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1. 发明申请

US20070299477A1 Secure and Efficacious Therapy Delivery for a Pacing Engine 审中-公开
标题翻译：安全和有效的治疗发送起搏发动机
公开(公告)号：US20070299477A1
公开(公告)日：2007-12-27
申请号：US11765260
申请日：2007-06-19
申请人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel , John Burnes
发明人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett , David Euler , Lawrence Mulligan , Edwin Duffin , David Igel , John Burnes
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译：据信上述方法和装置对患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益被指示。应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。

2. 发明申请

US20050090872A1 Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy 有权
标题翻译：心脏起搏模式具有改善的消隐，时机和治疗收费刺激起搏治疗方法
公开(公告)号：US20050090872A1
公开(公告)日：2005-04-28
申请号：US10692990
申请日：2003-10-24
申请人： D. Deno , Vincent Splett , Jeffrey Gillberg , Glenn Zillmer , Ruth Klepfer , Karen Kleckner
发明人： D. Deno , Vincent Splett , Jeffrey Gillberg , Glenn Zillmer , Ruth Klepfer , Karen Kleckner
IPC分类号： A61N20060101 , A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

3. 发明申请

US20050101998A1 Secure and efficacious therapy delivery for an extra-systolic stimulation pacing engine 有权
标题翻译：安全有效的治疗输精管收缩期刺激起搏引擎
公开(公告)号：US20050101998A1
公开(公告)日：2005-05-12
申请号：US10703956
申请日：2003-11-07
申请人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett
发明人： Karen Kleckner , Kathleen Prieve , Jeffrey Gillberg , Ren Zhou , Kenneth Anderson , D. Deno , Glenn Zillmer , Ruth Klepfer , Vincent Splett
IPC分类号： A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： An extra-systolic stimulation (ESS) therapy addresses cardiac dysfunction including heart failure. ESS therapy employs atrial and/or ventricular extra-systoles via pacing-level stimulation to a heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). The present invention relates to therapy delivery guidance and options for improved ESS therapy delivery. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：收缩期刺激（ESS）治疗涉及心脏功能障碍，包括心力衰竭。 ESS治疗通过对心脏的起搏水平刺激使用心房和/或心室超心动过速。这些额外的收缩期必须正确定时，以达到对心肌力学（功效）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。本发明涉及治疗递送指导和改善ESS治疗递送的选择。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

4. 发明申请

US20050075676A1 Refractory period tracking and arrhythmia detection 有权
$Refractory period tracking and arrhythmia detection$
标题翻译：难治期跟踪和心律失常检测
公开(公告)号：US20050075676A1
公开(公告)日：2005-04-07
申请号：US10680528
申请日：2003-10-07
申请人： D. Deno , Ruth Klepfer , William Havel , David Schneider , Vincent Splett
发明人： D. Deno , Ruth Klepfer , William Havel , David Schneider , Vincent Splett
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： Techniques for estimating the temporal refractory period of a heart, for adjusting a parameter for delivery of extra-systolic stimulation (ESS) therapy and for detecting an arrhythmia during delivery of ESS therapy are disclosed. In some embodiments, probe pulses are periodically delivered to estimate the location of the end boundary of the refractory period, and accordingly estimate its length. In some embodiments, the parameter is adjusted based on estimated length of the refractory period. For example, an extra-systolic interval (ESI) for delivery of ESS is adjusted to be a fixed interval longer than estimated lengths of the refractory period. In other embodiments, the parameter is adjusted based on a measured delay (or latency) between delivery of an ESS pulse and detection of an evoked response resulting from the pulse. In some embodiments, delays between delivery of an ESS pulse and detection of a subsequent depolarization are monitored to detect an arrhythmia.
摘要翻译：公开了用于估计心脏的时间不应期的技术，用于调整用于递送收缩期刺激（ESS）治疗的参数和用于在递送ESS治疗期间检测心律失常的技术。在一些实施例中，周期性地递送探针脉冲以估计不应期的末端边界的位置，并因此估计其长度。在一些实施例中，基于估计的不应期的长度来调整参数。例如，用于递送ESS的收缩期间期（ESI）被调整为比不应期的估计长度更长的固定间隔。在其他实施例中，基于在递送ESS脉冲和从脉冲产生的诱发响应的检测之间的测量延迟（或等待时间）来调整参数。在一些实施例中，监测递送ESS脉冲和随后去极化的检测之间的延迟以检测心律失常。

5. 发明申请

US20070073352A1 Method and apparatus for regulating a cardiac stimulation therapy 审中-公开
标题翻译：用于调节心脏刺激疗法的方法和装置
公开(公告)号：US20070073352A1
公开(公告)日：2007-03-29
申请号：US11237177
申请日：2005-09-28
申请人： David Euler , Tommy Bennett , Ven Manda , D. Deno , Vincent Splett
发明人： David Euler , Tommy Bennett , Ven Manda , D. Deno , Vincent Splett
IPC分类号： A61N1/00
CPC分类号： A61N1/36564 , A61B5/02028 , A61B5/0215 , A61B5/0422 , A61B5/7285 , A61N1/3627
摘要： A method comprising sensing a blood pressure signal, deriving a hemodynamic measure from the sensed blood pressure signal, adjusting an extra systolic stimulation control parameter in response to the hemodynamic measure, and delivering extra systolic stimulation pulses according to the adjusted control parameter. The sensed blood pressure signal may be a ventricular or arterial blood pressure signal from which an estimated cardiac output, end diastolic pressure, mean pressure or any other hemodynamic measure is derived. Adjusting the extra systolic stimulation control parameter may include adjusting a pacing rate, a pacing interval, an extra systolic stimulation ratio, an extra systolic stimulation interval or enabling or terminating the extra systolic stimulation.
摘要翻译：一种方法，包括感测血压信号，从感测到的血压信号导出血液动力学测量值，响应于血液动力学测量值调整额外的收缩刺激控制参数，以及根据所调整的控制参数递送额外的收缩刺激脉冲。所感测的血压信号可以是心室或动脉血压信号，从其导出估计的心输出量，舒张末期压力，平均压力或任何其它血液动力学测量值。调整额外的收缩刺激控制参数可以包括调整起搏速率，起搏间隔，额外的收缩期刺激比，额外的收缩期刺激间期或启用或终止额外的收缩期刺激。

6. 发明申请

US20060167358A1 Method and apparatus for muscle function measurement 有权
标题翻译：肌肉功能测量的方法和装置
公开(公告)号：US20060167358A1
公开(公告)日：2006-07-27
申请号：US11043819
申请日：2005-01-26
申请人： Mustafa Karamanoglu , Vincent Splett , Tommy Bennett
发明人： Mustafa Karamanoglu , Vincent Splett , Tommy Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, {dot over (E)}/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from {dot over (E)}/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译：本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。瞬时刚度比（E / E（t））以1 /秒为单位，与强键形成速率有关，并受肌肉纤维的钙处理性能和细胞内钙浓度的影响。因此，从{dot over（E / E（t））得到的指数提供肌肉肌力状态的量度。

7. 发明申请

US20050159786A1 Method and apparatus for hardware/firmware trap 有权
标题翻译：硬件/固件陷阱的方法和装置
公开(公告)号：US20050159786A1
公开(公告)日：2005-07-21
申请号：US11077242
申请日：2005-03-10
申请人： Vincent Splett , Carl Schu , Mark Haerle , Paul Huelskamp
发明人： Vincent Splett , Carl Schu , Mark Haerle , Paul Huelskamp
IPC分类号： A61N1/37 , A61N1/362 , A61N1/372 , G06F9/42 , G06F9/445 , G06F9/48 , G06F11/00 , A61N1/08
CPC分类号： G06F9/4812 , A61N1/362 , A61N1/37 , A61N1/37211 , A61N1/37264 , G06F8/60 , G06F9/328 , G06F9/4486
摘要： A method and an apparatus for a hardware/firmware trap. At least one set of a firmware code is executed for operation of the device. Modification to the operation of the device is performed. The modification to the operation comprises: receiving a patch code; creating a firmware trap; generating an interrupt in response to the firmware trap; and executing the patch code in response to the interrupt.
摘要翻译：一种用于硬件/固件陷阱的方法和装置。对设备的操作执行至少一组固件代码。执行对设备的操作的修改。对操作的修改包括：接收补丁码; 创建固件陷阱; 响应于固件陷阱产生中断; 并响应于中断来执行补丁代码。

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