2-[4-(3-trifluorometilpiridin-2-il)fenil]-3H-benzoimidazo-5-il} amina, 4-morfolin-4-il-6-trifluorometil-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 4-tiomorfolin-4-il-6-trifluorometil-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 4-pirrolidin-1-il-6-trifluorometil-2-[4-(3-trifluorometilpiridin-2-il)fenil]-1H-bencimidazol, 6-terc-butil-2-(4-piridin-2-ilfenil)-1H-bencimidazol, 6-((trifluorometil)-2-(4-(piridin-2-il)fenil)-1H-bencimidazol, 4-cloro-6-(trifluorometil)-2-(4-(piridin-2-il)fenil)-1H-bencimidazol, 5,6-dicloro-2-(4-(piridin-2-il)fenil)-1H-bencimidazol, 4,6-bis(trifluorometil)-2-(4-(piridin-2-il)fenil)-1H-bencimidazol, 55 6-fluoro-2-(4-(piridin-2-il)fenil)-1H-bencimidazol, 6-bromo-2-(4-(piridin-2-il)fenil)-1H-imidazo[4,5-b] piridina, 4,6-dibromo-2-(4-piridin-2-ilfenil)-1H-bencimidazol, 2-[4-(6-cloro-5-metilpiridacin-3-il)fenil]-4,6-bistrifluorometil-1H-bencimidazol, 2-[4-(6-cloro-5-metilpiridacin-3-il)fenil]-5,7-bistrifluorometil-1H-bencimidazol, 4-bromo-6-(trifluorometil)-2-(4-(4-(trifluoro-metil)pirimidin-2-il)fenil)-1H-bencimidazol, 4,6-dibromo-2-[4-(4-trifluorometilpirimidin-2-il)fenil]-1H-bencimidazol, 6-terc-butil-2-(4-(pirimidin-2-il)fenil)-1H-bencimidazol, 2-((4-(6-(trifluorometil)-1H-bencimidazol-2-il)fenil)piridin-3-carbonitrilo, 2-((4-(6-(terc-butil-1H-bencimidazol-2-il)fenil)piridin-3-carbonitrilo.

7. 发明专利

ES2438240T3 Nuevos derivados de biaril benzoimidazol y composición farmacéutica que los comprenden 未知
公开(公告)号：ES2438240T3
公开(公告)日：2014-01-16
申请号：ES07768695
申请日：2007-07-11
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , KIM IN WOO , HYUN HYAE JUNG
IPC分类号： C07D401/14 , A61K31/4439 , A61P29/00 , C07D401/04 , C07D413/14 , C07D471/04
摘要： Derivado de biaril benzoimidazol representado por la siguiente fórmula 1, o sal farmacéuticamente aceptable,solvato, o tautómero del mismo, en la que, R1 es hidrógeno o (CRaRa')mRb; m es un número entero de 0, 1 ó 2; Ra y Ra' son cada uno independientemente hidrógeno; halógeno; nitro; hidroxi; ciano; azida; amina; NH (alquilo C1-6); N (alquilo C1-6)2; alcoxi que tiene de 1 a 8 átomos de carbono; alquilo que tiene de 1 a 8 átomos de carbonosustituido o no sustituido con uno o más Rc; alquenilo que tiene de 2 a 8 átomos de carbono sustituido o nosustituido con uno o más Rc; fenilo sustituido o no sustituido con uno o más Rc; o bencilo sustituido o no sustituidocon uno o más Rc; Rb es hidrógeno; hidroxi, alquilo que tiene de 1 a 6 átomos de carbono sustituido o no sustituido con uno o más Rc; fenilo sustituido o no sustituido con uno o más Rc; o bencilo sustituido o no sustituido con uno más Rc; Rc es halógeno; ciano; nitro; azida; fenilo; bencilo; C (>=O) Rd ; C (>= O) ORd; C (>=O) NRdRd'; ORd; OC (>= O) Re; OC (>=O) ORe ; OC (>=O) NRdRd'; Oalquilo C1-6 ORd; Oalquilo C1-6 NRdRd'; SRd; S (>=O) Re; S (>=O)2Re; S (>=O)2 NRdRd';CRd>=NRd'; NRdRd'; NRdC (>=O) Re; NRdC (>=O) ORe; NRdC (>=O) NRd'Rd''; NRdC (>= NRd') NRd'' Rd'''; NRd S (>=O)2 Re,NRdORd'; NRd alquilo C1-6 NRd'Rd''; o NRd alquilo C1-6 ORd'; Rd, Rd', Rd'' y Rd''' son cada uno independientemente hidrógeno o Re; Re es fenilo sustituido o no sustituido con uno o más grupos seleccionados del grupo que comprende hidroxi,halógeno, alquilo que tiene de 1 a 4 átomos de carbono, haloalquilo que tiene de 1 a 3 átomos de carbono, alcoxique tiene de 1 a 4 átomos de carbono, amina, NH (alquilo C1-4 ), y N (alquilo C1-4)2; bencilo sustituido o no sustituidocon uno o más grupos seleccionados del grupo que comprende hidroxi, halógeno, alquilo que tiene de 1 a 4 átomosde carbono, haloalquilo que tiene de 1 a 3 átomos de carbono, alcoxi que tiene de 1 a 4 átomos de carbono, amina,NH (alquilo C1-4), y N (alquilo C1-4)2; alquilo que tiene de 1 a 6 átomos de carbono sustituido o no sustituido con uno omás grupos seleccionados del grupo que comprende hidroxi, halógeno, alquilo que tiene de 1 a 4 átomos decarbono, haloalquilo que tiene de 1 a 3 átomos de carbono, alcoxi que tiene de 1 a 4 átomos de carbono, amina, NH(alquilo C1-4), y N (alquilo C1-4)2, o ácido fosfórico.

8. 发明专利

PT1861387E DERIVADOS DE BENZIMIDAZOL E COMPOSIÇÕES FARMACÊUTICAS DOS MESMOS 未知
公开(公告)号：PT1861387E
公开(公告)日：2014-06-11
申请号：PT06715777
申请日：2006-01-27
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , KIM IN WOO , YOON HONG CHUL , HYUN HYAE JUNG
IPC分类号： C07D401/04 , A61K31/4164 , A61K31/4184 , A61P17/04 , A61P29/00 , C07D235/04

9. 发明专利

NZ587771A Novel benzoxazine benzimidazole derivatives, pharmaceutical composition comprising same, and a use thereof 未知
公开(公告)号：NZ587771A
公开(公告)日：2011-05-27
申请号：NZ58777109
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG , PARK HYUNJIN
IPC分类号： C07D413/14
摘要： Disclosed is a benzoxazine derivative of formula (1), or a salt, hydrate, solvate, or stereoisomer thereof, where the substituents and variables are as defined in the specification. Also disclosed is the use of the above compound to treat diseases associated with antagonistic activity of vanilloid receptor, such as acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, obesity, irritable bowel syndrome, cough, asthma, Chronic Obstructive Pulmonary Disease, glaucoma, burns, psoriasis, itching, vomiting, irritation of the skin, eyes, or mucous membranes, reflux esophagitis, gastricduodenal ulcers, and inflammatory diseases.

10. 发明专利

AU2006209117B2 Novel benzoimidazole derivatives and pharmaceutical composition comprising the same 未知
公开(公告)号：AU2006209117B2
公开(公告)日：2009-12-10
申请号：AU2006209117
申请日：2006-01-27
申请人： DAE WOONG PHARMA
发明人： HYUN HYAE JUNG , KIM JI DUCK , KIM IN WOO , YOON HONG CHUL
IPC分类号： C07D401/04 , A61K31/4164 , A61K31/4184 , A61P17/04 , A61P29/00 , C07D235/04
摘要： Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

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