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1. 发明申请

US20070179385A1 Method for continuous baroreflex sensitivity measurement 有权
标题翻译：连续压力反射灵敏度测量方法
公开(公告)号：US20070179385A1
公开(公告)日：2007-08-02
申请号：US11343635
申请日：2006-01-31
申请人： Yong Cho , Tommy Bennett
发明人： Yong Cho , Tommy Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0816 , A61B5/7285 , A61N1/3627 , A61N1/36521 , A61N1/368
摘要： A medical device and method for determining baroreflex sensitivity (BRS) based on one or more respiration cycles. The BRS determination may be performed continuously based on measurements of heart rate, blood pressure, and respiration cycles.
摘要翻译：一种用于根据一个或多个呼吸周期来确定压力反射灵敏度（BRS）的医疗装置和方法。可以基于心率，血压和呼吸周期的测量来连续进行BRS测定。

2. 发明申请

US20060173248A1 Derivation of flow contour from pressure waveform 有权
标题翻译：从压力波形推导流量轮廓
公开(公告)号：US20060173248A1
公开(公告)日：2006-08-03
申请号：US11045574
申请日：2005-01-27
申请人： Mustafa Karamanoglu , Tommy Bennett
发明人： Mustafa Karamanoglu , Tommy Bennett
IPC分类号： A61B5/00
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/029 , A61B5/7239
摘要： The present invention provides a system and method for estimating a blood flow waveform contour from a pressure signal. An arterial or ventricular pressure signal is acquired from a pressure sensor. Landmark points are identified on the pressure waveform that correspond to features of a flow waveform. In one embodiment, the landmark pressure waveform points correspond to the onset of flow, the peak flow, and the end of the systolic ejection phase. The landmark pressure waveform points define a contour that approximates the flow contour. Beat-by-beat flow contour estimation can be performed to allow computation of flow-related hemodynamic parameters such as stroke volume or cardiac output for use in patient monitoring and/or therapy management.
摘要翻译：本发明提供一种用于从压力信号估计血流波形轮廓的系统和方法。从压力传感器获取动脉或心室压力信号。在与流量波形的特征对应的压力波形上标识地标点。在一个实施例中，标记压力波形点对应于流动的开始，峰值流动和收缩期喷射阶段的结束。界标压力波形点定义近似流轮廓的轮廓。可以进行逐搏流轮廓估计，以允许计算流动相关的血液动力学参数，例如用于患者监测和/或治疗管理的中风体积或心输出量。

3. 发明申请

US20070156057A1 Method and system for interpreting hemodynamic data incorporating patient posture information 审中-公开
标题翻译：用于解释包含患者姿势信息的血液动力学数据的方法和系统
公开(公告)号：US20070156057A1
公开(公告)日：2007-07-05
申请号：US11323895
申请日：2005-12-30
申请人： Yong Cho , Yongduk Cho , Tommy Bennett
发明人： Yong Cho , Yongduk Cho , Tommy Bennett
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61N1/36535 , A61N1/36542
摘要： Systems and methods for improving hemodynamic data interpretation by accounting for the effects of patient posture is disclosed. In certain embodiments, a posture signal is acquired and used to categorize hemodynamic data according to posture to facilitate distinguishing posture-related changes in acquired hemodynamic data from those due to pathophysiologic changes. Posture information may be used to normalize data acquired in various postures to facilitate interpretation of such data. Baseline measurements of hemodynamic data acquired in various postures may also be used to subsequently detect changes in patient posture without the need for an implanted posture sensor.
摘要翻译：公开了通过考虑患者姿势的影响来改善血液动力学数据解释的系统和方法。在某些实施例中，获取姿势信号并用于根据姿势对血液动力学数据进行分类，以便于将所获得的血液动力学数据中的姿势相关变化与由于病理生理变化引起的姿势相关的变化区分开。姿势信息可以用于对在各种姿势中获取的数据进行归一化，以便于解释这些数据。在各种姿势中获取的血液动力学数据的基线测量也可用于随后检测患者姿势的变化，而不需要植入的姿势传感器。

4. 发明申请

US20060167360A1 System and method for detecting artifactual hemodynamic waveform data 有权
标题翻译：用于检测人为血液动力波形数据的系统和方法
公开(公告)号：US20060167360A1
公开(公告)日：2006-07-27
申请号：US11044618
申请日：2005-01-27
申请人： Tommy Bennett , Mark Choi , David Igel , Michael Hill , Teresa Whitman
发明人： Tommy Bennett , Mark Choi , David Igel , Michael Hill , Teresa Whitman
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02108
摘要： A system and method for cardiovascular analysis includes an implantable medical device capable of generating hemodynamic pressure waveform data based upon sensed pressure. Hemodynamic waveform data is analyzed to identify artifactual data represented in the hemodynamic waveform.
摘要翻译：用于心血管分析的系统和方法包括能够基于检测到的压力产生血流动力压力波形数据的可植入医疗装置。分析血流动力学波形数据以识别在血流动力学波形中表示的人为因素数据。

5. 发明申请

US20070255112A1 VOLUME DEPLETION DETECTION 有权
标题翻译：体积检测
公开(公告)号：US20070255112A1
公开(公告)日：2007-11-01
申请号：US11380710
申请日：2006-04-28
申请人： Robert Taepke , Yong Cho , Joel Lauer , Tommy Bennett
发明人： Robert Taepke , Yong Cho , Joel Lauer , Tommy Bennett
IPC分类号： A61B5/00
CPC分类号： A61B5/0215 , A61M5/14276 , A61M2205/3523 , A61N1/36521 , A61N1/36564 , A61N1/37258 , G06F19/00
摘要： Detection of volume depletion, particularly after an incidence of volume overload is disclosed. Various methods, systems, and devices are disclosed that sense and analyze a physiological parameter related to a patient's fluid level in order to warn patients of potentially dangerous volume depletion conditions while minimizing false notifications.
摘要翻译：体积消耗的检测，特别是容量过载发生之后。公开了各种方法，系统和装置，其感测和分析与患者的液体水平相关的生理参数，以便在最小化假通知的同时警告患者潜在危险的体积消耗条件。

6. 发明申请

US20070255327A1 Implantable Medical Device with Electromechanical Delay Measurement for Lead Position and Ventricular 有权
标题翻译：可植入医疗器械，用于引导位置和心室的机电延迟测量
公开(公告)号：US20070255327A1
公开(公告)日：2007-11-01
申请号：US11380350
申请日：2006-04-26
申请人： Yong Cho , Beth Geiman Ferri , Tommy Bennett
发明人： Yong Cho , Beth Geiman Ferri , Tommy Bennett
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N2001/083
摘要： The cardiac rhythm management system includes an implantable medical device (IMD) with leads carrying electrodes for sensing cardiac electrical activity, and a physiologic sensor for sensing cardiac mechanical activity. The IMD measures electromechanical delays between electrical activity sensed by the electrodes and mechanical activity sensed by the physiologic sensor. The measured electromechanical delays can be used to detect lead dislodgement and to assess dyssynchrony between two areas of the heart, such as the right ventricle and the left ventricle.
摘要翻译：心律管理系统包括具有承载用于感测心脏电活动的电极的引线的可植入医疗装置（IMD）和用于感测心脏机械活动的生理传感器。 IMD测量由电极感测的电活动和生理传感器感测到的机械活动之间的机电延迟。测量的机电延迟可用于检测引线移动并评估心脏两个区域之间的不同步，例如右心室和左心室。

7. 发明申请

US20070073352A1 Method and apparatus for regulating a cardiac stimulation therapy 审中-公开
标题翻译：用于调节心脏刺激疗法的方法和装置
公开(公告)号：US20070073352A1
公开(公告)日：2007-03-29
申请号：US11237177
申请日：2005-09-28
申请人： David Euler , Tommy Bennett , Ven Manda , D. Deno , Vincent Splett
发明人： David Euler , Tommy Bennett , Ven Manda , D. Deno , Vincent Splett
IPC分类号： A61N1/00
CPC分类号： A61N1/36564 , A61B5/02028 , A61B5/0215 , A61B5/0422 , A61B5/7285 , A61N1/3627
摘要： A method comprising sensing a blood pressure signal, deriving a hemodynamic measure from the sensed blood pressure signal, adjusting an extra systolic stimulation control parameter in response to the hemodynamic measure, and delivering extra systolic stimulation pulses according to the adjusted control parameter. The sensed blood pressure signal may be a ventricular or arterial blood pressure signal from which an estimated cardiac output, end diastolic pressure, mean pressure or any other hemodynamic measure is derived. Adjusting the extra systolic stimulation control parameter may include adjusting a pacing rate, a pacing interval, an extra systolic stimulation ratio, an extra systolic stimulation interval or enabling or terminating the extra systolic stimulation.
摘要翻译：一种方法，包括感测血压信号，从感测到的血压信号导出血液动力学测量值，响应于血液动力学测量值调整额外的收缩刺激控制参数，以及根据所调整的控制参数递送额外的收缩刺激脉冲。所感测的血压信号可以是心室或动脉血压信号，从其导出估计的心输出量，舒张末期压力，平均压力或任何其它血液动力学测量值。调整额外的收缩刺激控制参数可以包括调整起搏速率，起搏间隔，额外的收缩期刺激比，额外的收缩期刺激间期或启用或终止额外的收缩期刺激。

8. 发明申请

US20070073171A1 Methods for detecting and monitoring sleep disordered breathing using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测和监测睡眠无序呼吸的方法
公开(公告)号：US20070073171A1
公开(公告)日：2007-03-29
申请号：US11237354
申请日：2005-09-28
申请人： Yong Cho , Tommy Bennett , Barbro Kjellstrom
发明人： Yong Cho , Tommy Bennett , Barbro Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

9. 发明申请

US20060167516A1 System and method for monitoring a ventricular pressure index to predict worsening heart failure 有权
公开(公告)号：US20060167516A1
公开(公告)日：2006-07-27
申请号：US11045571
申请日：2005-01-27
申请人： Barbro Kjellstrom , Tommy Bennett
发明人： Barbro Kjellstrom , Tommy Bennett
IPC分类号： A61N1/36 , A61B5/02
CPC分类号： A61N1/36564
摘要： A medical device monitors a patient to predict worsening heart failure. An input circuit of the medical device receives a pressure signal representative of a pressure sensed within a ventricle of the patient's heart as a function of time. A processor derives from the pressure signal a ventricular pressure index for a ventricular contraction based upon pressures in the ventricle. The processor then provides an output based upon the ventricular pressure index.

10. 发明申请

US20060167361A1 Method and apparatus for continuous pulse contour cardiac output 审中-公开
公开(公告)号：US20060167361A1
公开(公告)日：2006-07-27
申请号：US11045573
申请日：2005-01-27
申请人： Tommy Bennett , Robert Taepke , Barbro Kjellstrom
发明人： Tommy Bennett , Robert Taepke , Barbro Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.

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