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1. 发明授权

US09066769B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US09066769B2
公开(公告)日：2015-06-30
申请号：US12345937
申请日：2008-12-30
申请人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61B19/00
CPC分类号： A61B17/8836 , A61B17/8816 , A61B17/8822 , A61B2017/00022 , A61B2017/00411 , A61B2017/00955 , A61B2017/8844 , A61B2090/064
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.
摘要翻译：讨论了治疗椎体压缩骨折的系统和方法。在一个实施方案中，一种方法包括混合骨水泥前体，从而引起第一化学固化反应，其特征在于第一时间粘度分布，可控地从外部来源向骨粘固剂施加能量以将第一时间粘度分布修改为第二次 - 粘度分布，并且在延长的工作时间内以大于约1000Pa·s至大于约5000Pa·s的基本上恒定的粘度将骨水泥注入骨中。在另一个实施例中，提供一种骨粘固剂注射器系统，其包括第一手柄部件，该第一手柄部件可拆卸地联接到具有用于定位在骨头中的远端的第二套筒部件和延伸穿过第一和第二部件的流动通道。该系统包括第一和第二热能发射器，用于分别在第一和第二部件中的流动通道部分中向骨水泥流输送能量。

2. 发明申请

US20090198242A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20090198242A1
公开(公告)日：2009-08-06
申请号：US12345937
申请日：2008-12-30
申请人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/58
CPC分类号： A61B17/8836 , A61B17/8816 , A61B17/8822 , A61B2017/00022 , A61B2017/00411 , A61B2017/00955 , A61B2017/8844 , A61B2090/064
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.
摘要翻译：讨论了治疗椎体压缩骨折的系统和方法。在一个实施方案中，一种方法包括混合骨水泥前体，从而引起第一化学固化反应，其特征在于第一时间粘度分布，可控地从外部来源向骨粘固剂施加能量以将第一时间粘度分布修改为第二次 - 粘度分布，并且在延长的工作时间内以大于约1000Pa.s至大于约5000Pa.s的基本上恒定的粘度将骨水泥注入骨中。在另一个实施例中，提供一种骨粘固剂注射器系统，其包括第一手柄部件，该第一手柄部件可拆卸地联接到具有用于定位在骨头中的远端的第二套筒部件和延伸穿过第一和第二部件的流动通道。该系统包括第一和第二热能发射器，用于分别在第一和第二部件中的流动通道部分中向骨水泥流输送能量。

3. 发明申请

US20100016467A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20100016467A1
公开(公告)日：2010-01-21
申请号：US12395527
申请日：2009-02-27
申请人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： C08L33/12
CPC分类号： A61L24/06 , A61B17/8805 , A61B17/8822 , A61B17/8833 , A61B2017/00022 , A61L24/0084 , A61L24/02 , A61L24/043 , A61L27/16 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.
摘要翻译：本公开内容涉及具有用于椎体成形术程序和其它骨成形术程序的延长工作时间的骨水泥制剂以及水泥注射器，其包括用于按需控制水泥粘度和流动参数的能量输送系统。骨水泥制剂可以包括具有至少一种单体和包含聚合物颗粒和过氧化苯甲酰（BPO））的非液体组分的液体组分。非液体组分可以进一步构造成允许BPO受控地暴露于液体单体，以便能够控制骨水泥组合物的粘度。

4. 发明申请

US20090247664A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20090247664A1
公开(公告)日：2009-10-01
申请号：US12395532
申请日：2009-02-27
申请人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： A61L24/04 , A61K6/08
CPC分类号： A61L24/0094 , A61B17/7095 , A61B17/8822 , A61B17/8833 , A61B17/8836 , A61B2017/00022 , A61K31/78 , A61L24/001 , A61L24/0084 , A61L24/0089 , A61L24/06 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.
摘要翻译：本公开内容涉及具有用于椎体成形术程序和其它骨成形术程序的延长工作时间的骨水泥制剂以及水泥注射器，其包括用于按需控制水泥粘度和流动参数的能量输送系统。骨水泥制剂可以包括具有至少一种单体和包含聚合物颗粒和过氧化苯甲酰（BPO））的非液体组分的液体组分。非液体组分可以进一步构造成允许BPO受控地暴露于液体单体，以便能够控制骨水泥组合物的粘度。

5. 发明授权

US08487021B2 Bone treatment systems and methods 有权
公开(公告)号：US08487021B2
公开(公告)日：2013-07-16
申请号：US12395532
申请日：2009-02-27
申请人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： C08K9/12 , A61F2/28 , A61L24/06
CPC分类号： A61L24/0094 , A61B17/7095 , A61B17/8822 , A61B17/8833 , A61B17/8836 , A61B2017/00022 , A61K31/78 , A61L24/001 , A61L24/0084 , A61L24/0089 , A61L24/06 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.

6. 发明授权

US09445854B2 Bone treatment systems and methods 有权
公开(公告)号：US09445854B2
公开(公告)日：2016-09-20
申请号：US12395527
申请日：2009-02-27
申请人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： A61L24/06 , A61B17/88 , A61L24/00 , A61L24/02 , A61L27/16 , A61L27/46 , A61L27/50 , A61L24/04 , A61B17/00
CPC分类号： A61L24/06 , A61B17/8805 , A61B17/8822 , A61B17/8833 , A61B2017/00022 , A61L24/0084 , A61L24/02 , A61L24/043 , A61L27/16 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.

7. 发明申请

US20100249793A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20100249793A1
公开(公告)日：2010-09-30
申请号：US12728127
申请日：2010-03-19
申请人： Csaba Truckai , Andrew Kohm , John Shadduck
发明人： Csaba Truckai , Andrew Kohm , John Shadduck
IPC分类号： A61B17/58
CPC分类号： A61B17/8836 , A61B17/8822 , A61B90/98 , A61B2017/00084
摘要： Systems and methods for treating vertebral compression fractures are provided. A kit can include at least one body containing a bone cement precursor to be mixed with at least one other bone cement precursor to form a bone cement. The body or a package containing the body can include at least one sensor. In some embodiments the sensor can be a temperature sensor. In some methods, data from the sensor can be used to determine certain parameters related to a treatment interval involving the bone cement.
摘要翻译：提供了治疗椎体压缩性骨折的系统和方法。试剂盒可以包括至少一个含有待与至少一种其他骨水泥前体混合以形成骨粘固剂的骨水泥前体的主体。身体或包含身体的包装可以包括至少一个传感器。在一些实施例中，传感器可以是温度传感器。在一些方法中，可以使用来自传感器的数据来确定与涉及骨水泥的治疗间隔相关的某些参数。

8. 发明授权

US08562620B2 Bone treatment systems 有权
标题翻译：骨治疗系统
公开(公告)号：US08562620B2
公开(公告)日：2013-10-22
申请号：US12427531
申请日：2009-04-21
申请人： Csaba Truckai , Andrew Kohm , John Shadduck
发明人： Csaba Truckai , Andrew Kohm , John Shadduck
IPC分类号： A61B17/58
CPC分类号： A61B17/8805 , A61B17/7095 , A61B17/8822 , A61B17/8827
摘要： Systems, bone cements and methods for treating vertebral compression fractures can utilize a bone cement comprising of a mixable liquid monomer component and a non-liquid component including polymer particles, wherein the non-liquid component is configured for controlled exposure to the liquid monomer over a setting interval of the bone cement. In a method of use, liquid and non-liquid components are mixed, and the bone cement is injected into bone wherein a lengthened setting interval is provided in which the mixture is configured for a flowability that prevents unwanted extravasation.
摘要翻译：用于治疗脊椎压缩性骨折的系统，骨水泥和方法可以利用包含可混合液体单体组分和包括聚合物颗粒在内的非液体组分的骨粘固剂，其中非液体组分构造成用于通过液体单体控制暴露于液体单体骨水泥的设定间隔。在使用方法中，将液体和非液体组分混合，并将骨粘固剂注入到骨中，其中提供了延长的凝固间隔，其中混合物配置为防止不想要的外渗的流动性。

9. 发明授权

US09161798B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US09161798B2
公开(公告)日：2015-10-20
申请号：US12728127
申请日：2010-03-19
申请人： Csaba Truckai , Andrew Kohm , John Shadduck
发明人： Csaba Truckai , Andrew Kohm , John Shadduck
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00 , A61B17/88 , A61B17/00 , A61B19/00
CPC分类号： A61B17/8836 , A61B17/8822 , A61B90/98 , A61B2017/00084
摘要： Systems and methods for treating vertebral compression fractures are provided. A kit can include at least one body containing a bone cement precursor to be mixed with at least one other bone cement precursor to form a bone cement. The body or a package containing the body can include at least one sensor. In some embodiments the sensor can be a temperature sensor. In some methods, data from the sensor can be used to determine certain parameters related to a treatment interval involving the bone cement.
摘要翻译：提供了治疗椎体压缩性骨折的系统和方法。试剂盒可以包括至少一个含有待与至少一种其他骨水泥前体混合以形成骨粘固剂的骨水泥前体的主体。身体或包含身体的包装可以包括至少一个传感器。在一些实施例中，传感器可以是温度传感器。在一些方法中，可以使用来自传感器的数据来确定与涉及骨水泥的治疗间隔相关的某些参数。

10. 发明申请

US20090292290A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20090292290A1
公开(公告)日：2009-11-26
申请号：US12427531
申请日：2009-04-21
申请人： Csaba Truckai , Andrew Kohm , John Shadduck
发明人： Csaba Truckai , Andrew Kohm , John Shadduck
IPC分类号： A61B17/58
CPC分类号： A61B17/8805 , A61B17/7095 , A61B17/8822 , A61B17/8827
摘要： Systems, bone cements and methods for treating vertebral compression fractures can utilize a bone cement comprising of a mixable liquid monomer component and a non-liquid component including polymer particles, wherein the non-liquid component is configured for controlled exposure to the liquid monomer over a setting interval of the bone cement. In a method of use, liquid and non-liquid components are mixed, and the bone cement is injected into bone wherein a lengthened setting interval is provided in which the mixture is configured for a flowability that prevents unwanted extravasation.
摘要翻译：用于治疗脊椎压缩性骨折的系统，骨水泥和方法可以利用包含可混合液体单体组分和包括聚合物颗粒在内的非液体组分的骨粘固剂，其中非液体组分构造成用于通过液体单体控制暴露于液体单体骨水泥的设定间隔。在使用方法中，将液体和非液体组分混合，并将骨粘固剂注入到骨中，其中提供了延长的凝固间隔，其中混合物配置为防止不想要的外渗的流动性。

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