专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2264031A4 A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF 有权
标题翻译：新型苯并恶嗪苯并咪唑衍生物，药物组合物和正确使用THEREOF
公开(公告)号：EP2264031A4
公开(公告)日：2012-06-13
申请号：EP09733372
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG
IPC分类号： C07D413/04 , A61K31/538 , A61P29/00 , C07D413/14
CPC分类号： C07D413/14 , C07D413/04

2. 发明专利

AU2009236824A1 A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof 未知
公开(公告)号：AU2009236824A1
公开(公告)日：2009-10-22
申请号：AU2009236824
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： CHO MIN JAE , KIM INWOO , LEE IN YOUNG , CHO SEONG HEE , YOON HONG-CHUL , PARK EUNKYUNG , HYUN HYAE JUNG , KIM JI DUCK
IPC分类号： C07D413/14
摘要： The present invention relates to a novel benzoxazine benzimidazole derivative of formula (1) as an antagonist against a vanilloid receptor-1, a pharmaceutical composition comprising the same as an active ingredient, and a use thereof. The benzoxazine benzimidazole derivative of the present invention may be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1: wherein, R 1 , R 2 , R 3 , R3', Q 1 , Q 2 , Q 3 and Q 4 have same meanings as defined in the specification.

3. 发明专利

NZ587771A Novel benzoxazine benzimidazole derivatives, pharmaceutical composition comprising same, and a use thereof 未知
公开(公告)号：NZ587771A
公开(公告)日：2011-05-27
申请号：NZ58777109
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG , PARK HYUNJIN
IPC分类号： C07D413/14
摘要： Disclosed is a benzoxazine derivative of formula (1), or a salt, hydrate, solvate, or stereoisomer thereof, where the substituents and variables are as defined in the specification. Also disclosed is the use of the above compound to treat diseases associated with antagonistic activity of vanilloid receptor, such as acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, obesity, irritable bowel syndrome, cough, asthma, Chronic Obstructive Pulmonary Disease, glaucoma, burns, psoriasis, itching, vomiting, irritation of the skin, eyes, or mucous membranes, reflux esophagitis, gastricduodenal ulcers, and inflammatory diseases.

4. 发明专利

CA2719515A1 A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF 未知
公开(公告)号：CA2719515A1
公开(公告)日：2009-10-22
申请号：CA2719515
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG
IPC分类号： C07D413/14
摘要： The present invention relates to a novel benzoxazine benzimidazole derivative, which is a vanilloid receptor-1 antagonist, to a pharmaceutical composition comprising the same, and to a use thereof. The benzoxazine benzimidazole derivative according to the present invention can be beneficially used in the prevention and treatment of medical conditions associated with vanilloid receptor antagonist activity.

5. 发明专利

ES2539290T3 Un derivado novedoso de benzoxazina bencimidazol, una composición farmacéutica que comprende el mismo y su uso 未知
公开(公告)号：ES2539290T3
公开(公告)日：2015-06-29
申请号：ES09733372
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG
IPC分类号： C07D413/04 , A61K31/538 , A61P29/00 , C07D413/14
摘要： Un compuesto de fórmula (1) o una de sus sales, hidratos o solvatos farmacéuticamente aceptables:**Fórmula** en la que, R1 es hidrógeno (CRaRa')mRb, siendo cada 5 Ra y Ra' independientemente hidrógeno; alquilo C1-C8; alquenilo C2- C8; halógeno; nitro; hidroxi; ciano; azido; amino; fenilo; bencilo; alcoxi C1-C8; alquilamino C1-C6; o alquilo C1-C6 , fenilo o bencilo sustituidos que tienen uno o más grupos Rc; y siendo Rb hidrógeno; hidroxi; o alquilo C1-C6 , fenilo o bencilo sustituidos que tienen uno o más grupos Rc; en el que Rc es halógeno; ciano; nitro; azido; fenilo; bencilo; C(>=O)Rd; C(>=O)ORd; C(>=O)NRdRd; ORd; OC(>=O)Re; OC(>=O)ORe; OC(>=O)NRdRd; O alquilo C1-C6 ORd; OalquiloC1-C6NRdRd; SRd; S(>=O)Re; S(>=O)2Re; S(>=O)2NRdRd; CRd>=NRd; NRdRd; NRdC(>=O)Re; NRdC(>=O)ORe; NRdC(>=O)NRdRd; NRdC(>=NRd)NRdRd; NRdS(>=O)2Re; NRdORd; NRdalquiloC1-C6NRdRd; o NRdalquil C1-C6ORd; en la que Rd es hidrógeno o Re; siendo Re fenilo; bencilo; alquilo C1-C6; o fenilo, bencilo o alquilo C1-C6 sustituidos que tienen uno o más grupos hidroxi, halógeno, alquilo C1-C4, haloalquilo C1-C3, alcoxi C1-4, amino, alquilamino C1-C4 o di(alquil C1-C4)amino; y m es 0, 1, o 2; R2 es (CH2)pU en el que p es 0, 1, o 2; y U es morfolinilo, o**Fórmula** R14, R15 y R16 son independientemente hidrógeno; alquilo C1-C8; cicloalquilo; alquenilo C2-C6; alcoxi C1-C6; haloalquilo C1-C6; haloalcoxi C1-C6; halógeno; nitro; hidroxi; hidroxialquilo C1-C6; ciano; sulfanilo; urea; amino; carboxilo; amino sustituido, o carboxilo que tiene uno o dos grupos alquilo C1-C3; o dos cualquiera de R14, R15 y R16 estando condensados entre sí para formar un anillo heteromonocíclico o heterobicíclico saturado o insaturado; R3 y R3' son independientemente hidrógeno; alquilo C1-C10; alquenilo C2-C10; alquinilo C2-C10; cicloalquilo C3-C10; bicicloalquilo C8-C14; cicloalquenilo C3-C10; bicicloalquenilo C8-C14; heterocicloalquilo C3-C7; heterobicicloalquilo C7-C10; hidroxialquilo C1-C6; alcoxi C1-C8; haloalquilo C1-C6; haloalcoxi C1-C6; halógeno; nitro; hidroxi; ciano; azido; amino; hidroxialquilo C1-C6, alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, cicloalquilo C3-C10; bicicloalquilo C8-C14, cicloalquenilo C3-C10, bicicloalquenilo C8-C14, heterocicloalquilo C3-C7 o heterobicicloalquilo C7-C10 sustituido que tiene uno o más sustituyentes Rf; fenilo; naftilo; bencilo; heteroarilo C5-C10; o fenilo, naftilo, bencilo o heteroarilo C5-C10 sustituidos que tienen uno o más sustituyentes Rf; en donde Q1 es N o CR4; Q2 es N o CR5; Q3 es N o CR6; Q4 es N o CR7; R4, R5, R6, y R7 son independientemente hidrógeno; alquilo C1-C10; alquenilo C2-C10; alquinilo C2-C10; cicloalquilo C3-C10; bicicloalquilo C8-C14; cicloalquenilo C3-C10; bicicloalquenilo C8-C14; heterocicloalquilo C3-C7; heterobicicloalquilo C7-C10; alcoxi C1-C8; haloalquilo C1-C6; haloalcoxi C1-C6; halógeno; nitro; hidroxi; ciano; azido; amino; alquilo C3- C10, alquenilo C2-C10, alquinilo C2-C10, cicloalquilo C3-C10; bicicloalquilo C8-C14, cicloalquenilo C3-C10, bicicloalquenilo C8-C14, heterocicloalquilo C3-C7 o heterobicicloalquilo C7-C10 sustituidos que tienen uno o más grupos Rh; fenilo; naftilo; bencilo; heteroarilo C5-C10; fenilo, naftilo, bencilo o heteroarilo C5-C10 sustituidos que tienen uno o más sustituyentes Rh; C(>=O)Ri; C(>=O)ORi; C(>=O)NRiRi; ORi; OC(>=O)Rj; OC(>=O)ORj; OC(>=O)NRiRi; OalquiloC1-C6ORi; O alquilo C1-C6 NRiRi; SRi, S(>=O)Rj; S(>=O)2Rj; S(>=O)2NRiRi; CRi>=NRi; NRiRi; NRiC(>=O)Rj; NRiC(>=O)ORj; NRiC(>=O)NRiRi; NRiC(>=NRi)NRiRi; NRiS(>=O)2Rj; NRiORi; NRi alquilo C1-C6NRiRi; o NRi alquilo C1- C6 ORi; o dos cualquiera de R4, R5, R6 y R7 estando condensados entre sí para formar un anillo heteromonocíclico saturado, parcialmente saturado o insaturado, de 5, 6 o 7 miembros, o un anillo heterobicíclico de 6, 7, 8, 9, 10 u 11 miembros saturado, parcialmente saturado o insaturado que tiene de uno a cuatro grupos nitrógeno, oxígeno o azufre; en las que Rf y Rh son cada uno independientemente alquilo C1-C6; alquenilo C2-C6; alquinilo C2-C6; cicloalquilo C3-C8; cicloalquenilo C5-C8; heterocicloalquilo C3-C5; haloalquilo C1-C6; haloalcoxi C1- C6; halógeno; azido; nitro; ciano; fenilo; bencilo; C(>=O)Ri; -C(O)ORi, C(>=O)NRiRi; ORi; OC(>=O)Rj; OC(>=O)ORj;

6. 发明专利

CA2719515C A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF 未知
公开(公告)号：CA2719515C
公开(公告)日：2013-11-05
申请号：CA2719515
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK EUNKYUNG
IPC分类号： C07D413/14
摘要： The present invention relates to a novel benzoxazine benzimidazole derivative of formula (1) as an antagonist against a vanilloid receptor-1, a pharmaceutical composition comprising the same as an active ingredient, and a use thereof. The benzoxazine benzimidazole derivative of the present invention may be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1: (see formula 1) wherein, R1, R2, R3, R3, Q1, Q2, Q-3 and Q4 have same meanings as defined in the specification.

7. 发明专利

AU2009236824A2 A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof 未知
公开(公告)号：AU2009236824A2
公开(公告)日：2010-10-28
申请号：AU2009236824
申请日：2009-04-16
申请人： DAE WOONG PHARMA
发明人： CHO MIN JAE , KIM INWOO , LEE IN YOUNG , CHO SEONG HEE , YOON HONG-CHUL , PARK EUNKYUNG , HYUN HYAE JUNG , KIM JI DUCK
IPC分类号： C07D413/14
摘要： The present invention relates to a novel benzoxazine benzimidazole derivative of formula (1) as an antagonist against a vanilloid receptor-1, a pharmaceutical composition comprising the same as an active ingredient, and a use thereof. The benzoxazine benzimidazole derivative of the present invention may be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1: wherein, R 1 , R 2 , R 3 , R3', Q 1 , Q 2 , Q 3 and Q 4 have same meanings as defined in the specification.

8. 发明申请

WO2016129933A8 SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译：钠通道阻塞剂
公开(公告)号：WO2016129933A8
公开(公告)日：2017-05-04
申请号：PCT/KR2016001395
申请日：2016-02-11
申请人： DAE WOONG PHARMA
发明人： KIM JI DUCK , LEE HYUNG-GEUN , KIM INWOO , JUN SUN AH , JUNG MYUNGGI , KIM HYO SHIN
IPC分类号： C07D231/54 , A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D209/10 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D403/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav 1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (PEPD).
摘要翻译：本发明涉及对钠离子通道具有阻断作用的化合物，特别是Nav 1.7，其制备方法及其用途。由式1表示的化合物或其药学上可接受的盐，水合物，溶剂化物或异构体可有效地用于预防或治疗疼痛，例如急性疼痛，慢性疼痛，神经疾病引起的疼痛，术后疼痛，偏头痛，关节痛，神经病变，神经损伤，糖尿病性神经病变，神经病性疾病，癫痫症，心律失常，肌强直，共济失调，多发性硬化症，肠易激综合征，尿失禁，内脏痛，抑郁症，红斑性肢痛，阵发性极痛（PEPD）。

9. 发明申请

WO2009128661A3 A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF 审中-公开
标题翻译：新型苯并噻唑苯并咪唑衍生物，包含其的药物组合物及其用途
公开(公告)号：WO2009128661A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009001977
申请日：2009-04-16
申请人： DAE WOONG PHARMA , KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK HYUNJIN , PARK EUNKYUNG
发明人： KIM JI DUCK , YOON HONG-CHUL , CHO SEONG HEE , KIM INWOO , CHO MIN JAE , LEE IN YOUNG , HYUN HYAE JUNG , PARK HYUNJIN , PARK EUNKYUNG
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention relates to a novel benzoxazine benzimidazole derivative, which is a vanilloid receptor-1 antagonist, to a pharmaceutical composition comprising the same, and to a use thereof. The benzoxazine benzimidazole derivative according to the present invention can be beneficially used in the prevention and treatment of medical conditions associated with vanilloid receptor antagonist activity.
摘要翻译：本发明涉及一种新颖的苯并恶嗪苯并咪唑衍生物，其为香草酸受体-1拮抗剂，涉及含有该化合物的药物组合物及其用途。根据本发明的苯并恶嗪苯并咪唑衍生物可有利地用于预防和治疗与香草素受体拮抗剂活性相关的医学病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式